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1,2-dimethylhydrazine and Kidney Neoplasms

1,2-dimethylhydrazine has been researched along with Kidney Neoplasms in 33 studies

1,2-Dimethylhydrazine: A DNA alkylating agent that has been shown to be a potent carcinogen and is widely used to induce colon tumors in experimental animals.
1,2-dimethylhydrazine : A member of the class of hydrazines that is hydrazine in which one of the hydrogens attached to each nitrogen is replaced by a methyl group. A powerful DNA alkylating agent and carcinogen, it is used to induce colon cancer in laboratory rats and mice.

Kidney Neoplasms: Tumors or cancers of the KIDNEY.

Research Excerpts

ExcerptRelevanceReference
"The modifying effect of pregnancy and lactation on carcinogenesis induced by single injection of 1,2-dimethylhydrazine to female rats 30 days before mating has been studied."7.68[Modifying effects of changes connected with pregnancy on 1,2-dimethylhydrazine-induced carcinogenesis in rats]. ( Blinova, GA; Mikheev, AM; Napalkov, NP, 1990)
"CBA male mice treated with 1,2-dimethylhydrazine (DMH) developed high incidence (up to 97%) of pararenal angiosarcomas."7.67Pararenal angiosarcoma induced in male mice by 1,2-dimethylhydrazine--a model for studying the role of androgens in chemical carcinogenesis. ( Chemeris, GY; Parfenov, YD; Turusov, VS, 1985)
"CBA female mice, at the 17th day of pregnancy, received single intraperitoneal injection of diethylstilbestrol (DES) at the dose of 1 mg/kg body weight (b."3.701,2-Dimethylhydrazine carcinogenesis in CBA male mice prenatally treated with diethylstilbestrol. ( Samoilov, D; Trukhanova, L; Turusov, V, 2000)
"The modifying effect of pregnancy and lactation on carcinogenesis induced by single injection of 1,2-dimethylhydrazine to female rats 30 days before mating has been studied."3.68[Modifying effects of changes connected with pregnancy on 1,2-dimethylhydrazine-induced carcinogenesis in rats]. ( Blinova, GA; Mikheev, AM; Napalkov, NP, 1990)
"Pararenal angiosarcomas appear in CBA male mice treated with 1,2-dimethylhydrazine (DMH)."3.67[Effect of sex hormones on the induction of renal capsule angiosarcomas in mice]. ( Chemeris, GIu, 1989)
"CBA male mice treated with 1,2-dimethylhydrazine (DMH) developed high incidence (up to 97%) of pararenal angiosarcomas."3.67Pararenal angiosarcoma induced in male mice by 1,2-dimethylhydrazine--a model for studying the role of androgens in chemical carcinogenesis. ( Chemeris, GY; Parfenov, YD; Turusov, VS, 1985)
"The effect of long-term administration of the novel maleimide derivative with antiproliferative activity on kidney morpho-functional state in experimental (1,2-dimethylhydrazine-induced) colon carcinogenesis has been investigated on 60 male rats."1.36[Effect of maleimide derivative on the morpho-functional state of the kidney in experimental colon carcinogenesis in rats]. ( Filins'ka, OM; Iablons'ka, SV; Kharchuk, IV; Rybal'chenko, VK, 2010)
" Treatments were begun 8 days post-operative and 17 days later, the single dosage of DMH as in the above was injected."1.29Tumors produced in rats with a single dosage of 1,2-dimethylhydrazine. ( Amir-Mokri, E; Brown, ME; Gershbein, LL; Rezai, VK, 1993)
" The dose-response study shows a sharp increase (from 5 to 75%) of the epithelial renal tumour incidence in the range of 2, 4 and 8 injections of DMH."1.28[1,2-dimethylhydrazine induction of epithelial tumors of the kidneys in CBA strain mice]. ( Chemeris, GIu; Lanko, NS; Parfenov, IuD; Turusov, VS, 1990)
"Nephroblastomas were induced at an early age in two of six cynomolgus monkeys by prenatal exposure to 1,2-dimethylhydrazine."1.28Induction of renal tumors in cynomolgus monkeys (Macaca fascicularis) by prenatal exposure to 1,2-dimethylhydrazine. ( Beniashvili, DS, 1989)
"Indomethacin was given orally to 40 of the rats."1.28Effect of indomethacin in autotransplanted colonic tumors. ( Duvander, A; Rubio, CA; Sveander, M; Wallin, B; Ware, J, 1989)
"This pathological resemblance to human nephroblastoma suggests the possibility of using dimethylhydrazine-induced renal tumours as a model of Wilms' tumour."1.27Induction of nephroblastoma-like renal tumours in rats by a single dose of 1,2-dimethylhydrazine. ( Cruse, JP; Lewin, MR; Sadrudin, AA, 1985)
" In a lifetime study with the CBA strain, groups of 19-30 animals of each sex were dosed s."1.27Carcinogenicity of deuterium-labeled 1,2-dimethylhydrazine in mice. ( Gordon, WP; Hillery, PS; Keefer, LK; Lanko, NS; Nelson, SD; Parfenov, YD; Turusov, VS, 1988)

Research

Studies (33)

TimeframeStudies, this research(%)All Research%
pre-199015 (45.45)18.7374
1990's12 (36.36)18.2507
2000's4 (12.12)29.6817
2010's2 (6.06)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Morozova, OV2
Karamysheva, AF1
Shavochkina, DA1
Trukhanova, LS2
Turusov, VS12
Kharchuk, IV1
Filins'ka, OM1
Iablons'ka, SV1
Rybal'chenko, VK1
Pliss, GB1
Mel'nikov, AS1
Malinin, VV1
Khavinson, VKh1
McConnell, EE1
Rutter, HA1
Ulland, BM1
Moore, JA1
Toth, B1
Patil, K1
Sunter, JP1
Senior, PV1
Chemeris, GIu5
Akagi, K3
Hirose, M4
Hoshiya, T2
Mizoguchi, Y1
Ito, N3
Shirai, T2
Yada, H1
Hakoi, K1
Takahashi, S3
Hara, Y1
Gershbein, LL1
Amir-Mokri, E1
Rezai, VK1
Brown, ME1
Kondalenko, VF2
Kimura, J1
Ogiso, T1
Yoshida, Y1
Hasegawa, R1
Kurata, M1
Samoĭlov, DV1
Turusov, V1
Trukhanova, L1
Samoilov, D1
Colussi, C1
Fiumicino, S1
Giuliani, A1
Rosini, S1
Musiani, P1
Macrí, C1
Potten, CS1
Crescenzi, M1
Bignami, M1
Napalkov, NP1
Mikheev, AM1
Blinova, GA1
Lanko, NS2
Parfenov, IuD1
Pozharisskiĭ, KM1
Kyshtoobaeva, ASh1
Klimashevskiĭ, VF1
Beniashvili, DS1
Beniashvili, DSh1
Daniel, FB1
DeAngelo, AB1
Stober, JA1
Pereira, MA1
Olson, GR1
Rubio, CA1
Wallin, B1
Ware, J1
Sveander, M1
Duvander, A1
Sadrudin, AA1
Lewin, MR1
Cruse, JP1
Sýkora, I1
Vortel, V1
Tretiník, P1
Parfenov, YD2
Gordon, WP1
Nelson, SD1
Hillery, PS1
Keefer, LK1
Smirnova, IO1
Chemeris, GY1

Other Studies

33 other studies available for 1,2-dimethylhydrazine and Kidney Neoplasms

ArticleYear
[Expression of VEGFA during 1,2-dimethylhydrazine induction of malignant hemangioendothelioma in the renal capsule in mice].
    Voprosy onkologii, 2013, Volume: 59, Issue:6

    Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Gene Expression Regulation, Neoplastic; Hemangioendothe

2013
[Influence of dichlorodiphenyldichloroethylene on 1,2 dimethylhydrazine-induced androgen-dependent renal capsule angiosarcoma development].
    Voprosy onkologii, 2008, Volume: 54, Issue:3

    Topics: 1,2-Dimethylhydrazine; Androgen Antagonists; Androgens; Animals; Carcinogens; Dichlorodiphenyl Dichl

2008
[Effect of maleimide derivative on the morpho-functional state of the kidney in experimental colon carcinogenesis in rats].
    Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994), 2010, Volume: 56, Issue:6

    Topics: 1,2-Dimethylhydrazine; Administration, Oral; Animals; Antineoplastic Agents; Cell Proliferation; Col

2010
[The effect of vilon (Lys-Glu) on 1.2-dimethylhydrazine-induced neoplasia].
    Voprosy onkologii, 2005, Volume: 51, Issue:4

    Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Dipeptides; Kidney Neoplasms; Mice; Precanc

2005
Chronic effects of dietary exposure to amosite asbestos and tremolite in F344 rats.
    Environmental health perspectives, 1983, Volume: 53

    Topics: 1,2-Dimethylhydrazine; Animals; Asbestos; Asbestos, Amosite; Asbestos, Amphibole; Body Weight; Cocar

1983
Enhancing effect of vitamin E on murine intestinal tumorigenesis by 1,2-dimethylhydrazine dihydrochloride.
    Journal of the National Cancer Institute, 1983, Volume: 70, Issue:6

    Topics: 1,2-Dimethylhydrazine; Anal Gland Neoplasms; Animals; Cecal Neoplasms; Colonic Neoplasms; Diet; Dime

1983
Role of host factors in carcinogenesis induced in mice by 1,2-dimethylhydrazine.
    IARC scientific publications, 1983, Issue:51

    Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Dimethylhydrazines; Female; Hemangiosarcoma; Hemorrhage

1983
Induction of renal tumours in rats by the administration of 1,2 dimethylhydrazine.
    The Journal of pathology, 1983, Volume: 140, Issue:1

    Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Dimethylhydrazines; Female; Injections, Subcutaneous; K

1983
[Effect of castration and mouse strain on 1, 2-dimethylhydrazine induction of pararenal angiosarcomas and kidney adenomas].
    Voprosy onkologii, 1982, Volume: 28, Issue:3

    Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Castration; Dimethylhydrazines; Hemangiosarcoma; Kidney Neo

1982
Modulating effects of ellagic acid, vanillin and quercetin in a rat medium term multi-organ carcinogenesis model.
    Cancer letters, 1995, Jul-20, Volume: 94, Issue:1

    Topics: 1,2-Dimethylhydrazine; Animals; Benzaldehydes; Butylhydroxybutylnitrosamine; Diethylnitrosamine; Dim

1995
Modification of carcinogenesis by alpha-tocopherol, t-butylhydroquinone, propyl gallate and butylated hydroxytoluene in a rat multi-organ carcinogenesis model.
    Carcinogenesis, 1993, Volume: 14, Issue:11

    Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Antioxidants; Butylated Hydroxytoluene; Car

1993
Effects of green tea catechins in a rat multi-organ carcinogenesis model.
    Carcinogenesis, 1993, Volume: 14, Issue:8

    Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Anticarcinogenic Agents; Body Weight; Butylhydroxybutylnitr

1993
Tumors produced in rats with a single dosage of 1,2-dimethylhydrazine.
    Research communications in chemical pathology and pharmacology, 1993, Volume: 80, Issue:2

    Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Colonic Neoplasms; Dimethylhydrazines;

1993
[Ultrastructure of renal-cell tumors induced in mice by 1,2-dimethylhydrazine].
    Biulleten' eksperimental'noi biologii i meditsiny, 1995, Volume: 120, Issue:9

    Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Biomarkers, Tumor; Carcinogens; Carcinoma, Renal Cell; Dime

1995
Lack of chemoprevention effects of the monoterpene d-limonene in a rat multi-organ carcinogenesis model.
    Japanese journal of cancer research : Gann, 1996, Volume: 87, Issue:6

    Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Anticarcinogenic Agents; Butylhydroxybutylnitrosamine; Carc

1996
Renal cell tumours in mice: electron microscopy versus immunohistochemistry.
    Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 1997, Volume: 49, Issue:1-2

    Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Biomarkers, Tumor; Dimethylhydrazines; gamma-Glutamyltransf

1997
[Effect of prenatal treatment with diethylstilbestrol on 1,2-dimethylhydrazine-induced carcinogenesis in male CBA mice].
    Voprosy onkologii, 1998, Volume: 44, Issue:3

    Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Carcinogens; Colonic Neoplasms; Diethylstilbestrol; Kidney

1998
1,2-Dimethylhydrazine carcinogenesis in CBA male mice prenatally treated with diethylstilbestrol.
    Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 2000, Volume: 52, Issue:3

    Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Carcinoma; Colonic Neoplasms; Diethylstilbestrol; Female; I

2000
1,2-Dimethylhydrazine-induced colon carcinoma and lymphoma in msh2(-/-) mice.
    Journal of the National Cancer Institute, 2001, Oct-17, Volume: 93, Issue:20

    Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Alkylating Agents; Animals; Apoptosis; Base Pair Mismatch; Ca

2001
Renal cell tumors induced in CBA male mice by 1,2-dimethylhydrazine.
    Toxicologic pathology, 1992, Volume: 20, Issue:4

    Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Carcinogens; Carcinoma, Renal Cell; Dimethylhydrazines; gam

1992
[Modifying effects of changes connected with pregnancy on 1,2-dimethylhydrazine-induced carcinogenesis in rats].
    Eksperimental'naia onkologiia, 1990, Volume: 12, Issue:6

    Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma, Bile Duct; Animals; Colonic Neoplasms; Dimethylhydra

1990
[1,2-dimethylhydrazine induction of epithelial tumors of the kidneys in CBA strain mice].
    Eksperimental'naia onkologiia, 1990, Volume: 12, Issue:3

    Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Carcinogens; Carcinoma; Cystadenocarcinoma; Dimethylhydrazi

1990
[Morphogenesis and histogenesis of experimental malignant hemangioendothelioma].
    Voprosy onkologii, 1990, Volume: 36, Issue:4

    Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Dimethylhydrazines; Hemangioendothelioma; Kidney; Kidne

1990
Induction of renal tumors in cynomolgus monkeys (Macaca fascicularis) by prenatal exposure to 1,2-dimethylhydrazine.
    Journal of the National Cancer Institute, 1989, Sep-06, Volume: 81, Issue:17

    Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Dimethylhydrazines; Female; Kidney Neoplasms; Macaca fa

1989
[Induction of renal tumors in monkeys as a result of probable prenatal effects of 1,2-dimethylhydrazine].
    Voprosy onkologii, 1989, Volume: 35, Issue:12

    Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Dimethylhydrazines; Female; Kidney; Kidney Neoplasms; M

1989
[Effect of sex hormones on the induction of renal capsule angiosarcomas in mice].
    Eksperimental'naia onkologiia, 1989, Volume: 11, Issue:2

    Topics: 1,2-Dimethylhydrazine; Animals; Castration; Dimethylhydrazines; Drug Interactions; Estradiol; Female

1989
Chloroform inhibition of 1,2-dimethylhydrazine-induced gastrointestinal tract tumors in the Fisher 344 rat.
    Fundamental and applied toxicology : official journal of the Society of Toxicology, 1989, Volume: 13, Issue:1

    Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Body Weight; Chloroform; Dimethylhydrazines; Gastrointestin

1989
Effect of indomethacin in autotransplanted colonic tumors.
    Diseases of the colon and rectum, 1989, Volume: 32, Issue:6

    Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Colonic Neoplasms; Dimethylhydrazines;

1989
Induction of nephroblastoma-like renal tumours in rats by a single dose of 1,2-dimethylhydrazine.
    The Journal of pathology, 1985, Volume: 145, Issue:3

    Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Dimethylhydrazines; Disease Models, Animal; Female; Kid

1985
Postnatal carcinogenic study of 1,2-dimethylhydrazine dihydrochloride in rats.
    Neoplasma, 1986, Volume: 33, Issue:3

    Topics: 1,2-Dimethylhydrazine; Adenoma, Bile Duct; Animals; Dimethylhydrazines; Female; Hemangioma, Cavernou

1986
Carcinogenicity of deuterium-labeled 1,2-dimethylhydrazine in mice.
    Cancer research, 1988, Apr-15, Volume: 48, Issue:8

    Topics: 1,2-Dimethylhydrazine; Animals; Biotransformation; Carcinogens; Colonic Neoplasms; Deuterium; Dimeth

1988
[Modifying action of neonatal androgenization on 1,2-dimethylhydrazine-induced carcinogenesis in male CBA-strain mice].
    Biulleten' eksperimental'noi biologii i meditsiny, 1985, Volume: 99, Issue:2

    Topics: 1,2-Dimethylhydrazine; Animals; Animals, Newborn; Dimethylhydrazines; Hemangiosarcoma; Intestinal Ne

1985
Pararenal angiosarcoma induced in male mice by 1,2-dimethylhydrazine--a model for studying the role of androgens in chemical carcinogenesis.
    Carcinogenesis, 1985, Volume: 6, Issue:3

    Topics: 1,2-Dimethylhydrazine; Adenoma; Androgens; Animals; Carcinogens; Castration; Colonic Neoplasms; Dime

1985