1,2-dimethylhydrazine has been researched along with Precancerous Conditions in 168 studies
1,2-Dimethylhydrazine: A DNA alkylating agent that has been shown to be a potent carcinogen and is widely used to induce colon tumors in experimental animals.
1,2-dimethylhydrazine : A member of the class of hydrazines that is hydrazine in which one of the hydrogens attached to each nitrogen is replaced by a methyl group. A powerful DNA alkylating agent and carcinogen, it is used to induce colon cancer in laboratory rats and mice.
Precancerous Conditions: Pathological conditions that tend eventually to become malignant.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The present study has aimed to evaluate chemopreventive potential of d-carvone on oxidative stress markers, biotransforming enzymes, incidence of colonic polyps and aberrant crypt foci (ACF) in 1,2-dimethylhydrazine (DMH)-induced experimental colon carcinogenesis." | 7.79 | Modulating effect of d-carvone on 1,2-dimethylhydrazine-induced pre-neoplastic lesions, oxidative stress and biotransforming enzymes, in an experimental model of rat colon carcinogenesis. ( Balasubramanian, T; Kabalimoorthy, J; Nalini, N; Sudha, M; Vinothkumar, R; Viswanathan, P, 2013) |
| "To investigate how intestinal bacteria affect host cytogenetic alterations in the early initiation step of colon carcinogenesis, we conducted a comet assay and micronucleus (MN) test using germ-free (GF) and conventionalized (Cvd) rats after a single subcutaneous injection of the carcinogen, 1,2-dimethylhydrazine dihydrochloride (DMH)." | 3.91 | Markedly enhanced micronucleus induction by 1,2-dimethylhydrazine dihydrochloride in colonic cells of rats with bacterial colonization in the intestine. ( Ohyama, W, 2019) |
| "The present study has aimed to evaluate chemopreventive potential of d-carvone on oxidative stress markers, biotransforming enzymes, incidence of colonic polyps and aberrant crypt foci (ACF) in 1,2-dimethylhydrazine (DMH)-induced experimental colon carcinogenesis." | 3.79 | Modulating effect of d-carvone on 1,2-dimethylhydrazine-induced pre-neoplastic lesions, oxidative stress and biotransforming enzymes, in an experimental model of rat colon carcinogenesis. ( Balasubramanian, T; Kabalimoorthy, J; Nalini, N; Sudha, M; Vinothkumar, R; Viswanathan, P, 2013) |
| "The expression of the putative markers LGR-5 (leucine-rich-repeat-containing G-protein-coupled receptor 5), MSI-1 (Musashi-1) and DCAMKL-1 (doublecortin and calcium/calmodulin-dependent protein kinase-like-1) was studied in normal colon mucosa (NM), in the precancerous lesions Mucin Depleted Foci (MDF) and in macroscopic tumours (adenomas) of 1,2-dimethylhydrazine-treated rats." | 3.79 | Expression of LGR-5, MSI-1 and DCAMKL-1, putative stem cell markers, in the early phases of 1,2-dimethylhydrazine-induced rat colon carcinogenesis: correlation with nuclear β-catenin. ( Caderni, G; Dolara, P; Femia, AP; Salvadori, M, 2013) |
| "To evaluate the preventive effect of sodium butyrate in the appearance of aberrant crypt foci (ACF) in rats after induction with the carcinogen 1,2-dimethylhydrazine (DMH)." | 3.76 | Sodium butyrate does not decrease the evolution of precancerous lesions in rats. ( Glória, MB; Mendes, MC; Peluzio, Mdo C; Penido, LC; Rosa, DD; Silva, FG; Valente, FX, 2010) |
| " We therefore examined the modifying effect of boiled garlic powder (BGP) on 1,2-dimethylhydrazine-induced mucin-depleted foci (MDF) and aberrant crypt foci (ACF), preneoplastic lesions, in the rat colorectum." | 3.76 | Inhibition of 1, 2-dimethylhydrazine-induced mucin-depleted foci and O⁶-methylguanine DNA adducts in the rat colorectum by boiled garlic powder. ( Beppu, H; Chihara, T; Higashiguchi, T; Kaneko, T; Mizutani, K; Shimpo, K; Sonoda, S, 2010) |
| " The lack of the protective layer of mucus may cause inflammation which has been linked to colon carcinogenesis, therefore, the expression of markers such as cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (i-NOS) and macrophage infiltration was studied with immunohistochemistry (IH) in MDF harvested from F344 rats treated with the colon carcinogen 1,2-dimethylhydrazine (DMH)." | 3.75 | Mucin-depleted foci show strong activation of inflammatory markers in 1,2-dimethylhydrazine-induced carcinogenesis and are promoted by the inflammatory agent sodium dextran sulfate. ( Caderni, G; Dolara, P; Femia, AP; Luceri, C; Salvadori, M, 2009) |
| "Supplementation of the diet of CF1 mice with sphingomyelin isolated from milk has been shown to reduce the number of aberrant crypt foci (ACF) and the appearance of colonic adenocarcinoma induced by 1,2-dimethylhydrazine (Schmelz et al." | 3.69 | Suppression of aberrant colonic crypt foci by synthetic sphingomyelins with saturated or unsaturated sphingoid base backbones. ( Bushnev, AS; Dillehay, DL; Liotta, DC; Merrill, AH; Schmelz, EM, 1997) |
| "The induction of adenocarcinomas in distal colons of noninbred female Swiss Webster white mice by 1,2-dimethylhydrazine (DMH) is preceded by the development of hyperplasia of mucosal glands, which includes absolute increases in both the total number of cells and labeled cells per crypt." | 3.66 | Changes in crypt cell populations of mouse colon during recovery from treatment with 1,2-dimethylhydrazine. ( Richards, TC, 1981) |
| "Moreover, LJE attenuated colon cancer initiation and progression by decreasing aberrant crypt foci and LJE recovered the gut microbiome." | 1.62 | Ellagitannins from jabuticaba (Myrciaria jaboticaba) seeds attenuated inflammation, oxidative stress, aberrant crypt foci, and modulated gut microbiota in rats with 1,2 dimethyl hydrazine-induced colon carcinogenesis. ( Almeida, LA; Azevedo, L; de Oliveira, PF; do Carmo, MAV; Feitoza, LQ; Ferreira, EB; Fidelis, M; Granato, D; Hellström, J; Marques, MJ; Novaes, RD; Oh, WY; Shahidi, F, 2021) |
| "Roflumilast was administered subcutaneously at two doses (1 and 5 mg/kg/day, from day 28 to 42)." | 1.56 | Roflumilast counteracts DMH-induced preneoplastic colon damage in albino Wistar rats. ( Ansari, MN; Rastogi, S; Saeedan, AS, 2020) |
| "A systematic investigation of the chemopreventive effect of sulindac (SL) in combination with either epigallocatechin gallate (EGCG) or kaempferol similar (KMP) has been carried out 1,2-dimethyl hydrazine-treated rats (DMH)." | 1.48 | Chemopreventive effect of sulindac in combination with epigallocatechin gallate or kaempferol against 1,2-dimethyl hydrazine-induced preneoplastic lesions in rats: A Comparative Study. ( Elahl, HMS; Hassan, ESG; Hassanein, NMA; Hegab, AM, 2018) |
| "Colon cancer is among the most dangerous tumors affecting humankind." | 1.42 | Pineal gland function is required for colon antipreneoplastic effects of physical exercise in rats. ( de Paula Garcia, W; Fernandes, CR; Frajacomo, FT; Garcia, SB; Kannen, V, 2015) |
| " DMH was given to fish by intraperitoneal injection in a dosage of 15 mg/kg body weight once a week for 6 weeks." | 1.37 | [Chemopreventive effects of 5-fluorouracil and lactoferrin on goldfish intestinal carcinogenesis induced by 1,2-dimethylhydrazine]. ( Kakuta, I; Takase, K, 2011) |
| "After our serum metabonomic study of colorectal cancer (CRC) patients recently published in J." | 1.36 | Urinary metabonomic study on colorectal cancer. ( Cai, G; Cai, S; Chen, T; Jia, W; Liu, Y; Ni, Y; Qiu, Y; Su, M; Xu, LX; Xu, Y; Zhao, A, 2010) |
| "The effect of long-term administration of the novel maleimide derivative with antiproliferative activity on kidney morpho-functional state in experimental (1,2-dimethylhydrazine-induced) colon carcinogenesis has been investigated on 60 male rats." | 1.36 | [Effect of maleimide derivative on the morpho-functional state of the kidney in experimental colon carcinogenesis in rats]. ( Filins'ka, OM; Iablons'ka, SV; Kharchuk, IV; Rybal'chenko, VK, 2010) |
| "The incidence of tumors/polyps in the colon cancer of rats and treated with morin showed reduced incidence (40%) of tumors, as compared to DMH (100%) treated rats." | 1.35 | Modifying effects of morin on the development of aberrant crypt foci and bacterial enzymes in experimental colon cancer. ( Karthik Kumar, V; Nalini, N; Vennila, S, 2009) |
| "Pioglitazone was chosen as agonist of PPAR-gamma and GW9662 used as a specific complete antagonist of PPAR-gamma." | 1.35 | [Role of peroxisome proliferators-activated receptor-gamma in the chemical prevention therapy of sulindac for precancerous lesions of rats]. ( Han, YJ; Jin, Z; Li, CF; Li, J; Lv, YM; Zhang, YP, 2009) |
| " DMH was induced subcutaneously at a dosage of 40 mg/kg body weight, twice a week for 2 weeks." | 1.35 | Antioxidative and antiproliferative effects of astaxanthin during the initiation stages of 1,2-dimethyl hydrazine-induced experimental colon carcinogenesis. ( Ashokkumar, P; Prabhu, PN; Sudhandiran, G, 2009) |
| "Vanadium treatment also abated the mRNA expression of iNOS (54." | 1.35 | Protective effects of vanadium against DMH-induced genotoxicity and carcinogenesis in rat colon: removal of O(6)-methylguanine DNA adducts, p53 expression, inducible nitric oxide synthase downregulation and apoptotic induction. ( Chatterjee, M; Rajkumar, M; Rana, A; Rana, B; Samanta, S; Suresh, D; Swamy, V, 2008) |
| "Orlistat is an anti-obesity agent that increases the fecal fat excretion, which promotes colon carcinogenesis." | 1.33 | The anti-obesity agent Orlistat is associated to increase in colonic preneoplastic markers in rats treated with a chemical carcinogen. ( Barros, LT; Garcia, SB; Martinello, F; Modiano, P; Ribeiro-Silva, A; Turatti, A; Uyemura, SA; Vespúcio, MV, 2006) |
| "Colon cancer has become one of the major causes of cancer mortality." | 1.33 | Dose dependent inhibitory effect of dietary caraway on 1,2-dimethylhydrazine induced colonic aberrant crypt foci and bacterial enzyme activity in rats. ( Deeptha, K; Kamaleeswari, M; Nalini, N; Sengottuvelan, M, 2006) |
| "Vanadium-treated rats significantly reduced (P < 0." | 1.32 | Vanadium inhibits placental glutathione S-transferase (GST-P) positive foci in 1,2-dimethyl hydrazine induced rat colon carcinogenesis. ( Chakraborty, P; Chatterjee, M; Datta, S; Hemalatha, P; Kanna, PS; Mahendrakumar, CB, 2003) |
| "The vanadium cotreatment reduced DNA damage in colon cells by 32% (P < 0." | 1.32 | Chemopreventive effects of vanadium toward 1,2-dimethylhydrazine-induced genotoxicity and preneoplastic lesions in rat colon. ( Chatterjee, M; Elayaraja, T; Indira, BN; Kalaiselvi, K; Kanna, PS; Mahendrakumar, CB; Srivastawa, S, 2004) |
| " The DMH was administered subcutaneously to six of the monkeys at a dosage of 25 mg/kg of body weight once a week for 16 weeks; control monkeys received an equivalent volume of the stock solution without DMH." | 1.31 | Failure to induce tumors in the large intestine of Capuchin mokeys (Cebus apella) by using 1,2-dimethylhydrazine. ( Borda, JT; Gimeno, EJ; Lertora, WJ; Montenegro, MA; Sánchez Negrette, M, 2000) |
| "Aspirin may suppress tumour incidence via salicylate by enhancing apoptosis in carcinogen-initiated cells." | 1.30 | Non-steroidol anti-inflammatory drug effect on crypt cell proliferation and apoptosis during initiation of rat colon carcinogenesis. ( Barnes, CJ; Cameron, IL; Hardman, WE; Lee, M, 1998) |
| "Transforming growth factor beta1 (TGF-beta1) is a cytokine known to play a key role in the control of cell growth." | 1.30 | Controlled release of TGF-beta1 impedes rat colon carcinogenesis in vivo. ( Fich, A; Kost, Y; Lamprecht, SA; Mikhailowski, R; Polak-Charcon, S; Segal, C; Segal, Y; Shpitz, B, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 22 (13.10) | 18.7374 |
| 1990's | 45 (26.79) | 18.2507 |
| 2000's | 56 (33.33) | 29.6817 |
| 2010's | 42 (25.00) | 24.3611 |
| 2020's | 3 (1.79) | 2.80 |
| Authors | Studies |
|---|---|
| Espírito Santo, SG | 1 |
| Da Silva, TC | 1 |
| Cogliati, B | 1 |
| Barbisan, LF | 6 |
| Romualdo, GR | 1 |
| Lee, CW | 1 |
| Chen, HJ | 1 |
| Xie, GR | 1 |
| Shih, CK | 1 |
| de Moura, NA | 2 |
| Caetano, BFR | 2 |
| Bidinotto, LT | 1 |
| Rodrigues, MAM | 2 |
| Saeedan, AS | 1 |
| Rastogi, S | 1 |
| Ansari, MN | 1 |
| do Carmo, MAV | 1 |
| Fidelis, M | 1 |
| de Oliveira, PF | 2 |
| Feitoza, LQ | 1 |
| Marques, MJ | 1 |
| Ferreira, EB | 1 |
| Oh, WY | 1 |
| Shahidi, F | 1 |
| Hellström, J | 1 |
| Almeida, LA | 1 |
| Novaes, RD | 3 |
| Granato, D | 1 |
| Azevedo, L | 1 |
| Sharma, SH | 1 |
| Chellappan, DR | 1 |
| Chinnaswamy, P | 1 |
| Nagarajan, S | 1 |
| Tablas, MB | 1 |
| Pereira, NEF | 1 |
| Carvalho, RF | 1 |
| Hassanein, NMA | 1 |
| Hassan, ESG | 1 |
| Hegab, AM | 1 |
| Elahl, HMS | 1 |
| Gavresea, F | 1 |
| Vagianos, C | 1 |
| Korontzi, M | 1 |
| Sotiropoulou, G | 1 |
| Dadioti, P | 1 |
| Triantafillidis, JK | 1 |
| Papalois, AE | 1 |
| Christudoss, P | 3 |
| Chacko, G | 1 |
| Selvakumar, R | 3 |
| Fleming, JJ | 3 |
| Pugazhendhi, S | 1 |
| Mathew, G | 3 |
| Ohyama, W | 1 |
| Sequetto, PL | 2 |
| Oliveira, TT | 2 |
| Soares, IA | 1 |
| Maldonado, IR | 2 |
| Mello, VJ | 2 |
| Pizziolo, VR | 2 |
| Almeida, MR | 2 |
| Gomides, AF | 1 |
| Paula, SO | 1 |
| Rosa, DD | 2 |
| Oliveira, LL | 1 |
| Comastri, DS | 1 |
| Peluzio, Mdo C | 2 |
| Hamiza, OO | 1 |
| Rehman, MU | 1 |
| Khan, R | 1 |
| Tahir, M | 1 |
| Khan, AQ | 1 |
| Lateef, A | 1 |
| Sultana, S | 1 |
| Pulimood, AB | 2 |
| Vinothkumar, R | 2 |
| Sudha, M | 1 |
| Viswanathan, P | 1 |
| Kabalimoorthy, J | 1 |
| Balasubramanian, T | 1 |
| Nalini, N | 11 |
| de Andrade, KJ | 1 |
| Paula, MC | 1 |
| Oliveira Acésio, N | 1 |
| da Silva Moraes, T | 1 |
| Borges, PS | 1 |
| Barcelos, GR | 1 |
| Tavares, DC | 3 |
| Augusto, LE | 1 |
| Silva, ME | 1 |
| Heidor, R | 1 |
| Furtado, KS | 1 |
| Ortega, JF | 1 |
| de Oliveira, TF | 1 |
| Tavares, PE | 1 |
| Vieira, A | 1 |
| Miranda, ML | 1 |
| Purgatto, E | 1 |
| Moreno, FS | 1 |
| Munari, CC | 1 |
| Furtado, RA | 2 |
| Santiago, ML | 1 |
| Manhas, SS | 1 |
| Bastos, JK | 1 |
| Frajacomo, FT | 1 |
| de Paula Garcia, W | 1 |
| Fernandes, CR | 2 |
| Garcia, SB | 3 |
| Kannen, V | 1 |
| Siddique, AI | 1 |
| Mani, V | 1 |
| Arivalagan, S | 1 |
| Thomas, NS | 1 |
| Namasivayam, N | 1 |
| Ziliotto, L | 1 |
| Rodrigues, MA | 2 |
| Aranganathan, S | 4 |
| Selvam, JP | 1 |
| Ribeiro-Santos, G | 1 |
| Lopes, FC | 1 |
| Spinardi-Barbisan, AL | 1 |
| da Eira, AF | 1 |
| Kaneno, R | 2 |
| Karthik Kumar, V | 1 |
| Vennila, S | 1 |
| Lunz, W | 2 |
| Peluzio, MC | 2 |
| Dias, CM | 2 |
| Moreira, AP | 2 |
| Natali, AJ | 2 |
| Sangeetha, N | 2 |
| Zhang, YP | 1 |
| Lv, YM | 1 |
| Li, J | 1 |
| Han, YJ | 1 |
| Jin, Z | 1 |
| Li, CF | 1 |
| Panneerselvam, J | 1 |
| Femia, AP | 7 |
| Dolara, P | 10 |
| Luceri, C | 6 |
| Salvadori, M | 7 |
| Caderni, G | 11 |
| Prabhu, PN | 1 |
| Ashokkumar, P | 1 |
| Sudhandiran, G | 2 |
| Felix, AJ | 1 |
| Broekaert, WF | 1 |
| François, IE | 1 |
| Delcour, JA | 1 |
| Courtin, CM | 1 |
| Asaoka, Y | 1 |
| Sakai, H | 2 |
| Hirata, A | 2 |
| Sasaki, J | 1 |
| Goryo, M | 1 |
| Miyamoto, Y | 1 |
| Yanai, T | 1 |
| Masegi, T | 1 |
| Okada, K | 1 |
| Sabarense, CM | 1 |
| Glória, MB | 2 |
| Chihara, T | 2 |
| Shimpo, K | 2 |
| Kaneko, T | 2 |
| Beppu, H | 2 |
| Tomatsu, A | 1 |
| Sonoda, S | 2 |
| Qiu, Y | 2 |
| Cai, G | 1 |
| Su, M | 2 |
| Chen, T | 1 |
| Liu, Y | 1 |
| Xu, Y | 1 |
| Ni, Y | 1 |
| Zhao, A | 1 |
| Cai, S | 1 |
| Xu, LX | 1 |
| Jia, W | 2 |
| Umesalma, S | 1 |
| Kim, JM | 1 |
| Park, E | 2 |
| Alfaras, I | 1 |
| Juan, ME | 1 |
| Planas, JM | 1 |
| Wei, H | 1 |
| Dong, L | 1 |
| Wang, T | 1 |
| Zhang, M | 1 |
| Hua, W | 1 |
| Zhang, C | 1 |
| Pang, X | 1 |
| Chen, M | 1 |
| Zhou, M | 1 |
| Yang, S | 1 |
| Chen, Z | 1 |
| Rantalainen, M | 1 |
| Nicholson, JK | 1 |
| Wu, D | 1 |
| Zhao, L | 1 |
| Silva, FG | 1 |
| Penido, LC | 1 |
| Valente, FX | 1 |
| Mendes, MC | 1 |
| Mizutani, K | 1 |
| Higashiguchi, T | 1 |
| Perše, M | 1 |
| Cerar, A | 1 |
| Kharchuk, IV | 1 |
| Filins'ka, OM | 1 |
| Iablons'ka, SV | 1 |
| Rybal'chenko, VK | 1 |
| Turatti, A | 2 |
| Gouvea, DR | 1 |
| Gobbo-Neto, L | 1 |
| Diniz, A | 1 |
| Ribeiro-Silva, A | 2 |
| Lopes, NP | 1 |
| Takase, K | 1 |
| Kakuta, I | 1 |
| Salvianti, F | 2 |
| Pinzani, P | 3 |
| de Paula Carli, A | 1 |
| de Abreu Vieira, PM | 1 |
| Silva, KT | 1 |
| de Sá Cota, RG | 1 |
| Carneiro, CM | 1 |
| Castro-Borges, W | 1 |
| de Andrade, MH | 1 |
| Kumar, KN | 1 |
| Raja, SB | 1 |
| Vidhya, N | 1 |
| Devaraj, SN | 1 |
| Triolet, J | 1 |
| Shaik, AA | 1 |
| Gallaher, DD | 1 |
| O'Sullivan, MG | 1 |
| Xing, C | 1 |
| Bianchini, F | 3 |
| Calorini, L | 1 |
| Karthikkumar, V | 1 |
| Sivagami, G | 1 |
| Rajkumar, D | 1 |
| Verma, A | 1 |
| Shukla, G | 1 |
| Poulsen, M | 1 |
| Mølck, AM | 1 |
| Jacobsen, BL | 1 |
| Smith, TK | 1 |
| Mithen, R | 1 |
| Johnson, IT | 2 |
| Kanna, PS | 3 |
| Mahendrakumar, CB | 3 |
| Chakraborty, T | 1 |
| Hemalatha, P | 2 |
| Banerjee, P | 1 |
| Chatterjee, M | 4 |
| Jia, X | 2 |
| Wang, W | 1 |
| Cui, W | 1 |
| Han, C | 2 |
| Lemonnier, LA | 1 |
| Dillehay, DL | 4 |
| Vespremi, MJ | 1 |
| Abrams, J | 1 |
| Brody, E | 1 |
| Schmelz, EM | 5 |
| Wei, M | 1 |
| Morimura, K | 2 |
| Wanibuchi, H | 3 |
| Shen, J | 1 |
| Doi, K | 1 |
| Mitsuhashi, M | 1 |
| Moku, M | 1 |
| Salim, EI | 2 |
| Fukushima, S | 3 |
| Datta, S | 1 |
| Chakraborty, P | 1 |
| Hsu, CK | 1 |
| Liao, JW | 1 |
| Chung, YC | 1 |
| Hsieh, CP | 1 |
| Chan, YC | 1 |
| Indira, BN | 1 |
| Srivastawa, S | 1 |
| Kalaiselvi, K | 1 |
| Elayaraja, T | 1 |
| Yoshimi, N | 3 |
| Morioka, T | 3 |
| Kinjo, T | 3 |
| Inamine, M | 3 |
| Kaneshiro, T | 3 |
| Shimizu, T | 1 |
| Suzui, M | 3 |
| Yamada, Y | 1 |
| Mori, H | 1 |
| Bendinelli, B | 1 |
| Giannini, A | 4 |
| Onose, J | 1 |
| Imai, T | 2 |
| Hasumura, M | 2 |
| Cho, YM | 2 |
| Hirose, M | 3 |
| Pliss, GB | 1 |
| Mel'nikov, AS | 1 |
| Malinin, VV | 1 |
| Khavinson, VKh | 1 |
| Sugishita, T | 1 |
| Okada, T | 1 |
| Barros, LT | 1 |
| Martinello, F | 1 |
| Modiano, P | 1 |
| Vespúcio, MV | 1 |
| Uyemura, SA | 1 |
| Tsukamoto, T | 1 |
| Fukami, H | 1 |
| Tatematsu, M | 1 |
| Deeptha, K | 1 |
| Kamaleeswari, M | 1 |
| Sengottuvelan, M | 3 |
| Senthilkumar, R | 1 |
| Nabandith, V | 1 |
| Arakaki, J | 1 |
| Nishimaki, T | 1 |
| Singh, V | 1 |
| Belloir, C | 1 |
| Siess, MH | 1 |
| Le Bon, AM | 1 |
| Zoghbi, S | 1 |
| Drouin, E | 1 |
| Claustre, J | 1 |
| Bara, J | 3 |
| Scoazec, JY | 1 |
| Plaisancié, P | 1 |
| Jeon, GI | 1 |
| Park, JS | 1 |
| Paik, HD | 1 |
| Winkelmann, I | 1 |
| Diehl, D | 1 |
| Oesterle, D | 1 |
| Daniel, H | 1 |
| Wenzel, U | 1 |
| Xu, H | 1 |
| Sengupta, R | 1 |
| Du, J | 1 |
| Banerjee, S | 1 |
| Sarkar, FH | 1 |
| Rishi, AK | 1 |
| Majumdar, AP | 1 |
| Dani, V | 1 |
| Goel, A | 1 |
| Vaiphei, K | 1 |
| Dhawan, DK | 1 |
| Tarquini, E | 1 |
| Ferri, S | 1 |
| Lee, SJ | 1 |
| Lim, KT | 1 |
| Samanta, S | 1 |
| Swamy, V | 1 |
| Suresh, D | 1 |
| Rajkumar, M | 1 |
| Rana, B | 1 |
| Rana, A | 1 |
| Panneer Selvam, J | 1 |
| Ota, Y | 1 |
| Takami, S | 1 |
| Nishikawa, A | 1 |
| Rodrigues, EP | 1 |
| Araújo, FR | 1 |
| Oliveira, WL | 1 |
| Furtado, MA | 1 |
| Castro, MB | 1 |
| Cunha, WR | 1 |
| Koch, TC | 1 |
| Briviba, K | 1 |
| Watzl, B | 1 |
| Bub, A | 1 |
| Barth, SW | 1 |
| James, JT | 2 |
| Autrup, H | 1 |
| Decaëns, C | 2 |
| Rosa, B | 1 |
| Daher, N | 1 |
| Burtin, P | 2 |
| Shamsuddin, AM | 1 |
| Trump, BF | 1 |
| Faustov, LA | 1 |
| Senior, PV | 1 |
| Sunter, JP | 1 |
| Appleton, DR | 1 |
| Watson, AJ | 1 |
| Richards, TC | 2 |
| Tacha, DE | 1 |
| Delapierre, F | 1 |
| Laumonier, R | 1 |
| Tayot, J | 1 |
| Halkin, E | 1 |
| Bird, RP | 6 |
| Lancioni, L | 2 |
| Biggeri, A | 2 |
| Pascale, RM | 1 |
| Simile, MM | 1 |
| De Miglio, MR | 1 |
| Nufris, A | 1 |
| Daino, L | 1 |
| Seddaiu, MA | 1 |
| Rao, PM | 4 |
| Rajalakshmi, S | 5 |
| Sarma, DS | 4 |
| Feo, F | 1 |
| Rossiello, MR | 1 |
| Paulsen, JE | 3 |
| Steffensen, IL | 3 |
| Namork, E | 1 |
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| Mereto, E | 1 |
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| Robblee, NM | 1 |
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| Ito, N | 4 |
| Spagnesi, MT | 2 |
| Testolin, G | 1 |
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| Cameron, IL | 2 |
| Garza, J | 1 |
| Hardman, WE | 2 |
| Moen, CJ | 1 |
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| Adams, J | 1 |
| Merrill, AH | 3 |
| Duranton, B | 2 |
| Nsi-Emvo, E | 1 |
| Schleiffer, R | 2 |
| Gossé, F | 2 |
| Galluser, M | 1 |
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| Kado, S | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Plasma and Urine Metabolomics for Biomarker Discovery in Children With Eosinophilic Esophagitis[NCT03107819] | 24 participants (Actual) | Observational | 2017-03-29 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for 1,2-dimethylhydrazine and Precancerous Conditions
| Article | Year |
|---|---|
Morphological and molecular alterations in 1,2 dimethylhydrazine and azoxymethane induced colon carcinogenesis in rats.
Topics: 1,2-Dimethylhydrazine; Animals; Azoxymethane; Biomarkers, Tumor; Colonic Neoplasms; Humans; Precance | 2011 |
Role of aberrant crypt foci in understanding the pathogenesis of colon cancer.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Animals; Azoxymethane; Carcinogens; Cholic Acid; Cho | 1995 |
166 other studies available for 1,2-dimethylhydrazine and Precancerous Conditions
| Article | Year |
|---|---|
Panx1 knockout promotes preneoplastic aberrant crypt foci development in a chemically induced model of mouse colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Carcinogenesis; Colon; Colonic Neoplasms; Conne | 2023 |
Djulis (
Topics: 1,2-Dimethylhydrazine; Animal Feed; Animals; Anticarcinogenic Agents; Antioxidants; Apoptosis; Apopt | 2019 |
Dietary hemin promotes colonic preneoplastic lesions and DNA damage but not tumor development in a medium-term model of colon carcinogenesis in rats.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animal Feed; Animals; Caco-2 Cells; Cocarcinogenesis; Co | 2019 |
Roflumilast counteracts DMH-induced preneoplastic colon damage in albino Wistar rats.
Topics: 1,2-Dimethylhydrazine; Aminopyridines; Animals; Anti-Inflammatory Agents; Antioxidants; Benzamides; | 2020 |
Ellagitannins from jabuticaba (Myrciaria jaboticaba) seeds attenuated inflammation, oxidative stress, aberrant crypt foci, and modulated gut microbiota in rats with 1,2 dimethyl hydrazine-induced colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Chromosome Aberrations; Colonic Neoplasms; Gastrointest | 2021 |
Protective effect of p-coumaric acid against 1,2 dimethylhydrazine induced colonic preneoplastic lesions in experimental rats.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Anticarcinogenic Agents; Carcinogenesis; Carcin | 2017 |
Capsaicin reduces genotoxicity, colonic cell proliferation and preneoplastic lesions induced by 1,2-dimethylhydrazine in rats.
Topics: 1,2-Dimethylhydrazine; Animals; Caco-2 Cells; Capsaicin; Cell Proliferation; Colon; Colonic Neoplasm | 2018 |
Chemopreventive effect of sulindac in combination with epigallocatechin gallate or kaempferol against 1,2-dimethyl hydrazine-induced preneoplastic lesions in rats: A Comparative Study.
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; beta Catenin; Carcinogens; Catechin; Coloni | 2018 |
Beneficial effect of synbiotics on experimental colon cancer in rats.
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Carcinogens; Colon; Colonic Neoplasms; Male | 2018 |
Expression of Metallothionein after Administration of Aspirin, Vitamin C or Zinc Supplement in the DMH Induced Colon Carcinoma in Rat
Topics: 1,2-Dimethylhydrazine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Ascorbic Acid; Aspirin; Col | 2018 |
Markedly enhanced micronucleus induction by 1,2-dimethylhydrazine dihydrochloride in colonic cells of rats with bacterial colonization in the intestine.
Topics: 1,2-Dimethylhydrazine; Animals; Apoptosis; Carcinogenesis; Carcinogens; Cell Proliferation; Colon; C | 2019 |
The flavonoid chrysin attenuates colorectal pathological remodeling reducing the number and severity of pre-neoplastic lesions in rats exposed to the carcinogen 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Colon; Colorectal Neoplasms; Female; Flavonoids; Precan | 2013 |
Use of defatted flaxseed meal reduces precancerous colon lesions in C57BL/6 mice.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Carcinogens; Colon; Colonic Neoplasms; Fatty Ac | 2013 |
Chemopreventive effects of aloin against 1,2-dimethylhydrazine-induced preneoplastic lesions in the colon of Wistar rats.
Topics: 1,2-Dimethylhydrazine; Animals; Antioxidants; Colonic Diseases; Emodin; Gene Expression Regulation, | 2014 |
Protective role of aspirin, vitamin C, and zinc and their effects on zinc status in the DMH-induced colon carcinoma model.
Topics: 1,2-Dimethylhydrazine; Alkaline Phosphatase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antio | 2013 |
Modulating effect of d-carvone on 1,2-dimethylhydrazine-induced pre-neoplastic lesions, oxidative stress and biotransforming enzymes, in an experimental model of rat colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Body Weight; Carcinogenesis; Chemoprevention; C | 2013 |
Bixin protects hepatocytes against 1,2-dimethylhydrazine-induced genotoxicity but does not suppress DNA damage and pre-neoplastic lesions in the colon of Wistar rats.
Topics: 1,2-Dimethylhydrazine; Animals; Carotenoids; Colonic Neoplasms; DNA Damage; Hepatocytes; Male; Preca | 2014 |
Naringin accelerates the regression of pre-neoplastic lesions and the colorectal structural reorganization in a murine model of chemical carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Colorectal Neoplasms; Female; Flavanones; Mice; Microsc | 2014 |
The chemopreventive activity of the histone deacetylase inhibitor tributyrin in colon carcinogenesis involves the induction of apoptosis and reduction of DNA damage.
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Apoptosis; Colonic Neoplasms; Deoxyguanosin | 2014 |
Inhibitory effects of Baccharis dracunculifolia on 1,2-dimethylhidrazine-induced genotoxicity and preneoplastic lesions in rat colon.
Topics: 1,2-Dimethylhydrazine; Alkylating Agents; Animals; Baccharis; Colon; Colonic Neoplasms; Comet Assay; | 2014 |
Pineal gland function is required for colon antipreneoplastic effects of physical exercise in rats.
Topics: 1,2-Dimethylhydrazine; Animals; Colonic Neoplasms; Cyclooxygenase 2; DNA; DNA Damage; Enteric Nervou | 2015 |
Asiatic acid attenuates pre-neoplastic lesions, oxidative stress, biotransforming enzymes and histopathological alterations in 1,2-dimethylhydrazine-induced experimental rat colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Ascorbic Acid; Biotransformation; Catalase; | 2017 |
Lack of chemoprevention of dietary Agaricus blazei against rat colonic aberrant crypt foci.
Topics: 1,2-Dimethylhydrazine; Agaricus; Animal Feed; Animals; Anticarcinogenic Agents; Biomarkers, Tumor; C | 2008 |
Effect of hesperetin, a citrus flavonoid, on bacterial enzymes and carcinogen-induced aberrant crypt foci in colon cancer rats: a dose-dependent study.
Topics: 1,2-Dimethylhydrazine; Animals; Bacteria; Body Weight; Carcinogens; Cell Transformation, Neoplastic; | 2008 |
Lack of chemopreventive activity of Agaricus blazei mushroom on the development of 1,2-dimethylhydrazine-induced colonic aberrant crypt foci in rats.
Topics: 1,2-Dimethylhydrazine; Agaricus; Animals; Colonic Neoplasms; Glutathione S-Transferase pi; Killer Ce | 2008 |
Modifying effects of morin on the development of aberrant crypt foci and bacterial enzymes in experimental colon cancer.
Topics: 1,2-Dimethylhydrazine; Animals; Antioxidants; beta-Glucosidase; Carcinogens; Colon; Colonic Neoplasm | 2009 |
Long-term aerobic swimming training by rats reduces the number of aberrant crypt foci in 1,2-dimethylhydrazine-induced colon cancer.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Colonic Neoplasms; Disease Models, Animal; Male; Physic | 2008 |
Silibinin ameliorates oxidative stress induced aberrant crypt foci and lipid peroxidation in 1, 2 dimethylhydrazine induced rat colon cancer.
Topics: 1,2-Dimethylhydrazine; Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Colonic Neoplasms; | 2010 |
[Role of peroxisome proliferators-activated receptor-gamma in the chemical prevention therapy of sulindac for precancerous lesions of rats].
Topics: 1,2-Dimethylhydrazine; Anilides; Animals; Colorectal Neoplasms; Male; Pioglitazone; PPAR gamma; Prec | 2009 |
Inhibitory effect of bread crust antioxidant pronyl-lysine on two different categories of colonic premalignant lesions induced by 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Animals; Antioxidants; Bread; Colon; Lysine; Male; Precancerous Conditions; P | 2009 |
Mucin-depleted foci show strong activation of inflammatory markers in 1,2-dimethylhydrazine-induced carcinogenesis and are promoted by the inflammatory agent sodium dextran sulfate.
Topics: 1,2-Dimethylhydrazine; Animals; Azoxymethane; Carcinogens; Cell Transformation, Neoplastic; Colitis; | 2009 |
Antioxidative and antiproliferative effects of astaxanthin during the initiation stages of 1,2-dimethyl hydrazine-induced experimental colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Administration, Oral; Animals; Antigens, Nuclear; Antioxidants; Cell Prolifer | 2009 |
Silibinin modulates biotransforming microbial enzymes and prevents 1,2-dimethylhydrazine-induced preneoplastic changes in experimental colon cancer.
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Bacteria; Body Weight; Colon; Colonic Neopl | 2009 |
Arabinoxylan-oligosaccharides (AXOS) reduce preneoplastic lesions in the colon of rats treated with 1,2-dimethylhydrazine (DMH).
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Carcinogens; Colon; Colonic Neoplasms; Diet | 2010 |
Detection of initiation activity of 1,2-dimethylhydrazine in in vivo medium-term liver initiation assay system using 4-week-old rats without hepatocellular proliferative stimuli during the test chemical treatment period.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogenicity Tests; Cell Proliferation; Cytochrome P-450 Enzyme S | 2010 |
Fish oil ingestion reduces the number of aberrant crypt foci and adenoma in 1,2-dimethylhydrazine-induced colon cancer in rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Carcinoma; Colonic Neoplasms; Fatty Aci | 2009 |
Inhibitory effects of high temperature- and pressure-treated garlic on formation of 1,2-dimethylhydrazine-induced mucin-depleted foci and O(6)-methylguanine DNA adducts in the rat colorectum.
Topics: 1,2-Dimethylhydrazine; Animals; Colon; Cytochrome P-450 CYP2E1; DNA Adducts; Garlic; Guanine; Hot Te | 2009 |
Urinary metabonomic study on colorectal cancer.
Topics: 1,2-Dimethylhydrazine; Adult; Aged; Animals; Case-Control Studies; Colorectal Neoplasms; Discriminan | 2010 |
Differential inhibitory effects of the polyphenol ellagic acid on inflammatory mediators NF-kappaB, iNOS, COX-2, TNF-alpha, and IL-6 in 1,2-dimethylhydrazine-induced rat colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Bi | 2010 |
Coenzyme Q10 attenuated DMH-induced precancerous lesions in SD rats.
Topics: 1,2-Dimethylhydrazine; Analysis of Variance; Animals; Anticarcinogenic Agents; Antioxidants; Colon; | 2010 |
trans-Resveratrol reduces precancerous colonic lesions in dimethylhydrazine-treated rats.
Topics: 1,2-Dimethylhydrazine; Animals; Colon; Colonic Neoplasms; Disease Models, Animal; Humans; Male; Prec | 2010 |
Structural shifts of gut microbiota as surrogate endpoints for monitoring host health changes induced by carcinogen exposure.
Topics: 1,2-Dimethylhydrazine; Animals; Bacteria; Biomarkers; Carcinogens; DNA, Bacterial; Gastrointestinal | 2010 |
Sodium butyrate does not decrease the evolution of precancerous lesions in rats.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Butyrates; Carcinogens; Colorectal Neoplasms; D | 2010 |
Inhibition of 1, 2-dimethylhydrazine-induced mucin-depleted foci and O⁶-methylguanine DNA adducts in the rat colorectum by boiled garlic powder.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Colon; Colonic Neoplasms; DNA Adducts; Garlic; | 2010 |
[Effect of maleimide derivative on the morpho-functional state of the kidney in experimental colon carcinogenesis in rats].
Topics: 1,2-Dimethylhydrazine; Administration, Oral; Animals; Antineoplastic Agents; Cell Proliferation; Col | 2010 |
The protective role of Lychnophora ericoides Mart. (Brazilian arnica) in 1,2-dimethylhydrazine-induced experimental colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antica | 2011 |
[Chemopreventive effects of 5-fluorouracil and lactoferrin on goldfish intestinal carcinogenesis induced by 1,2-dimethylhydrazine].
Topics: 1,2-Dimethylhydrazine; Animals; Anti-Infective Agents; Antimetabolites, Antineoplastic; Blood Cell C | 2011 |
Sustained proliferation and resistance to apoptosis after a cytotoxic insult are early alterations in rat colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Apoptosis; Aspirin; bcl-2 Homologous Antagonist-Killer Protein; Biom | 2012 |
Bowman-Birk inhibitors, proteasome peptidase activities and colorectal pre neoplasias induced by 1,2-dimethylhydrazine in Swiss mice.
Topics: 1,2-Dimethylhydrazine; Animals; Blotting, Western; Carcinogens; Chromatography, Gel; Colorectal Neop | 2012 |
Ellagic acid modulates antioxidant status, ornithine decarboxylase expression, and aberrant crypt foci progression in 1,2-dimethylhydrazine-instigated colon preneoplastic lesions in rats.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Anticarcinogenic Agents; Antioxidants; Carcinog | 2012 |
Zinc and zinc related enzymes in precancerous and cancerous tissue in the colon of dimethyl hydrazine treated rats.
Topics: 1,2-Dimethylhydrazine; Alkaline Phosphatase; Animals; Carcinogens; Colon; Colonic Neoplasms; Gastric | 2012 |
Reduction in colon cancer risk by consumption of kava or kava fractions in carcinogen-treated rats.
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Body Weight; Carcinogens; Colonic Neoplasms | 2012 |
Marie Ménard apples with high polyphenol content and a low-fat diet reduce 1,2-dimethylhydrazine-induced colon carcinogenesis in rats: effects on inflammation and apoptosis.
Topics: 1,2-Dimethylhydrazine; Animals; Anti-Infective Agents; Apoptosis; Colitis; Colon; Colonic Neoplasms; | 2012 |
Modulatory efficacy of rosmarinic acid on premalignant lesions and antioxidant status in 1,2-dimethylhydrazine induced rat colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Anticarcinogenic Agents; Antioxidants; Carcinog | 2012 |
Probiotics Lactobacillus rhamnosus GG, Lactobacillus acidophilus suppresses DMH-induced procarcinogenic fecal enzymes and preneoplastic aberrant crypt foci in early colon carcinogenesis in Sprague Dawley rats.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Body Weight; Colonic Neoplasms; Feces; Glucuron | 2013 |
Expression of LGR-5, MSI-1 and DCAMKL-1, putative stem cell markers, in the early phases of 1,2-dimethylhydrazine-induced rat colon carcinogenesis: correlation with nuclear β-catenin.
Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; beta Catenin; Biomarkers, Tumor; Celecoxib; Cell Nucleus; C | 2013 |
Different effects of short- and long-chained fructans on large intestinal physiology and carcinogen-induced aberrant crypt foci in rats.
Topics: 1,2-Dimethylhydrazine; Animals; Body Weight; Cecum; Cell Division; Colonic Neoplasms; Colony Count, | 2002 |
Effects of Brassica vegetable juice on the induction of apoptosis and aberrant crypt foci in rat colonic mucosal crypts in vivo.
Topics: 1,2-Dimethylhydrazine; Animals; Apoptosis; Brassica; Carcinogens; Colon; Intestinal Mucosa; Male; Pl | 2003 |
Effect of vanadium on colonic aberrant crypt foci induced in rats by 1,2 dimethyl hydrazine.
Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Carcinogens; Carcinoma; Colon; Colonic Neoplasms; Cytochrom | 2003 |
[Effects of tea on aberrant crypt foci and colorectal tumors in rats].
Topics: 1,2-Dimethylhydrazine; Animals; Antineoplastic Agents, Phytogenic; Colon; Colorectal Neoplasms; Pigm | 2000 |
Sphingomyelin in the suppression of colon tumors: prevention versus intervention.
Topics: 1,2-Dimethylhydrazine; Administration, Oral; Animals; Apoptosis; Cell Differentiation; Cell Division | 2003 |
Chemopreventive effect of JTE-522, a selective cyclooxygenase-2 inhibitor, on 1, 2-dimethylhydrazine-induced rat colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Benzenesulfonates; Bromodeoxyuridine; Carcinogens; Cell Division; Co | 2003 |
Vanadium inhibits placental glutathione S-transferase (GST-P) positive foci in 1,2-dimethyl hydrazine induced rat colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Antineoplastic Agents; Body Weight; Carcinogens; Colonic Neoplasms; | 2003 |
Xylooligosaccharides and fructooligosaccharides affect the intestinal microbiota and precancerous colonic lesion development in rats.
Topics: 1,2-Dimethylhydrazine; Animals; Bifidobacterium; Carcinogens; Cecum; Colonic Diseases; Colony Count, | 2004 |
Chemopreventive effects of vanadium toward 1,2-dimethylhydrazine-induced genotoxicity and preneoplastic lesions in rat colon.
Topics: 1,2-Dimethylhydrazine; Animals; Catalase; Colon; Comet Assay; DNA Damage; Glutathione Reductase; Int | 2004 |
Histological and immunohistochemical observations of mucin-depleted foci (MDF) stained with Alcian blue, in rat colon carcinogenesis induced with 1,2-dimethylhydrazine dihydrochloride.
Topics: 1,2-Dimethylhydrazine; Alcian Blue; Animals; beta Catenin; Biomarkers, Tumor; Carcinogens; Colonic N | 2004 |
Mucin-depleted foci have beta-catenin gene mutations, altered expression of its protein, and are dose- and time-dependent in the colon of 1,2-dimethylhydrazine-treated rats.
Topics: 1,2-Dimethylhydrazine; Animals; beta Catenin; Colonic Neoplasms; Cytoskeletal Proteins; Dose-Respons | 2005 |
A new medium-term rat colon bioassay applying neoplastic lesions as endpoints for detection of carcinogenesis modifiers-validation with known modifiers.
Topics: 1,2-Dimethylhydrazine; Animals; Anthraquinones; Carcinogenicity Tests; Colorectal Neoplasms; Deoxych | 2006 |
[The effect of vilon (Lys-Glu) on 1.2-dimethylhydrazine-induced neoplasia].
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Dipeptides; Kidney Neoplasms; Mice; Precanc | 2005 |
Inhibitory effect of dietary monoglucosylceramide 1-O-beta-glucosyl-N-2'-hydroxyarachidoyl-4,8-sphingadienine on two different categories of colon preneoplastic lesions induced by 1,2-dimethylhydrazine in F344 rats.
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Carcinogens; Colonic Neoplasms; Diet; Gluco | 2005 |
The anti-obesity agent Orlistat is associated to increase in colonic preneoplastic markers in rats treated with a chemical carcinogen.
Topics: 1,2-Dimethylhydrazine; Animals; Anti-Obesity Agents; Carcinogens; Cell Proliferation; Colonic Neopla | 2006 |
Three-dimensional analysis of isolated hexosaminidase-altered aberrant crypts from colons of 1,2-dimethylhydrazine-treated rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; beta-N-Acetylhexosaminidases; Biomarkers, Tumor; Bro | 2006 |
Dose dependent inhibitory effect of dietary caraway on 1,2-dimethylhydrazine induced colonic aberrant crypt foci and bacterial enzyme activity in rats.
Topics: 1,2-Dimethylhydrazine; Animals; Antineoplastic Agents, Phytogenic; Bacteria; Carcinogens; Carum; Cat | 2006 |
Modulatory influence of dietary resveratrol during different phases of 1,2-dimethylhydrazine induced mucosal lipid-peroxidation, antioxidant status and aberrant crypt foci development in rat colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Antioxidants; Catalase; Diet; Glutathione; Intestinal Neoplasms; Lip | 2006 |
Distribution of preneoplastic lesions and tumors, and beta-catenin gene mutations in colon carcinomas induced by 1,2-dimethylhydrazine plus dextran sulfate sodium.
Topics: 1,2-Dimethylhydrazine; Animals; beta Catenin; Carcinogens; Colon; Colonic Neoplasms; Dextran Sulfate | 2006 |
Dietary supplementation of resveratrol suppresses colonic tumour incidence in 1,2-dimethylhydrazine-treated rats by modulating biotransforming enzymes and aberrant crypt foci development.
Topics: 1,2-Dimethylhydrazine; Animals; Antineoplastic Agents, Phytogenic; Bacteria; Carcinogens; Colon; Col | 2006 |
Inhibition of carcinogen-induced DNA damage in rat liver and colon by garlic powders with varying alliin content.
Topics: 1,2-Dimethylhydrazine; Aflatoxin B1; Animals; Antineoplastic Agents; Chemoprevention; Colon; Colonic | 2006 |
Intestinal MUC2 and gastric M1/MUC5AC in preneoplastic lesions induced by 1,2-dimethylhydrazine in rat: a sequential analysis.
Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; beta Catenin; Carcinogens; Carcinoma; Cell Line, Tumor; Col | 2007 |
A probiotic strain of Bacillus polyfermenticus reduces DMH induced precancerous lesions in F344 male rat.
Topics: 1,2-Dimethylhydrazine; Animals; Antioxidants; Bacillus; Colon; Colonic Neoplasms; Eating; Injections | 2007 |
The suppression of aberrant crypt multiplicity in colonic tissue of 1,2-dimethylhydrazine-treated C57BL/6J mice by dietary flavone is associated with an increased expression of Krebs cycle enzymes.
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Carcinogens; Cell Line, Tumor; Citric Acid | 2007 |
Regression of early and intermediate stages of colon cancer by targeting multiple members of the EGFR family with EGFR-related protein.
Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Apoptosis; Carcinogens; Cell Growth Processes; Colonic Neop | 2007 |
Chemopreventive potential of zinc in experimentally induced colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Administration, Oral; Alkylating Agents; Animals; Anticarcinogenic Agents; An | 2007 |
K-ras mutations and mucin profile in preneoplastic lesions and colon tumors induced in rats by 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Animals; Cell Transformation, Neoplastic; Colonic Neoplasms; Genes, APC; Gene | 2008 |
Inhibitory effect of phytoglycoprotein on tumor necrosis factor-alpha and interleukin-6 at initiation stage of colon cancer in 1,2-dimethylhydrazine-treated ICR mice.
Topics: 1,2-Dimethylhydrazine; Animals; Antioxidants; Colon; Colonic Neoplasms; DNA-Binding Proteins; Dose-R | 2007 |
Protective effects of vanadium against DMH-induced genotoxicity and carcinogenesis in rat colon: removal of O(6)-methylguanine DNA adducts, p53 expression, inducible nitric oxide synthase downregulation and apoptotic induction.
Topics: 1,2-Dimethylhydrazine; Animals; Apoptosis; Colon; Colonic Neoplasms; DNA Adducts; Down-Regulation; F | 2008 |
Aberrant crypt foci and AgNORs as putative biomarkers to evaluate the chemopreventive efficacy of pronyl-lysine in rat colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Administration, Oral; Animals; Anticarcinogenic Agents; Antigens, Nuclear; An | 2008 |
A new medium-term rat colorectal bioassay applying neoplastic lesions as end points for detection of carcinogenesis modifiers effects with weak or controversial modifiers.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Body Weight; Carcinogenicity Tests; Carcinogens; Col | 2008 |
Ursolic acid and oleanolic acid suppress preneoplastic lesions induced by 1,2-dimethylhydrazine in rat colon.
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Colonic Neoplasms; Male; Melastomataceae; O | 2008 |
Obesity-related promotion of aberrant crypt foci in DMH-treated obese Zucker rats correlates with dyslipidemia rather than hyperinsulinemia.
Topics: 1,2-Dimethylhydrazine; Animals; Caloric Restriction; Cell Division; Colonic Neoplasms; Comet Assay; | 2008 |
Methylated DNA adducts in the large intestine of ICR/Ha and C57BL/Ha mice given 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Disease Suscepti | 1983 |
Effect of 13 cis retinoic acid on early precancerous antigenic goblet-cell modifications and induction of cancer during 1,2-dimethylhydrazine carcinogenesis in rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; | 1983 |
Comparative study of the morphologic, histochemical, and proliferative changes induced in the large intestine of ICR/Ha and C57BL/Ha mice by 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Animals; Cell Division; Colonic Neoplasms; Dimethylhydrazines; Female; Histoc | 1983 |
Early precancerous modifications in the mucus of human and rat distal colon: a comparative immunohistologic study.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Colon; Colonic Neoplasms; Dimethylhydrazines; Female; H | 1983 |
[Pathomorphology of endocrine glands during the latent period of experimental intestinal carcinogenesis].
Topics: 1,2-Dimethylhydrazine; Adrenal Cortex; Animals; Dimethylhydrazines; Endocrine Glands; Female; Hypoth | 1983 |
Morphological studies on the long-term organ culture of colonic mucosa from normal and dimethylhydrazine treated rats.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Colon; Colonic Neoplasms; Dimethylhydrazines; Female; I | 1984 |
Changes in crypt cell populations of mouse colon during recovery from treatment with 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Colonic Neoplasms; Dimethylhydrazines; Drug Administ | 1981 |
Effects of sublethal irradiation on changes in crypts of the mouse colon during treatment with 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Animals; Autoradiography; Carcinogens; Cell Division; Colon; Colonic Neoplasm | 1982 |
Preneoplastic changes in epithelium and mesenchyme in colon of rats treated with 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Animals; Basement Membrane; Carcinogens; Colon; Colonic Neoplasms; Dimethylhy | 1981 |
Characterisation of aberrant crypt foci in carcinogen-treated rats: association with intestinal carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Azoxymethane; Carcinogens; Colon; Colonic Neoplasms; Dimethylhydrazi | 1995 |
Chemoprevention by S-adenosyl-L-methionine of rat liver carcinogenesis initiated by 1,2-dimethylhydrazine and promoted by orotic acid.
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Cocarcinogenesis; Dimethylhydrazines; Liver | 1995 |
Similar patterns of hypomethylation in the beta-hydroxy-beta-methylglutaryl coenzyme A reductase gene in hepatic nodules induced by different carcinogens.
Topics: 1,2-Dimethylhydrazine; Animals; Aristolochic Acids; Carcinogens; Cell Cycle; Dimethylhydrazines; DNA | 1994 |
Scanning electron microscopy of aberrant crypt foci in rat colon.
Topics: 1,2-Dimethylhydrazine; Animals; Colonic Neoplasms; Dimethylhydrazines; Evaluation Studies as Topic; | 1994 |
Effect of aspirin on incidence and growth of aberrant crypt foci induced in the rat colon by 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Aspirin; Body Weight; Carcinogens; Cell Div | 1994 |
Effects of high corn oil diet on preneoplastic murine colons: prostanoid production and lipid composition.
Topics: 1,2-Dimethylhydrazine; Animals; Colonic Neoplasms; Corn Oil; Dimethylhydrazines; Dinoprostone; Epopr | 1994 |
Modification of carcinogenesis by alpha-tocopherol, t-butylhydroquinone, propyl gallate and butylated hydroxytoluene in a rat multi-organ carcinogenesis model.
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Antioxidants; Butylated Hydroxytoluene; Car | 1993 |
The growth of preneoplastic lesions by 1,2-dimethylhydrazine in rat colon is inhibited by dietary starch.
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Carcinogens; Cell Division; Colon; Colonic | 1993 |
Non-homogeneous marking of distal colonic mucosa using Dolichos biflorus lectin.
Topics: 1,2-Dimethylhydrazine; Animals; Binding Sites; Biomarkers, Tumor; Carcinogens; Chimera; Colonic Neop | 1995 |
Unexpected antagonistic action of 3,2'-dimethyl-4-aminobiphenyl on aberrant crypt induction by 1,2-dimethylhydrazine or azoxymethane in rat colon.
Topics: 1,2-Dimethylhydrazine; Aminobiphenyl Compounds; Animals; Azoxymethane; Carcinogens; Colon; Colonic N | 1995 |
Distribution of lymphoid nodules, aberrant crypt foci and tumours in the colon of carcinogen-treated rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Colon; Colonic Neoplasms; Dimethylhydra | 1996 |
Different genetic susceptibility to aberrant crypts and colon adenomas in mice.
Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Carcinogens; Colonic Diseases; Colonic Neoplasms; Crosses, | 1996 |
Sphingomyelin consumption suppresses aberrant colonic crypt foci and increases the proportion of adenomas versus adenocarcinomas in CF1 mice treated with 1,2-dimethylhydrazine: implications for dietary sphingolipids and colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Animals; Colonic Neoplasms; Dimethylhydrazines; Fema | 1996 |
Suppression of preneoplastic changes in the intestine of rats fed low levels of polyamines.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Cell Movement; Colon; Colonic Neoplasms; Dimethylhydraz | 1997 |
Specific species of intestinal bacteria influence the induction of aberrant crypt foci by 1,2-dimethylhydrazine in rats.
Topics: 1,2-Dimethylhydrazine; Animals; Bacteroides; Bifidobacterium; Carcinogens; Clostridium; Colonic Dise | 1997 |
Administration of anti-asialo GM1 serum increases aberrant crypt foci induced by 1,2-dimethylhydrazine in the large bowel of rats.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Cocarcinogenesis; Colonic Neoplasms; Dimethylhydrazines | 1996 |
Dietary sucrose and starch affect dysplastic characteristics in carcinogen-induced aberrant crypt foci in rat colon.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Colonic Neoplasms; Dietary Sucrose; Dimethylhydrazines; | 1997 |
Monoclonal and polyclonal development of digestive tract tumors in chimeric mice.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Carrier Proteins; Chimera; Colonic Neoplasms; Diethylni | 1997 |
Suppression of aberrant colonic crypt foci by synthetic sphingomyelins with saturated or unsaturated sphingoid base backbones.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Antineoplastic Agents; Colonic Neoplasms; Diet; Dime | 1997 |
Influence of diets containing high and low risk factors for colon cancer on early stages of carcinogenesis in human flora-associated (HFA) rats.
Topics: 1,2-Dimethylhydrazine; Animals; Bacteria; Biomarkers; Body Weight; Colon; Colonic Diseases; Colonic | 1997 |
Higher frequency of aberrant crypt foci in rapid than slow acetylator inbred rats administered the colon carcinogen 3,2'-dimethyl-4-aminobiphenyl.
Topics: 1,2-Dimethylhydrazine; Acetylation; Aminobiphenyl Compounds; Animals; Arylamine N-Acetyltransferase; | 1997 |
Inhibition of development of N,N'-dimethylhydrazine-induced rat colonic aberrant crypt foci by pre, post and simultaneous treatments with 24R,25-dihydroxyvitamin D3.
Topics: 1,2-Dimethylhydrazine; 24,25-Dihydroxyvitamin D 3; Animals; Anticarcinogenic Agents; Body Weight; Ca | 1997 |
Non-steroidol anti-inflammatory drug effect on crypt cell proliferation and apoptosis during initiation of rat colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apopt | 1998 |
Controlled release of TGF-beta1 impedes rat colon carcinogenesis in vivo.
Topics: 1,2-Dimethylhydrazine; Animals; Colonic Neoplasms; Drug Implants; Male; Polymers; Precancerous Condi | 1998 |
Natural killer activity in a medium-term multi-organ bioassay for carcinogenesis.
Topics: 1,2-Dimethylhydrazine; 2-Acetylaminofluorene; Animals; Biological Assay; Carcinogenicity Tests; Carc | 1999 |
Dietary n-3 PUFA increases the apoptotic response to 1,2-dimethylhydrazine, reduces mitosis and suppresses the induction of carcinogenesis in the rat colon.
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Apoptosis; Carcinogens; Cell Division; Cell | 1999 |
Increased tight junctional permeability is associated with the development of colon cancer.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Cell Membrane Permeability; Colon; Colonic Neoplasms; E | 1999 |
The drinking water chlorination by-products 3,4-dichloro-5-hydroxy-2[5H]-furanone(mucochloric acid) and 3-chloro-4-(dichloromethyl)-5-hydroxy-2[5H]-furanone do not induce preneoplastic or neoplastic intestinal lesions in F344 rats, balb/ca mice or C57bl/6
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Furans; Intestinal Neoplasms; Male; Mice; Mice, Inbred | 1999 |
Ceramide-beta-D-glucuronide: synthesis, digestion, and suppression of early markers of colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Bacterial Proteins; Carcinogens; Ceramides; | 1999 |
Apoptosis (programmed cell death) in colonic cells: from normal to transformed stage.
Topics: 1,2-Dimethylhydrazine; Animals; Apoptosis; Biomarkers; Carcinogens; Caspase 1; Cell Transformation, | 2001 |
Failure to induce tumors in the large intestine of Capuchin mokeys (Cebus apella) by using 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Cebus; Hyperplasia; Injections, Subcutaneous; Intestina | 2000 |
Blood polyamine levels after oral ornithine load, a diagnostic marker of hyperproliferative premalignant and malignant stages in a model of colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Animals; Biomarkers, Tumor; Biotransformation; Body | 2000 |
[Colitis enhances the colorectal carcinogenesis in rats: correlation between the incidence of aberrant crypt foci and the incidence of tumors].
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Colitis; Colorectal Neoplasms; Precancerous Conditions; | 2001 |
Orotic acid, a new promoter for experimental liver carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Arginine; Carcinogens; Diet; Disease Models, Animal; DNA; gamma-Glut | 1984 |
Pronounced inhibition by a natural anthocyanin, purple corn color, of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-associated colorectal carcinogenesis in male F344 rats pretreated with 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenocarcinoma, Mucinous; Adenoma; Administration, Oral; Anim | 2001 |
Effect of pleuran (beta-glucan from Pleurotus ostreatus) on the antioxidant status of the organism and on dimethylhydrazine-induced precancerous lesions in rat colon.
Topics: 1,2-Dimethylhydrazine; Animals; Antineoplastic Agents; Antioxidants; beta-Glucans; Colonic Neoplasms | 2001 |
Plant tannins inhibit the induction of aberrant crypt foci and colonic tumors by 1,2-dimethylhydrazine in mice.
Topics: 1,2-Dimethylhydrazine; Animals; Apoptosis; Carcinogens; Colon; Colonic Neoplasms; Drug Administratio | 2001 |
Inhibition by ginseng of colon carcinogenesis in rats.
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Carcinogenicity Tests; Carcinogens; Colonic | 2001 |
Effects of green tea on colonic aberrant crypt foci and proliferative indexes in rats.
Topics: 1,2-Dimethylhydrazine; Animals; Blotting, Western; Cell Division; Colonic Neoplasms; Immunohistochem | 2001 |
Effect of lactobacilli, bifidobacteria and inulin on the formation of aberrant crypt foci in rats.
Topics: 1,2-Dimethylhydrazine; Animals; Bifidobacterium; Carcinogens; Colonic Neoplasms; Dietary Fats; Inuli | 2001 |
Prevention by natural food anthocyanins, purple sweet potato color and red cabbage color, of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-associated colorectal carcinogenesis in rats initiated with 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Adenoma; Administration, Oral; Animals; Anthocyanins; Anticarcinogenic Agents | 2002 |
Proliferating cell nuclear antigen expression in normal, preneoplastic, and neoplastic colonic epithelium of the rat.
Topics: 1,2-Dimethylhydrazine; Animals; Antigens, Neoplasm; Carcinogens; Colonic Neoplasms; Dimethylhydrazin | 1992 |
Induction of aberrant crypts in the colons of rats by alkylating agents.
Topics: 1,2-Dimethylhydrazine; Aging; Alkylating Agents; Animals; Carcinogens; Colonic Neoplasms; Dimethylhy | 1992 |
Individual variability of pathological parameters in chemically induced rat colon tumors.
Topics: 1,2-Dimethylhydrazine; Animals; Biomarkers, Tumor; Carcinogens; Colonic Neoplasms; Deoxycholic Acid; | 1992 |
Inhibition of the Na+,K(+)-ATPase pump during induction of experimental colon cancer.
Topics: 1,2-Dimethylhydrazine; Animals; Barium; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Female; | 1991 |
Uncoupling of sodium chloride transport in premalignant mouse colon.
Topics: 1,2-Dimethylhydrazine; Action Potentials; Animals; Bicarbonates; Carcinogens; Chlorides; Colonic Neo | 1990 |
Reduction of aberrant crypt formation in the colon of CF1 mice by potential chemopreventive agents.
Topics: 1,2-Dimethylhydrazine; Animals; Butylated Hydroxyanisole; Cecum; Colonic Neoplasms; Colorectal Neopl | 1991 |
Evaluation of dietary dehydroepiandrosterone for chemoprotection against tumorigenesis in premalignant colonic epithelium of male F344 rats.
Topics: 1,2-Dimethylhydrazine; Animals; Antineoplastic Agents; Azoxymethane; Carcinogens; Colon; Colonic Neo | 1991 |
Induction of aberrant crypt foci in the large intestine of F344 rats by oral administration of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
Topics: 1,2-Dimethylhydrazine; Administration, Oral; Animals; Dimethylhydrazines; Imidazoles; Intestine, Lar | 1991 |
Sequential analyses of the growth and morphological characteristics of aberrant crypt foci: putative preneoplastic lesions.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Cell Division; Colonic Neoplasms; Dimethylhydrazines; F | 1991 |
Dose response and proliferative characteristics of aberrant crypt foci: putative preneoplastic lesions in rat colon.
Topics: 1,2-Dimethylhydrazine; Analysis of Variance; Animals; Carcinogens; Cell Division; Colonic Neoplasms; | 1991 |
Mutations in the K-ras oncogene induced by 1,2-dimethylhydrazine in preneoplastic and neoplastic rat colonic mucosa.
Topics: 1,2-Dimethylhydrazine; Animals; Base Sequence; Cell Transformation, Neoplastic; Codon; Colonic Neopl | 1991 |
Effect of disulfiram on 1,2-dimethylhydrazine- and azoxymethane-induced aberrant crypt foci.
Topics: 1,2-Dimethylhydrazine; Animals; Azoxymethane; Body Weight; Colonic Neoplasms; Dimethylhydrazines; Di | 1991 |
Effect of dietary carbohydrates on the growth of dysplastic crypt foci in the colon of rats treated with 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Animals; Calcium, Dietary; Carcinogens; Cellulose; Colon; Colonic Neoplasms; | 1991 |
1,2-Dimethylhydrazine-induced alterations in protein kinase C activity in the rat preneoplastic colon.
Topics: 1,2-Dimethylhydrazine; Animals; Colonic Neoplasms; Diglycerides; Dimethylhydrazines; Inositol Phosph | 1990 |
1,2-Dimethylhydrazine-induced alterations in lipid peroxidation in preneoplastic and neoplastic colonic tissues.
Topics: 1,2-Dimethylhydrazine; Animals; Colon; Colonic Neoplasms; Dimethylhydrazines; Fatty Acids; Intestina | 1990 |
Studies on hypomethylation of liver DNA during early stages of chemical carcinogenesis in rat liver.
Topics: 1,2-Dimethylhydrazine; Animals; Dimethylhydrazines; DNA, Neoplasm; Genes, ras; Liver Neoplasms, Expe | 1989 |
The electrical and sodium transport characteristics of sutured premalignant mouse colon.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Catgut; Cell Membrane; Colon; Colonic Neoplasms; Dimeth | 1989 |
Sequential histochemical and morphometric studies on preneoplastic and neoplastic lesions induced in rat colon by 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Acid Phosphatase; Animals; Colonic Neoplasms; Dimethylhydrazines; gamma-Gluta | 1987 |
Premalignant alterations in rat colonic N1-acetylspermidine levels induced by 1,2-dimethylhydrazine: effects of a high corn oil dietary regimen.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Biogenic Polyamines; Colonic Neoplasms; Corn Oil; Di | 1989 |
Expression of N-acetylglucosaminyltransferase III in hepatic nodules during rat liver carcinogenesis promoted by orotic acid.
Topics: 1,2-Dimethylhydrazine; Animals; Cocarcinogenesis; Dimethylhydrazines; Enzyme Activation; Glucosyltra | 1988 |
Postnatal carcinogenic study of 1,2-dimethylhydrazine dihydrochloride in rats.
Topics: 1,2-Dimethylhydrazine; Adenoma, Bile Duct; Animals; Dimethylhydrazines; Female; Hemangioma, Cavernou | 1986 |
Premalignant alterations in the glycosphingolipids of small intestinal mucosa of rats treated with 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Animals; Carbohydrates; Ceramides; Chromatography, High Pressure Liquid; Dime | 1988 |
1,2-Dimethylhydrazine-induced premalignant alterations in the S-adenosylmethionine/S-adenosylhomocysteine ratio and membrane lipid lateral diffusion of the rat distal colon.
Topics: 1,2-Dimethylhydrazine; Animals; Colonic Neoplasms; Decanoic Acids; Diffusion; Dimethylhydrazines; Ho | 1988 |
Early mucosal changes in dimethylhydrazine-induced colonic carcinogenesis in rats.
Topics: 1,2-Dimethylhydrazine; Animals; Cell Transformation, Neoplastic; Colon; Colonic Neoplasms; Cytophoto | 1986 |
Premalignant alterations in the glycosphingolipid composition of colonic epithelial cells of rats treated with 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Animals; Chromatography, Gas; Chromatography, High Pressure Liquid; Chromatog | 1987 |
Experimental colitis and colonic cancer in the rat.
Topics: 1,2-Dimethylhydrazine; Animals; Cell Transformation, Neoplastic; Colitis, Ulcerative; Colon; Colonic | 1985 |
Are animal models of colon cancer relevant to human disease.
Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Carcinoma; Colonic Neoplasms; Colonoscopy; Dimethylhydrazin | 1985 |