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1,2-dimethylhydrazine and Folic Acid Deficiency

1,2-dimethylhydrazine has been researched along with Folic Acid Deficiency in 3 studies

1,2-Dimethylhydrazine: A DNA alkylating agent that has been shown to be a potent carcinogen and is widely used to induce colon tumors in experimental animals.
1,2-dimethylhydrazine : A member of the class of hydrazines that is hydrazine in which one of the hydrogens attached to each nitrogen is replaced by a methyl group. A powerful DNA alkylating agent and carcinogen, it is used to induce colon cancer in laboratory rats and mice.

Folic Acid Deficiency: A nutritional condition produced by a deficiency of FOLIC ACID in the diet. Many plant and animal tissues contain folic acid, abundant in green leafy vegetables, yeast, liver, and mushrooms but destroyed by long-term cooking. Alcohol interferes with its intermediate metabolism and absorption. Folic acid deficiency may develop in long-term anticonvulsant therapy or with use of oral contraceptives. This deficiency causes anemia, macrocytic anemia, and megaloblastic anemia. It is indistinguishable from vitamin B 12 deficiency in peripheral blood and bone marrow findings, but the neurologic lesions seen in B 12 deficiency do not occur. (Merck Manual, 16th ed)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (66.67)18.2507
2000's0 (0.00)29.6817
2010's1 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ventrella-Lucente, LF1
Unnikrishnan, A1
Pilling, AB1
Patel, HV1
Kushwaha, D1
Dombkowski, AA1
Schmelz, EM1
Cabelof, DC1
Heydari, AR1
Meenan, J1
Choi, SW1
Kim, YI1
Weitzel, JN1
Mason, JB1

Other Studies

3 other studies available for 1,2-dimethylhydrazine and Folic Acid Deficiency

ArticleYear
Folate deficiency provides protection against colon carcinogenesis in DNA polymerase beta haploinsufficient mice.
    The Journal of biological chemistry, 2010, Jun-18, Volume: 285, Issue:25

    Topics: 1,2-Dimethylhydrazine; Animal Feed; Animals; Apoptosis; Colonic Neoplasms; DNA Damage; DNA Polymeras

2010
Co-carcinogenic effect of sulphasalazine.
    British journal of cancer, 1993, Volume: 68, Issue:5

    Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Cocarcinogenesis; Dimethylhydrazines; Folic Acid Defici

1993
Folate depletion impairs DNA excision repair in the colon of the rat.
    Gut, 1998, Volume: 43, Issue:1

    Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Colon; DNA Repair; Electrophoresis, Agar Gel; Folic Aci

1998