1,3-dipropyl-8-cyclopentylxanthine has been researched along with Ache in 13 studies
DPCPX : An oxopurine that is 7H-xanthine substituted at positions 1 and 3 by propyl groups and at position 8 by a cyclohexyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The positive allosteric adenosine receptor modulator, T62 (2-amino-3-(4-chlorobenzoyl)-5,6,7,8-tetrahydrobenzothiophene), has been shown to reduce mechanical allodynia in a rat model of neuropathic pain." | 7.72 | Repeated dosing with oral allosteric modulator of adenosine A1 receptor produces tolerance in rats with neuropathic pain. ( Bantel, C; Childers, SR; Conklin, D; Eisenach, JC; Li, X, 2004) |
| "The positive allosteric adenosine receptor modulator, T62 (2-amino-3-(4-chlorobenzoyl)-5,6,7,8-tetrahydrobenzothiophene), has been shown to reduce mechanical allodynia in a rat model of neuropathic pain." | 3.72 | Repeated dosing with oral allosteric modulator of adenosine A1 receptor produces tolerance in rats with neuropathic pain. ( Bantel, C; Childers, SR; Conklin, D; Eisenach, JC; Li, X, 2004) |
| "Adenosine and adenosine agonists reduce hypersensitivity following inflammation and peripheral nerve injury models of chronic pain." | 3.71 | Allosteric adenosine modulation to reduce allodynia. ( Eisenach, JC; Leung, E; Pan, HL; Xu, Z, 2001) |
| "These data show that prolonged alleviation of hypersensitivity observed with intrathecal adenosine in this animal model of neuropathic pain is not due to prolonged residence in cerebrospinal fluid, although pharmacokinetics in tissues are unknown." | 3.71 | Intrathecal adenosine following spinal nerve ligation in rat: short residence time in cerebrospinal fluid and no change in A(1) receptor binding. ( Bantel, C; Chen, SR; Childers, SR; Eisenach, JC; Li, X; Tobin, JR, 2002) |
| "Acetaminophen (paracetamol) is a widely used analgesic, but its sites and mechanisms of action remain incompletely understood." | 1.39 | Antinociception by systemically-administered acetaminophen (paracetamol) involves spinal serotonin 5-HT7 and adenosine A1 receptors, as well as peripheral adenosine A1 receptors. ( Liu, J; Reid, AR; Sawynok, J, 2013) |
| "Gabapentin and R-PIA were administered to obtain the dose-response curve and the 50% effective dose (ED(50))." | 1.35 | The interaction of gabapentin and N6-(2-phenylisopropyl)-adenosine R-(-)isomer (R-PIA) on mechanical allodynia in rats with a spinal nerve ligation. ( Jun, IG; Park, JY, 2008) |
| "Allopurinol is a potent inhibitor of the enzyme xanthine oxidase, used primarily in the treatment of hyperuricemia and gout." | 1.35 | Anti-nociceptive properties of the xanthine oxidase inhibitor allopurinol in mice: role of A1 adenosine receptors. ( Antunes, C; Böhmer, AE; Elisabetsky, E; Lara, DR; Porciúncula, LO; Schallenberger, C; Schmidt, AP; Souza, DO, 2009) |
| "Morphine and R-PIA were administered to obtain the dose-response curve and the 50% effective dose (ED(50))." | 1.33 | Morphine can enhance the antiallodynic effect of intrathecal R-PIA in rats with nerve ligation injury. ( Cho, SK; Han, SM; Hwang, GS; Hwang, JH, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (7.69) | 18.2507 |
| 2000's | 11 (84.62) | 29.6817 |
| 2010's | 1 (7.69) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, H | 1 |
| Altenbach, RJ | 1 |
| Carr, TL | 1 |
| Chandran, P | 1 |
| Hsieh, GC | 1 |
| Lewis, LG | 1 |
| Manelli, AM | 1 |
| Milicic, I | 1 |
| Marsh, KC | 1 |
| Miller, TR | 1 |
| Strakhova, MI | 1 |
| Vortherms, TA | 1 |
| Wakefield, BD | 1 |
| Wetter, JM | 1 |
| Witte, DG | 1 |
| Honore, P | 1 |
| Esbenshade, TA | 1 |
| Brioni, JD | 1 |
| Cowart, MD | 1 |
| Park, JY | 1 |
| Jun, IG | 1 |
| Schmidt, AP | 1 |
| Böhmer, AE | 1 |
| Antunes, C | 1 |
| Schallenberger, C | 1 |
| Porciúncula, LO | 1 |
| Elisabetsky, E | 1 |
| Lara, DR | 1 |
| Souza, DO | 1 |
| Liu, J | 1 |
| Reid, AR | 1 |
| Sawynok, J | 1 |
| Tanase, D | 1 |
| Baghdoyan, HA | 1 |
| Lydic, R | 1 |
| Furuta, S | 1 |
| Onodera, K | 1 |
| Kumagai, M | 1 |
| Honma, I | 1 |
| Miyazaki, S | 1 |
| Sato, T | 1 |
| Sakurada, S | 1 |
| Li, X | 2 |
| Bantel, C | 2 |
| Conklin, D | 1 |
| Childers, SR | 2 |
| Eisenach, JC | 3 |
| Hwang, JH | 1 |
| Hwang, GS | 1 |
| Cho, SK | 1 |
| Han, SM | 1 |
| Malec, D | 1 |
| Poleszak, E | 1 |
| Vuckovic, S | 1 |
| Tomic, M | 1 |
| Stepanovic-Petrovic, R | 1 |
| Ugresic, N | 1 |
| Prostran, M | 1 |
| Boskovic, B | 1 |
| Khandwala, H | 1 |
| Zhang, Z | 1 |
| Loomis, CW | 1 |
| Pan, HL | 1 |
| Xu, Z | 1 |
| Leung, E | 1 |
| Tobin, JR | 1 |
| Chen, SR | 1 |
13 other studies available for 1,3-dipropyl-8-cyclopentylxanthine and Ache
| Article | Year |
|---|---|
cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzofurans; Carrageenan; Disease Models, Animal; | 2008 |
The interaction of gabapentin and N6-(2-phenylisopropyl)-adenosine R-(-)isomer (R-PIA) on mechanical allodynia in rats with a spinal nerve ligation.
Topics: Adenosine; Amines; Animals; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Drug Syne | 2008 |
Anti-nociceptive properties of the xanthine oxidase inhibitor allopurinol in mice: role of A1 adenosine receptors.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor | 2009 |
Antinociception by systemically-administered acetaminophen (paracetamol) involves spinal serotonin 5-HT7 and adenosine A1 receptors, as well as peripheral adenosine A1 receptors.
Topics: Acetaminophen; Adenosine A1 Receptor Antagonists; Analgesics, Non-Narcotic; Animals; Male; Mice; Mic | 2013 |
Microinjection of an adenosine A1 agonist into the medial pontine reticular formation increases tail flick latency to thermal stimulation.
Topics: Analgesics; Animals; Cats; Hot Temperature; Male; Microinjections; Pain; Purinergic P1 Receptor Agon | 2002 |
Involvement of adenosine A1 receptors in forced walking stress-induced analgesia in mice.
Topics: Adenosine A1 Receptor Antagonists; Analgesia; Animals; Behavior, Animal; Formaldehyde; Male; Mice; M | 2003 |
Repeated dosing with oral allosteric modulator of adenosine A1 receptor produces tolerance in rats with neuropathic pain.
Topics: Adenosine; Administration, Oral; Allosteric Regulation; Animals; Drug Tolerance; Male; Pain; Rats; R | 2004 |
Morphine can enhance the antiallodynic effect of intrathecal R-PIA in rats with nerve ligation injury.
Topics: Adenosine A1 Receptor Agonists; Analgesics, Opioid; Animals; Circadian Rhythm; Dose-Response Relatio | 2005 |
Adenosine receptor ligands and dizocilpine-induced antinociception in mice.
Topics: Acetic Acid; Animals; Behavior, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Male | 2005 |
Peripheral antinociception by carbamazepine in an inflammatory mechanical hyperalgesia model in the rat: a new target for carbamazepine?
Topics: Analgesics; Animals; Caffeine; Carbamazepine; Concanavalin A; Disease Models, Animal; Dose-Response | 2006 |
Inhibition of strychnine-allodynia is mediated by spinal adenosine A1- but not A2-receptors in the rat.
Topics: Adenosine; Animals; Blood Pressure; Caffeine; Heart Rate; Injections, Spinal; Male; Pain; Phenethyla | 1998 |
Allosteric adenosine modulation to reduce allodynia.
Topics: Adenosine; Animals; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Injections, Spina | 2001 |
Intrathecal adenosine following spinal nerve ligation in rat: short residence time in cerebrospinal fluid and no change in A(1) receptor binding.
Topics: Adenosine; Analgesics; Animals; Injections, Spinal; Ligation; Male; Microdialysis; Pain; Radioligand | 2002 |