1,2-dimethylhydrazine has been researched along with Weight Gain in 15 studies
1,2-Dimethylhydrazine: A DNA alkylating agent that has been shown to be a potent carcinogen and is widely used to induce colon tumors in experimental animals.
1,2-dimethylhydrazine : A member of the class of hydrazines that is hydrazine in which one of the hydrogens attached to each nitrogen is replaced by a methyl group. A powerful DNA alkylating agent and carcinogen, it is used to induce colon cancer in laboratory rats and mice.
Weight Gain: Increase in BODY WEIGHT over existing weight.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This work investigated the effects of Vitamin E (VE) on aberrant crypt foci (ACF) incidence, oxidative stress parameters (serum and hepatic VE concentration, and homocysteine, glutathione (GSH), and malondialdehyde (MDA) levels), and expression of both cyclooxygenase-2 (COX2) and proliferating cellular nuclear antigen (PCNA) in experimental colorectal carcinogenesis." | 3.80 | Vitamin E supplementation in chemical colorectal carcinogenesis: a two-edged knife. ( Cardoso, JF; Cohen, C; Garcia, SB; Vannucchi, H, 2014) |
| "Supplementation of the diet of CF1 mice with sphingomyelin isolated from milk has been shown to reduce the number of aberrant crypt foci (ACF) and the appearance of colonic adenocarcinoma induced by 1,2-dimethylhydrazine (Schmelz et al." | 3.69 | Suppression of aberrant colonic crypt foci by synthetic sphingomyelins with saturated or unsaturated sphingoid base backbones. ( Bushnev, AS; Dillehay, DL; Liotta, DC; Merrill, AH; Schmelz, EM, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (40.00) | 18.2507 |
| 2000's | 3 (20.00) | 29.6817 |
| 2010's | 5 (33.33) | 24.3611 |
| 2020's | 1 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Dos Reis, SO | 1 |
| da Luz, TC | 1 |
| da Silva Couto, CVM | 1 |
| Dalbó, J | 1 |
| Nunes, LC | 1 |
| Martins, MC | 1 |
| Silva, PI | 1 |
| da Silva, AMA | 1 |
| Trivilin, LO | 1 |
| Heidor, R | 1 |
| Furtado, KS | 1 |
| Ortega, JF | 1 |
| de Oliveira, TF | 1 |
| Tavares, PE | 1 |
| Vieira, A | 1 |
| Miranda, ML | 1 |
| Purgatto, E | 1 |
| Moreno, FS | 1 |
| Zhu, QC | 1 |
| Gao, RY | 1 |
| Wu, W | 1 |
| Guo, BM | 1 |
| Peng, JY | 1 |
| Qin, HL | 1 |
| Cohen, C | 1 |
| Cardoso, JF | 1 |
| Garcia, SB | 1 |
| Vannucchi, H | 1 |
| Bertkova, I | 1 |
| Hijova, E | 1 |
| Chmelarova, A | 1 |
| Mojzisova, G | 1 |
| Petrasova, D | 1 |
| Strojny, L | 1 |
| Bomba, A | 1 |
| Zitnan, R | 1 |
| Van Nieuwenhove, CP | 1 |
| Cano, PG | 1 |
| Pérez-Chaia, AB | 1 |
| González, SN | 1 |
| Symolon, H | 1 |
| Schmelz, EM | 4 |
| Dillehay, DL | 4 |
| Merrill, AH | 4 |
| Park, E | 1 |
| Jeon, GI | 1 |
| Park, JS | 1 |
| Paik, HD | 1 |
| Webb, SK | 1 |
| Takeshita, M | 1 |
| Ueda, H | 1 |
| Shirabe, K | 1 |
| Higuchi, Y | 1 |
| Yoshida, S | 1 |
| Bushnev, AS | 2 |
| Liotta, DC | 2 |
| Steffensen, IL | 1 |
| Paulsen, JE | 1 |
| Engeset, D | 1 |
| Kronberg, L | 1 |
| Alexander, J | 1 |
| Sullards, MC | 1 |
| Gee, JM | 1 |
| Noteborn, HP | 1 |
| Polley, AC | 1 |
| Johnson, IT | 1 |
| Narisawa, T | 1 |
| Fukaura, Y | 1 |
| Kotanagi, H | 1 |
| Asakawa, Y | 1 |
15 other studies available for 1,2-dimethylhydrazine and Weight Gain
| Article | Year |
|---|---|
Juçara (
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Carcinogenesis; Colorectal Neoplasms; Dietary S | 2020 |
The chemopreventive activity of the histone deacetylase inhibitor tributyrin in colon carcinogenesis involves the induction of apoptosis and reduction of DNA damage.
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Apoptosis; Colonic Neoplasms; Deoxyguanosin | 2014 |
Effect of a high-fat diet in development of colonic adenoma in an animal model.
Topics: 1,2-Dimethylhydrazine; Adenoma; Adiposity; Animals; Biomarkers, Tumor; Cell Cycle; Cell Proliferatio | 2014 |
Vitamin E supplementation in chemical colorectal carcinogenesis: a two-edged knife.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Biomarkers; Carcinogenesis; Carcinogens; Cell P | 2014 |
The effect of probiotic microorganisms and bioactive compounds on chemically induced carcinogenesis in rats.
Topics: 1,2-Dimethylhydrazine; Aesculus; Animals; Bacterial Load; Bile Acids and Salts; Cell Line, Tumor; Co | 2010 |
Effect of functional buffalo cheese on fatty acid profile and oxidative status of liver and intestine of mice.
Topics: 1,2-Dimethylhydrazine; Administration, Oral; Animals; Buffaloes; Cheese; Chromatography, High Pressu | 2011 |
Dietary soy sphingolipids suppress tumorigenesis and gene expression in 1,2-dimethylhydrazine-treated CF1 mice and ApcMin/+ mice.
Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Carcinogens; Cell Division; Colon; Colonic Neoplasms; Diet; | 2004 |
A probiotic strain of Bacillus polyfermenticus reduces DMH induced precancerous lesions in F344 male rat.
Topics: 1,2-Dimethylhydrazine; Animals; Antioxidants; Bacillus; Colon; Colonic Neoplasms; Eating; Injections | 2007 |
Dietary sphingomyelin inhibits 1,2-dimethylhydrazine-induced colon cancer in CF1 mice.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Administration, Oral; Animals; Carcinogens; Cell Div | 1994 |
Lack of promotion of colon carcinogenesis by high-oleic safflower oil.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogenicity Tests; Carcinogens; Colon; Colonic Neoplasms; Dimeth | 1997 |
Suppression of aberrant colonic crypt foci by synthetic sphingomyelins with saturated or unsaturated sphingoid base backbones.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Antineoplastic Agents; Colonic Neoplasms; Diet; Dime | 1997 |
The drinking water chlorination by-products 3,4-dichloro-5-hydroxy-2[5H]-furanone(mucochloric acid) and 3-chloro-4-(dichloromethyl)-5-hydroxy-2[5H]-furanone do not induce preneoplastic or neoplastic intestinal lesions in F344 rats, balb/ca mice or C57bl/6
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Furans; Intestinal Neoplasms; Male; Mice; Mice, Inbred | 1999 |
Ceramide-beta-D-glucuronide: synthesis, digestion, and suppression of early markers of colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Bacterial Proteins; Carcinogens; Ceramides; | 1999 |
Increased induction of aberrant crypt foci by 1,2-dimethylhydrazine in rats fed diets containing purified genistein or genistein-rich soya protein.
Topics: 1,2-Dimethylhydrazine; Administration, Oral; Animals; Anticarcinogenic Agents; Apoptosis; Colon; Gen | 2000 |
Inhibitory effect of cryptoporic acid E, a product from fungus Cryptoporus volvatus, on colon carcinogenesis induced with N-methyl-N-nitrosourea in rats and with 1,2-dimethylhydrazine in mice.
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Biomarkers, Tumor; Carcinogens; Colon; Colo | 1992 |