1,2-dimethylhydrazine has been researched along with Uterine Neoplasms in 21 studies
1,2-Dimethylhydrazine: A DNA alkylating agent that has been shown to be a potent carcinogen and is widely used to induce colon tumors in experimental animals.
1,2-dimethylhydrazine : A member of the class of hydrazines that is hydrazine in which one of the hydrogens attached to each nitrogen is replaced by a methyl group. A powerful DNA alkylating agent and carcinogen, it is used to induce colon cancer in laboratory rats and mice.
Uterine Neoplasms: Tumors or cancer of the UTERUS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "CBA female mice treated with 1,2-dimethylhydrazine (DMH) alone or in combination with oestradiol dipropionate (EP) or ascorbic acid (AA) developed, as expected, a high incidence of uterine sarcomas." | 7.69 | Sarcomatous lesions in CBA female mice treated with 1,2-dimethylhydrazine: independent primaries or metastases? ( Trukhanova, LS; Turusov, VS, 1995) |
| "CBA female mice treated with 1,2-dimethylhydrazine (DMH) alone or in combination with oestradiol dipropionate (EP) or ascorbic acid (AA) developed, as expected, a high incidence of uterine sarcomas." | 3.69 | Sarcomatous lesions in CBA female mice treated with 1,2-dimethylhydrazine: independent primaries or metastases? ( Trukhanova, LS; Turusov, VS, 1995) |
| "Colon cancer was detected in two male monkeys after total DMH doses of 1080 and 3696 mg (528 and 400 mg/kg body wt." | 1.28 | Tumor induction in monkeys after administration of dimethylhydrazine. ( Beniashvili, DS; Krutovskikh, VA; Sartania, MS; Turusov, VS, 1992) |
| " The inhibitory effect depended upon dosage to some extent." | 1.27 | [Effect of ascorbic acid on the induction of uterine sarcomas in mice]. ( Trukhanova, LS, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (57.14) | 18.7374 |
| 1990's | 8 (38.10) | 18.2507 |
| 2000's | 1 (4.76) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Turusov, VS | 12 |
| Linnik, AB | 1 |
| Morozova, OV | 5 |
| Parfenov, IuD | 4 |
| Ird, EA | 1 |
| Smirnova, IO | 3 |
| Lanko, NS | 1 |
| Krutovskikh, VA | 2 |
| Parfenov, YD | 1 |
| Trukhanova, LS | 8 |
| Kushlinskiĭ, NE | 1 |
| Samoilov, DV | 1 |
| Raikhlin, NT | 1 |
| Smirnova, EA | 1 |
| Zhang, Z | 1 |
| Li, J | 1 |
| Lantry, LE | 1 |
| Wang, Y | 1 |
| Wiseman, RW | 1 |
| Lubet, RA | 1 |
| You, M | 1 |
| Beniashvili, DS | 1 |
| Sartania, MS | 1 |
| Merkulova, IB | 2 |
| Vvedenskaia, NA | 1 |
| Kiselev, VI | 1 |
| Klepikov, NN | 1 |
21 other studies available for 1,2-dimethylhydrazine and Uterine Neoplasms
| Article | Year |
|---|---|
[Analysis of uterine sarcoma induced in mice in terms of the two-staged development of tumors].
Topics: 1,2-Dimethylhydrazine; Animals; Cocarcinogenesis; Dimethylhydrazines; Estradiol; Female; Mice; Mice, | 1984 |
[Tumors induced by 1,2-dimethylhydrazine in hybrid mice with the pituitary gland transplanted in the kidney].
Topics: 1,2-Dimethylhydrazine; Animals; Anus Neoplasms; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; | 1983 |
[Effect of neonatal androgenization on uterine sarcomagenesis induced by 1,2-dimethylhydrazine in female CBA mice].
Topics: 1,2-Dimethylhydrazine; Androgens; Animals; Animals, Newborn; Carcinogens; Dimethylhydrazines; Female | 1983 |
Role of host factors in carcinogenesis induced in mice by 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Dimethylhydrazines; Female; Hemangiosarcoma; Hemorrhage | 1983 |
Strain differences in susceptibility of female mice to 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Anal Gland Neoplasms; Animals; Carcinogens; Colonic Neoplasms; Dimethylhydraz | 1982 |
Sarcomatous lesions in CBA female mice treated with 1,2-dimethylhydrazine: independent primaries or metastases?
Topics: 1,2-Dimethylhydrazine; Animals; Ascorbic Acid; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; E | 1995 |
[Comparative characteristics of specific binding of estradiol-17beta with proteins-receptors in CBA and C57Bl/6 murine line uterine cytosol during sarcomagenesis induced by 1,2-dimethylhydrazine].
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Cytosol; Dimethylhydrazines; Estradiol; Female; Mice; M | 1995 |
Estrogen modification of 1,2-dimethylhydrazine carcinogenesis in C3HA mice.
Topics: 1,2-Dimethylhydrazine; Animals; Cholangiocarcinoma; Colonic Neoplasms; Dimethylhydrazines; Estradiol | 1994 |
Uterine sarcomas in CBA mice induced by combined treatment with 1,2-dimethylhydrazine and estradiol dipropionate. Light and electron microscopy.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Dimethylhydrazines; Estradiol; Female; Mice; Mice, Inbr | 1993 |
p53 transgenic mice are highly susceptible to 1, 2-dimethylhydrazine-induced uterine sarcomas.
Topics: 1,2-Dimethylhydrazine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carcinogens; Cell Cycle Pro | 2002 |
Tumor induction in monkeys after administration of dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Colonic Neoplasms; Dimethylhydrazines; Dose-Response | 1992 |
Modifying effect of ascorbic acid and sodium ascorbate on the promoting stage of uterine sarcomogenesis induced in CBA mice by 1,2-dimethylhydrazine and estradiol-dipropionate.
Topics: 1,2-Dimethylhydrazine; Animals; Ascorbic Acid; Carcinogens; Dimethylhydrazines; Drug Antagonism; Est | 1991 |
[Effects of cortiphen and cyclophosphamide in uterine sarcoma induced primarily by 1,2-dimethylhydrazine and estradiol dipropionate in CBA mice].
Topics: 1,2-Dimethylhydrazine; Animals; Antineoplastic Agents; Carcinogens; Corticosterone; Cyclophosphamide | 1990 |
[The inhibitory effect of ascorbic acid on the estrogen-stimulated promotion of uterine sarcoma development in mice].
Topics: 1,2-Dimethylhydrazine; Animals; Ascorbic Acid; Carcinogens; Dimethylhydrazines; Drug Interactions; D | 1990 |
[Effect of estradiol dipropionate on the development of uterine sarcoma induced by 1,2-dimethylhydrazine in mice].
Topics: 1,2-Dimethylhydrazine; Alleles; Animals; Carcinogens; Cocarcinogenesis; Dimethylhydrazines; Estradio | 1989 |
1,2-Dimethylhydrazine carcinogenesis in neonatally androgenized CBA mice.
Topics: 1,2-Dimethylhydrazine; Animals; Animals, Newborn; Colonic Neoplasms; Dimethylhydrazines; Estrus; Fem | 1988 |
[Modifying effect of ascorbic acid and sodium ascorbate on uterine carcomogenesis induced by 1,2-dimethylhydrazine in CBA mice].
Topics: 1,2-Dimethylhydrazine; Animals; Ascorbic Acid; Cocarcinogenesis; Dimethylhydrazines; Drug Synergism; | 1988 |
[Effect of ascorbic acid on the induction of uterine sarcomas in mice].
Topics: 1,2-Dimethylhydrazine; Animals; Ascorbic Acid; Body Weight; Dimethylhydrazines; Estradiol; Estrogen | 1987 |
[Effect of estradiol dipropionate in various doses on induced uterine sarcomagenesis in mice].
Topics: 1,2-Dimethylhydrazine; Animals; Dimethylhydrazines; Dose-Response Relationship, Drug; Drug Synergism | 1986 |
[Effect of 1,2-dimethylhydrazine on the estrous cycle in different strains of mice].
Topics: 1,2-Dimethylhydrazine; Animals; Dimethylhydrazines; Dose-Response Relationship, Drug; Estrus; Female | 1986 |
[Proliferative activity of the uterine epithelium and mesenchymal elements in CBA-strain mice administered 1,2-dimethylhydrazine and estradiol dipropionate].
Topics: 1,2-Dimethylhydrazine; Animals; Cell Division; Dimethylhydrazines; Drug Synergism; Endometrial Hyper | 1986 |