1-2-hexadecanediamine and Edema

1-2-hexadecanediamine has been researched along with Edema* in 2 studies

Other Studies

2 other study(ies) available for 1-2-hexadecanediamine and Edema

Article	Year
Synthesis, in vitro cytotoxicity and in vivo anti-inflammatory activity of long chain 3-amino-1,2-diols. Bioorganic & medicinal chemistry letters, 1999, Mar-22, Volume: 9, Issue:6 The synthesis of long chain 3-amino-1,2-diols was carried out based on Sharpless asymmetric epoxidation of long chain allylic alcohols and regioselective nucleophilic ring opening by azido group. The in vitro cytotoxicity of the compounds prepared was evaluated against six solid tumor cell lines (A2780, H322, LL, WiDr, C26-10, UMSCC-22B). Free 3-amino-1,2-diols exhibited IC50 values between 1.45 microM and 32 microM. These compounds also presented interesting inhibition of carrageenin-induced paw edema in rats (85.3% - 79.6% at a concentration of 0.15 mmol/kg). Topics: Amino Alcohols; Animals; Anti-Inflammatory Agents; Cell Survival; Edema; Inhibitory Concentration 50; Kinetics; Models, Chemical; Rats; Sphingosine; Tumor Cells, Cultured	1999
Synthetic routes to lipidic diamines and amino alcohols: a class of potential antiinflammatory agents. Lipids, 1999, Volume: 34, Issue:3 Simple and efficient methods for the synthesis of lipidic amino alcohols and diamines are described in this paper. Lipidic 2-amino alcohols and 1,3-diamines can be synthesized starting from synthetic lipidic alpha-amino acids. Alternatively, commercially available lipidic 1,2-diols may be used as starting material for the synthesis of 2-amino alcohols. Initial experiments on the in vivo antiinflammatory activity of the compounds synthesized gave promising results. Topics: Alkanes; Amines; Amino Alcohols; Animals; Anti-Inflammatory Agents; Diamines; Edema; Lipids; Magnetic Resonance Spectroscopy; Molecular Mimicry; Rats	1999

Article

Year

Synthesis, in vitro cytotoxicity and in vivo anti-inflammatory activity of long chain 3-amino-1,2-diols.

Bioorganic & medicinal chemistry letters, 1999, Mar-22, Volume: 9, Issue:6

The synthesis of long chain 3-amino-1,2-diols was carried out based on Sharpless asymmetric epoxidation of long chain allylic alcohols and regioselective nucleophilic ring opening by azido group. The in vitro cytotoxicity of the compounds prepared was evaluated against six solid tumor cell lines (A2780, H322, LL, WiDr, C26-10, UMSCC-22B). Free 3-amino-1,2-diols exhibited IC50 values between 1.45 microM and 32 microM. These compounds also presented interesting inhibition of carrageenin-induced paw edema in rats (85.3% - 79.6% at a concentration of 0.15 mmol/kg).

Topics: Amino Alcohols; Animals; Anti-Inflammatory Agents; Cell Survival; Edema; Inhibitory Concentration 50; Kinetics; Models, Chemical; Rats; Sphingosine; Tumor Cells, Cultured

1999

Synthetic routes to lipidic diamines and amino alcohols: a class of potential antiinflammatory agents.

Lipids, 1999, Volume: 34, Issue:3

Simple and efficient methods for the synthesis of lipidic amino alcohols and diamines are described in this paper. Lipidic 2-amino alcohols and 1,3-diamines can be synthesized starting from synthetic lipidic alpha-amino acids. Alternatively, commercially available lipidic 1,2-diols may be used as starting material for the synthesis of 2-amino alcohols. Initial experiments on the in vivo antiinflammatory activity of the compounds synthesized gave promising results.

Topics: Alkanes; Amines; Amino Alcohols; Animals; Anti-Inflammatory Agents; Diamines; Edema; Lipids; Magnetic Resonance Spectroscopy; Molecular Mimicry; Rats

1999