1,3-dipropyl-8-cyclopentylxanthine has been researched along with Anoxemia in 39 studies
DPCPX : An oxopurine that is 7H-xanthine substituted at positions 1 and 3 by propyl groups and at position 8 by a cyclohexyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Adenosine is a neuromodulator that protects neurons from hypoxia." | 7.83 | Adenosine A₁ receptors control the metabolic recovery after hypoxia in rat hippocampal slices. ( Carvalho, RA; Cunha, RA; Duarte, JM, 2016) |
| " We have investigated how CHU affects cardiovascular responses evoked by acute systemic hypoxia in adult male offspring, recognising that adenosine contributes to hypoxia-induced muscle vasodilatation and bradycardia by acting on A(1) receptors in normal (N) rats." | 7.76 | Effects of maternal hypoxia on muscle vasodilatation evoked by acute systemic hypoxia in adult rat offspring: changed roles of adenosine and A1 receptors. ( Coney, AM; Marshall, JM, 2010) |
| "The present study was undertaken to investigate adenosine as a simultaneous mediator of hypoxia-induced hyperventilation and regulated hypothermia in the anteroventral preoptic region (AVPO), the thermointegrative region of the central nervous system (CNS)." | 7.73 | Respiratory and body temperature modulation by adenosine A1 receptors in the anteroventral preoptic region during normoxia and hypoxia. ( Barros, RC; Branco, LG; Cárnio, EC, 2006) |
| " In anaesthetised rats, the increase in femoral vascular conductance (FVC) evoked by moderate systemic hypoxia is mediated by adenosine acting on A(1) receptors." | 7.71 | Oxygen delivery and oxygen consumption in rat hindlimb during systemic hypoxia: role of adenosine. ( Edmunds, NJ; Marshall, JM, 2001) |
| " In anaesthetized rats we tested responses evoked by systemic hypoxia (breathing 8% O2 for 5 min) and adenosine (i." | 7.70 | Adenosine receptor subtypes and vasodilatation in rat skeletal muscle during systemic hypoxia: a role for A1 receptors. ( Bryan, PT; Marshall, JM, 1999) |
| "The effects of adenosinergic antagonists caffeine and DPCPX, and of the adenosinergic agonists L-PIA, CPA and CGS 21680 were investigated on fully and partially reversible hypoxia-induced electrophysiological changes in rat hippocampal slices." | 7.68 | Effects of adenosinergic drugs on hypoxia-induced electrophysiological changes in rat hippocampal slices. ( Domenici, MR; Frank, C; Sagratella, S; Scotti de Carolis, A; Zeng, YC, 1992) |
| "Adenosine is a neuromodulator that protects neurons from hypoxia." | 3.83 | Adenosine A₁ receptors control the metabolic recovery after hypoxia in rat hippocampal slices. ( Carvalho, RA; Cunha, RA; Duarte, JM, 2016) |
| " We have investigated how CHU affects cardiovascular responses evoked by acute systemic hypoxia in adult male offspring, recognising that adenosine contributes to hypoxia-induced muscle vasodilatation and bradycardia by acting on A(1) receptors in normal (N) rats." | 3.76 | Effects of maternal hypoxia on muscle vasodilatation evoked by acute systemic hypoxia in adult rat offspring: changed roles of adenosine and A1 receptors. ( Coney, AM; Marshall, JM, 2010) |
| "The present study was undertaken to investigate adenosine as a simultaneous mediator of hypoxia-induced hyperventilation and regulated hypothermia in the anteroventral preoptic region (AVPO), the thermointegrative region of the central nervous system (CNS)." | 3.73 | Respiratory and body temperature modulation by adenosine A1 receptors in the anteroventral preoptic region during normoxia and hypoxia. ( Barros, RC; Branco, LG; Cárnio, EC, 2006) |
| "Hypoxia-evoked vasodilatation is a fundamental regulatory mechanism that is often attributed to adenosine." | 3.72 | Does nitric oxide allow endothelial cells to sense hypoxia and mediate hypoxic vasodilatation? In vivo and in vitro studies. ( Edmunds, NJ; Marshall, JM; Moncada, S, 2003) |
| " Seven minutes before hypoxia reoxygenation, muscles were exposed to 4 min of hypoxia and 7 min of reoxygenation or 15 min of sevoflurane at concentrations of 1, 2, and 3%." | 3.72 | Mechanisms of sevoflurane-induced myocardial preconditioning in isolated human right atria in vitro. ( Babatasi, G; Bricard, H; Ducouret, P; Gérard, JL; Haelewyn, B; Hanouz, JL; Khayat, A; Massetti, M; Terrien, X; Yvon, A, 2003) |
| " In anaesthetised rats, the increase in femoral vascular conductance (FVC) evoked by moderate systemic hypoxia is mediated by adenosine acting on A(1) receptors." | 3.71 | Oxygen delivery and oxygen consumption in rat hindlimb during systemic hypoxia: role of adenosine. ( Edmunds, NJ; Marshall, JM, 2001) |
| " In anaesthetized rats we tested responses evoked by systemic hypoxia (breathing 8% O2 for 5 min) and adenosine (i." | 3.70 | Adenosine receptor subtypes and vasodilatation in rat skeletal muscle during systemic hypoxia: a role for A1 receptors. ( Bryan, PT; Marshall, JM, 1999) |
| "In an in vitro preparation of the intact carotid body (CB) of the rabbit, adenosine (100 microM) inhibited hypoxia-induced catecholamine release by 25%." | 3.70 | Adenosine inhibits L-type Ca2+ current and catecholamine release in the rabbit carotid body chemoreceptor cells. ( Almaraz, L; Gonzalez, C; Rocher, A, 1999) |
| "The effects of adenosinergic antagonists caffeine and DPCPX, and of the adenosinergic agonists L-PIA, CPA and CGS 21680 were investigated on fully and partially reversible hypoxia-induced electrophysiological changes in rat hippocampal slices." | 3.68 | Effects of adenosinergic drugs on hypoxia-induced electrophysiological changes in rat hippocampal slices. ( Domenici, MR; Frank, C; Sagratella, S; Scotti de Carolis, A; Zeng, YC, 1992) |
| "Although the physiology of anoxia tolerance has been much studied, the adaptations that permit survival of reoxygenation stress have been largely ignored." | 1.34 | Suppression of reactive oxygen species production enhances neuronal survival in vitro and in vivo in the anoxia-tolerant turtle Trachemys scripta. ( Kara, L; Kesaraju, S; Milton, SL; Nayak, G; Prentice, HM, 2007) |
| "DPCPX administration hindered the hypoxemia-induced decrease in GFR and diuresis." | 1.32 | Renal effects of adenosine A1-receptor blockade with 8-cyclopentyl-1,3-dipropylxanthine in hypoxemic newborn rabbits. ( Guignard, JP; Mosig, D; Prévot, A; Rijtema, M, 2003) |
| "During anoxia, however, these antagonists provoked maximal efflux of K+ (anoxic depolarization)." | 1.29 | Adenosine, a "retaliatory" metabolite, promotes anoxia tolerance in turtle brain. ( Lutz, PL; Pérez-Pinzón, MA; Rosenthal, M; Sick, TJ, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 16 (41.03) | 18.2507 |
| 2000's | 17 (43.59) | 29.6817 |
| 2010's | 6 (15.38) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Huang, W | 1 |
| Bai, S | 1 |
| Zuo, X | 1 |
| Tang, W | 1 |
| Chen, P | 1 |
| Chen, X | 1 |
| Wang, G | 1 |
| Wang, H | 1 |
| Xie, P | 1 |
| Jarosch, MS | 1 |
| Gebhardt, C | 1 |
| Fano, S | 1 |
| Huchzermeyer, C | 1 |
| Ul Haq, R | 1 |
| Behrens, CJ | 1 |
| Heinemann, U | 1 |
| Duarte, JM | 1 |
| Cunha, RA | 2 |
| Carvalho, RA | 1 |
| Maeda, T | 1 |
| Koos, BJ | 2 |
| Coney, AM | 1 |
| Marshall, JM | 5 |
| Zhang, D | 1 |
| Xiong, W | 1 |
| Albensi, BC | 1 |
| Parkinson, FE | 1 |
| Cipriani, R | 1 |
| Villa, P | 1 |
| Chece, G | 1 |
| Lauro, C | 1 |
| Paladini, A | 1 |
| Micotti, E | 1 |
| Perego, C | 1 |
| De Simoni, MG | 1 |
| Fredholm, BB | 2 |
| Eusebi, F | 1 |
| Limatola, C | 1 |
| Edmunds, NJ | 2 |
| Moncada, S | 1 |
| Prévot, A | 1 |
| Mosig, D | 1 |
| Rijtema, M | 1 |
| Guignard, JP | 1 |
| Yvon, A | 1 |
| Hanouz, JL | 1 |
| Haelewyn, B | 1 |
| Terrien, X | 1 |
| Massetti, M | 1 |
| Babatasi, G | 1 |
| Khayat, A | 1 |
| Ducouret, P | 1 |
| Bricard, H | 1 |
| Gérard, JL | 1 |
| Pugliese, AM | 1 |
| Latini, S | 1 |
| Corradetti, R | 1 |
| Pedata, F | 1 |
| Hammond, LC | 1 |
| Bonnet, C | 1 |
| Kemp, PJ | 1 |
| Yates, MS | 1 |
| Bowmer, CJ | 1 |
| Kawasaki, Y | 1 |
| Kim, YH | 1 |
| Bohorquez, F | 1 |
| Barros, RC | 1 |
| Branco, LG | 1 |
| Cárnio, EC | 1 |
| Walsh, MP | 1 |
| Conde, SV | 1 |
| Obeso, A | 1 |
| Vicario, I | 1 |
| Rigual, R | 1 |
| Rocher, A | 2 |
| Gonzalez, C | 2 |
| Milton, SL | 1 |
| Nayak, G | 1 |
| Kesaraju, S | 1 |
| Kara, L | 1 |
| Prentice, HM | 1 |
| Fewell, JE | 1 |
| Zhang, C | 1 |
| Gillis, AM | 1 |
| Sperlágh, B | 1 |
| Zsilla, G | 1 |
| Baranyi, M | 1 |
| Illes, P | 1 |
| Vizi, ES | 1 |
| Brust, TB | 1 |
| Cayabyab, FS | 1 |
| MacVicar, BA | 1 |
| Schmidt, C | 1 |
| Bellingham, MC | 1 |
| Richter, DW | 1 |
| Canhão, P | 1 |
| de Mendonça, A | 3 |
| Ribeiro, JA | 3 |
| Hara, A | 1 |
| Abiko, Y | 1 |
| Randall, MD | 1 |
| Ujiie, H | 1 |
| Griffith, TM | 1 |
| Kacimi, R | 1 |
| Richalet, JP | 1 |
| Crozatier, B | 1 |
| Katchman, AN | 1 |
| Hershkowitz, N | 1 |
| Pérez-Pinzón, MA | 2 |
| Lutz, PL | 2 |
| Sick, TJ | 1 |
| Rosenthal, M | 1 |
| Lasley, RD | 1 |
| Anderson, GM | 1 |
| Mentzer, RM | 1 |
| Croning, MD | 1 |
| Zetterström, TS | 1 |
| Grahame-Smith, DG | 1 |
| Newberry, NR | 1 |
| Gleiter, CH | 1 |
| Brause, M | 1 |
| Delabar, U | 1 |
| Zebski, H | 1 |
| Eckardt, KU | 1 |
| Bryan, PT | 1 |
| Almaraz, L | 1 |
| Manuel, L | 1 |
| Born, JG | 1 |
| Centeno, JM | 1 |
| Sebastião, AM | 1 |
| Adén, U | 1 |
| Leverin, AL | 1 |
| Hagberg, H | 1 |
| Zeng, YC | 1 |
| Domenici, MR | 1 |
| Frank, C | 1 |
| Sagratella, S | 1 |
| Scotti de Carolis, A | 1 |
39 other studies available for 1,3-dipropyl-8-cyclopentylxanthine and Anoxemia
| Article | Year |
|---|---|
An adenosine A1R-A2aR imbalance regulates low glucose/hypoxia-induced microglial activation, thereby contributing to oligodendrocyte damage through NF-κB and CREB phosphorylation.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Animals; CREB-Binding Protein; Glucose; Hypoxia; Microgli | 2018 |
Early adenosine release contributes to hypoxia-induced disruption of stimulus-induced sharp wave-ripple complexes in rat hippocampal area CA3.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Animals; Bicuculline; CA3 Region, Hippocampal; Excitat | 2015 |
Adenosine A₁ receptors control the metabolic recovery after hypoxia in rat hippocampal slices.
Topics: Adenosine; Animals; Excitatory Postsynaptic Potentials; Hippocampus; Hypoxia; Male; Neurons; Recepto | 2016 |
Adenosine A1 and A2a receptors modulate insulinemia, glycemia, and lactatemia in fetal sheep.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Blood Gas | 2009 |
Effects of maternal hypoxia on muscle vasodilatation evoked by acute systemic hypoxia in adult rat offspring: changed roles of adenosine and A1 receptors.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Animals; Bradycardia; Endothelium, Vascular; Female; H | 2010 |
Expression of human equilibrative nucleoside transporter 1 in mouse neurons regulates adenosine levels in physiological and hypoxic-ischemic conditions.
Topics: Action Potentials; Adenosine; Adenosine A1 Receptor Antagonists; Animals; Dose-Response Relationship | 2011 |
CX3CL1 is neuroprotective in permanent focal cerebral ischemia in rodents.
Topics: Adenosine A1 Receptor Antagonists; Analysis of Variance; Animals; Animals, Genetically Modified; Ani | 2011 |
Does nitric oxide allow endothelial cells to sense hypoxia and mediate hypoxic vasodilatation? In vivo and in vitro studies.
Topics: Adenosine; Animals; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Hindlimb; Hypoxia; In Vitr | 2003 |
Renal effects of adenosine A1-receptor blockade with 8-cyclopentyl-1,3-dipropylxanthine in hypoxemic newborn rabbits.
Topics: Adenosine A1 Receptor Antagonists; Animals; Animals, Newborn; Glomerular Filtration Rate; Hemodynami | 2003 |
Mechanisms of sevoflurane-induced myocardial preconditioning in isolated human right atria in vitro.
Topics: Aged; Anesthetics, Inhalation; ATP-Binding Cassette Transporters; Benzamides; Decanoic Acids; Heart | 2003 |
Brief, repeated, oxygen-glucose deprivation episodes protect neurotransmission from a longer ischemic episode in the in vitro hippocampus: role of adenosine receptors.
Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Adenosine A3 Receptor Antagoni | 2003 |
Chronic hypoxia up-regulates expression of adenosine A1 receptors in DDT1-MF2 cells.
Topics: Animals; Cell Line; Cell Membrane; Cycloheximide; Dactinomycin; Hypoxia; Muscle, Smooth; Oxygen; Pro | 2004 |
Adenosine A2A-receptor blockade abolishes the roll-off respiratory response to hypoxia in awake lambs.
Topics: Adenosine A2 Receptor Antagonists; Animals; Animals, Newborn; Blood Pressure; Body Temperature; Carb | 2005 |
Respiratory and body temperature modulation by adenosine A1 receptors in the anteroventral preoptic region during normoxia and hypoxia.
Topics: Adaptation, Physiological; Adenosine; Adenosine A1 Receptor Antagonists; Aminophylline; Analysis of | 2006 |
The role of adenosine in the early respiratory and cardiovascular changes evoked by chronic hypoxia in the rat.
Topics: Adenosine; Animals; Blood Pressure; Cardiovascular System; Enzyme Inhibitors; Guanidines; Heart Rate | 2006 |
Caffeine inhibition of rat carotid body chemoreceptors is mediated by A2A and A2B adenosine receptors.
Topics: Adenosine; Animals; Caffeine; Carotid Body; Catecholamines; Central Nervous System Stimulants; Chemo | 2006 |
Suppression of reactive oxygen species production enhances neuronal survival in vitro and in vivo in the anoxia-tolerant turtle Trachemys scripta.
Topics: Adenosine Diphosphate; Animals; Brain; Cell Survival; Cells, Cultured; Hydrogen Peroxide; Hypoxia; M | 2007 |
Influence of adenosine A(1)-receptor blockade and vagotomy on the gasping and heart rate response to hypoxia in rats during early postnatal maturation.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Animals; Animals, Newb | 2007 |
Purinergic modulation of glutamate release under ischemic-like conditions in the hippocampus.
Topics: Adenosine; Adenosine Triphosphate; Analgesics; Animals; Dose-Response Relationship, Drug; Glucose; G | 2007 |
C-Jun N-terminal kinase regulates adenosine A1 receptor-mediated synaptic depression in the rat hippocampus.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Animals; Animals, Newb | 2007 |
Adenosinergic modulation of respiratory neurones and hypoxic responses in the anaesthetized cat.
Topics: Adenosine; Animals; Cats; Electric Stimulation; Female; Hypoxia; Injections; Intracellular Membranes | 1995 |
1,3-Dipropyl-8-cyclopentylxanthine attenuates the NMDA response to hypoxia in the rat hippocampus.
Topics: Animals; Evoked Potentials; Hippocampus; Hypoxia; In Vitro Techniques; Male; N-Methylaspartate; Puri | 1994 |
Protective effect of hypoxia on mechanical and metabolic changes induced by hydrogen peroxide in rat hearts.
Topics: Animals; Glyburide; Heart; Hydrogen Peroxide; Hypoxia; In Vitro Techniques; Male; Myocardium; Purine | 1995 |
Modulation of vasodilatation to levcromakalim by adenosine analogues in the rabbit ear: an explanation for hypoxic augmentation.
Topics: Adenosine; Animals; Arginine; Benzopyrans; Blood Pressure; Cromakalim; Drug Synergism; Ear, External | 1994 |
Hypoxia-induced differential modulation of adenosinergic and muscarinic receptors in rat heart.
Topics: Animals; Binding, Competitive; Hypoxia; Kinetics; Male; Models, Biological; Myocardium; Quinuclidiny | 1993 |
Adenosine antagonists prevent hypoxia-induced depression of excitatory but not inhibitory synaptic currents.
Topics: Adenosine; Animals; Electrophysiology; Hypoxia; In Vitro Techniques; Models, Neurological; Purinergi | 1993 |
Adenosine, a "retaliatory" metabolite, promotes anoxia tolerance in turtle brain.
Topics: Adenosine; Animals; Brain; Cerebellum; Hypoxia; In Vitro Techniques; Purinergic Antagonists; Theophy | 1993 |
Ischaemic and hypoxic preconditioning enhance postischaemic recovery of function in the rat heart.
Topics: Animals; Hypoxia; Male; Myocardial Ischemia; Myocardial Reperfusion; Organ Culture Techniques; Purin | 1993 |
Action of adenosine receptor antagonists on hypoxia-induced effects in the rat hippocampus in vitro.
Topics: Adenosine; Animals; Corpus Striatum; Dizocilpine Maleate; Hypoxia; Male; Membrane Potentials; Microe | 1995 |
Evidence against a major role of adenosine in oxygen-dependent regulation of erythropoietin in rats.
Topics: Adenine; Adenosine; Adenosine Diphosphate; Animals; Antihypertensive Agents; Carbon Monoxide; Dipyri | 1997 |
Contribution of metabotropic glutamate receptors to the depression of excitatory postsynaptic potentials during hypoxia.
Topics: Alanine; Animals; Benzoates; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; | 1997 |
Adenosine receptor subtypes and vasodilatation in rat skeletal muscle during systemic hypoxia: a role for A1 receptors.
Topics: Adenosine; Animals; Antihypertensive Agents; Blood Gas Analysis; Hydrogen-Ion Concentration; Hypoxia | 1999 |
Adenosine inhibits L-type Ca2+ current and catecholamine release in the rabbit carotid body chemoreceptor cells.
Topics: Adenosine; Adrenergic alpha-Antagonists; Animals; Calcium; Calcium Channel Blockers; Calcium Channel | 1999 |
Maintenance of adenosine A1 receptor function during long-term anoxia in the turtle brain.
Topics: Animals; Brain; Hypoxia; Prosencephalon; Rats; Receptors, Purinergic P1; Rhombencephalon; Time Facto | 1999 |
Calcium and increase excitability promote tolerance against anoxia in hippocampal slices.
Topics: Adaptation, Physiological; Animals; Calcium; Conditioning, Psychological; Cortical Spreading Depress | 1999 |
Modification of adenosine modulation of synaptic transmission in the hippocampus of aged rats.
Topics: Adenosine; Adenosine Deaminase; Aging; Animals; Dose-Response Relationship, Drug; Excitatory Postsyn | 2000 |
Adenosine A(1) receptor agonism in the immature rat brain and heart.
Topics: Adenosine; Animals; Animals, Newborn; Binding, Competitive; Body Temperature; Brain; Brain Ischemia; | 2001 |
Oxygen delivery and oxygen consumption in rat hindlimb during systemic hypoxia: role of adenosine.
Topics: Adenosine; Animals; Hemodynamics; Hindlimb; Hypoxia; Male; NG-Nitroarginine Methyl Ester; Nitric Oxi | 2001 |
Effects of adenosinergic drugs on hypoxia-induced electrophysiological changes in rat hippocampal slices.
Topics: Adenosine; Animals; Caffeine; Dizocilpine Maleate; Electrophysiology; Hippocampus; Hypoxia; In Vitro | 1992 |