1,3-dipropyl-8-cyclopentylxanthine has been researched along with Alzheimer Disease in 6 studies
DPCPX : An oxopurine that is 7H-xanthine substituted at positions 1 and 3 by propyl groups and at position 8 by a cyclohexyl group.
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Immunostaining of adenosine receptors in the hippocampus and cerebral cortex from necropsies of Alzheimer disease (AD) patients shows that there is a change in the pattern of expression and a redistribution of receptors in these brain areas when compared with samples from controls." | 7.72 | A1 adenosine receptors accumulate in neurodegenerative structures in Alzheimer disease and mediate both amyloid precursor protein processing and tau phosphorylation and translocation. ( Angulo, E; Canela, EI; Casadó, V; Ferrer, I; Franco, R; Lluis, C; Mallol, J; Viñals, F, 2003) |
| "Immunostaining of adenosine receptors in the hippocampus and cerebral cortex from necropsies of Alzheimer disease (AD) patients shows that there is a change in the pattern of expression and a redistribution of receptors in these brain areas when compared with samples from controls." | 3.72 | A1 adenosine receptors accumulate in neurodegenerative structures in Alzheimer disease and mediate both amyloid precursor protein processing and tau phosphorylation and translocation. ( Angulo, E; Canela, EI; Casadó, V; Ferrer, I; Franco, R; Lluis, C; Mallol, J; Viñals, F, 2003) |
| " In this study, we addressed whether the chronic administration of 8-cyclopentyl-1,3-dipropylxanthine, a potent and selective adenosine A1 antagonist, could reverse the memory deficits found in aged APPswe/PS1dE9 mice." | 1.39 | Chronic treatment with DCPCX, an adenosine A(1) antagonist, worsens long-term memory. ( Bond, RA; Eriksen, JL; Forkuo, GS; Vollert, C, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Vollert, C | 1 |
| Forkuo, GS | 1 |
| Bond, RA | 1 |
| Eriksen, JL | 1 |
| Villar-Menéndez, I | 1 |
| Díaz-Sánchez, S | 1 |
| Blanch, M | 1 |
| Albasanz, JL | 2 |
| Pereira-Veiga, T | 1 |
| Monje, A | 1 |
| Planchat, LM | 1 |
| Ferrer, I | 3 |
| Martín, M | 2 |
| Barrachina, M | 2 |
| Angulo, E | 1 |
| Casadó, V | 1 |
| Mallol, J | 1 |
| Canela, EI | 1 |
| Viñals, F | 1 |
| Lluis, C | 1 |
| Franco, R | 1 |
| Perez, S | 1 |
| Ułas, J | 1 |
| Brunner, LC | 1 |
| Nguyen, L | 1 |
| Cotman, CW | 1 |
| Jaarsma, D | 1 |
| Sebens, JB | 1 |
| Korf, J | 1 |
6 other studies available for 1,3-dipropyl-8-cyclopentylxanthine and Alzheimer Disease
| Article | Year |
|---|---|
Chronic treatment with DCPCX, an adenosine A(1) antagonist, worsens long-term memory.
Topics: Adenosine A1 Receptor Antagonists; Alzheimer Disease; Animals; Memory Disorders; Memory, Long-Term; | 2013 |
Reduced striatal adenosine A2A receptor levels define a molecular subgroup in schizophrenia.
Topics: Actins; Adenosine A1 Receptor Antagonists; Adult; Aged; Aged, 80 and over; Alzheimer Disease; Cell M | 2014 |
A1 adenosine receptors accumulate in neurodegenerative structures in Alzheimer disease and mediate both amyloid precursor protein processing and tau phosphorylation and translocation.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Aged; Alzheimer Diseas | 2003 |
Up-regulation of adenosine receptors in the frontal cortex in Alzheimer's disease.
Topics: Adenylyl Cyclases; Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Cell Membrane; | 2008 |
Reduced density of adenosine A1 receptors and preserved coupling of adenosine A1 receptors to G proteins in Alzheimer hippocampus: a quantitative autoradiographic study.
Topics: Adenosine; Aged; Aged, 80 and over; Alzheimer Disease; Autoradiography; Dizocilpine Maleate; Female; | 1993 |
Reduction of adenosine A1-receptors in the perforant pathway terminal zone in Alzheimer hippocampus.
Topics: Adenosine; Aged; Aged, 80 and over; Alzheimer Disease; Autoradiography; Female; Hippocampus; Humans; | 1991 |