1,2-dimethylhydrazine has been researched along with Invasiveness, Neoplasm in 10 studies
1,2-Dimethylhydrazine: A DNA alkylating agent that has been shown to be a potent carcinogen and is widely used to induce colon tumors in experimental animals.
1,2-dimethylhydrazine : A member of the class of hydrazines that is hydrazine in which one of the hydrogens attached to each nitrogen is replaced by a methyl group. A powerful DNA alkylating agent and carcinogen, it is used to induce colon cancer in laboratory rats and mice.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Colon cancer is the third most malignant neoplasm in the world and it remains an important cause of mortality in Asian and Western countries." | 1.37 | Astaxanthin inhibits tumor invasion by decreasing extracellular matrix production and induces apoptosis in experimental rat colon carcinogenesis by modulating the expressions of ERK-2, NFkB and COX-2. ( Nagendraprabhu, P; Sudhandiran, G, 2011) |
| "Colon cancer was induced in 40 Sprague Dawley rats using a 10-week course of 1,2 dimethylhydrazine (DMH)." | 1.29 | The growth of carcinogen-induced colon cancer in rats is inhibited by cimetidine. ( Adams, WJ; Cook, TA; Lawson, JA; Morris, DL; Nicholson, SE, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (40.00) | 18.7374 |
| 1990's | 4 (40.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 1 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Panchenko, AV | 1 |
| Petrishchev, NN | 1 |
| Kvetnoĭ, IM | 1 |
| Anisimov, VN | 1 |
| Nagendraprabhu, P | 1 |
| Sudhandiran, G | 1 |
| Ee, HC | 1 |
| Erler, T | 1 |
| Bhathal, PS | 1 |
| Young, GP | 1 |
| James, RJ | 1 |
| Adams, WJ | 1 |
| Lawson, JA | 1 |
| Nicholson, SE | 1 |
| Cook, TA | 1 |
| Morris, DL | 1 |
| Carter, JW | 1 |
| Lancaster, H | 1 |
| Hardman, WE | 1 |
| Cameron, IL | 1 |
| Lieubeau, B | 1 |
| Heymann, MF | 1 |
| Henry, F | 1 |
| Barbieux, I | 1 |
| Meflah, K | 1 |
| Grégoire, M | 1 |
| Rowlatt, C | 1 |
| Cruse, JP | 1 |
| Barton, T | 1 |
| Sadrudin, AA | 1 |
| Lewin, MR | 1 |
| Ljubimov, AV | 1 |
| Krutovskikh, VA | 1 |
| Martin, MS | 1 |
| Hammann, A | 1 |
| Martin, F | 1 |
| Gabbert, H | 1 |
1 review available for 1,2-dimethylhydrazine and Invasiveness, Neoplasm
| Article | Year |
|---|---|
Mechanisms of tumor invasion: evidence from in vivo observations.
Topics: 1,2-Dimethylhydrazine; Animals; Atrophy; Basement Membrane; Cell Differentiation; Cell Division; Cel | 1985 |
9 other studies available for 1,2-dimethylhydrazine and Invasiveness, Neoplasm
| Article | Year |
|---|---|
[Colon carcinogenesis in rat vs. variable light].
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Antioxidants; Carcinogens; Cell Differentiation; Cel | 2008 |
Astaxanthin inhibits tumor invasion by decreasing extracellular matrix production and induces apoptosis in experimental rat colon carcinogenesis by modulating the expressions of ERK-2, NFkB and COX-2.
Topics: 1,2-Dimethylhydrazine; Animals; Apoptosis; Cell Count; Colonic Neoplasms; Cyclooxygenase 2; DNA Frag | 2011 |
Cdx-2 homeodomain protein expression in human and rat colorectal adenoma and carcinoma.
Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Carcinoma; CDX2 Transcription Factor; Colon; Colonic Neopla | 1995 |
The growth of carcinogen-induced colon cancer in rats is inhibited by cimetidine.
Topics: 1,2-Dimethylhydrazine; Animals; Antigens, Neoplasm; Carcinogens; Cell Division; Chi-Square Distribut | 1993 |
Zinc deprivation promotes progression of 1,2-dimethylhydrazine-induced colon tumors but reduces malignant invasion in mice.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Body Weight; Carcinogens; Carcinoma in Situ; Collage | 1997 |
Immunomodulatory effects of tumor-associated fibroblasts in colorectal-tumor development.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Cell Division; Colonic Neoplasms; Fibroblasts; Gene | 1999 |
Comparison of the significance of three histopathological thresholds of malignancy in experimental colorectal tumours.
Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Carcinogens; Carcinoma in Situ; Colonic Neoplasms; Dimethyl | 1989 |
Distribution of laminin and collagen type IV in rat colon tumors induced by 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Basement Membrane; Carcinoma in Situ; Collagen; Colon; Colo | 1987 |
Gut-associated lymphoid tissue and 1,2-dimethylhydrazine intestinal tumors in the rat: an histological and immunoenzymatic study.
Topics: 1,2-Dimethylhydrazine; Animals; Antibodies, Monoclonal; Carcinogens; Colon; Dimethylhydrazines; Hist | 1986 |