1,2-dimethylhydrazine has been researched along with Hyperplasia in 21 studies
1,2-Dimethylhydrazine: A DNA alkylating agent that has been shown to be a potent carcinogen and is widely used to induce colon tumors in experimental animals.
1,2-dimethylhydrazine : A member of the class of hydrazines that is hydrazine in which one of the hydrogens attached to each nitrogen is replaced by a methyl group. A powerful DNA alkylating agent and carcinogen, it is used to induce colon cancer in laboratory rats and mice.
Hyperplasia: An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The running experiment was designed to test the chemopreventive activity of α-hederin when used as an adjuvant to carboplatin in an experimental model of mouse colon hyperplasia induced by 1,2-dimethylhydrazine (DMH)." | 8.02 | Chemopreventive effect of α-hederin/carboplatin combination against experimental colon hyperplasia and impact on JNK signaling. ( Bahr, HI; El-Sherbiny, M; Elbahaie, AM; Elmahdi, HS; Gabr, AM; Ibrahiem, AT; Soliman, N; Youssef, AM; Zaitone, SA, 2021) |
| "Male, Sprague-Dawley rats were injected subcutaneously with the colon carcinogen 1,2-dimethylhydrazine (DMH) at a dosage of 9." | 5.29 | Colonic crypts located over lymphoid nodules of 1,2-dimethylhydrazine-treated rats are hyperplastic and at high risk of forming adenocarcinomas. ( Cameron, IL; Hardman, WE, 1994) |
| " The running experiment was designed to test the chemopreventive activity of α-hederin when used as an adjuvant to carboplatin in an experimental model of mouse colon hyperplasia induced by 1,2-dimethylhydrazine (DMH)." | 4.02 | Chemopreventive effect of α-hederin/carboplatin combination against experimental colon hyperplasia and impact on JNK signaling. ( Bahr, HI; El-Sherbiny, M; Elbahaie, AM; Elmahdi, HS; Gabr, AM; Ibrahiem, AT; Soliman, N; Youssef, AM; Zaitone, SA, 2021) |
| "Weekly injections of dimethylhydrazine (DMH) (25 mg/kg), or azoxymethane (AOM) (8 mg/kg) to young adult male CDI mice for 1-2 months produced generalized intestinal crypt hyperplasia, which we measured in duodenum in terms of number of interphase and mitotic cells present in crypts." | 3.69 | Initiated stem cells in murine intestinal carcinogenesis: prolonged survival, control by NK cells, and progression. ( Altmann, GG; Lala, PK, 1994) |
| " The present study examined whether NK cells control 1,2-dimethylhydrazine (DMH)-induced hyperplasia of the duodenal crypt in CD1 mice." | 3.68 | Hyperplasia of mouse duodenal crypts and its control by NK cells during the initial phase of DMH carcinogenesis. ( Altmann, GG; Lala, PK; Parhar, RS, 1990) |
| "The induction of adenocarcinomas in distal colons of noninbred female Swiss Webster white mice by 1,2-dimethylhydrazine (DMH) is preceded by the development of hyperplasia of mucosal glands, which includes absolute increases in both the total number of cells and labeled cells per crypt." | 3.66 | Changes in crypt cell populations of mouse colon during recovery from treatment with 1,2-dimethylhydrazine. ( Richards, TC, 1981) |
| " The DMH was administered subcutaneously to six of the monkeys at a dosage of 25 mg/kg of body weight once a week for 16 weeks; control monkeys received an equivalent volume of the stock solution without DMH." | 1.31 | Failure to induce tumors in the large intestine of Capuchin mokeys (Cebus apella) by using 1,2-dimethylhydrazine. ( Borda, JT; Gimeno, EJ; Lertora, WJ; Montenegro, MA; Sánchez Negrette, M, 2000) |
| "Male, Sprague-Dawley rats were injected subcutaneously with the colon carcinogen 1,2-dimethylhydrazine (DMH) at a dosage of 9." | 1.29 | Colonic crypts located over lymphoid nodules of 1,2-dimethylhydrazine-treated rats are hyperplastic and at high risk of forming adenocarcinomas. ( Cameron, IL; Hardman, WE, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (33.33) | 18.7374 |
| 1990's | 8 (38.10) | 18.2507 |
| 2000's | 5 (23.81) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (4.76) | 2.80 |
| Authors | Studies |
|---|---|
| Bahr, HI | 1 |
| Ibrahiem, AT | 1 |
| Gabr, AM | 1 |
| Elbahaie, AM | 1 |
| Elmahdi, HS | 1 |
| Soliman, N | 1 |
| Youssef, AM | 1 |
| El-Sherbiny, M | 1 |
| Zaitone, SA | 1 |
| Appleton, DR | 1 |
| Csuka, O | 1 |
| Szentirmay, Z | 1 |
| Sugár, J | 1 |
| Richards, TC | 2 |
| Krutovskikh, VA | 1 |
| Turusov, VS | 1 |
| Celik, C | 1 |
| Mittelman, A | 1 |
| Paolini, NS | 1 |
| Lewis, D | 1 |
| Evans, JT | 1 |
| Hardman, WE | 1 |
| Cameron, IL | 1 |
| Altmann, GG | 3 |
| Lala, PK | 3 |
| Hirose, M | 3 |
| Yada, H | 1 |
| Hakoi, K | 1 |
| Takahashi, S | 1 |
| Ito, N | 3 |
| Sánchez Negrette, M | 2 |
| Borda, JT | 2 |
| Montenegro, MA | 2 |
| Lertora, JW | 1 |
| Kimoto, N | 2 |
| Kawabe, M | 2 |
| Satoh, T | 1 |
| Miyataka, H | 1 |
| Shirai, T | 4 |
| Lertora, WJ | 1 |
| Gimeno, EJ | 1 |
| Schleiffer, R | 1 |
| Duranton, B | 1 |
| Gossé, F | 1 |
| Hasselmann, M | 1 |
| Raul, F | 1 |
| Futakuchi, M | 1 |
| Iwata, T | 1 |
| Kasai, M | 1 |
| Hagiwara, A | 2 |
| Miyashita, K | 1 |
| Nakanishi, T | 1 |
| Sano, M | 1 |
| Tamano, S | 2 |
| Kadota, T | 1 |
| Koda, T | 2 |
| Nakamura, M | 2 |
| Imaida, K | 2 |
| Yoshino, H | 1 |
| Ichihara, T | 1 |
| Aoki, H | 1 |
| Viñas-Salas, J | 1 |
| Fortuny, JC | 1 |
| Panades, J | 1 |
| Piñol, C | 1 |
| Prim, M | 1 |
| Fermiñan, A | 1 |
| Corbella, G | 1 |
| Calderó, J | 1 |
| Egido, R | 1 |
| Parhar, RS | 1 |
| Fil'chenko, AA | 1 |
| Garmanchuk, LV | 1 |
| Ivashchenko, IuD | 1 |
| Bykorez, AI | 1 |
21 other studies available for 1,2-dimethylhydrazine and Hyperplasia
| Article | Year |
|---|---|
Chemopreventive effect of α-hederin/carboplatin combination against experimental colon hyperplasia and impact on JNK signaling.
Topics: 1,2-Dimethylhydrazine; Animals; Apoptosis; Carboplatin; Colon; Colonic Neoplasms; Hyperplasia; Male; | 2021 |
Aspects of statistics in studies of cell proliferation. I. Multistage sampling.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Cell Division; Cells, Cultured; Dimethylhydrazines; His | 1984 |
The effect of promoters on 1,2-dimethylhydrazine-induced colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Colon; Colonic Neoplasms; Dimethylhydrazines; DNA; Fema | 1984 |
Changes in crypt cell populations of mouse colon during recovery from treatment with 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Colonic Neoplasms; Dimethylhydrazines; Drug Administ | 1981 |
[Morphogenesis of experimental cancer of the large intestine (according to the results of scanning electron and light microscopy)].
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Animals; Carcinogens; Colonic Neoplasms; Dimethylhyd | 1982 |
Effects of 1,2-symmetrical dimethylhydrazine on jejunocolic transposition in Sprague-Dawley rats.
Topics: 1,2-Dimethylhydrazine; Animals; Colonic Neoplasms; Dimethylhydrazines; Female; Hyperplasia; Injectio | 1981 |
The effect of the carcinogen, 1,2-dimethylhydrazine, on turnover of 3H-thymidine labeled cells from mucosal glands of mouse colon.
Topics: 1,2-Dimethylhydrazine; Animals; Autoradiography; Carcinogens; Cell Division; Colon; Dimethylhydrazin | 1981 |
Colonic crypts located over lymphoid nodules of 1,2-dimethylhydrazine-treated rats are hyperplastic and at high risk of forming adenocarcinomas.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Cell Cycle; Cell Division; Cocarcinogen | 1994 |
Initiated stem cells in murine intestinal carcinogenesis: prolonged survival, control by NK cells, and progression.
Topics: 1,2-Dimethylhydrazine; Animals; Azoxymethane; Brunner Glands; Cell Survival; Cell Transformation, Ne | 1994 |
Modification of carcinogenesis by alpha-tocopherol, t-butylhydroquinone, propyl gallate and butylated hydroxytoluene in a rat multi-organ carcinogenesis model.
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Antioxidants; Butylated Hydroxytoluene; Car | 1993 |
[Histological and histochemical study of hyperplastic and dysplastic lesions of the large intestine in Cebus Apella (primate) treated with 1,2-dimethylhydrazine].
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Cebus; Colon; Epithelium; Hyperplasia; Male | 1998 |
Post-initiation effects of a super critical extract of propolis in a rat two-stage carcinogenesis model in female F344 rats.
Topics: 1,2-Dimethylhydrazine; 9,10-Dimethyl-1,2-benzanthracene; Administration, Oral; Animals; Anticarcinog | 1999 |
Failure to induce tumors in the large intestine of Capuchin mokeys (Cebus apella) by using 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Cebus; Hyperplasia; Injections, Subcutaneous; Intestina | 2000 |
Blood polyamine levels after oral ornithine load, a diagnostic marker of hyperproliferative premalignant and malignant stages in a model of colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Animals; Biomarkers, Tumor; Biotransformation; Body | 2000 |
Site-dependent modulating effects of conjugated fatty acids from safflower oil in a rat two-stage carcinogenesis model in female Sprague-Dawley rats.
Topics: 1,2-Dimethylhydrazine; 9,10-Dimethyl-1,2-benzanthracene; Animals; Body Weight; Butylhydroxybutylnitr | 2001 |
Pronounced inhibition by a natural anthocyanin, purple corn color, of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-associated colorectal carcinogenesis in male F344 rats pretreated with 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenocarcinoma, Mucinous; Adenoma; Administration, Oral; Anim | 2001 |
Prevention by natural food anthocyanins, purple sweet potato color and red cabbage color, of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-associated colorectal carcinogenesis in rats initiated with 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Adenoma; Administration, Oral; Animals; Anthocyanins; Anticarcinogenic Agents | 2002 |
Appearance of ear tumors in Sprague-Dawley rats treated with 1,2-dimethylhydrazine when used as a model for colonic carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Carcinoma, Squamous Cell; Colonic Neoplasms; Dimethylhy | 1992 |
Control of 1,2-dimethylhydrazine-induced crypt hyperplasia by natural-killer cells and its relevance to carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Cell Division; Dimethylhydrazines; Hyperplasia; Intesti | 1991 |
Hyperplasia of mouse duodenal crypts and its control by NK cells during the initial phase of DMH carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Dimethylhydrazines; Dose-Response Relationship, Drug; D | 1990 |
[The production of epidermal growth factor and polypeptides similar to it in the intestinal mucosa of rats in 1,2-dimethylhydrazine-induced carcinogenesis and compensatory regeneration].
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Chromatography, High Pressure Liquid; Dimethylhydrazine | 1989 |