Compounds > 1-2-oleoylphosphatidylcholine

1-2-oleoylphosphatidylcholine and Brain-Neoplasms

1-2-oleoylphosphatidylcholine has been researched along with Brain-Neoplasms* in 2 studies

Other Studies

2 other study(ies) available for 1-2-oleoylphosphatidylcholine and Brain-Neoplasms

Article	Year
Peptide density targets and impedes triple negative breast cancer metastasis. Nature communications, 2018, 07-04, Volume: 9, Issue:1 The C-X-C chemokine receptor type 4 (CXCR4, CD184) pathway is a key regulator of cancer metastasis. Existing therapeutics that block CXCR4 signaling are dependent on single molecule-receptor interactions or silencing CXCR4 expression. CXCR4 localizes in lipid rafts and forms dimers therefore CXCR4 targeting and signaling may depend on ligand density. Herein, we report liposomes presenting a CXCR4 binding peptide (DV1) as a three-dimensional molecular array, ranging from 9k to 74k molecules μm Topics: Animals; Antineoplastic Agents; Binding, Competitive; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Female; Gene Expression; Genes, Reporter; Humans; Liposomes; Liver Neoplasms; Luciferases; Lung Neoplasms; Membrane Microdomains; Mice; Mice, Nude; Peptides; Phosphatidylcholines; Phosphatidylethanolamines; Polyethylene Glycols; Protein Binding; Receptors, CXCR4; Triple Negative Breast Neoplasms; Xenograft Model Antitumor Assays	2018
Liposomally formulated phospholipid-conjugated indocyanine green for intra-operative brain tumor detection and resection. International journal of pharmaceutics, 2015, Dec-30, Volume: 496, Issue:2 Some tumor-specific near-infrared (NIR) fluorescent dyes such as indocyanine green (ICG), IDRye800CW, and 5-aminolevulinic acid have been used clinically for detecting tumor margins or micro-cancer lesions. In this study, we evaluated the physicochemical properties of liposomally formulated phospholipid-conjugated ICG, denoted by LP-iDOPE, as a clinically translatable NIR imaging nanoparticle for brain tumors. We also confirmed its brain-tumor-specific biodistribution and its characteristics as the intra-operative NIR imaging nanoparticles for brain tumor surgery. These properties of LP-iDOPE may enable neurosurgeons to achieve more accurate identification and more complete resection of brain tumor. Topics: Animals; Brain Neoplasms; Chemistry, Pharmaceutical; Indocyanine Green; Liposomes; Male; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipids; Rats; Rats, Inbred F344; Spectrometry, Fluorescence; Spectroscopy, Near-Infrared	2015

Article

Year

Peptide density targets and impedes triple negative breast cancer metastasis.

Nature communications, 2018, 07-04, Volume: 9, Issue:1

The C-X-C chemokine receptor type 4 (CXCR4, CD184) pathway is a key regulator of cancer metastasis. Existing therapeutics that block CXCR4 signaling are dependent on single molecule-receptor interactions or silencing CXCR4 expression. CXCR4 localizes in lipid rafts and forms dimers therefore CXCR4 targeting and signaling may depend on ligand density. Herein, we report liposomes presenting a CXCR4 binding peptide (DV1) as a three-dimensional molecular array, ranging from 9k to 74k molecules μm

Topics: Animals; Antineoplastic Agents; Binding, Competitive; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Female; Gene Expression; Genes, Reporter; Humans; Liposomes; Liver Neoplasms; Luciferases; Lung Neoplasms; Membrane Microdomains; Mice; Mice, Nude; Peptides; Phosphatidylcholines; Phosphatidylethanolamines; Polyethylene Glycols; Protein Binding; Receptors, CXCR4; Triple Negative Breast Neoplasms; Xenograft Model Antitumor Assays

2018

Liposomally formulated phospholipid-conjugated indocyanine green for intra-operative brain tumor detection and resection.

International journal of pharmaceutics, 2015, Dec-30, Volume: 496, Issue:2

Some tumor-specific near-infrared (NIR) fluorescent dyes such as indocyanine green (ICG), IDRye800CW, and 5-aminolevulinic acid have been used clinically for detecting tumor margins or micro-cancer lesions. In this study, we evaluated the physicochemical properties of liposomally formulated phospholipid-conjugated ICG, denoted by LP-iDOPE, as a clinically translatable NIR imaging nanoparticle for brain tumors. We also confirmed its brain-tumor-specific biodistribution and its characteristics as the intra-operative NIR imaging nanoparticles for brain tumor surgery. These properties of LP-iDOPE may enable neurosurgeons to achieve more accurate identification and more complete resection of brain tumor.

Topics: Animals; Brain Neoplasms; Chemistry, Pharmaceutical; Indocyanine Green; Liposomes; Male; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipids; Rats; Rats, Inbred F344; Spectrometry, Fluorescence; Spectroscopy, Near-Infrared

2015