1,2-dimethylhydrazine has been researched along with Wilms Tumor in 4 studies
1,2-Dimethylhydrazine: A DNA alkylating agent that has been shown to be a potent carcinogen and is widely used to induce colon tumors in experimental animals.
1,2-dimethylhydrazine : A member of the class of hydrazines that is hydrazine in which one of the hydrogens attached to each nitrogen is replaced by a methyl group. A powerful DNA alkylating agent and carcinogen, it is used to induce colon cancer in laboratory rats and mice.
Wilms Tumor: A malignant kidney tumor, caused by the uncontrolled multiplication of renal stem (blastemal), stromal (STROMAL CELLS), and epithelial (EPITHELIAL CELLS) elements. However, not all three are present in every case. Several genes or chromosomal areas have been associated with Wilms tumor which is usually found in childhood as a firm lump in a child's side or ABDOMEN.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Treatments were begun 8 days post-operative and 17 days later, the single dosage of DMH as in the above was injected." | 1.29 | Tumors produced in rats with a single dosage of 1,2-dimethylhydrazine. ( Amir-Mokri, E; Brown, ME; Gershbein, LL; Rezai, VK, 1993) |
| "Nephroblastomas were induced at an early age in two of six cynomolgus monkeys by prenatal exposure to 1,2-dimethylhydrazine." | 1.28 | Induction of renal tumors in cynomolgus monkeys (Macaca fascicularis) by prenatal exposure to 1,2-dimethylhydrazine. ( Beniashvili, DS, 1989) |
| "This pathological resemblance to human nephroblastoma suggests the possibility of using dimethylhydrazine-induced renal tumours as a model of Wilms' tumour." | 1.27 | Induction of nephroblastoma-like renal tumours in rats by a single dose of 1,2-dimethylhydrazine. ( Cruse, JP; Lewin, MR; Sadrudin, AA, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (75.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gershbein, LL | 1 |
| Amir-Mokri, E | 1 |
| Rezai, VK | 1 |
| Brown, ME | 1 |
| Beniashvili, DS | 1 |
| Beniashvili, DSh | 1 |
| Sadrudin, AA | 1 |
| Lewin, MR | 1 |
| Cruse, JP | 1 |
4 other studies available for 1,2-dimethylhydrazine and Wilms Tumor
| Article | Year |
|---|---|
Tumors produced in rats with a single dosage of 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; | 1993 |
Induction of renal tumors in cynomolgus monkeys (Macaca fascicularis) by prenatal exposure to 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Dimethylhydrazines; Female; Kidney Neoplasms; Macaca fa | 1989 |
[Induction of renal tumors in monkeys as a result of probable prenatal effects of 1,2-dimethylhydrazine].
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Dimethylhydrazines; Female; Kidney; Kidney Neoplasms; M | 1989 |
Induction of nephroblastoma-like renal tumours in rats by a single dose of 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Dimethylhydrazines; Disease Models, Animal; Female; Kid | 1985 |