1,3-dipropyl-8-(4-sulfophenyl)xanthine has been researched along with Hypertension in 22 studies
1,3-dipropyl-8-(4-sulfophenyl)xanthine: adenosine receptor antagonist
Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Captopril was given (30 or 100 mg kg(-l) day(-l); p." | 1.31 | Angiotensin converting enzyme inhibition prevents trophic and hypertensive effects of an antagonist of adenosine receptors. ( Albino-Teixeira, A; Morato, M; Sousa, T, 2002) |
| "The study was undertaken to test the endothelium-mediated vascular responses in rats rendered hypertensive by chronic administration of 1,3-dipropyl-8-sulphophenylxanthine (DPSPX)." | 1.30 | Endothelium-dependent vascular responses in 1,3-dipropyl-8-sulphophenylxanthine (DPSPX) hypertensive rats. ( Albino-Teixeira, A; Paiva, MQ; Santos, MJ, 1997) |
| " Long-term administration of the adenosine receptor antagonist, 1,3-dipropyl-8-sulfophenylxanthine (DPSPX), causes arterial hypertension and cardiovascular hypertrophic and hyperplastic changes (Matias, Albino-Teixeira, Polónia & Azevedo, 1991)." | 1.30 | Prevention by a somatostatin analogue of the hypertensive and cardiovascular structural changes induced by blockade of adenosine receptors. ( Alçada, MN; Azevedo, I; Calhau, C; Martel, F, 1997) |
| "Adenosine is an ubiquitously occurring endogenous nucleoside that via cell surface receptors exerts multiple antihypertensive actions, and mediates a number of biological responses that may reduce cardiovascular disease risk." | 1.30 | Effects of adenosine deaminase inhibition on blood pressure in old spontaneously hypertensive rats. ( Jackson, EK; Kusaka, H; Li, P; Tofovic, SP, 1998) |
| " The study was undertaken to compare the beta-adrenoceptor-mediated facilitation of noradrenaline release in the tail artery of vehicle-treated rats and of rats rendered hypertensive by chronic administration of 1,3-dipropyl-8-sulphophenylxanthine (DPSPX)." | 1.29 | Hypertension and enhanced beta-adrenoceptor-mediated facilitation of noradrenaline release produced by chronic blockade of adenosine receptors. ( Albino-Teixeira, A; Guimarães, S; Paiva, MQ, 1995) |
| "Adenosine has been shown recently to be the main factor responsible for the trophic effects of sympathetic innervation." | 1.28 | Long-term administration of 1,3-dipropyl-8-sulfophenylxanthine causes arterial hypertension. ( Albino-Teixeira, A; Azevedo, I; Matias, A; Polónia, J, 1991) |
| " Antagonism of adenosine receptors with 1,3-dipropyl-8-p-sulfophenylxanthine shifted the dose-response curve to exogenous adenosine sixfold to the right yet did not influence vascular responses to PNS or NE in either SHR or WKY." | 1.27 | Role of adenosine in noradrenergic neurotransmission in spontaneously hypertensive rats. ( Jackson, EK, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.55) | 18.7374 |
| 1990's | 11 (50.00) | 18.2507 |
| 2000's | 10 (45.45) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sousa, T | 9 |
| Pinho, D | 4 |
| Morato, M | 9 |
| Marques-Lopes, J | 1 |
| Fernandes, E | 2 |
| Afonso, J | 1 |
| Oliveira, S | 1 |
| Carvalho, F | 2 |
| Albino-Teixeira, A | 15 |
| Guimarães, S | 7 |
| Moura, D | 4 |
| Tavares, I | 2 |
| Jackson, EK | 3 |
| Mi, Z | 1 |
| Dubey, RK | 1 |
| Rubino, A | 2 |
| Burnstock, G | 2 |
| Paiva, MQ | 3 |
| Vaz-da-Silva, MJ | 1 |
| Relevic, V | 1 |
| Santos, MJ | 1 |
| Calhau, C | 1 |
| Martel, F | 1 |
| Alçada, MN | 1 |
| Azevedo, I | 3 |
| Tofovic, SP | 1 |
| Kusaka, H | 1 |
| Li, P | 1 |
| Matias, A | 2 |
| Polónia, J | 2 |
| Persson, MG | 1 |
| Ohlén, A | 1 |
| Lindbom, L | 1 |
| Hedqvist, P | 1 |
| Gustafsson, LE | 1 |
2 reviews available for 1,3-dipropyl-8-(4-sulfophenyl)xanthine and Hypertension
| Article | Year |
|---|---|
Hypertension due to blockade of adenosine receptors.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Heart; Hypertension; Norepinephrine; Purinergic P1 | 2003 |
Hypertension due to chronic blockade of P1-purinoceptors.
Topics: Animals; Hypertension; Mesenteric Arteries; Myocardial Contraction; Purinergic P1 Receptor Antagonis | 1996 |
20 other studies available for 1,3-dipropyl-8-(4-sulfophenyl)xanthine and Hypertension
| Article | Year |
|---|---|
Role of superoxide and hydrogen peroxide in hypertension induced by an antagonist of adenosine receptors.
Topics: Acetophenones; Animals; Blood Vessels; Catalase; Hydrogen Peroxide; Hypertension; Lipid Peroxidation | 2008 |
The role of angiotensin II in hypertension due to adenosine receptors blockade.
Topics: Angiotensin II; Animals; Blood Pressure; Dose-Response Relationship, Drug; Hypertension; In Vitro Te | 2002 |
Losartan and atenolol on hypertension induced by adenosine receptor blockade.
Topics: Administration, Oral; Adrenergic beta-1 Receptor Antagonists; Angiotensin II Type 2 Receptor Blocker | 2003 |
Xanthine oxidase inhibition by 1,3-dipropyl-8-sulfophenylxanthine (DPSPX), an antagonist of adenosine receptors.
Topics: Animals; Blood Pressure; Cardiovascular Diseases; Free Radical Scavengers; Hypertension; Oxidants; O | 2004 |
Pre- and postjunctional effects of angiotensin II in hypertension due to adenosine receptor blockade.
Topics: Angiotensin II; Animals; Blood Pressure; Dose-Response Relationship, Drug; Electric Stimulation; Hyp | 2006 |
Inhibition of nociceptive responses of spinal cord neurones during hypertension involves the spinal GABAergic system and a pain modulatory center located at the caudal ventrolateral medulla.
Topics: Animals; Blood Pressure; gamma-Aminobutyric Acid; Gene Expression; Genes, fos; Hindlimb; Hypertensio | 2006 |
Lesion of the caudal ventrolateral medulla prevents the induction of hypertension by adenosine receptor blockade in rats.
Topics: Analysis of Variance; Animals; Blood Pressure; Hypertension; Male; Medulla Oblongata; Purinergic P1 | 2006 |
The extracellular cAMP-adenosine pathway significantly contributes to the in vivo production of adenosine.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Animals; Cyclic AMP; Hypertension; Male; Rats; Rats, Inbred | 2007 |
Changes in sympathetic neurotransmission and adrenergic control of cardiac contractility during 1,3-dipropyl-8-sulfophenylxanthine-induced hypertension.
Topics: Adenosine; Adrenergic beta-Agonists; Animals; Calcium; Cardiotonic Agents; Depression, Chemical; Dis | 1995 |
Hypertension and enhanced beta-adrenoceptor-mediated facilitation of noradrenaline release produced by chronic blockade of adenosine receptors.
Topics: Animals; Arteries; Dose-Response Relationship, Drug; Electric Stimulation; Hypertension; Isoproteren | 1995 |
Long-term administration of 1,3-dipropyl-8-sulphophenylxanthine (DPSPX) alters alpha 2-adrenoceptor-mediated effects at the pre- but not at the postjunctional level.
Topics: Adrenergic alpha-Agonists; Animals; Arginine; Arteries; Brimonidine Tartrate; Hypertension; Male; Ne | 1994 |
Augmented sensory-motor vasodilatation of the rat mesenteric arterial bed after chronic infusion of the P1-purinoceptor antagonist, DPSPX.
Topics: Adenosine; Animals; Calcitonin Gene-Related Peptide; Electric Stimulation; Hypertension; In Vitro Te | 1996 |
Endothelium-dependent vascular responses in 1,3-dipropyl-8-sulphophenylxanthine (DPSPX) hypertensive rats.
Topics: Animals; Blood Pressure; Carbachol; Endothelium, Vascular; Hypertension; Male; NG-Nitroarginine Meth | 1997 |
Prevention by a somatostatin analogue of the hypertensive and cardiovascular structural changes induced by blockade of adenosine receptors.
Topics: Animals; Blood Pressure; Hormones; Hypertension; Muscle, Smooth, Vascular; Octreotide; Purinergic P1 | 1997 |
Effects of adenosine deaminase inhibition on blood pressure in old spontaneously hypertensive rats.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Aging; Animals; Blood Pressure; Enzyme Inhibitor | 1998 |
Angiotensin converting enzyme inhibition prevents trophic and hypertensive effects of an antagonist of adenosine receptors.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Arteries; Blood Pressure; Body Weight; Captopril; | 2002 |
Blockade of adenosine receptors causes hypertension and cardiovascular structural changes in the rat.
Topics: Adenosine; Animals; Arteries; Blood Pressure; Dose-Response Relationship, Drug; Hypertension; Mesent | 1991 |
Role of adenosine in functional hyperemia in skeletal muscle as indicated by pharmacological tools.
Topics: Adenosine; Administration, Topical; Animals; Arterioles; Dipyridamole; Dose-Response Relationship, D | 1991 |
Long-term administration of 1,3-dipropyl-8-sulfophenylxanthine causes arterial hypertension.
Topics: Adenosine; Animals; Arteries; Blood Pressure; Blood Vessels; Hypertension; In Vitro Techniques; Musc | 1991 |
Role of adenosine in noradrenergic neurotransmission in spontaneously hypertensive rats.
Topics: Adenosine; Animals; Blood Pressure; Dose-Response Relationship, Drug; Electric Stimulation; Hyperten | 1987 |