1,2-dimethylhydrazine has been researched along with Lung Neoplasms in 17 studies
1,2-Dimethylhydrazine: A DNA alkylating agent that has been shown to be a potent carcinogen and is widely used to induce colon tumors in experimental animals.
1,2-dimethylhydrazine : A member of the class of hydrazines that is hydrazine in which one of the hydrogens attached to each nitrogen is replaced by a methyl group. A powerful DNA alkylating agent and carcinogen, it is used to induce colon cancer in laboratory rats and mice.
Lung Neoplasms: Tumors or cancer of the LUNG.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Fischer F344 rats receiving 20mg/kg of 1,2-dimethylhydrazine per week for 20 weeks developed adenocarcinoma of the colon." | 3.68 | [Establishment of a transplantable rat colon cancer and a model of metastasis]. ( Yasuda, S, 1993) |
| "The tumors of lung and liver, malignant lymphoma, and other tumors were induced." | 1.28 | Tumor induction in mice administered neonatally with 1,2-dimethylhydrazine. ( Fujii, K; Komano, H, 1989) |
| "This pathological resemblance to human nephroblastoma suggests the possibility of using dimethylhydrazine-induced renal tumours as a model of Wilms' tumour." | 1.27 | Induction of nephroblastoma-like renal tumours in rats by a single dose of 1,2-dimethylhydrazine. ( Cruse, JP; Lewin, MR; Sadrudin, AA, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (29.41) | 18.7374 |
| 1990's | 5 (29.41) | 18.2507 |
| 2000's | 7 (41.18) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yamagishi, M | 1 |
| Natsume, M | 1 |
| Osakabe, N | 1 |
| Okazaki, K | 2 |
| Furukawa, F | 1 |
| Imazawa, T | 2 |
| Nishikawa, A | 2 |
| Hirose, M | 5 |
| Il'nitskiĭ, AP | 1 |
| Ryzhova, NI | 1 |
| Chudina, AP | 1 |
| Nevzorova, NI | 1 |
| Nekrasova, EA | 1 |
| Kitamura, Y | 1 |
| Umemura, T | 1 |
| Kanki, K | 1 |
| Masegi, T | 1 |
| Di Pace, RF | 1 |
| Massa, S | 1 |
| Ribeiro, OG | 1 |
| Cabrera, WH | 1 |
| De Franco, M | 1 |
| Starobinas, N | 1 |
| Seman, M | 1 |
| Ibañez, OC | 1 |
| Chin, YW | 1 |
| Jung, HA | 1 |
| Liu, Y | 1 |
| Su, BN | 1 |
| Castoro, JA | 1 |
| Keller, WJ | 1 |
| Pereira, MA | 1 |
| Kinghorn, AD | 1 |
| Turusov, VS | 1 |
| Akagi, K | 3 |
| Hoshiya, T | 3 |
| Mizoguchi, Y | 2 |
| Ito, N | 2 |
| Shirai, T | 2 |
| Yasuda, S | 1 |
| Takahashi, S | 1 |
| Hara, Y | 1 |
| Kim, DJ | 2 |
| Takasuka, N | 2 |
| Kim, JM | 1 |
| Sekine, K | 1 |
| Ota, T | 1 |
| Asamoto, M | 1 |
| Murakoshi, M | 1 |
| Nishino, H | 2 |
| Nir, Z | 1 |
| Tsuda, H | 2 |
| Nakamura, A | 1 |
| Gunning, WT | 1 |
| Castonguay, A | 1 |
| Goldblatt, PJ | 1 |
| Stoner, GD | 1 |
| Fujii, K | 1 |
| Komano, H | 1 |
| Ravikumar, TS | 1 |
| D'Emilia, J | 1 |
| Cocchiaro, C | 1 |
| Wolf, B | 1 |
| King, V | 1 |
| Steele, G | 1 |
| Sadrudin, AA | 1 |
| Lewin, MR | 1 |
| Cruse, JP | 1 |
| Kroes, R | 1 |
| Beems, RB | 1 |
| Bosland, MC | 1 |
| Bunnik, GS | 1 |
| Sinkeldam, EJ | 1 |
2 reviews available for 1,2-dimethylhydrazine and Lung Neoplasms
| Article | Year |
|---|---|
[Effect of dose fractionation on the carcinogenicity of chemical substances].
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Cricetinae; Dimethylhydrazines; Dose-Response Relations | 1984 |
Nutritional factors in lung, colon, and prostate carcinogenesis in animal models.
Topics: 1,2-Dimethylhydrazine; Androgens; Animals; Benzo(a)pyrene; Colonic Neoplasms; Diet; Dietary Fats; Di | 1986 |
15 other studies available for 1,2-dimethylhydrazine and Lung Neoplasms
| Article | Year |
|---|---|
Chemoprevention of lung carcinogenesis by cacao liquor proanthocyanidins in a male rat multi-organ carcinogenesis model.
Topics: 1,2-Dimethylhydrazine; Animals; Anthocyanins; Anticarcinogenic Agents; Butylhydroxybutylnitrosamine; | 2003 |
[Sodium nitrite-induced potentiation of spontaneous and 1,2-dimethylhydrazine-induced carcinogenesis in male mice F1 (C57 B1xCBA)].
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Cocarcinogenesis; Drug Synergism; Leukemia; Lung Neopla | 2004 |
Enhancing effects of simultaneous treatment with sodium nitrite on 2-amino-3-methylimidazo[4,5-f]quinoline-induced rat liver, colon and Zymbal's gland carcinogenesis after initiation with diethylnitrosamine and 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Administration, Oral; Alkylating Agents; Animals; Carcinogens; Cell Transform | 2006 |
Inverse genetic predisposition to colon versus lung carcinogenesis in mouse lines selected based on acute inflammatory responsiveness.
Topics: 1,2-Dimethylhydrazine; Acute Disease; Adenocarcinoma; Adenoma; Animals; Antiviral Agents; Carcinogen | 2006 |
Anti-oxidant constituents of the roots and stolons of licorice (Glycyrrhiza glabra).
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Anticarcinogenic Agents; Antioxidants; Carcinogens; Chalcones | 2007 |
Modulating effects of ellagic acid, vanillin and quercetin in a rat medium term multi-organ carcinogenesis model.
Topics: 1,2-Dimethylhydrazine; Animals; Benzaldehydes; Butylhydroxybutylnitrosamine; Diethylnitrosamine; Dim | 1995 |
[Establishment of a transplantable rat colon cancer and a model of metastasis].
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Cell Division; Colonic Neoplasms; Dimethylhydrazines | 1993 |
Effects of green tea catechins in a rat multi-organ carcinogenesis model.
Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Anticarcinogenic Agents; Body Weight; Butylhydroxybutylnitr | 1993 |
Chemoprevention by lycopene of mouse lung neoplasia after combined initiation treatment with DEN, MNU and DMH.
Topics: 1,2-Dimethylhydrazine; Animals; Body Weight; Carotenoids; Chemoprevention; Colonic Neoplasms; Diethy | 1997 |
Chemoprevention of lung cancer by lycopene.
Topics: 1,2-Dimethylhydrazine; Administration, Oral; Animals; Anticarcinogenic Agents; Carcinogens; Caroteno | 2000 |
Green tea catechins enhance tumor development in the colon without effects in the lung or thyroid after pretreatment with 1,2-Dimethylhydrazine or 2,2'-dihydroxy-di-n-propylnitrosamine in male F344 rats.
Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Body Weight; Carcinogens; Carcinoma; Catechin; Colonic Neop | 2001 |
Strain A/J mouse lung adenoma growth patterns vary when induced by different carcinogens.
Topics: 1,2-Dimethylhydrazine; Adenoma; Aflatoxins; Animals; Benzo(a)pyrene; Carcinogens; Cell Transformatio | 1991 |
Tumor induction in mice administered neonatally with 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Animals; Animals, Newborn; Carcinogens; Colonic Neoplasms; Dimethylhydrazines | 1989 |
Experimental liver metastasis. Implications of clonal proclivity and organ specificity.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Cecal Neoplasms; Colonic Neoplasms; Dimethylhydrazin | 1989 |
Induction of nephroblastoma-like renal tumours in rats by a single dose of 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Dimethylhydrazines; Disease Models, Animal; Female; Kid | 1985 |