1,2-dimethylhydrazine has been researched along with Liver Neoplasms in 30 studies
1,2-Dimethylhydrazine: A DNA alkylating agent that has been shown to be a potent carcinogen and is widely used to induce colon tumors in experimental animals.
1,2-dimethylhydrazine : A member of the class of hydrazines that is hydrazine in which one of the hydrogens attached to each nitrogen is replaced by a methyl group. A powerful DNA alkylating agent and carcinogen, it is used to induce colon cancer in laboratory rats and mice.
Liver Neoplasms: Tumors or cancer of the LIVER.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study aimed to evaluate the cancer chemopreventive activity of vanillic acid (VA) in diethylnitrosamine- and 1,2-dimethylhydrazine-induced liver and colon carcinogenesis in rats." | 8.02 | Protective Role of Vanillic Acid against Diethylnitrosamine- and 1,2-Dimethylhydrazine-Induced Hepatocarcinogenesis in Rats. ( Chariyakornkul, A; Jarukamjorn, K; Punvittayagul, C; Wongpoomchai, R, 2021) |
| "The modifying effect of pregnancy and lactation on carcinogenesis induced by single injection of 1,2-dimethylhydrazine to female rats 30 days before mating has been studied." | 7.68 | [Modifying effects of changes connected with pregnancy on 1,2-dimethylhydrazine-induced carcinogenesis in rats]. ( Blinova, GA; Mikheev, AM; Napalkov, NP, 1990) |
| "This study aimed to evaluate the cancer chemopreventive activity of vanillic acid (VA) in diethylnitrosamine- and 1,2-dimethylhydrazine-induced liver and colon carcinogenesis in rats." | 4.02 | Protective Role of Vanillic Acid against Diethylnitrosamine- and 1,2-Dimethylhydrazine-Induced Hepatocarcinogenesis in Rats. ( Chariyakornkul, A; Jarukamjorn, K; Punvittayagul, C; Wongpoomchai, R, 2021) |
| " Fischer F344 rats receiving 20mg/kg of 1,2-dimethylhydrazine per week for 20 weeks developed adenocarcinoma of the colon." | 3.68 | [Establishment of a transplantable rat colon cancer and a model of metastasis]. ( Yasuda, S, 1993) |
| "The modifying effect of pregnancy and lactation on carcinogenesis induced by single injection of 1,2-dimethylhydrazine to female rats 30 days before mating has been studied." | 3.68 | [Modifying effects of changes connected with pregnancy on 1,2-dimethylhydrazine-induced carcinogenesis in rats]. ( Blinova, GA; Mikheev, AM; Napalkov, NP, 1990) |
| " A dosage of 40 micrograms/kg was lethal when given i." | 2.67 | Injection of recombinant tumor necrosis factor directly into liver metastases: an experimental and clinical approach. ( Geerling, RA; IJzermans, JN; Jeekel, J; Marquet, RL; Scheringa, M; van der Schelling, GP, 1992) |
| " To study the effects of PSC on liver cancer development, a daily dose of 30 mg PSC/kg body wt (PSC30) was chosen based on an initial dose-response experiment." | 1.32 | Effect of PSC 833, an inhibitor of P-glycoprotein, on 1,2-dimethylhydrazine-induced liver carcinogenesis in rats. ( Bradley, G; Kankesan, J; Laconi, E; Ling, V; Rajalakshmi, S; Rao, PM; Sarma, DS; Thiessen, JJ; Vanama, R; Yusuf, A, 2003) |
| "Rats of 3 inbred strains (DA, HS and AS2) were dosed with 1,2-dimethylhydrazine 2HCl (DMH) or saline by gavage weekly for 10 wk." | 1.26 | The response of three inbred strains of rat to the carcinogen 1,2-dimethylhydrazine. ( Gavin, JB; Herdson, PB; Teague, CA, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (40.00) | 18.7374 |
| 1990's | 9 (30.00) | 18.2507 |
| 2000's | 7 (23.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 2 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Ramos Caetano, BF | 1 |
| Baptista Tablas, M | 1 |
| Ribeiro Romualdo, G | 1 |
| Marchesan Rodrigues, MA | 1 |
| Barbisan, LF | 2 |
| Punvittayagul, C | 1 |
| Chariyakornkul, A | 1 |
| Jarukamjorn, K | 1 |
| Wongpoomchai, R | 1 |
| Blum, CA | 1 |
| Tanaka, T | 1 |
| Zhong, X | 1 |
| Li, Q | 1 |
| Dashwood, WM | 1 |
| Pereira, C | 1 |
| Xu, M | 2 |
| Dashwood, RH | 2 |
| Kankesan, J | 1 |
| Yusuf, A | 1 |
| Laconi, E | 1 |
| Vanama, R | 1 |
| Bradley, G | 1 |
| Thiessen, JJ | 1 |
| Ling, V | 1 |
| Rao, PM | 3 |
| Rajalakshmi, S | 4 |
| Sarma, DS | 3 |
| Durowicz, S | 1 |
| Olszewski, WL | 1 |
| Kitamura, Y | 1 |
| Umemura, T | 1 |
| Okazaki, K | 1 |
| Kanki, K | 1 |
| Imazawa, T | 1 |
| Masegi, T | 3 |
| Nishikawa, A | 1 |
| Hirose, M | 1 |
| Denda, A | 1 |
| Teague, CA | 1 |
| Gavin, JB | 1 |
| Herdson, PB | 1 |
| Solt, DB | 1 |
| Cayama, E | 1 |
| Tsuda, H | 2 |
| Enomoto, K | 1 |
| Lee, G | 1 |
| Farber, E | 1 |
| McConnell, EE | 1 |
| Rutter, HA | 1 |
| Ulland, BM | 1 |
| Moore, JA | 1 |
| Sato, N | 1 |
| Kaku, T | 1 |
| Dempo, K | 1 |
| Kikuchi, K | 1 |
| Ird, EA | 1 |
| Smirnova, IO | 1 |
| Metzger, U | 1 |
| Meier, J | 1 |
| Uhlschmid, G | 1 |
| Weihe, H | 1 |
| Rossiello, MR | 1 |
| Turusov, VS | 1 |
| Morozova, OV | 1 |
| Samoilov, DV | 1 |
| Yasuda, S | 1 |
| Salim, AS | 1 |
| Kim, DJ | 1 |
| Takasuka, N | 1 |
| Kim, JM | 1 |
| Sekine, K | 1 |
| Ota, T | 1 |
| Asamoto, M | 1 |
| Murakoshi, M | 1 |
| Nishino, H | 1 |
| Nir, Z | 1 |
| Spinardi, AL | 1 |
| Kaneno, R | 1 |
| Rodrigues, MA | 1 |
| Salvadori, DM | 1 |
| Rocha, NS | 1 |
| Ribeiro, LR | 1 |
| de Camargo, JL | 1 |
| Fujita, H | 1 |
| Nagano, K | 1 |
| Ochiai, M | 1 |
| Ushijima, T | 1 |
| Sugimura, T | 1 |
| Nagao, M | 1 |
| Matsushima, T | 1 |
| Sakai, H | 2 |
| Tsukamoto, T | 2 |
| Yamamoto, M | 2 |
| Yanai, T | 2 |
| Inada, K | 1 |
| Nakanishi, H | 1 |
| Tatematsu, M | 2 |
| Orner, GA | 1 |
| Bailey, GS | 1 |
| Stoner, GD | 1 |
| Horio, DT | 1 |
| Hirata, A | 1 |
| Inagami, A | 1 |
| Shirai, N | 1 |
| Iidaka, T | 1 |
| IJzermans, JN | 1 |
| Scheringa, M | 1 |
| van der Schelling, GP | 1 |
| Geerling, RA | 1 |
| Marquet, RL | 1 |
| Jeekel, J | 1 |
| Napalkov, NP | 1 |
| Mikheev, AM | 1 |
| Blinova, GA | 1 |
| Narasimhan, S | 1 |
| Schachter, H | 1 |
| Sýkora, I | 1 |
| Vortel, V | 1 |
| Tretiník, P | 1 |
| McLean, AE | 1 |
| Driver, HE | 1 |
| McDanell, R | 1 |
| Tacchi-Bedford, AM | 1 |
| Oravec, CT | 1 |
| Jones, CA | 1 |
| Huberman, E | 1 |
| Lindenschmidt, RC | 1 |
| Tryka, AF | 1 |
| Goad, ME | 1 |
| Witschi, HP | 1 |
1 review available for 1,2-dimethylhydrazine and Liver Neoplasms
| Article | Year |
|---|---|
The influence of diet on activation and inactivation of chemicals--evidence from animals and man.
Topics: 1,2-Dimethylhydrazine; Acetaminophen; Animals; Biotransformation; Carbon Tetrachloride Poisoning; Co | 1986 |
1 trial available for 1,2-dimethylhydrazine and Liver Neoplasms
| Article | Year |
|---|---|
Injection of recombinant tumor necrosis factor directly into liver metastases: an experimental and clinical approach.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adult; Aged; Animals; Carcinogens; Colitis, Ulcerative; Colon | 1992 |
28 other studies available for 1,2-dimethylhydrazine and Liver Neoplasms
| Article | Year |
|---|---|
Early molecular events associated with liver and colon sub-acute responses to 1,2-dimethylhydrazine: Potential implications on preneoplastic and neoplastic lesion development.
Topics: 1,2-Dimethylhydrazine; Animals; Apoptosis; Carcinogens; Cell Proliferation; Colon; Colonic Neoplasms | 2020 |
Protective Role of Vanillic Acid against Diethylnitrosamine- and 1,2-Dimethylhydrazine-Induced Hepatocarcinogenesis in Rats.
Topics: 1,2-Dimethylhydrazine; Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Carcin | 2021 |
Mutational analysis of Ctnnb1 and Apc in tumors from rats given 1,2-dimethylhydrazine or 2-amino-3-methylimidazo[4,5-f]quinoline: mutational 'hotspots' and the relative expression of beta-catenin and c-jun.
Topics: 1,2-Dimethylhydrazine; Animals; Base Sequence; beta Catenin; Carcinogens; Codon; Colonic Neoplasms; | 2003 |
Effect of PSC 833, an inhibitor of P-glycoprotein, on 1,2-dimethylhydrazine-induced liver carcinogenesis in rats.
Topics: 1,2-Dimethylhydrazine; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Body Weight | 2003 |
The normal and metastases-bearing livers retain various specific subsets of live lymphocytes from portal circulation.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Analysis of Variance; Animals; Antigens, CD; Carcinogens; Cel | 2003 |
Enhancing effects of simultaneous treatment with sodium nitrite on 2-amino-3-methylimidazo[4,5-f]quinoline-induced rat liver, colon and Zymbal's gland carcinogenesis after initiation with diethylnitrosamine and 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Administration, Oral; Alkylating Agents; Animals; Carcinogens; Cell Transform | 2006 |
Is there more than one critical lesion relevant for experimental liver carcinogenesis?
Topics: 1,2-Dimethylhydrazine; Animals; Azacitidine; Carcinogens; Dimethylhydrazines; DNA Replication; Drug | 1984 |
The response of three inbred strains of rat to the carcinogen 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma, Bile Duct; Animals; Carcinoma, Hepatocellular; Dimet | 1981 |
Promotion of liver cancer development by brief exposure to dietary 2-acetylaminofluorene plus partial hepatectomy or carbon tetrachloride.
Topics: 1,2-Dimethylhydrazine; 2-Acetylaminofluorene; Animals; Benzo(a)pyrene; Benzopyrenes; Carbon Tetrachl | 1983 |
Chronic effects of dietary exposure to amosite asbestos and tremolite in F344 rats.
Topics: 1,2-Dimethylhydrazine; Animals; Asbestos; Asbestos, Amosite; Asbestos, Amphibole; Body Weight; Cocar | 1983 |
The relationship of colonic carcinogenesis and hepatic vascular tumors induced by subcutaneously injected-1,2-dimethylhydrazine dihydrochloride in specific pathogen free mice.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Female; Germ-Fre | 1984 |
[Tumors induced by 1,2-dimethylhydrazine in hybrid mice with the pituitary gland transplanted in the kidney].
Topics: 1,2-Dimethylhydrazine; Animals; Anus Neoplasms; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; | 1983 |
Influence of various prostaglandin synthesis inhibitors on DMH-induced rat colon cancer.
Topics: 1,2-Dimethylhydrazine; Animals; Body Weight; Colonic Neoplasms; Dimethylhydrazines; Drinking; Eating | 1984 |
Similar patterns of hypomethylation in the beta-hydroxy-beta-methylglutaryl coenzyme A reductase gene in hepatic nodules induced by different carcinogens.
Topics: 1,2-Dimethylhydrazine; Animals; Aristolochic Acids; Carcinogens; Cell Cycle; Dimethylhydrazines; DNA | 1994 |
Estrogen modification of 1,2-dimethylhydrazine carcinogenesis in C3HA mice.
Topics: 1,2-Dimethylhydrazine; Animals; Cholangiocarcinoma; Colonic Neoplasms; Dimethylhydrazines; Estradiol | 1994 |
[Establishment of a transplantable rat colon cancer and a model of metastasis].
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Cell Division; Colonic Neoplasms; Dimethylhydrazines | 1993 |
Pilot study on alcohol-induced chemonecrosis of hepatic metastases from colonic cancer. A new approach for percutaneous localized dynamic destruction of the hepatic spread.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adult; Aged; Animals; Carcinogens; Colectomy; Colon; Colonic | 1993 |
Chemoprevention by lycopene of mouse lung neoplasia after combined initiation treatment with DEN, MNU and DMH.
Topics: 1,2-Dimethylhydrazine; Animals; Body Weight; Carotenoids; Chemoprevention; Colonic Neoplasms; Diethy | 1997 |
Natural killer activity in a medium-term multi-organ bioassay for carcinogenesis.
Topics: 1,2-Dimethylhydrazine; 2-Acetylaminofluorene; Animals; Biological Assay; Carcinogenicity Tests; Carc | 1999 |
Difference in target organs in carcinogenesis with a heterocyclic amine, 2-amino-3,4-dimethylimidazo[4,5-f]quinoline, in different strains of mice.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Carcinoma, Hepatocellular; Cecal Neopla | 1999 |
Summation of initiation activities of low doses of the non-hepatocarcinogen 1,2-dimethylhydrazine in the liver after carbon tetrachloride administration.
Topics: 1,2-Dimethylhydrazine; Animals; Bromodeoxyuridine; Carbon Tetrachloride; Carcinogens; Cell Division; | 2000 |
Post-initiation effects of chlorophyllin and indole-3-carbinol in rats given 1,2-dimethylhydrazine or 2-amino-3-methyl- imidazo.
Topics: 1,2-Dimethylhydrazine; Adenosarcoma; Animals; Anticarcinogenic Agents; Antimutagenic Agents; Carcino | 2001 |
Summation of initiation activities in the liver after partial hepatectomy.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Cell Division; Diethylnitrosamine; Dose-Response Relati | 2002 |
[Modifying effects of changes connected with pregnancy on 1,2-dimethylhydrazine-induced carcinogenesis in rats].
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma, Bile Duct; Animals; Colonic Neoplasms; Dimethylhydra | 1990 |
Expression of N-acetylglucosaminyltransferase III in hepatic nodules during rat liver carcinogenesis promoted by orotic acid.
Topics: 1,2-Dimethylhydrazine; Animals; Cocarcinogenesis; Dimethylhydrazines; Enzyme Activation; Glucosyltra | 1988 |
Postnatal carcinogenic study of 1,2-dimethylhydrazine dihydrochloride in rats.
Topics: 1,2-Dimethylhydrazine; Adenoma, Bile Duct; Animals; Dimethylhydrazines; Female; Hemangioma, Cavernou | 1986 |
Activation of the colon carcinogen 1,2-dimethylhydrazine in a rat colon cell-mediated mutagenesis assay.
Topics: 1,2-Dimethylhydrazine; Animals; Benzo(a)pyrene; Biotransformation; Carcinogens; Cells, Cultured; Col | 1986 |
The effects of dietary butylated hydroxytoluene on liver and colon tumor development in mice.
Topics: 1,2-Dimethylhydrazine; Animals; Body Weight; Butylated Hydroxytoluene; Carcinogens; Colonic Neoplasm | 1986 |