1,2-dimethylhydrazine has been researched along with Sarcoma in 5 studies
1,2-Dimethylhydrazine: A DNA alkylating agent that has been shown to be a potent carcinogen and is widely used to induce colon tumors in experimental animals.
1,2-dimethylhydrazine : A member of the class of hydrazines that is hydrazine in which one of the hydrogens attached to each nitrogen is replaced by a methyl group. A powerful DNA alkylating agent and carcinogen, it is used to induce colon cancer in laboratory rats and mice.
Sarcoma: A connective tissue neoplasm formed by proliferation of mesodermal cells; it is usually highly malignant.
| Excerpt | Relevance | Reference |
|---|---|---|
| "CBA female mice treated with 1,2-dimethylhydrazine (DMH) alone or in combination with oestradiol dipropionate (EP) or ascorbic acid (AA) developed, as expected, a high incidence of uterine sarcomas." | 7.69 | Sarcomatous lesions in CBA female mice treated with 1,2-dimethylhydrazine: independent primaries or metastases? ( Trukhanova, LS; Turusov, VS, 1995) |
| "CBA female mice, at the 17th day of pregnancy, received single intraperitoneal injection of diethylstilbestrol (DES) at the dose of 1 mg/kg body weight (b." | 3.70 | 1,2-Dimethylhydrazine carcinogenesis in CBA male mice prenatally treated with diethylstilbestrol. ( Samoilov, D; Trukhanova, L; Turusov, V, 2000) |
| "CBA female mice treated with 1,2-dimethylhydrazine (DMH) alone or in combination with oestradiol dipropionate (EP) or ascorbic acid (AA) developed, as expected, a high incidence of uterine sarcomas." | 3.69 | Sarcomatous lesions in CBA female mice treated with 1,2-dimethylhydrazine: independent primaries or metastases? ( Trukhanova, LS; Turusov, VS, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 3 (60.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Turusov, VS | 2 |
| Trukhanova, LS | 1 |
| Popovich, IG | 1 |
| Zabezhinski, MA | 1 |
| Kovalenko, AL | 1 |
| Anisimov, VN | 1 |
| Turusov, V | 1 |
| Trukhanova, L | 1 |
| Samoilov, D | 1 |
| Zhang, Z | 1 |
| Li, J | 1 |
| Lantry, LE | 1 |
| Wang, Y | 1 |
| Wiseman, RW | 1 |
| Lubet, RA | 1 |
| You, M | 1 |
5 other studies available for 1,2-dimethylhydrazine and Sarcoma
| Article | Year |
|---|---|
Role of host factors in carcinogenesis induced in mice by 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Dimethylhydrazines; Female; Hemangiosarcoma; Hemorrhage | 1983 |
Sarcomatous lesions in CBA female mice treated with 1,2-dimethylhydrazine: independent primaries or metastases?
Topics: 1,2-Dimethylhydrazine; Animals; Ascorbic Acid; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; E | 1995 |
Inhibitory effect of synthetic interferon inductor Cycloferone on 1,2-dimethylhydrazine-induced colon carcinogenesis in rats.
Topics: 1,2-Dimethylhydrazine; Acridines; Adenocarcinoma; Animals; Anticarcinogenic Agents; Body Weight; Car | 2000 |
1,2-Dimethylhydrazine carcinogenesis in CBA male mice prenatally treated with diethylstilbestrol.
Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Carcinoma; Colonic Neoplasms; Diethylstilbestrol; Female; I | 2000 |
p53 transgenic mice are highly susceptible to 1, 2-dimethylhydrazine-induced uterine sarcomas.
Topics: 1,2-Dimethylhydrazine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carcinogens; Cell Cycle Pro | 2002 |