1,2-dimethylhydrazine has been researched along with Experimental Neoplasms in 117 studies
1,2-Dimethylhydrazine: A DNA alkylating agent that has been shown to be a potent carcinogen and is widely used to induce colon tumors in experimental animals.
1,2-dimethylhydrazine : A member of the class of hydrazines that is hydrazine in which one of the hydrogens attached to each nitrogen is replaced by a methyl group. A powerful DNA alkylating agent and carcinogen, it is used to induce colon cancer in laboratory rats and mice.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Colorectal cancer has been found to be attenuated either with prophylactic manipulation of gut microbiome with probiotics or celecoxib, a non-steroidal anti-inflammatory drug mainly by suppressing early pro-carcinogenic markers in various experimental studies." | 7.88 | Prophylactic intervention of probiotics (L.acidophilus, L.rhamnosus GG) and celecoxib modulate Bax-mediated apoptosis in 1,2-dimethylhydrazine-induced experimental colon carcinogenesis. ( Chandel, D; Sharaf, LK; Sharma, M; Shukla, G, 2018) |
| "The modifying effect of pregnancy and lactation on carcinogenesis induced by single injection of 1,2-dimethylhydrazine to female rats 30 days before mating has been studied." | 7.68 | [Modifying effects of changes connected with pregnancy on 1,2-dimethylhydrazine-induced carcinogenesis in rats]. ( Blinova, GA; Mikheev, AM; Napalkov, NP, 1990) |
| "Colorectal cancer has been found to be attenuated either with prophylactic manipulation of gut microbiome with probiotics or celecoxib, a non-steroidal anti-inflammatory drug mainly by suppressing early pro-carcinogenic markers in various experimental studies." | 3.88 | Prophylactic intervention of probiotics (L.acidophilus, L.rhamnosus GG) and celecoxib modulate Bax-mediated apoptosis in 1,2-dimethylhydrazine-induced experimental colon carcinogenesis. ( Chandel, D; Sharaf, LK; Sharma, M; Shukla, G, 2018) |
| "This study was aimed to investigate the effect of sinapic acid (SA) on 1,2-dimethylhydrazine (DMH) induced experimental rat colon carcinogenesis." | 3.81 | Effect of sinapic acid on 1,2 dimethylhydrazine induced aberrant crypt foci, biotransforming bacterial enzymes and circulatory oxidative stress status in experimental rat colon carcinogenesis. ( Balaji, C; Muthukumaran, J; Nalini, N, 2015) |
| "The modifying effect of pregnancy and lactation on carcinogenesis induced by single injection of 1,2-dimethylhydrazine to female rats 30 days before mating has been studied." | 3.68 | [Modifying effects of changes connected with pregnancy on 1,2-dimethylhydrazine-induced carcinogenesis in rats]. ( Blinova, GA; Mikheev, AM; Napalkov, NP, 1990) |
| "Gut endocrine cells in a total of 122 intestinal-tract adenocarcinomas induced in inbred Wistar rats by 1,2-dimethylhydrazine dihydrochloride were examined histologically, ultrastructurally, and immunohistochemically for gastrin, somatostatin, vasoactive-intestinal polypeptide (VIP), and glicentin (enteroglucagon)." | 3.66 | Gut endocrine cells in rat intestinal-tract carcinoma induced by 1,2-dimethylhydrazine. ( Shimamoto, F; Tahara, E; Yanaihara, N, 1983) |
| "The induction of adenocarcinomas in distal colons of noninbred female Swiss Webster white mice by 1,2-dimethylhydrazine (DMH) is preceded by the development of hyperplasia of mucosal glands, which includes absolute increases in both the total number of cells and labeled cells per crypt." | 3.66 | Changes in crypt cell populations of mouse colon during recovery from treatment with 1,2-dimethylhydrazine. ( Richards, TC, 1981) |
| "To study the effect of acetic acid colitis on 1,2-dimethylhydrazine-induced colon tumorigenesis, fischer 344 male rats, 10 weeks of age, were divided into three groups: one receiving 5% acetic acid enema (subgroup 1a); one receiving 10% acetic acid enema (subgroup 1b); and one not receiving acetic acid enema (group 2)." | 3.66 | Experimental colitis as a promoter in large-bowel tumorigenesis. ( Hagihara, PF, 1982) |
| "CICC was induced with the colon cancer agent 1,2 dimethyl hydrazine (DMH) along with dextran sodium sulfate (DSS)." | 1.46 | Dietary selenium protects adiponectin knockout mice against chronic inflammation induced colon cancer. ( Carson, JA; Chanda, A; Fayad, R; Greer, J; Kaur, K; Saxena, A; Truman, S, 2017) |
| "DLD-1 human colon cancer cells were utilized to investigate the effect of AGE on anti-cell proliferation." | 1.42 | Aged garlic extract inhibits 1,2-dimethylhydrazine-induced colon tumor development by suppressing cell proliferation. ( Hirokawa, M; Jikihara, H; Nozoe, K; Qi, G; Sato, H; Shimamoto, F; Sugihara, Y, 2015) |
| "Colon cancer is one of the most commonly diagnosed cancers, and is a major cause of cancer morbidity and mortality worldwide." | 1.42 | Combined therapeutic efficacy of carvacrol and X-radiation against 1,2-dimethyl hydrazine-induced experimental rat colon carcinogenesis. ( Arivalagan, S; Chandrasekaran, B; Kuppsamy, T; Mani, V; Namasivayam, N; Siddique, AI; Thomas, NS, 2015) |
| "Colon cancer is becoming increasingly common in Asian countries and still remains the second leading cause of cancer death in the United States." | 1.33 | Effect of ginger on bacterial enzymes in 1,2-dimethylhydrazine induced experimental colon carcinogenesis. ( Manju, V; Nalini, N, 2006) |
| " To study the effects of PSC on liver cancer development, a daily dose of 30 mg PSC/kg body wt (PSC30) was chosen based on an initial dose-response experiment." | 1.32 | Effect of PSC 833, an inhibitor of P-glycoprotein, on 1,2-dimethylhydrazine-induced liver carcinogenesis in rats. ( Bradley, G; Kankesan, J; Laconi, E; Ling, V; Rajalakshmi, S; Rao, PM; Sarma, DS; Thiessen, JJ; Vanama, R; Yusuf, A, 2003) |
| " The DMH was administered subcutaneously to six of the monkeys at a dosage of 25 mg/kg of body weight once a week for 16 weeks; control monkeys received an equivalent volume of the stock solution without DMH." | 1.31 | Failure to induce tumors in the large intestine of Capuchin mokeys (Cebus apella) by using 1,2-dimethylhydrazine. ( Borda, JT; Gimeno, EJ; Lertora, WJ; Montenegro, MA; Sánchez Negrette, M, 2000) |
| "For mutagenic study chromosome aberrations tests (ChA) in bone marrow cells and sperm head anomaly test (SHA) were used." | 1.30 | [The influence of melatonin on mutagenicity and antitumor action of cytostatic drugs in mice]. ( Anisimov, VN; Mikheev, VS; Musatov, SA; Rosenfeld, SV; Togo, EF, 1997) |
| "Colon cancer was detected in two male monkeys after total DMH doses of 1080 and 3696 mg (528 and 400 mg/kg body wt." | 1.28 | Tumor induction in monkeys after administration of dimethylhydrazine. ( Beniashvili, DS; Krutovskikh, VA; Sartania, MS; Turusov, VS, 1992) |
| "The tumors of lung and liver, malignant lymphoma, and other tumors were induced." | 1.28 | Tumor induction in mice administered neonatally with 1,2-dimethylhydrazine. ( Fujii, K; Komano, H, 1989) |
| "1,2-dimethylhydrazine (DMH)-induced colon cancer in Wistar/Furth (W/Fu) rats is analogous in many ways to human colorectal cancer." | 1.27 | The effect of 1,2-dimethylhydrazine (DMH) carcinogenesis on peripheral T cell subsets in the Wistar Furth rat. ( Bleday, RS; Deasy, JM; Lahey, SJ; Milford, E; Rayner, AA; Rodrick, ML; Ross, DS; Steele, G; Wilson, RE, 1984) |
| "05) was lost when these dosed groups were compared with temporal control groups." | 1.27 | Chronic effects of dietary exposure to amosite and chrysotile asbestos in Syrian golden hamsters. ( McConnell, EE; Moore, JA; Rust, JH; Shefner, AM, 1983) |
| " Because dosage schedules are known from previous experiments with the Nb rat, this animal model may be useful for evaluating the effects of cytotoxic drugs on experimental bowel cancer." | 1.27 | Experimental cancer of the bowel in the Nb rat. ( Drago, JR; Joehl, RJ, 1983) |
| " In a lifetime study with the CBA strain, groups of 19-30 animals of each sex were dosed s." | 1.27 | Carcinogenicity of deuterium-labeled 1,2-dimethylhydrazine in mice. ( Gordon, WP; Hillery, PS; Keefer, LK; Lanko, NS; Nelson, SD; Parfenov, YD; Turusov, VS, 1988) |
| "Rats of 3 inbred strains (DA, HS and AS2) were dosed with 1,2-dimethylhydrazine 2HCl (DMH) or saline by gavage weekly for 10 wk." | 1.26 | The response of three inbred strains of rat to the carcinogen 1,2-dimethylhydrazine. ( Gavin, JB; Herdson, PB; Teague, CA, 1981) |
| "Cholesterol feeding of rats with colon cancer induced by dimethylhydrazine results in reduced survival and an increased incidence of metastatic colon cancer." | 1.26 | Dietary cholesterol deprivation improves survival and reduces incidence of metastatic colon cancer in dimethylhydrazine-pretreated rats. ( Clark, CG; Cruse, JP; Lewin, MR, 1982) |
| "The histogenesis of perianal squamous cell carcinomas induced by subcutaneous and intraperitoneal injection of 1,2-dimethylhydrazine dihydrochloride (DMH) and painting of methylazoxymethanol (MAM)-acetate on the anal region was investigated in 212 female BALB/c mice." | 1.26 | Perianal lesions of BALB/c mice induced by 1,2-dimethylhydrazine dihydrochloride and methylazoxymethanol-acetate: their classification and histogenesis. ( Furuya, K; Izumi, K; Kawaura, A; Kumagai, H; Otsuka, H, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 72 (61.54) | 18.7374 |
| 1990's | 16 (13.68) | 18.2507 |
| 2000's | 12 (10.26) | 29.6817 |
| 2010's | 15 (12.82) | 24.3611 |
| 2020's | 2 (1.71) | 2.80 |
| Authors | Studies |
|---|---|
| Sadighparvar, S | 2 |
| Darband, SG | 2 |
| Ghaderi-Pakdel, F | 2 |
| Mihanfar, A | 2 |
| Majidinia, M | 2 |
| Kumar, VL | 1 |
| Verma, S | 1 |
| Das, P | 1 |
| Yousefi, B | 1 |
| Kaviani, M | 1 |
| Rahimi, Y | 1 |
| Mobaraki, K | 1 |
| Sharaf, LK | 1 |
| Sharma, M | 1 |
| Chandel, D | 1 |
| Shukla, G | 1 |
| da Silva, FR | 1 |
| Dias, MC | 1 |
| Barbisan, LF | 3 |
| Rodrigues, MA | 2 |
| Munari, CC | 1 |
| Furtado, RA | 1 |
| Santiago, ML | 1 |
| Manhas, SS | 1 |
| Bastos, JK | 1 |
| Tavares, DC | 1 |
| Zhu, QC | 1 |
| Gao, RY | 1 |
| Wu, W | 1 |
| Guo, BM | 1 |
| Peng, JY | 1 |
| Qin, HL | 1 |
| Jikihara, H | 1 |
| Qi, G | 1 |
| Nozoe, K | 1 |
| Hirokawa, M | 1 |
| Sato, H | 1 |
| Sugihara, Y | 1 |
| Shimamoto, F | 2 |
| Arivalagan, S | 1 |
| Thomas, NS | 1 |
| Chandrasekaran, B | 1 |
| Mani, V | 1 |
| Siddique, AI | 1 |
| Kuppsamy, T | 1 |
| Namasivayam, N | 1 |
| Balaji, C | 1 |
| Muthukumaran, J | 1 |
| Nalini, N | 2 |
| Kuugbee, ED | 1 |
| Shang, X | 1 |
| Gamallat, Y | 1 |
| Bamba, D | 1 |
| Awadasseid, A | 1 |
| Suliman, MA | 1 |
| Zang, S | 1 |
| Ma, Y | 1 |
| Chiwala, G | 1 |
| Xin, Y | 1 |
| Shang, D | 1 |
| Bordini, HP | 1 |
| Kremer, JL | 1 |
| Fagundes, TR | 1 |
| Melo, GP | 1 |
| Conchon-Costa, I | 1 |
| da Silva, SS | 1 |
| Cecchini, AL | 1 |
| Panis, C | 1 |
| Luiz, RC | 1 |
| Sun, T | 1 |
| Liu, S | 1 |
| Zhou, Y | 1 |
| Yao, Z | 1 |
| Zhang, D | 1 |
| Cao, S | 1 |
| Wei, Z | 1 |
| Tan, B | 1 |
| Li, Y | 1 |
| Lian, Z | 1 |
| Wang, S | 1 |
| Taya, S | 1 |
| Thumvijit, T | 1 |
| Chewonarin, T | 1 |
| Punvittayagul, C | 1 |
| Wongpoomchai, R | 1 |
| Saxena, A | 1 |
| Fayad, R | 1 |
| Kaur, K | 1 |
| Truman, S | 1 |
| Greer, J | 1 |
| Carson, JA | 1 |
| Chanda, A | 1 |
| Fernandes, CR | 1 |
| Turatti, A | 1 |
| Gouvea, DR | 1 |
| Gobbo-Neto, L | 1 |
| Diniz, A | 1 |
| Ribeiro-Silva, A | 1 |
| Lopes, NP | 1 |
| Garcia, SB | 1 |
| Banu, NA | 1 |
| Daly, RS | 1 |
| Buda, A | 1 |
| Moorghen, M | 1 |
| Baker, J | 1 |
| Pignatelli, M | 1 |
| Steele, G | 3 |
| Chrissey, M | 1 |
| Gittes, R | 2 |
| Corson, J | 2 |
| Wilson, R | 2 |
| Yamagishi, M | 1 |
| Natsume, M | 1 |
| Osakabe, N | 1 |
| Okazaki, K | 1 |
| Furukawa, F | 1 |
| Imazawa, T | 1 |
| Nishikawa, A | 1 |
| Hirose, M | 6 |
| Kankesan, J | 1 |
| Yusuf, A | 1 |
| Laconi, E | 1 |
| Vanama, R | 1 |
| Bradley, G | 1 |
| Thiessen, JJ | 1 |
| Ling, V | 1 |
| Rao, PM | 1 |
| Rajalakshmi, S | 1 |
| Sarma, DS | 1 |
| Doi, K | 1 |
| Wanibuchi, H | 2 |
| Salim, EI | 2 |
| Shen, J | 1 |
| Wei, M | 1 |
| Mitsuhashi, M | 1 |
| Kudoh, S | 1 |
| Hirata, K | 1 |
| Fukushima, S | 3 |
| Delage, B | 1 |
| Groubet, R | 1 |
| Pallet, V | 1 |
| Bairras, C | 1 |
| Higueret, P | 1 |
| Cassand, P | 1 |
| Kinjo, T | 1 |
| Suzui, M | 1 |
| Morioka, T | 1 |
| Nabandith, V | 1 |
| Inamine, M | 1 |
| Kaneshiro, T | 1 |
| Arakaki, J | 1 |
| Nishimaki, T | 1 |
| Yoshimi, N | 1 |
| Wang, R | 1 |
| Dashwood, WM | 1 |
| Bailey, GS | 1 |
| Williams, DE | 1 |
| Dashwood, RH | 1 |
| Manju, V | 1 |
| Chadha, VD | 1 |
| Vaiphei, K | 1 |
| Dhawan, DK | 1 |
| Oumouna-Benachour, K | 1 |
| Oumouna, M | 1 |
| Zerfaoui, M | 1 |
| Hans, C | 1 |
| Fallon, K | 1 |
| Boulares, AH | 1 |
| Toth, B | 1 |
| Gurkalo, VK | 1 |
| Tahara, E | 1 |
| Yanaihara, N | 1 |
| Ross, DS | 1 |
| Rodrick, ML | 1 |
| Milford, E | 1 |
| Bleday, RS | 1 |
| Lahey, SJ | 1 |
| Deasy, JM | 1 |
| Rayner, AA | 1 |
| Wilson, RE | 1 |
| Teague, CA | 1 |
| Gavin, JB | 1 |
| Herdson, PB | 1 |
| Singh, D | 1 |
| Loven, DP | 1 |
| Stevens, RH | 2 |
| Sloan, DA | 1 |
| Fleiszer, DM | 1 |
| Richards, GK | 1 |
| Murray, D | 1 |
| Brown, RA | 1 |
| Jacobs, LR | 1 |
| McConnell, EE | 2 |
| Shefner, AM | 1 |
| Rust, JH | 1 |
| Moore, JA | 2 |
| Rutter, HA | 1 |
| Ulland, BM | 1 |
| Turusov, VS | 10 |
| Choluj, B | 1 |
| Hladík, V | 1 |
| Vozenílek, J | 1 |
| Wargovich, MJ | 1 |
| Medline, A | 1 |
| Bruce, WR | 1 |
| Decaëns, C | 1 |
| Rosa, B | 1 |
| Bara, J | 1 |
| Daher, N | 1 |
| Burtin, P | 1 |
| Deschner, EE | 2 |
| Long, FC | 2 |
| Hakissian, M | 2 |
| Cupo, SH | 1 |
| Maley, MA | 1 |
| House, AK | 1 |
| Ird, EA | 1 |
| Smirnova, IO | 2 |
| Joehl, RJ | 1 |
| Drago, JR | 1 |
| Freeman, HJ | 2 |
| Cole, DA | 1 |
| Meek, ES | 1 |
| Wagner, I | 1 |
| Habs, M | 1 |
| Schmähl, D | 1 |
| Amberger, H | 1 |
| Bachmann, U | 1 |
| Hamada, S | 1 |
| Scudamore, CH | 1 |
| Hattori, T | 1 |
| Helpap, B | 1 |
| Gedigk, P | 1 |
| Carachi, R | 1 |
| Beeley, JG | 1 |
| Mizutani, T | 1 |
| Mitsuoka, T | 1 |
| Snow, AD | 1 |
| Altmann, GG | 1 |
| Sunter, JP | 1 |
| Senior, PV | 1 |
| Lanko, NS | 4 |
| Murovannyĭ, AN | 1 |
| Bazlova, LS | 1 |
| Karamysheva, AF | 1 |
| Nauss, KM | 1 |
| Locniskar, M | 1 |
| Newberne, PM | 1 |
| Richards, TC | 2 |
| Kowal, EP | 1 |
| Markus, G | 1 |
| Martin, MS | 2 |
| Justrabo, E | 1 |
| Olsson, NO | 1 |
| Leclerc, A | 1 |
| Tacha, DE | 1 |
| Oscarson, JE | 1 |
| Veen, HF | 1 |
| Ross, JS | 1 |
| Malt, RA | 1 |
| Traynor, OJ | 1 |
| Wood, CB | 1 |
| Costa, N | 1 |
| Cruse, JP | 3 |
| Lewin, MR | 3 |
| Clark, CG | 3 |
| Koga, S | 1 |
| Kaibara, N | 1 |
| Takeda, R | 1 |
| Krutovskikh, VA | 2 |
| Parfenov, YD | 2 |
| Pozharisski, KM | 1 |
| Klimashevski, VF | 1 |
| Gushchin, VA | 1 |
| Tatematsu, M | 1 |
| Katsuyama, T | 1 |
| Nakanowatari, J | 1 |
| Hasegawa, R | 2 |
| Imaida, K | 2 |
| Ito, N | 5 |
| Hagihara, PF | 1 |
| Kumagai, H | 2 |
| Kawaura, A | 2 |
| Furuya, K | 2 |
| Izumi, K | 2 |
| Otsuka, H | 3 |
| Shimizu, H | 1 |
| Kimura, S | 1 |
| Kiyasu, Y | 1 |
| Toyonaga, F | 1 |
| Sakai, K | 1 |
| Sato, M | 1 |
| Reddy, BS | 1 |
| Hirota, N | 1 |
| Katayama, S | 2 |
| Shibata, M | 1 |
| Togei, K | 1 |
| Oida, T | 1 |
| Nakazawa, S | 1 |
| Ferulano, GP | 1 |
| Chemeris, GIu | 1 |
| Crissey, M | 1 |
| Harte, P | 1 |
| Castleden, WM | 1 |
| Rubio, CA | 1 |
| Nylander, G | 1 |
| Jacobs, MM | 1 |
| Forst, CF | 1 |
| Beams, FA | 1 |
| Silverman, J | 1 |
| Zelenakas, K | 1 |
| Lauber, J | 1 |
| Musser, TK | 1 |
| Reddy, M | 1 |
| Levenstein, MJ | 1 |
| Weisburger, H | 1 |
| Parfenov, IuD | 2 |
| Akagi, K | 3 |
| Hoshiya, T | 2 |
| Mizoguchi, Y | 1 |
| Shirai, T | 2 |
| Yada, H | 1 |
| Hakoi, K | 1 |
| Takahashi, S | 4 |
| Hara, Y | 1 |
| Kimura, J | 1 |
| Ogiso, T | 1 |
| Yoshida, Y | 1 |
| Kurata, M | 1 |
| Barnes, CJ | 1 |
| Lee, M | 1 |
| Hardman, WE | 1 |
| Cameron, IL | 2 |
| Van de Vrie, W | 1 |
| Marquet, RL | 1 |
| Eggermont, AM | 1 |
| Takeshita, M | 1 |
| Ueda, H | 1 |
| Shirabe, K | 1 |
| Higuchi, Y | 1 |
| Yoshida, S | 1 |
| Arutiunian, AV | 1 |
| Prokopenko, VM | 1 |
| Burmistrov, SO | 1 |
| Oparina, TI | 1 |
| Frolova, EV | 1 |
| Zabezhinskiĭ, MA | 2 |
| Popovich, IG | 2 |
| Anisimov, VN | 3 |
| Musatov, SA | 1 |
| Rosenfeld, SV | 1 |
| Togo, EF | 1 |
| Mikheev, VS | 1 |
| Liberman, AI | 1 |
| Shmidt, JL | 1 |
| Spinardi, AL | 1 |
| Kaneno, R | 2 |
| Salvadori, DM | 1 |
| Rocha, NS | 1 |
| Ribeiro, LR | 1 |
| de Camargo, JL | 1 |
| Taniyama, T | 1 |
| Yano, Y | 1 |
| Otani, S | 1 |
| Nishizawa, Y | 1 |
| Morii, H | 1 |
| Spinardi-Barbisan, AL | 1 |
| Marchesan Rodrigues, MA | 1 |
| Fávero Salvadori, DM | 1 |
| Trindade Moreira, EL | 1 |
| Viana de Camargo, JL | 1 |
| Sánchez Negrette, M | 1 |
| Borda, JT | 1 |
| Montenegro, MA | 1 |
| Lertora, WJ | 1 |
| Gimeno, EJ | 1 |
| Beniashvili, DS | 1 |
| Sartania, MS | 1 |
| Napalkov, NP | 1 |
| Mikheev, AM | 1 |
| Blinova, GA | 1 |
| Yamaguchi, S | 1 |
| Halline, AG | 1 |
| Dudeja, PK | 1 |
| Jacoby, RF | 1 |
| Llor, X | 1 |
| Teng, BB | 1 |
| Chowdhury, LN | 1 |
| Davidson, NO | 1 |
| Brasitus, TA | 1 |
| Heitman, DW | 1 |
| Ord, VA | 1 |
| Hunter, KE | 1 |
| Fujii, K | 1 |
| Komano, H | 1 |
| Baten, A | 1 |
| Ullah, A | 1 |
| Tomazic, VJ | 1 |
| Shamsuddin, AM | 1 |
| Ip, C | 1 |
| Gordon, WP | 1 |
| Nelson, SD | 1 |
| Hillery, PS | 1 |
| Keefer, LK | 1 |
| Goldin, BR | 1 |
| Nikonova, TV | 1 |
| Montesano, R | 1 |
| Politova, SN | 1 |
| Chang, WW | 1 |
| Samelson, SL | 1 |
| Nelson, RL | 1 |
| Nyhus, LM | 1 |
| Likhachev, A | 1 |
| Anisimov, V | 1 |
| Parvanova, L | 1 |
| Pozharisski, K | 1 |
4 reviews available for 1,2-dimethylhydrazine and Experimental Neoplasms
| Article | Year |
|---|---|
[Effect of dose fractionation on the carcinogenicity of chemical substances].
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Cricetinae; Dimethylhydrazines; Dose-Response Relations | 1984 |
[Experimental colorectal carcinogenesis (author's transl)].
Topics: 1,2-Dimethylhydrazine; Animals; Colonic Neoplasms; Dimethylhydrazines; Female; Male; Neoplasms, Expe | 1982 |
1,2-Dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Humans; Mutagenicity Tests; Mutagens; Neoplasms, Experi | 1999 |
The metabolism of the intestinal microflora and its relationship to dietary fat, colon and breast cancer.
Topics: 1,2-Dimethylhydrazine; Amino Acids; Animals; Biotransformation; Breast Neoplasms; Carcinogens; Colon | 1986 |
113 other studies available for 1,2-dimethylhydrazine and Experimental Neoplasms
| Article | Year |
|---|---|
Parasympathetic, but not sympathetic denervation, suppressed colorectal cancer progression.
Topics: 1,2-Dimethylhydrazine; Animals; Atropine; Carcinogenesis; Carcinogens; Colon; Colorectal Neoplasms; | 2021 |
Artesunate suppresses inflammation and oxidative stress in a rat model of colorectal cancer.
Topics: 1,2-Dimethylhydrazine; Administration, Oral; Animals; Anti-Inflammatory Agents; Antineoplastic Agent | 2019 |
Quercetin attenuated oxidative DNA damage through NRF2 signaling pathway in rats with DMH induced colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Antioxidants; Carcinogens; Catalase; Colonic Neoplasms; DNA Damage; | 2020 |
Prophylactic intervention of probiotics (L.acidophilus, L.rhamnosus GG) and celecoxib modulate Bax-mediated apoptosis in 1,2-dimethylhydrazine-induced experimental colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Apoptosis; bcl-2-Associated X Protein; Carcinogenesis; Carcinogens; | 2018 |
Lack of protective effects of zinc gluconate against rat colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Administration, Oral; Animals; Anticarcinogenic Agents; | 2013 |
Inhibitory effects of Baccharis dracunculifolia on 1,2-dimethylhidrazine-induced genotoxicity and preneoplastic lesions in rat colon.
Topics: 1,2-Dimethylhydrazine; Alkylating Agents; Animals; Baccharis; Colon; Colonic Neoplasms; Comet Assay; | 2014 |
Effect of a high-fat diet in development of colonic adenoma in an animal model.
Topics: 1,2-Dimethylhydrazine; Adenoma; Adiposity; Animals; Biomarkers, Tumor; Cell Cycle; Cell Proliferatio | 2014 |
Aged garlic extract inhibits 1,2-dimethylhydrazine-induced colon tumor development by suppressing cell proliferation.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Animals; Anticarcinogenic Agents; Blotting, Western; | 2015 |
Combined therapeutic efficacy of carvacrol and X-radiation against 1,2-dimethyl hydrazine-induced experimental rat colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Antigens, Nuclear; Antineoplastic Agents; Chemoradiotherapy; Colonic | 2015 |
Effect of sinapic acid on 1,2 dimethylhydrazine induced aberrant crypt foci, biotransforming bacterial enzymes and circulatory oxidative stress status in experimental rat colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Anti-Infective Agents; Carcinogenesis; Catalase | 2015 |
Structural Change in Microbiota by a Probiotic Cocktail Enhances the Gut Barrier and Reduces Cancer via TLR2 Signaling in a Rat Model of Colon Cancer.
Topics: 1,2-Dimethylhydrazine; Animals; Bifidobacterium bifidum; Bifidobacterium longum subspecies infantis; | 2016 |
Protective effect of metformin in an aberrant crypt foci model induced by 1,2-dimethylhydrazine: Modulation of oxidative stress and inflammatory process.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; AMP-Activated Protein Kinases; Animals; Cell Proliferati | 2017 |
Evolutionary biologic changes of gut microbiota in an 'adenoma-carcinoma sequence' mouse colorectal cancer model induced by 1, 2-Dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Adenomatous Polyposis Coli Protein; Animals; Bacteri | 2017 |
Effect of Spirogyra neglecta on the early stages of 1, 2-dimethylhydrazine-induced colon carcinogenesis in rats.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Anticarcinogenic Agents; Apoptosis; Aryl Hydroc | 2018 |
Dietary selenium protects adiponectin knockout mice against chronic inflammation induced colon cancer.
Topics: 1,2-Dimethylhydrazine; Adiponectin; Animals; Basic Helix-Loop-Helix Transcription Factors; Carcinoge | 2017 |
The protective role of Lychnophora ericoides Mart. (Brazilian arnica) in 1,2-dimethylhydrazine-induced experimental colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antica | 2011 |
Reduced tumour progression and angiogenesis in 1,2-dimethylhydrazine mice treated with NS-398 is associated with down-regulation of cyclooxygenase-2 and decreased beta-catenin nuclear localisation.
Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Apoptosis; beta Catenin; Bromodeoxyuridine; Carcinogens; Ce | 2011 |
Potentiation of 1-2-dimethylhydrazine-induced bowel carcinogenesis by the urinary bladder carcinogen N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Cocarcinogenesis; Drug Synergism; FANFT | 1980 |
Chemoprevention of lung carcinogenesis by cacao liquor proanthocyanidins in a male rat multi-organ carcinogenesis model.
Topics: 1,2-Dimethylhydrazine; Animals; Anthocyanins; Anticarcinogenic Agents; Butylhydroxybutylnitrosamine; | 2003 |
Effect of PSC 833, an inhibitor of P-glycoprotein, on 1,2-dimethylhydrazine-induced liver carcinogenesis in rats.
Topics: 1,2-Dimethylhydrazine; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Body Weight | 2003 |
Revised rat multi-organ carcinogenesis bioassay for whole-body detection of chemopreventive agents: modifying potential of S-methylcysteine.
Topics: 1,2-Dimethylhydrazine; Alkylating Agents; Animals; Biological Assay; Carcinogens; Chemoprevention; C | 2004 |
Vitamin A prevents high fat diet-induced ACF development and modifies the pattern of expression of peroxisome proliferator and retinoic acid receptor m-RNA.
Topics: 1,2-Dimethylhydrazine; Animals; Colon; Colonic Neoplasms; Dietary Fats; Fatty Acids, Omega-6; Intest | 2004 |
Distribution of preneoplastic lesions and tumors, and beta-catenin gene mutations in colon carcinomas induced by 1,2-dimethylhydrazine plus dextran sulfate sodium.
Topics: 1,2-Dimethylhydrazine; Animals; beta Catenin; Carcinogens; Colon; Colonic Neoplasms; Dextran Sulfate | 2006 |
Tumors from rats given 1,2-dimethylhydrazine plus chlorophyllin or indole-3-carbinol contain transcriptional changes in beta-catenin that are independent of beta-catenin mutation status.
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; beta Catenin; Carcinogens; Chlorophyllides; | 2006 |
Effect of ginger on bacterial enzymes in 1,2-dimethylhydrazine induced experimental colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Bacteria; Colonic Neoplasms; Glucuronidase; Incidence; Intestinal Mu | 2006 |
Zinc mediated normalization of histoarchitecture and antioxidant status offers protection against initiation of experimental carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Antioxidants; Carcinogens; Colonic Neoplasms; Drug Evaluation, Precl | 2007 |
Intrinsic resistance to apoptosis of colon epithelial cells is a potential determining factor in the susceptibility of the A/J mouse strain to dimethylhydrazine-induced colon tumorigenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Apoptosis; Carcinogens; Caspase 3; Colon; Colonic Neoplasms; Disease | 2007 |
Effect of Metamucil on tumour formation by 1,2-dimethylhydrazine dihydrochloride in mice.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Colonic Diseases; Colonic Neoplasms; Dietary Fiber; Dim | 1984 |
[Neuropharmacologic regulation of the carcinogenic action of 1,2-dimethylhydrazine].
Topics: 1,2-Dimethylhydrazine; Adrenergic alpha-Antagonists; Animals; Atropine; Autonomic Nervous System; Ca | 1981 |
Gut endocrine cells in rat intestinal-tract carcinoma induced by 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Chromaffin System; Dimethylhydrazines; | 1983 |
The effect of 1,2-dimethylhydrazine (DMH) carcinogenesis on peripheral T cell subsets in the Wistar Furth rat.
Topics: 1,2-Dimethylhydrazine; Animals; Antibodies, Monoclonal; Carcinogens; Colonic Neoplasms; Dimethylhydr | 1984 |
The response of three inbred strains of rat to the carcinogen 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma, Bile Duct; Animals; Carcinoma, Hepatocellular; Dimet | 1981 |
Adenosine 3',5'-cyclic monophosphate dependent and independent protein kinase activities in 1,2-dimethylhydrazine induced rat colon cancer.
Topics: 1,2-Dimethylhydrazine; Animals; Colonic Neoplasms; Cyclic AMP; Dimethylhydrazines; Hydrogen-Ion Conc | 1982 |
Increased incidence of experimental colon cancer associated with long-term metronidazole therapy.
Topics: 1,2-Dimethylhydrazine; Animals; Cocarcinogenesis; Colon; Colonic Neoplasms; Dietary Fiber; Dimethylh | 1983 |
Enhancement of rat colon carcinogenesis by wheat bran consumption during the stage of 1,2-dimethylhydrazine administration.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Colonic Neoplasms; Dietary Fiber; Dimet | 1983 |
Chronic effects of dietary exposure to amosite and chrysotile asbestos in Syrian golden hamsters.
Topics: 1,2-Dimethylhydrazine; Animals; Asbestos; Asbestos, Amosite; Asbestos, Serpentine; Body Weight; Coca | 1983 |
Chronic effects of dietary exposure to amosite asbestos and tremolite in F344 rats.
Topics: 1,2-Dimethylhydrazine; Animals; Asbestos; Asbestos, Amosite; Asbestos, Amphibole; Body Weight; Cocar | 1983 |
[An experimental model of cancer of the large intestine].
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Animals; Carcinogens; Cholestyramine Resin; Colonic | 1984 |
Early histopathologic events to evolution of colon cancer in C57BL/6 and CF1 mice treated with 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Animals; Cell Transformation, Neoplastic; Chromosome Aberrations; Colon; Colo | 1983 |
Effect of 13 cis retinoic acid on early precancerous antigenic goblet-cell modifications and induction of cancer during 1,2-dimethylhydrazine carcinogenesis in rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; | 1983 |
Differential susceptibility of inbred mouse strains forecast by acute colonic proliferative response to methylazoxymethanol.
Topics: 1,2-Dimethylhydrazine; Animals; Azo Compounds; Carcinogens; Cell Division; Colon; Dimethylhydrazines | 1984 |
The immune status of the rat with carcinoma of the bowel.
Topics: 1,2-Dimethylhydrazine; Animals; B-Lymphocytes; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; I | 1983 |
[Tumors induced by 1,2-dimethylhydrazine in hybrid mice with the pituitary gland transplanted in the kidney].
Topics: 1,2-Dimethylhydrazine; Animals; Anus Neoplasms; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; | 1983 |
Experimental cancer of the bowel in the Nb rat.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Colonic Neoplasms; Dimethylhydrazines; Disease Model | 1983 |
Role of host factors in carcinogenesis induced in mice by 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Dimethylhydrazines; Female; Hemangiosarcoma; Hemorrhage | 1983 |
Lectin histochemistry of 1,2-dimethylhydrazine-induced rat colon neoplasia.
Topics: 1,2-Dimethylhydrazine; Animals; Colonic Neoplasms; Dimethylhydrazines; Lectins; Male; Neoplasms, Exp | 1983 |
Antibody-dependent cell cytotoxicity in chemical-induced rat pancreas and colon cancer.
Topics: 1,2-Dimethylhydrazine; 9,10-Dimethyl-1,2-benzanthracene; Adenocarcinoma; Animals; Antibody-Dependent | 1981 |
Chemotherapeutic studies on N-nitrosoacetoxymethyl-methylamine-and 1,2-dimethylhydrazine-induced colonic tumors in rats: monotherapy with 5-fluorouracil, ftorafur, CGP 6809, and CGP 15'720A.
Topics: 1,2-Dimethylhydrazine; Animals; Antineoplastic Agents; Carcinogens; Colonic Neoplasms; Dimethylhydra | 1982 |
[Anticancer effect of levamisole and tegafur on 1,2-dimethylhydrazine (DMH)-induced colonic cancers in rats].
Topics: 1,2-Dimethylhydrazine; Animals; Antineoplastic Agents; Colonic Neoplasms; Dimethylhydrazines; Fluoro | 1982 |
Effects of small bowel transection, resection, or bypass in 1,2-dimethylhydrazine-induced rat intestinal neoplasia.
Topics: 1,2-Dimethylhydrazine; Animals; Body Weight; Colonic Neoplasms; Dimethylhydrazines; Feces; Gastroint | 1983 |
Development and cell kinetics of colonic tumors induced in mice by dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Animals; Autoradiography; Carcinoma; Cell Division; | 1983 |
Polyamines in colorectal cancer--a clinical and experimental approach.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Humans; Male; Ne | 1983 |
Effect of Konjac mannan on 1,2-dimethylhydrazine-induced intestinal carcinogenesis in Fischer 344 rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Body Weight; Carcinogens; Colonic Neoplasms; Dimethy | 1983 |
Time-related increase of nucleolar size and villus cell number during DMH carcinogenesis in the rat duodenal epithelium.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Cell Count; Cell Nucleolus; Dimethylhydrazines; Duodena | 1983 |
Induction of renal tumours in rats by the administration of 1,2 dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Dimethylhydrazines; Female; Injections, Subcutaneous; K | 1983 |
[Influence of the rhythm and route of 1,2-dimethylhydrazine administration on its carcinogenic effect in mice].
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Cytochrome b Group; Cytochrome P-450 Enzyme System; Cyt | 1983 |
Effect of alterations in the quality and quantity of dietary fat on 1,2-dimethylhydrazine-induced colon tumorigenesis in rats.
Topics: 1,2-Dimethylhydrazine; Animals; Body Weight; Carcinogens; Colonic Neoplasms; Diet; Dietary Fats; Dim | 1983 |
Changes in crypt cell populations of mouse colon during recovery from treatment with 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Colonic Neoplasms; Dimethylhydrazines; Drug Administ | 1981 |
Kinetic properties of thymidine kinase from the cytosol of a rat colon adenocarcinoma.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Colonic Neoplasms; Cytosol; Dimethylhyd | 1982 |
[Hemoccult and experimental intestinal tumours (author's transl)].
Topics: 1,2-Dimethylhydrazine; Animals; Dimethylhydrazines; False Negative Reactions; Gastrointestinal Hemor | 1981 |
Effects of sublethal irradiation on changes in crypts of the mouse colon during treatment with 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Animals; Autoradiography; Carcinogens; Cell Division; Colon; Colonic Neoplasm | 1982 |
Dimethylhydrazine-induced colonic neoplasia: dissociation from endogenous gastrin levels.
Topics: 1,2-Dimethylhydrazine; Animals; Colonic Neoplasms; Dimethylhydrazines; Gastric Fundus; Gastrins; Mal | 1982 |
Ultrastructural alterations in the colonic mucus layer during carcinogenesis : a scanning electron microscopy study.
Topics: 1,2-Dimethylhydrazine; Animals; Colonic Neoplasms; Dimethylhydrazines; Humans; Intestinal Mucosa; Ma | 1982 |
Dietary cholesterol deprivation improves survival and reduces incidence of metastatic colon cancer in dimethylhydrazine-pretreated rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Cholesterol, Dietary; Colonic Neoplasms; Dimethylhyd | 1982 |
Effect of bile acids on 1,2-dimethylhydrazine-induced colon cancer in rats.
Topics: 1,2-Dimethylhydrazine; Animals; Bile Acids and Salts; Carcinogens; Colonic Neoplasms; Dimethylhydraz | 1982 |
Strain differences in susceptibility of female mice to 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Anal Gland Neoplasms; Animals; Carcinogens; Colonic Neoplasms; Dimethylhydraz | 1982 |
Study of kinetics of epithelial cell populations in normal tissues of the rat's intestines and in carcinogenesis. III. Changes in kinetics of enterocyte populations in the course of experimental intestinal tumour induction in rats.
Topics: 1,2-Dimethylhydrazine; Animals; Colon; Dimethylhydrazines; Epithelial Cells; Ileum; Intestinal Neopl | 1982 |
Region-specific patterns of mucin reaction demonstrated by paradoxical concanavalin A-staining in normal colonic epithelium and in colorectal cancers induced in rats by 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Animals; Colon; Colonic Neoplasms; Concanavalin A; Dimethylhydrazines; Epithe | 1982 |
Experimental colitis as a promoter in large-bowel tumorigenesis.
Topics: 1,2-Dimethylhydrazine; Acetates; Adenocarcinoma; Adenoma; Animals; Colitis; Colonic Neoplasms; Dimet | 1982 |
Perianal lesions of BALB/c mice induced by 1,2-dimethylhydrazine dihydrochloride and methylazoxymethanol-acetate: their classification and histogenesis.
Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Anus Neoplasms; Azo Compounds; Carcinogens; Carcinoma, Squa | 1982 |
[The prophylactic effects of a streptococcal preparation OK-432 on carcinogenesis in rats by MNNG and DMH].
Topics: 1,2-Dimethylhydrazine; Animals; Biological Products; Carcinogens; Dimethylhydrazines; Male; Methylhy | 1982 |
Effect of dietary sodium ascorbate on 1,2-dimethylhydrazine- or methylnitrosourea-induced colon carcinogenesis in rats.
Topics: 1,2-Dimethylhydrazine; Animals; Ascorbic Acid; Colonic Neoplasms; Diet; Dimethylhydrazines; Female; | 1982 |
Effect of dietary degraded carrageenan on intestinal carcinogenesis in rats treated with 1,2-dimethylhydrazine dihydrochloride.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Carrageenan; Dietary Carbohydrates; Dimethylhydrazines; | 1982 |
[Experimental colonic cancer induced by 1,2-dimethylhydrazine (DMH). Especially, emphasis on sequential observations by endoscopy and X-ray].
Topics: 1,2-Dimethylhydrazine; Animals; Colon; Colonic Neoplasms; Colonoscopy; Dimethylhydrazines; Male; Met | 1982 |
Subtotal colectomy in the dimethylhydrazine-treated rat. A surgical model of colorectal cancer.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Colectomy; Colonic Neoplasms; Dimethylhydrazines; Femal | 1982 |
[Effect of castration and mouse strain on 1, 2-dimethylhydrazine induction of pararenal angiosarcomas and kidney adenomas].
Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Castration; Dimethylhydrazines; Hemangiosarcoma; Kidney Neo | 1982 |
Potentiation of dimethylhydrazine bowel carcinogenesis in rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinoma, Transitional Cell; Cocarcinogenesis; Colo | 1981 |
Metachronous carcinomas of the large and small bowel.
Topics: 1,2-Dimethylhydrazine; Animals; Colonic Neoplasms; Diet; Dimethylhydrazines; Humans; Neoplasms, Expe | 1980 |
Further studies on the carcinogenesis of the colon of the rat with special reference to the absence of intestinal contents.
Topics: 1,2-Dimethylhydrazine; Animals; Bile Acids and Salts; Cocarcinogenesis; Colonic Neoplasms; Dimethylh | 1981 |
The effects of cholic acid and bile salt binding agents on 1,2-dimethylhydrazine-induced colon carcinogenesis in the rat.
Topics: 1,2-Dimethylhydrazine; Aluminum Hydroxide; Animals; Bile Acids and Salts; Body Weight; Cholestyramin | 1981 |
Biochemical and clinical effects of selenium on dimethylhydrazine-induced colon cancer in rats.
Topics: 1,2-Dimethylhydrazine; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Blood Cell Count; | 1981 |
Effect of retinoids on the induction of colon cancer in F344 rats by N-methyl-N-nitrosourea or by 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Administration, Oral; Animals; Carcinogens; Colonic Neoplasms; Dimethylhydraz | 1981 |
[Effect of age on induction of intestinal tumors in mice by 1,2-dimethylhydrazine].
Topics: 1,2-Dimethylhydrazine; Age Factors; Animals; Carcinogens; Dimethylhydrazines; Intestinal Neoplasms; | 1981 |
Effects of colonic ligation on the carcinogenesis by 1,2-dimethylhydrazine dihydrochloride in Balb/C mice.
Topics: 1,2-Dimethylhydrazine; Animals; Colon; Colonic Neoplasms; Dimethylhydrazines; Female; Ligation; Meth | 1981 |
Modulating effects of ellagic acid, vanillin and quercetin in a rat medium term multi-organ carcinogenesis model.
Topics: 1,2-Dimethylhydrazine; Animals; Benzaldehydes; Butylhydroxybutylnitrosamine; Diethylnitrosamine; Dim | 1995 |
Modification of carcinogenesis by alpha-tocopherol, t-butylhydroquinone, propyl gallate and butylated hydroxytoluene in a rat multi-organ carcinogenesis model.
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Antioxidants; Butylated Hydroxytoluene; Car | 1993 |
Effects of green tea catechins in a rat multi-organ carcinogenesis model.
Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Anticarcinogenic Agents; Body Weight; Butylhydroxybutylnitr | 1993 |
Lack of chemoprevention effects of the monoterpene d-limonene in a rat multi-organ carcinogenesis model.
Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Anticarcinogenic Agents; Butylhydroxybutylnitrosamine; Carc | 1996 |
Aspirin suppresses 1,2-dimethylhydrazine-induced alteration of proliferative parameters in rat colonic crypts.
Topics: 1,2-Dimethylhydrazine; Animals; Aspirin; Cell Division; Dimethylhydrazines; Intestinal Mucosa; Male; | 1996 |
Cyclosporin A enhances locoregional metastasis of the CC531 rat colon tumour.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Antibiotics, Antineoplastic; Carcinogens; Colonic Ne | 1997 |
Lack of promotion of colon carcinogenesis by high-oleic safflower oil.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogenicity Tests; Carcinogens; Colon; Colonic Neoplasms; Dimeth | 1997 |
[Free-radical processes in blood serum, liver and large bowel during 1,2-dimethylhydrazine-induced carcinogenesis in rats].
Topics: 1,2-Dimethylhydrazine; Animals; Ceruloplasmin; Free Radicals; Intestine, Large; Liver; Male; Neoplas | 1997 |
[The influence of melatonin on mutagenicity and antitumor action of cytostatic drugs in mice].
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Antineoplastic Agents; Bone Marrow Cells; C | 1997 |
[Effect of the enterosorbent Aqualen on intestinal carcinogenesis induced by 1,2-dimethylhydrazine in rats].
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Colorectal Neoplasms; Enterosorption; Femal | 1998 |
Natural killer activity in a medium-term multi-organ bioassay for carcinogenesis.
Topics: 1,2-Dimethylhydrazine; 2-Acetylaminofluorene; Animals; Biological Assay; Carcinogenicity Tests; Carc | 1999 |
Chemopreventive effect of 24R,25-dihydroxyvitamin D(3) in N, N'-dimethylhydrazine-induced rat colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; 24,25-Dihydroxyvitamin D 3; Animals; Anticarcinogenic Agents; Butylhydroxybut | 2000 |
Lymphoproliferative response and T lymphocyte subsets in a medium-term multi-organ bioassay for carcinogenesis in Wistar rats.
Topics: 1,2-Dimethylhydrazine; 2-Acetylaminofluorene; Alkylating Agents; Animals; Body Weight; Butylhydroxyb | 2000 |
Failure to induce tumors in the large intestine of Capuchin mokeys (Cebus apella) by using 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Cebus; Hyperplasia; Injections, Subcutaneous; Intestina | 2000 |
Tumor induction in monkeys after administration of dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Colonic Neoplasms; Dimethylhydrazines; Dose-Response | 1992 |
[Modifying effects of changes connected with pregnancy on 1,2-dimethylhydrazine-induced carcinogenesis in rats].
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma, Bile Duct; Animals; Colonic Neoplasms; Dimethylhydra | 1990 |
Effects of naturally occurring antioxidants on combined 1,2-dimethylhydrazine- and 1-methyl-1-nitrosourea-initiated carcinogenesis in F344 male rats.
Topics: 1,2-Dimethylhydrazine; Animals; Antioxidants; beta Carotene; Carotenoids; Coumaric Acids; Dimethylhy | 1990 |
Effect of polyamine oxidase inhibition on the colonic malignant transformation process induced by 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Acetyltransferases; Adenocarcinoma; Animals; Base Sequence; Carcinogens; Colo | 1990 |
Effect of dietary cellulose on cell proliferation and progression of 1,2-dimethylhydrazine-induced colon carcinogenesis in rats.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinoma; Cell Division; Cellulose; Colon; Colonic Neoplasms; Dieta | 1989 |
Tumor induction in mice administered neonatally with 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Animals; Animals, Newborn; Carcinogens; Colonic Neoplasms; Dimethylhydrazines | 1989 |
Inositol-phosphate-induced enhancement of natural killer cell activity correlates with tumor suppression.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Cells, Cultured; Cytotoxicity, Immunologic; Dimethylhyd | 1989 |
Selenium and experimental cancer.
Topics: 1,2-Dimethylhydrazine; 2-Acetylaminofluorene; 9,10-Dimethyl-1,2-benzanthracene; Animals; Ascorbic Ac | 1986 |
1,2-Dimethylhydrazine carcinogenesis in neonatally androgenized CBA mice.
Topics: 1,2-Dimethylhydrazine; Animals; Animals, Newborn; Colonic Neoplasms; Dimethylhydrazines; Estrus; Fem | 1988 |
Susceptibility to 1,2-dimethylhydrazine-induced colonic tumors and epithelial cell proliferation characteristics of F1, F2, and reciprocal backcrosses derived from SWR/J and AKR/J parental mouse strains.
Topics: 1,2-Dimethylhydrazine; Animals; Colonic Neoplasms; Crosses, Genetic; Dimethylhydrazines; Injections, | 1988 |
Carcinogenicity of deuterium-labeled 1,2-dimethylhydrazine in mice.
Topics: 1,2-Dimethylhydrazine; Animals; Biotransformation; Carcinogens; Colonic Neoplasms; Deuterium; Dimeth | 1988 |
[Effect of the duration of administration of 1,2-dimethylhydrazine on its carcinogenic effect].
Topics: 1,2-Dimethylhydrazine; Animals; Dimethylhydrazines; Dose-Response Relationship, Drug; Female; Methyl | 1987 |
The mode of growth and compartmentalization of neoplastic glands during experimental colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Cell Cycle; Colonic Neoplasms; Dimethylhydrazines; Female; Growth; M | 1986 |
Protective role of faecal pH in experimental colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Colonic Neoplasms; Diet; Dimethylhydrazines; Feces; Hyd | 1985 |
Effect of exogenous beta-glucuronidase on the carcinogenicity of 1,2-dimethylhydrazine in rats: evidence that carcinogenic intermediates form conjugates and act through their subsequent enzymatic release.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Dimethylhydrazines; Glucuronates; Glucuronidase; Male; | 1985 |