1,2-dimethylhydrazine has been researched along with Innate Inflammatory Response in 23 studies
1,2-Dimethylhydrazine: A DNA alkylating agent that has been shown to be a potent carcinogen and is widely used to induce colon tumors in experimental animals.
1,2-dimethylhydrazine : A member of the class of hydrazines that is hydrazine in which one of the hydrogens attached to each nitrogen is replaced by a methyl group. A powerful DNA alkylating agent and carcinogen, it is used to induce colon cancer in laboratory rats and mice.
| Excerpt | Relevance | Reference |
|---|---|---|
| "2 mol% PlsEtn in EtnGpl) in 1,2-dimethylhydrazine (DMH)-induced aberrant crypt foci (ACF) in vivo, and elucidated the possible underlying mechanisms behind it." | 8.02 | Dietary PlsEtn Ameliorates Colon Mucosa Inflammatory Stress and ACF in DMH-Induced Colon Carcinogenesis Mice: Protective Role of Vinyl Ether Linkage. ( Kinoshita, M; Miyazawa, T; Nakagawa, K; Nguma, E; Otoki, Y; Tominaga, Y; Yamamoto, A; Yamashita, S, 2021) |
| "Phytic acid (PA) has been demonstrated to have a potent anticarcinogenic activity against colorectal cancer (CRC)." | 7.88 | Phytic acid improves intestinal mucosal barrier damage and reduces serum levels of proinflammatory cytokines in a 1,2-dimethylhydrazine-induced rat colorectal cancer model. ( Chen, C; Cheng, L; Li, X; Liu, C; Song, Y; Yang, F, 2018) |
| " In the present study, we investigated whether colonic neoplasms can be developed in mice initiated with a single injection of another genotoxic colonic carcinogen 1,2-dimethylhydrazine (DMH), instead of AOM and followed by exposure of DSS in drinking water." | 7.73 | Beta-Catenin mutations in a mouse model of inflammation-related colon carcinogenesis induced by 1,2-dimethylhydrazine and dextran sodium sulfate. ( Kohno, H; Sugie, S; Suzuki, R; Tanaka, T, 2005) |
| " The present study aimed to determine the preventive action of Ficus dubia latex extract (FDLE) on 1,2-dimethylhydrazine (DMH)-induced rat colorectal carcinogenesis and its mechanisms." | 4.12 | Ficus dubia latex extract prevent DMH-induced rat early colorectal carcinogenesis through the regulation of xenobiotic metabolism, inflammation, cell proliferation and apoptosis. ( Chantana, W; Chantarasuwan, B; Chewonarin, T; Hu, R; Pitchakarn, P; Subhawa, S; Temviriyanukul, P, 2022) |
| "2 mol% PlsEtn in EtnGpl) in 1,2-dimethylhydrazine (DMH)-induced aberrant crypt foci (ACF) in vivo, and elucidated the possible underlying mechanisms behind it." | 4.02 | Dietary PlsEtn Ameliorates Colon Mucosa Inflammatory Stress and ACF in DMH-Induced Colon Carcinogenesis Mice: Protective Role of Vinyl Ether Linkage. ( Kinoshita, M; Miyazawa, T; Nakagawa, K; Nguma, E; Otoki, Y; Tominaga, Y; Yamamoto, A; Yamashita, S, 2021) |
| "Phytic acid (PA) has been demonstrated to have a potent anticarcinogenic activity against colorectal cancer (CRC)." | 3.88 | Phytic acid improves intestinal mucosal barrier damage and reduces serum levels of proinflammatory cytokines in a 1,2-dimethylhydrazine-induced rat colorectal cancer model. ( Chen, C; Cheng, L; Li, X; Liu, C; Song, Y; Yang, F, 2018) |
| " Glycyrrhizic acid (GA) is an active constituent of licorice with anti-inflammatory and anticarcinogenesis effects." | 3.88 | Glycyrrhizic acid suppresses 1,2-dimethylhydrazine-induced colon tumorigenesis in Wistar rats: Alleviation of inflammatory, proliferation, angiogenic, and apoptotic markers. ( Khan, AQ; Khan, R; Rehman, MU; Sultana, S; Tahir, M, 2018) |
| "Several studies have shown the anti-neoplastic effects of non-steroidal anti-inflammatory drugs (NSAIDs) on 1,2-dimethylhydrazine (DMH)-induced colon carcinogenesis, but how these drugs act in case of inflammation-augmented tumorigenesis is still not clear." | 3.80 | Activation of NF-κB: bridging the gap between inflammation and cancer in colitis-mediated colon carcinogenesis. ( Nehru, B; Sanyal, SN; Setia, S, 2014) |
| " The lack of the protective layer of mucus may cause inflammation which has been linked to colon carcinogenesis, therefore, the expression of markers such as cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (i-NOS) and macrophage infiltration was studied with immunohistochemistry (IH) in MDF harvested from F344 rats treated with the colon carcinogen 1,2-dimethylhydrazine (DMH)." | 3.75 | Mucin-depleted foci show strong activation of inflammatory markers in 1,2-dimethylhydrazine-induced carcinogenesis and are promoted by the inflammatory agent sodium dextran sulfate. ( Caderni, G; Dolara, P; Femia, AP; Luceri, C; Salvadori, M, 2009) |
| " In the present study, we investigated whether colonic neoplasms can be developed in mice initiated with a single injection of another genotoxic colonic carcinogen 1,2-dimethylhydrazine (DMH), instead of AOM and followed by exposure of DSS in drinking water." | 3.73 | Beta-Catenin mutations in a mouse model of inflammation-related colon carcinogenesis induced by 1,2-dimethylhydrazine and dextran sodium sulfate. ( Kohno, H; Sugie, S; Suzuki, R; Tanaka, T, 2005) |
| "Moreover, LJE attenuated colon cancer initiation and progression by decreasing aberrant crypt foci and LJE recovered the gut microbiome." | 1.62 | Ellagitannins from jabuticaba (Myrciaria jaboticaba) seeds attenuated inflammation, oxidative stress, aberrant crypt foci, and modulated gut microbiota in rats with 1,2 dimethyl hydrazine-induced colon carcinogenesis. ( Almeida, LA; Azevedo, L; de Oliveira, PF; do Carmo, MAV; Feitoza, LQ; Ferreira, EB; Fidelis, M; Granato, D; Hellström, J; Marques, MJ; Novaes, RD; Oh, WY; Shahidi, F, 2021) |
| "Colon cancer is the third most malignant neoplasm in the world and it remains an important cause of mortality in Asian and Western countries." | 1.37 | Astaxanthin inhibits tumor invasion by decreasing extracellular matrix production and induces apoptosis in experimental rat colon carcinogenesis by modulating the expressions of ERK-2, NFkB and COX-2. ( Nagendraprabhu, P; Sudhandiran, G, 2011) |
| "Diclofenac treatment resulted in a significant reduction in COX-2 expression and its activity." | 1.36 | Modulation of inflammatory changes in early stages of colon cancer through activation of PPARgamma by diclofenac. ( Kaur, J; Sanyal, SN, 2010) |
| "Carcinoma was found in both the prolonged reactivation and saline-DMH groups." | 1.34 | Prolonged chronic inflammation progresses to dysplasia in a novel rat model of colitis-associated colon cancer. ( Appleyard, CB; Isidro, AA; Pagán, B; Santiago, C, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (4.35) | 18.2507 |
| 2000's | 5 (21.74) | 29.6817 |
| 2010's | 11 (47.83) | 24.3611 |
| 2020's | 6 (26.09) | 2.80 |
| Authors | Studies |
|---|---|
| Shree, A | 3 |
| Islam, J | 3 |
| Yadav, V | 1 |
| Sultana, S | 4 |
| Khan, HA | 1 |
| Hu, R | 1 |
| Chantana, W | 1 |
| Pitchakarn, P | 1 |
| Subhawa, S | 1 |
| Chantarasuwan, B | 1 |
| Temviriyanukul, P | 1 |
| Chewonarin, T | 1 |
| Ghazizadeh Darband, S | 1 |
| Saboory, E | 1 |
| Sadighparvar, S | 1 |
| Kaviani, M | 1 |
| Mobaraki, K | 1 |
| Jabbari, N | 1 |
| Majidinia, M | 1 |
| Vafa, A | 2 |
| Mohammad Afzal, S | 1 |
| Nguma, E | 1 |
| Tominaga, Y | 1 |
| Yamashita, S | 1 |
| Otoki, Y | 1 |
| Yamamoto, A | 1 |
| Nakagawa, K | 1 |
| Miyazawa, T | 1 |
| Kinoshita, M | 1 |
| do Carmo, MAV | 1 |
| Fidelis, M | 1 |
| de Oliveira, PF | 1 |
| Feitoza, LQ | 1 |
| Marques, MJ | 1 |
| Ferreira, EB | 1 |
| Oh, WY | 1 |
| Shahidi, F | 1 |
| Hellström, J | 1 |
| Almeida, LA | 1 |
| Novaes, RD | 1 |
| Granato, D | 1 |
| Azevedo, L | 1 |
| Thangaraj, K | 1 |
| Vaiyapuri, M | 1 |
| Liu, C | 1 |
| Chen, C | 1 |
| Yang, F | 1 |
| Li, X | 1 |
| Cheng, L | 1 |
| Song, Y | 1 |
| Khan, R | 1 |
| Rehman, MU | 1 |
| Khan, AQ | 1 |
| Tahir, M | 1 |
| Hasan, SK | 1 |
| Afzal, SM | 1 |
| Barnwal, P | 1 |
| Siddiqi, A | 1 |
| Ali, R | 1 |
| Setia, S | 1 |
| Nehru, B | 1 |
| Sanyal, SN | 2 |
| Chen, ZF | 1 |
| Ai, LY | 1 |
| Wang, JL | 1 |
| Ren, LL | 1 |
| Yu, YN | 1 |
| Xu, J | 1 |
| Chen, HY | 1 |
| Yu, J | 1 |
| Li, M | 1 |
| Qin, WX | 1 |
| Ma, X | 1 |
| Shen, N | 1 |
| Chen, YX | 1 |
| Hong, J | 1 |
| Fang, JY | 1 |
| Nanda, N | 1 |
| Dhawan, DK | 1 |
| Bhatia, A | 1 |
| Mahmood, A | 1 |
| Mahmood, S | 1 |
| Téllez-Bañuelos, MC | 1 |
| Haramati, J | 1 |
| Franco-Topete, K | 1 |
| Peregrina-Sandoval, J | 1 |
| Franco-Topete, R | 1 |
| Zaitseva, GP | 1 |
| Femia, AP | 1 |
| Dolara, P | 1 |
| Luceri, C | 1 |
| Salvadori, M | 1 |
| Caderni, G | 1 |
| Nagendraprabhu, P | 1 |
| Sudhandiran, G | 1 |
| Kaur, J | 1 |
| Toyoda-Hokaiwado, N | 1 |
| Yasui, Y | 1 |
| Muramatsu, M | 1 |
| Masumura, K | 1 |
| Takamune, M | 1 |
| Yamada, M | 1 |
| Ohta, T | 1 |
| Tanaka, T | 2 |
| Nohmi, T | 1 |
| Kohno, H | 1 |
| Suzuki, R | 1 |
| Sugie, S | 1 |
| Di Pace, RF | 1 |
| Massa, S | 1 |
| Ribeiro, OG | 1 |
| Cabrera, WH | 1 |
| De Franco, M | 1 |
| Starobinas, N | 1 |
| Seman, M | 1 |
| Ibañez, OC | 1 |
| Imai, T | 1 |
| Fukuta, K | 1 |
| Hasumura, M | 1 |
| Cho, YM | 1 |
| Ota, Y | 1 |
| Takami, S | 1 |
| Nakagama, H | 1 |
| Hirose, M | 1 |
| Santiago, C | 1 |
| Pagán, B | 1 |
| Isidro, AA | 1 |
| Appleyard, CB | 1 |
| Perdigón, G | 1 |
| Valdez, JC | 1 |
| Rachid, M | 1 |
23 other studies available for 1,2-dimethylhydrazine and Innate Inflammatory Response
| Article | Year |
|---|---|
Hesperetin alleviates DMH induced toxicity via suppressing oxidative stress and inflammation in the colon of Wistar rats.
Topics: 1,2-Dimethylhydrazine; Animals; Antioxidants; Catalase; Colon; Colonic Neoplasms; Glutathione; Hespe | 2022 |
Ficus dubia latex extract prevent DMH-induced rat early colorectal carcinogenesis through the regulation of xenobiotic metabolism, inflammation, cell proliferation and apoptosis.
Topics: 1,2-Dimethylhydrazine; Animals; Apoptosis; Carcinogenesis; Cell Proliferation; Colonic Neoplasms; Di | 2022 |
The modulatory effects of exercise on the inflammatory and apoptotic markers in rats with 1,2-dimethylhydrazine-induced colorectal cancer.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Apoptosis; Apoptosis Regulatory Proteins; Carci | 2020 |
Gallic acid prevents 1, 2-Dimethylhydrazine induced colon inflammation, toxicity, mucin depletion, and goblet cell disintegration.
Topics: 1,2-Dimethylhydrazine; Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Cell Proliferatio | 2020 |
Dietary PlsEtn Ameliorates Colon Mucosa Inflammatory Stress and ACF in DMH-Induced Colon Carcinogenesis Mice: Protective Role of Vinyl Ether Linkage.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Apoptosis; Carcinogenesis; Colon; Dietary Expos | 2021 |
Ellagitannins from jabuticaba (Myrciaria jaboticaba) seeds attenuated inflammation, oxidative stress, aberrant crypt foci, and modulated gut microbiota in rats with 1,2 dimethyl hydrazine-induced colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Chromosome Aberrations; Colonic Neoplasms; Gastrointest | 2021 |
Orientin, a C-glycosyl dietary flavone, suppresses colonic cell proliferation and mitigates NF-κB mediated inflammatory response in 1,2-dimethylhydrazine induced colorectal carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Biomarkers, Tumor; | 2017 |
Phytic acid improves intestinal mucosal barrier damage and reduces serum levels of proinflammatory cytokines in a 1,2-dimethylhydrazine-induced rat colorectal cancer model.
Topics: 1,2-Dimethylhydrazine; Animals; Body Weight; Cadherins; Claudin-1; Colon; Colorectal Neoplasms; Cyto | 2018 |
Glycyrrhizic acid suppresses 1,2-dimethylhydrazine-induced colon tumorigenesis in Wistar rats: Alleviation of inflammatory, proliferation, angiogenic, and apoptotic markers.
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Apoptosis; Biomarkers; Carcinogenesis; Cell | 2018 |
Colono-protective Potentiality of Methanolic Bark Extract of Acacia catechu: A Medicinal Plant against 1,2-Dimethylhydrazine-Induced Toxicity in Wistar Rats.
Topics: 1,2-Dimethylhydrazine; Acacia; Animals; Biomarkers; Carcinogens; Colon; Drug Administration Schedule | 2018 |
Activation of NF-κB: bridging the gap between inflammation and cancer in colitis-mediated colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Celecoxib; Colitis, Ulcerative; Colonic Neoplasms; Cyclooxygenase 2 | 2014 |
Probiotics Clostridium butyricum and Bacillus subtilis ameliorate intestinal tumorigenesis.
Topics: 1,2-Dimethylhydrazine; Administration, Oral; Animals; Apoptosis; Bacillus subtilis; Carcinogenesis; | 2015 |
Doxycycline Promotes Carcinogenesis & Metastasis via Chronic Inflammatory Pathway: An In Vivo Approach.
Topics: 1,2-Dimethylhydrazine; Animals; Body Weight; Carcinogenesis; Caspase 3; Caspase 9; Cell Proliferatio | 2016 |
Chronic exposure to endosulfan induces inflammation in murine colon via β-catenin expression and IL-6 production.
Topics: 1,2-Dimethylhydrazine; Administration, Oral; Animals; beta Catenin; Colitis; Colon; Colorectal Neopl | 2016 |
Mucin-depleted foci show strong activation of inflammatory markers in 1,2-dimethylhydrazine-induced carcinogenesis and are promoted by the inflammatory agent sodium dextran sulfate.
Topics: 1,2-Dimethylhydrazine; Animals; Azoxymethane; Carcinogens; Cell Transformation, Neoplastic; Colitis; | 2009 |
Astaxanthin inhibits tumor invasion by decreasing extracellular matrix production and induces apoptosis in experimental rat colon carcinogenesis by modulating the expressions of ERK-2, NFkB and COX-2.
Topics: 1,2-Dimethylhydrazine; Animals; Apoptosis; Cell Count; Colonic Neoplasms; Cyclooxygenase 2; DNA Frag | 2011 |
Modulation of inflammatory changes in early stages of colon cancer through activation of PPARgamma by diclofenac.
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Apoptosis; Apoptotic Protease-Activating Fa | 2010 |
Chemopreventive effects of silymarin against 1,2-dimethylhydrazine plus dextran sodium sulfate-induced inflammation-associated carcinogenicity and genotoxicity in the colon of gpt delta rats.
Topics: 1,2-Dimethylhydrazine; Animals; Antioxidants; Carcinogens; Colon; Colonic Neoplasms; Dextran Sulfate | 2011 |
Beta-Catenin mutations in a mouse model of inflammation-related colon carcinogenesis induced by 1,2-dimethylhydrazine and dextran sodium sulfate.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Azoxymethane; beta Catenin; Colitis; Colonic Neoplas | 2005 |
Inverse genetic predisposition to colon versus lung carcinogenesis in mouse lines selected based on acute inflammatory responsiveness.
Topics: 1,2-Dimethylhydrazine; Acute Disease; Adenocarcinoma; Adenoma; Animals; Antiviral Agents; Carcinogen | 2006 |
Significance of inflammation-associated regenerative mucosa characterized by Paneth cell metaplasia and beta-catenin accumulation for the onset of colorectal carcinogenesis in rats initiated with 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Animals; beta Catenin; Carcinogens; Colorectal Neoplasms; Inflammation; Injec | 2007 |
Prolonged chronic inflammation progresses to dysplasia in a novel rat model of colitis-associated colon cancer.
Topics: 1,2-Dimethylhydrazine; Adenomatous Polyposis Coli Protein; Animals; Carcinoma; Chronic Disease; Coli | 2007 |
Antitumour activity of yogurt: study of possible immune mechanisms.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; CD4 Lymphocyte Count; CD8-Positive T-Lymphocytes; Colon | 1998 |