1,2-dimethylhydrazine has been researched along with Metastase in 10 studies
1,2-Dimethylhydrazine: A DNA alkylating agent that has been shown to be a potent carcinogen and is widely used to induce colon tumors in experimental animals.
1,2-dimethylhydrazine : A member of the class of hydrazines that is hydrazine in which one of the hydrogens attached to each nitrogen is replaced by a methyl group. A powerful DNA alkylating agent and carcinogen, it is used to induce colon cancer in laboratory rats and mice.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Tegafur was effective, but levamisole with or without tegafur was not effective against early cancer." | 5.27 | Longer survival and fewer metastases by levamisole and tegafur in 1, 2-dimethylhydrazine-induced murine colonic cancers. ( Aoki, N; Hamada, S; Hirayama, R; Matsumura, J; Mishima, Y; Miyanaga, T; Takagi, Y, 1985) |
| "Gut endocrine cells in a total of 122 intestinal-tract adenocarcinomas induced in inbred Wistar rats by 1,2-dimethylhydrazine dihydrochloride were examined histologically, ultrastructurally, and immunohistochemically for gastrin, somatostatin, vasoactive-intestinal polypeptide (VIP), and glicentin (enteroglucagon)." | 3.66 | Gut endocrine cells in rat intestinal-tract carcinoma induced by 1,2-dimethylhydrazine. ( Shimamoto, F; Tahara, E; Yanaihara, N, 1983) |
| "Tegafur was effective, but levamisole with or without tegafur was not effective against early cancer." | 1.27 | Longer survival and fewer metastases by levamisole and tegafur in 1, 2-dimethylhydrazine-induced murine colonic cancers. ( Aoki, N; Hamada, S; Hirayama, R; Matsumura, J; Mishima, Y; Miyanaga, T; Takagi, Y, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (70.00) | 18.7374 |
| 1990's | 1 (10.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 1 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nanda, N | 1 |
| Dhawan, DK | 1 |
| Bhatia, A | 1 |
| Mahmood, A | 1 |
| Mahmood, S | 1 |
| Kinjo, T | 1 |
| Suzui, M | 1 |
| Morioka, T | 1 |
| Nabandith, V | 1 |
| Inamine, M | 1 |
| Kaneshiro, T | 1 |
| Arakaki, J | 1 |
| Nishimaki, T | 1 |
| Yoshimi, N | 1 |
| Shimamoto, F | 1 |
| Tahara, E | 1 |
| Yanaihara, N | 1 |
| Decaëns, C | 1 |
| Rosa, B | 1 |
| Bara, J | 1 |
| Daher, N | 1 |
| Burtin, P | 1 |
| Naito, Y | 1 |
| Cruse, JP | 1 |
| Lewin, MR | 1 |
| Clark, CG | 1 |
| Denda, A | 1 |
| Laconi, E | 1 |
| Rao, PM | 1 |
| Rajalakshmi, S | 1 |
| Sarma, DS | 1 |
| Martin, MS | 1 |
| Hammann, A | 1 |
| Martin, F | 1 |
| Hamada, S | 1 |
| Hirayama, R | 1 |
| Matsumura, J | 1 |
| Takagi, Y | 1 |
| Miyanaga, T | 1 |
| Aoki, N | 1 |
| Mishima, Y | 1 |
| Ahnen, DJ | 1 |
10 other studies available for 1,2-dimethylhydrazine and Metastase
| Article | Year |
|---|---|
Doxycycline Promotes Carcinogenesis & Metastasis via Chronic Inflammatory Pathway: An In Vivo Approach.
Topics: 1,2-Dimethylhydrazine; Animals; Body Weight; Carcinogenesis; Caspase 3; Caspase 9; Cell Proliferatio | 2016 |
Distribution of preneoplastic lesions and tumors, and beta-catenin gene mutations in colon carcinomas induced by 1,2-dimethylhydrazine plus dextran sulfate sodium.
Topics: 1,2-Dimethylhydrazine; Animals; beta Catenin; Carcinogens; Colon; Colonic Neoplasms; Dextran Sulfate | 2006 |
Gut endocrine cells in rat intestinal-tract carcinoma induced by 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Chromaffin System; Dimethylhydrazines; | 1983 |
Effect of 13 cis retinoic acid on early precancerous antigenic goblet-cell modifications and induction of cancer during 1,2-dimethylhydrazine carcinogenesis in rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; | 1983 |
Studies on experimental colon tumorigenesis in rats. 1. Strain differences in incidence, location and tumor types of 1, 2-dimethylhydrazine-induced tumors.
Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Body Weight; Colonic Neoplasms; Dimethylhydrazines; Female; | 1981 |
The effects of cholic acid and bile salt binding agents on 1,2-dimethylhydrazine-induced colon carcinogenesis in the rat.
Topics: 1,2-Dimethylhydrazine; Aluminum Hydroxide; Animals; Bile Acids and Salts; Body Weight; Cholestyramin | 1981 |
Sequential histopathological analysis of hepatocarcinogenesis in rats during promotion with orotic acid.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Carcinoma, Hepatocellular; Cocarcinogenesis; Diet; Dime | 1994 |
Gut-associated lymphoid tissue and 1,2-dimethylhydrazine intestinal tumors in the rat: an histological and immunoenzymatic study.
Topics: 1,2-Dimethylhydrazine; Animals; Antibodies, Monoclonal; Carcinogens; Colon; Dimethylhydrazines; Hist | 1986 |
Longer survival and fewer metastases by levamisole and tegafur in 1, 2-dimethylhydrazine-induced murine colonic cancers.
Topics: 1,2-Dimethylhydrazine; Animals; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Colonic | 1985 |
Are animal models of colon cancer relevant to human disease.
Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Carcinoma; Colonic Neoplasms; Colonoscopy; Dimethylhydrazin | 1985 |