1,2-dimethylhydrazine has been researched along with Disease Models, Animal in 110 studies
1,2-Dimethylhydrazine: A DNA alkylating agent that has been shown to be a potent carcinogen and is widely used to induce colon tumors in experimental animals.
1,2-dimethylhydrazine : A member of the class of hydrazines that is hydrazine in which one of the hydrogens attached to each nitrogen is replaced by a methyl group. A powerful DNA alkylating agent and carcinogen, it is used to induce colon cancer in laboratory rats and mice.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Phytic acid (PA) has been demonstrated to have a potent anticarcinogenic activity against colorectal cancer (CRC)." | 7.88 | Phytic acid improves intestinal mucosal barrier damage and reduces serum levels of proinflammatory cytokines in a 1,2-dimethylhydrazine-induced rat colorectal cancer model. ( Chen, C; Cheng, L; Li, X; Liu, C; Song, Y; Yang, F, 2018) |
| "In a previous study, we developed a novel mouse model for colitis-related carcinogenesis, utilizing a single dose of azoxymethane (AOM) followed by dextran sodium sulfate (DSS) in drinking water." | 7.73 | Beta-Catenin mutations in a mouse model of inflammation-related colon carcinogenesis induced by 1,2-dimethylhydrazine and dextran sodium sulfate. ( Kohno, H; Sugie, S; Suzuki, R; Tanaka, T, 2005) |
| "Colorectal cancer is one of the primary causes of cancer-related mortality worldwide." | 5.62 | Promising targets of chrysin and daidzein in colorectal cancer: Amphiregulin, CXCL1, and MMP-9. ( Allam, RM; Salama, AAA, 2021) |
| "Background Colorectal cancer (CRC) is a major public health problem, with almost 1." | 5.56 | Protective effect of Matricaria chamomilla extract against 1,2-dimethylhydrazine-induced colorectal cancer in mice. ( Borjac, JM; El Joumaa, MM; Rizk, S; Taleb, RI, 2020) |
| "Colon cancer is thought to develop in a stepwise fashion." | 5.48 | Precancerous ACF induction affects their regional distribution forsaking oxidative stress implication in 1,2-dimethylhydrazine-induced colon carcinogenesis model. ( Clichici, S; Djerdjouri, B; Moulahoum, H; Nagy, AL, 2018) |
| "Colon carcinogenesis is long known to be associated with ulcerative colitis (UC), a chronic gastrointestinal disorder." | 5.43 | Melatonin modulated autophagy and Nrf2 signaling pathways in mice with colitis-associated colon carcinogenesis. ( Jena, GB; Kumar, V; Tikoo, KB; Trivedi, PP, 2016) |
| " Colorectal cancer was induced in all animals by weekly subcutaneous injections of the colonic procarcinogen 1,2-dimethylhydrazine (DMH) at a dosage of 20 mg/kg body weight." | 5.29 | Effect of supplemental L-arginine in a chemical-induced model of colorectal cancer. ( Anderson, N; Hoper, M; Ma, Q; Rowlands, BJ, 1996) |
| "Phytic acid (PA) has been demonstrated to have a potent anticarcinogenic activity against colorectal cancer (CRC)." | 3.88 | Phytic acid improves intestinal mucosal barrier damage and reduces serum levels of proinflammatory cytokines in a 1,2-dimethylhydrazine-induced rat colorectal cancer model. ( Chen, C; Cheng, L; Li, X; Liu, C; Song, Y; Yang, F, 2018) |
| "Several studies have shown the anti-neoplastic effects of non-steroidal anti-inflammatory drugs (NSAIDs) on 1,2-dimethylhydrazine (DMH)-induced colon carcinogenesis, but how these drugs act in case of inflammation-augmented tumorigenesis is still not clear." | 3.80 | Activation of NF-κB: bridging the gap between inflammation and cancer in colitis-mediated colon carcinogenesis. ( Nehru, B; Sanyal, SN; Setia, S, 2014) |
| "This work investigated the effects of Vitamin E (VE) on aberrant crypt foci (ACF) incidence, oxidative stress parameters (serum and hepatic VE concentration, and homocysteine, glutathione (GSH), and malondialdehyde (MDA) levels), and expression of both cyclooxygenase-2 (COX2) and proliferating cellular nuclear antigen (PCNA) in experimental colorectal carcinogenesis." | 3.80 | Vitamin E supplementation in chemical colorectal carcinogenesis: a two-edged knife. ( Cardoso, JF; Cohen, C; Garcia, SB; Vannucchi, H, 2014) |
| "To evaluate the preventive effect of sodium butyrate in the appearance of aberrant crypt foci (ACF) in rats after induction with the carcinogen 1,2-dimethylhydrazine (DMH)." | 3.76 | Sodium butyrate does not decrease the evolution of precancerous lesions in rats. ( Glória, MB; Mendes, MC; Peluzio, Mdo C; Penido, LC; Rosa, DD; Silva, FG; Valente, FX, 2010) |
| " The lack of the protective layer of mucus may cause inflammation which has been linked to colon carcinogenesis, therefore, the expression of markers such as cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (i-NOS) and macrophage infiltration was studied with immunohistochemistry (IH) in MDF harvested from F344 rats treated with the colon carcinogen 1,2-dimethylhydrazine (DMH)." | 3.75 | Mucin-depleted foci show strong activation of inflammatory markers in 1,2-dimethylhydrazine-induced carcinogenesis and are promoted by the inflammatory agent sodium dextran sulfate. ( Caderni, G; Dolara, P; Femia, AP; Luceri, C; Salvadori, M, 2009) |
| "In a previous study, we developed a novel mouse model for colitis-related carcinogenesis, utilizing a single dose of azoxymethane (AOM) followed by dextran sodium sulfate (DSS) in drinking water." | 3.73 | Beta-Catenin mutations in a mouse model of inflammation-related colon carcinogenesis induced by 1,2-dimethylhydrazine and dextran sodium sulfate. ( Kohno, H; Sugie, S; Suzuki, R; Tanaka, T, 2005) |
| " Fischer F344 rats receiving 20mg/kg of 1,2-dimethylhydrazine per week for 20 weeks developed adenocarcinoma of the colon." | 3.68 | [Establishment of a transplantable rat colon cancer and a model of metastasis]. ( Yasuda, S, 1993) |
| "A striking anticancer effect of IP6 was demonstrated in different experimental models." | 2.42 | Cancer inhibition by inositol hexaphosphate (IP6) and inositol: from laboratory to clinic. ( Shamsuddin, AM; Vucenik, I, 2003) |
| "Some human epidemiological studies on colon cancer point to a possible preventive role of dietary fiber, but the results are confounded by the difference in the intake of many other food substances such as fat and the overall differences in the dietary pattern of the populations investigated." | 2.36 | Recent advances in dietary fiber and colorectal diseases. ( Freeman, HJ; Spiller, GA, 1981) |
| "The DMH treatment increased aberrant crypt foci (ACF), Proliferating cell nuclear antigen (PCNA), and TBARS levels, along with decreased antioxidant defenses (GSH, GSH-Px, and catalase)." | 1.62 | Piclamilast mitigates 1,2-dimethylhydrazine induced colon cancer in rats through modulation of Ras/PI3K/Akt/mTOR and NF-κβ signaling. ( Abdel-Wahab, BA; Albarqi, HA; Aljadaan, AM; Alqhtani, H; Hassanein, EHM; Khateeb, MM; Walbi, IA, 2021) |
| "Colorectal cancer is one of the primary causes of cancer-related mortality worldwide." | 1.62 | Promising targets of chrysin and daidzein in colorectal cancer: Amphiregulin, CXCL1, and MMP-9. ( Allam, RM; Salama, AAA, 2021) |
| " Our study investigates the role of EGCG on N,N'-dimethylhydrazine (DMH), a toxic environmental pollutant, induced colon toxicity." | 1.62 | Amelioration of N,N'-dimethylhydrazine induced colon toxicity by epigallocatechin gallate in Wistar rats. ( Afzal, SM; Ali, N; Islam, J; Rashid, S; Shree, A; Sultana, S; Vafa, A, 2021) |
| "Colorectal cancer is a highly prevalent disease, requiring effective strategies for prevention and treatment." | 1.62 | The Use of Natural Fiber-Rich Food Product Is Safe and Reduces Aberrant Crypt Foci in a Pre-Clinical Model. ( Baranoski, A; Bittencourt Junior, FF; da Silva Fleming de Almeida, T; do Amaral, LA; Duenhas Monreal, AC; Freitas Dos Santos, E; Leite Kassuya, CA; Milan Brochado Antoniolli-Silva, AC; Murino Rafacho, BP; Oliveira de Souza, GH; Oliveira, RJ; Souza Maris, R, 2021) |
| "Background Colorectal cancer (CRC) is a major public health problem, with almost 1." | 1.56 | Protective effect of Matricaria chamomilla extract against 1,2-dimethylhydrazine-induced colorectal cancer in mice. ( Borjac, JM; El Joumaa, MM; Rizk, S; Taleb, RI, 2020) |
| "Colon cancer is thought to develop in a stepwise fashion." | 1.48 | Precancerous ACF induction affects their regional distribution forsaking oxidative stress implication in 1,2-dimethylhydrazine-induced colon carcinogenesis model. ( Clichici, S; Djerdjouri, B; Moulahoum, H; Nagy, AL, 2018) |
| "After the induction of colorectal cancer, adult male Wistar rats were treated with saline (n = 7), DOX (1." | 1.46 | Cardiac autonomic modulation induced by doxorubicin in a rodent model of colorectal cancer and the influence of fullerenol pretreatment. ( Cerar, A; Finderle, Ž; Injac, R; Perše, M; Potočnik, N, 2017) |
| "Colon carcinogenesis is long known to be associated with ulcerative colitis (UC), a chronic gastrointestinal disorder." | 1.43 | Melatonin modulated autophagy and Nrf2 signaling pathways in mice with colitis-associated colon carcinogenesis. ( Jena, GB; Kumar, V; Tikoo, KB; Trivedi, PP, 2016) |
| "Colon cancer is one of the most common cancers in both men and women." | 1.42 | Rosmarinic acid inhibits DMH-induced cell proliferation in experimental rats. ( Karthikkumar, V; Nalini, N; Sivagami, G; Viswanathan, P, 2015) |
| " In conclusion, the data collectively show that a 50% reduction in K-ras gene dosage and RNA expression promoted experimental colorectal tumourigenesis, consistent with wild-type K-ras having a tumour suppressor effect on carcinogen-induced murine colorectal adenoma formation." | 1.40 | Wild-type K-ras has a tumour suppressor effect on carcinogen-induced murine colorectal adenoma formation. ( Arends, MJ; Dong, G; Hamoudi, R; Ibrahim, AE; Luo, F; Poulogiannis, G; Ye, H; Zhang, W, 2014) |
| "Groups 3-6 were induced colon cancer by injecting DMH (20 mg/kgb." | 1.39 | The effect of rosmarinic acid on 1,2-dimethylhydrazine induced colon carcinogenesis. ( Gunasekaran, S; Jesudoss, VA; Namasivayam, N; Venkatachalam, K, 2013) |
| "Myricetin is a well known bioflavonoid that is claimed to have anti cancer action particularly in colorectal cancer." | 1.37 | Effect of myricetin on 1,2 dimethylhydrazine induced rat colon carcinogenesis. ( Nirmala, P; Ramanathan, M, 2011) |
| "Diclofenac treatment resulted in a significant reduction in COX-2 expression and its activity." | 1.36 | Modulation of inflammatory changes in early stages of colon cancer through activation of PPARgamma by diclofenac. ( Kaur, J; Sanyal, SN, 2010) |
| "Colon cancer is one of the major causes of cancer mortality worldwide." | 1.35 | Antioxidative and antiproliferative effects of astaxanthin during the initiation stages of 1,2-dimethyl hydrazine-induced experimental colon carcinogenesis. ( Ashokkumar, P; Prabhu, PN; Sudhandiran, G, 2009) |
| "The incidence of tumors/polyps in the colon cancer of rats and treated with morin showed reduced incidence (40%) of tumors, as compared to DMH (100%) treated rats." | 1.35 | Modifying effects of morin on the development of aberrant crypt foci and bacterial enzymes in experimental colon cancer. ( Karthik Kumar, V; Nalini, N; Vennila, S, 2009) |
| "Colon cancer is a major cause of morbidity and mortality in developed and developing countries." | 1.35 | Dose-dependent effect of oregano (Origanum vulgare L.) on lipid peroxidation and antioxidant status in 1,2-dimethylhydrazine-induced rat colon carcinogenesis. ( Nalini, N; Sengottuvelan, M; Srihari, T, 2008) |
| "Colon cancer is the third most common cancer and second leading cause of cancer-related death in the United States." | 1.33 | Rat colonic lipid peroxidation and antioxidant status: the effects of dietary luteolin on 1,2-dimethylhydrazine challenge. ( Balasubramaniyan, V; Manju, V; Nalini, N, 2005) |
| "Rofecoxib in lower doses had the same effect on adenomas (p < 0." | 1.33 | Cyclooxygenase-2 inhibition in colon experimental carcinogenesis. ( Amengual Antich, I; Gamundí Gamundí, A; Ibarra de la Rosa, J; Noguera Aguilar, JF; Plaza Martínez, A; Pujol Tugores, JJ; Tortajada Collado, C, 2005) |
| "Yoghurt feeding inhibits induced colon cancer in mice." | 1.33 | Reduction of beta-glucuronidase and nitroreductase activity by yoghurt in a murine colon cancer model. ( de Moreno de LeBlanc, A; Perdigón, G, 2005) |
| "Colorectal tumors were induced by means of 15 s." | 1.31 | Animal model in the study of colorectal carcinogenesis. ( Cerar, A; Glavac, D; Ravnik-Glavac, M, 2000) |
| "The incidence of intestinal cancer in each group was compared." | 1.29 | Effect of selenium on 1,2-dimethylhydrazine-induced intestinal cancer in rats. ( Ho, YS; Jao, SW; Lee, W; Shen, KL, 1996) |
| " Colorectal cancer was induced in all animals by weekly subcutaneous injections of the colonic procarcinogen 1,2-dimethylhydrazine (DMH) at a dosage of 20 mg/kg body weight." | 1.29 | Effect of supplemental L-arginine in a chemical-induced model of colorectal cancer. ( Anderson, N; Hoper, M; Ma, Q; Rowlands, BJ, 1996) |
| " Because dosage schedules are known from previous experiments with the Nb rat, this animal model may be useful for evaluating the effects of cytotoxic drugs on experimental bowel cancer." | 1.27 | Experimental cancer of the bowel in the Nb rat. ( Drago, JR; Joehl, RJ, 1983) |
| "This pathological resemblance to human nephroblastoma suggests the possibility of using dimethylhydrazine-induced renal tumours as a model of Wilms' tumour." | 1.27 | Induction of nephroblastoma-like renal tumours in rats by a single dose of 1,2-dimethylhydrazine. ( Cruse, JP; Lewin, MR; Sadrudin, AA, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (12.73) | 18.7374 |
| 1990's | 14 (12.73) | 18.2507 |
| 2000's | 38 (34.55) | 29.6817 |
| 2010's | 37 (33.64) | 24.3611 |
| 2020's | 7 (6.36) | 2.80 |
| Authors | Studies |
|---|---|
| Abdel-Wahab, BA | 1 |
| Alqhtani, H | 1 |
| Walbi, IA | 1 |
| Albarqi, HA | 1 |
| Aljadaan, AM | 1 |
| Khateeb, MM | 1 |
| Hassanein, EHM | 1 |
| Sharma, SH | 3 |
| Suresh Kumar, J | 1 |
| Madhavan, S | 1 |
| Nagarajan, S | 3 |
| El Joumaa, MM | 1 |
| Taleb, RI | 1 |
| Rizk, S | 1 |
| Borjac, JM | 1 |
| Jisha, N | 1 |
| Vysakh, A | 1 |
| Vijeesh, V | 1 |
| Latha, MS | 1 |
| Salama, AAA | 1 |
| Allam, RM | 1 |
| Afzal, SM | 1 |
| Vafa, A | 1 |
| Rashid, S | 1 |
| Shree, A | 1 |
| Islam, J | 1 |
| Ali, N | 1 |
| Sultana, S | 1 |
| do Amaral, LA | 1 |
| da Silva Fleming de Almeida, T | 1 |
| Oliveira de Souza, GH | 1 |
| Baranoski, A | 1 |
| Souza Maris, R | 1 |
| Bittencourt Junior, FF | 1 |
| Murino Rafacho, BP | 1 |
| Duenhas Monreal, AC | 1 |
| Leite Kassuya, CA | 1 |
| Milan Brochado Antoniolli-Silva, AC | 1 |
| Freitas Dos Santos, E | 1 |
| Oliveira, RJ | 1 |
| Yu, W | 1 |
| Liu, C | 3 |
| Li, X | 2 |
| Yang, F | 2 |
| Cheng, L | 2 |
| Song, Y | 2 |
| Potočnik, N | 1 |
| Perše, M | 2 |
| Cerar, A | 3 |
| Injac, R | 1 |
| Finderle, Ž | 1 |
| Moulahoum, H | 1 |
| Nagy, AL | 1 |
| Djerdjouri, B | 1 |
| Clichici, S | 1 |
| Chellappan, DR | 1 |
| Chinnaswamy, P | 1 |
| Siddique, AI | 1 |
| Mani, V | 1 |
| Renganathan, S | 1 |
| Ayyanar, R | 1 |
| Nagappan, A | 1 |
| Namasivayam, N | 3 |
| Rubio, CA | 1 |
| Walia, S | 1 |
| Kamal, R | 1 |
| Dhawan, DK | 1 |
| Kanwar, SS | 1 |
| Eissa, MM | 1 |
| Ismail, CA | 1 |
| El-Azzouni, MZ | 1 |
| Ghazy, AA | 1 |
| Hadi, MA | 1 |
| Chen, C | 1 |
| Rajamanickam, V | 1 |
| López-Mejia, A | 1 |
| Ortega-Pérez, LG | 1 |
| Godinez-Hernández, D | 1 |
| Nateras-Marin, B | 1 |
| Meléndez-Herrera, E | 1 |
| Rios-Chavez, P | 1 |
| Sadik, NA | 1 |
| Shaker, OG | 1 |
| Christudoss, P | 1 |
| Selvakumar, R | 1 |
| Pulimood, AB | 1 |
| Fleming, JJ | 1 |
| Mathew, G | 1 |
| Chen, HM | 2 |
| Lin, YW | 2 |
| Wang, JL | 2 |
| Kong, X | 2 |
| Hong, J | 2 |
| Fang, JY | 2 |
| Setia, S | 1 |
| Nehru, B | 1 |
| Sanyal, SN | 4 |
| Luo, F | 2 |
| Poulogiannis, G | 2 |
| Ye, H | 2 |
| Hamoudi, R | 2 |
| Dong, G | 2 |
| Zhang, W | 2 |
| Ibrahim, AE | 1 |
| Arends, MJ | 2 |
| Gunasekaran, S | 2 |
| Venkatachalam, K | 2 |
| Jeyavel, K | 1 |
| Cohen, C | 1 |
| Cardoso, JF | 1 |
| Garcia, SB | 1 |
| Vannucchi, H | 1 |
| Karthikkumar, V | 1 |
| Sivagami, G | 1 |
| Viswanathan, P | 1 |
| Nalini, N | 10 |
| Trivedi, PP | 1 |
| Jena, GB | 1 |
| Tikoo, KB | 1 |
| Kumar, V | 1 |
| Liu, WX | 1 |
| Gu, SZ | 1 |
| Zhang, S | 1 |
| Ren, Y | 1 |
| Sang, LX | 1 |
| Dai, C | 1 |
| Zhang, M | 1 |
| Fan, X | 1 |
| Fang, B | 1 |
| Zhu, C | 1 |
| Zhu, J | 1 |
| Ren, F | 1 |
| Novaes, RD | 1 |
| Sequetto, PL | 1 |
| Vilela Gonçalves, R | 1 |
| Cupertino, MC | 1 |
| Santos, EC | 1 |
| Mello, VJ | 1 |
| Araújo, MR | 1 |
| Silva, E | 1 |
| Oliveira, TT | 1 |
| Ubillos, L | 1 |
| Freire, T | 1 |
| Berriel, E | 1 |
| Chiribao, ML | 1 |
| Chiale, C | 1 |
| Festari, MF | 1 |
| Medeiros, A | 1 |
| Mazal, D | 1 |
| Rondán, M | 1 |
| Bollati-Fogolín, M | 1 |
| Rabinovich, GA | 1 |
| Robello, C | 1 |
| Osinaga, E | 1 |
| Kuugbee, ED | 1 |
| Shang, X | 1 |
| Gamallat, Y | 1 |
| Bamba, D | 1 |
| Awadasseid, A | 1 |
| Suliman, MA | 1 |
| Zang, S | 1 |
| Ma, Y | 1 |
| Chiwala, G | 1 |
| Xin, Y | 1 |
| Shang, D | 1 |
| Qamar, TR | 1 |
| Syed, F | 1 |
| Nasir, M | 1 |
| Rehman, H | 1 |
| Zahid, MN | 1 |
| Liu, RH | 1 |
| Iqbal, S | 1 |
| Pérez-Holanda, S | 2 |
| Rodrigo, L | 2 |
| Pinyol-Felis, C | 1 |
| Vinyas-Salas, J | 1 |
| Aranganathan, S | 2 |
| Selvam, JP | 1 |
| Karthik Kumar, V | 1 |
| Vennila, S | 1 |
| Lunz, W | 1 |
| Peluzio, MC | 1 |
| Dias, CM | 1 |
| Moreira, AP | 1 |
| Natali, AJ | 1 |
| Sengottuvelan, M | 3 |
| Deeptha, K | 1 |
| Saini, MK | 1 |
| Sharma, P | 1 |
| Kaur, J | 3 |
| Femia, AP | 1 |
| Dolara, P | 1 |
| Luceri, C | 1 |
| Salvadori, M | 1 |
| Caderni, G | 1 |
| Prabhu, PN | 1 |
| Ashokkumar, P | 1 |
| Sudhandiran, G | 2 |
| Sangeetha, N | 1 |
| Felix, AJ | 1 |
| Umesalma, S | 1 |
| Alfaras, I | 1 |
| Juan, ME | 1 |
| Planas, JM | 1 |
| Chung, CP | 1 |
| Hsu, HY | 1 |
| Huang, DW | 1 |
| Hsu, HH | 1 |
| Lin, JT | 1 |
| Shih, CK | 1 |
| Chiang, W | 1 |
| Silva, FG | 1 |
| Penido, LC | 1 |
| Valente, FX | 1 |
| Mendes, MC | 1 |
| Rosa, DD | 1 |
| Glória, MB | 1 |
| Peluzio, Mdo C | 1 |
| Nirmala, P | 2 |
| Ramanathan, M | 2 |
| Xiong, H | 1 |
| Shen, N | 1 |
| Jesudoss, VA | 1 |
| Hirose, M | 2 |
| Yamaguchi, T | 1 |
| Mizoguchi, Y | 1 |
| Akagi, K | 2 |
| Futakuchi, M | 1 |
| Shirai, T | 1 |
| Sakai, H | 1 |
| Tsukamoto, T | 1 |
| Yamamoto, M | 1 |
| Shirai, N | 1 |
| Iidaka, T | 1 |
| Hirata, A | 1 |
| Yanai, T | 1 |
| Masegi, T | 1 |
| Donehower, LA | 1 |
| Tatematsu, M | 1 |
| Vucenik, I | 1 |
| Shamsuddin, AM | 1 |
| Durowicz, S | 1 |
| Olszewski, WL | 1 |
| Wang, JG | 1 |
| Wang, DF | 1 |
| Lv, BJ | 1 |
| Si, JM | 1 |
| Newell, LE | 1 |
| Heddle, JA | 1 |
| Taxonera, C | 1 |
| Mendoza, JL | 1 |
| Noguera Aguilar, JF | 2 |
| Plaza Martínez, A | 2 |
| Amengual Antich, I | 2 |
| Morón Canis, JM | 1 |
| Tortajada Collado, C | 2 |
| Pujol Tugores, JJ | 2 |
| Kohno, H | 1 |
| Suzuki, R | 1 |
| Sugie, S | 1 |
| Tanaka, T | 1 |
| Viñas-Salas, J | 1 |
| Piñol-Felis, C | 1 |
| de Moreno de LeBlanc, A | 2 |
| Perdigón, G | 2 |
| Manju, V | 2 |
| Balasubramaniyan, V | 1 |
| Coca, S | 1 |
| Enrech, S | 1 |
| Moreno García, V | 1 |
| Sáez, MA | 1 |
| Gutiérrez, C | 1 |
| Colmenarejo, A | 1 |
| Hernández, JM | 1 |
| Pérez Piqueras, J | 1 |
| Ibarra de la Rosa, J | 1 |
| Gamundí Gamundí, A | 1 |
| Katsuki, T | 1 |
| Hirata, K | 1 |
| Ishikawa, H | 1 |
| Matsuura, N | 1 |
| Sumi, S | 1 |
| Itoh, H | 1 |
| Di Pace, RF | 1 |
| Massa, S | 1 |
| Ribeiro, OG | 1 |
| Cabrera, WH | 1 |
| De Franco, M | 1 |
| Starobinas, N | 1 |
| Seman, M | 1 |
| Ibañez, OC | 1 |
| Mori, F | 1 |
| Piro, FR | 1 |
| Della Rocca, C | 1 |
| Mesiti, G | 1 |
| Giampaoli, S | 1 |
| Silvestre, G | 1 |
| Lazzaro, D | 1 |
| Pérez Holanda, S | 1 |
| LeBlanc, JG | 1 |
| Miyoshi, A | 1 |
| Langella, P | 1 |
| Azevedo, V | 1 |
| Sesma, F | 1 |
| Koch, TC | 1 |
| Briviba, K | 1 |
| Watzl, B | 1 |
| Bub, A | 1 |
| Barth, SW | 1 |
| Srihari, T | 1 |
| Spiller, GA | 1 |
| Freeman, HJ | 1 |
| Joehl, RJ | 1 |
| Drago, JR | 1 |
| Filipe, MI | 1 |
| Scurr, JH | 1 |
| Ellis, H | 1 |
| Jacoby, RF | 1 |
| Hohman, C | 1 |
| Marshall, DJ | 1 |
| Frick, TJ | 1 |
| Schlack, S | 1 |
| Broda, M | 1 |
| Smutko, J | 1 |
| Elliott, RW | 1 |
| Rubio, C | 1 |
| Shetye, J | 1 |
| Zhang, J | 1 |
| Lam, LK | 1 |
| Yasuda, S | 1 |
| Hoshiya, T | 1 |
| Takahashi, S | 1 |
| Hara, Y | 1 |
| Ito, N | 1 |
| Jao, SW | 1 |
| Shen, KL | 1 |
| Lee, W | 1 |
| Ho, YS | 1 |
| McIntosh, GH | 1 |
| Le Leu, RK | 1 |
| Royle, PJ | 1 |
| Young, GP | 1 |
| Ma, Q | 1 |
| Hoper, M | 1 |
| Anderson, N | 1 |
| Rowlands, BJ | 1 |
| Hambly, RJ | 1 |
| Rumney, CJ | 1 |
| Cunninghame, M | 1 |
| Fletcher, JM | 1 |
| Rijken, PJ | 1 |
| Rowland, IR | 1 |
| Rudzki, Z | 1 |
| LeDuy, L | 1 |
| Jothy, S | 1 |
| Pliss, GB | 1 |
| Vlasov, NN | 1 |
| Anikin, IV | 1 |
| Thompson, MJ | 1 |
| Slack, R | 1 |
| Double, JA | 1 |
| Bibby, MC | 1 |
| Watanabe, H | 1 |
| Uesaka, T | 1 |
| Kido, S | 1 |
| Ishimura, Y | 1 |
| Shiraki, K | 1 |
| Kuramoto, K | 1 |
| Hirata, S | 1 |
| Shoji, S | 1 |
| Katoh, O | 1 |
| Fujimoto, N | 1 |
| Ravnik-Glavac, M | 1 |
| Glavac, D | 1 |
| Xu, M | 1 |
| Orner, GA | 1 |
| Bailey, GS | 1 |
| Stoner, GD | 1 |
| Horio, DT | 1 |
| Dashwood, RH | 1 |
| Sequeira, JL | 1 |
| Kobayasi, SS | 1 |
| Rodrigues, MA | 1 |
| Mokady, E | 1 |
| Schwartz, B | 1 |
| Shany, S | 1 |
| Lamprecht, SA | 1 |
| Rao, PM | 1 |
| Nagamine, Y | 1 |
| Roomi, MW | 1 |
| Rajalakshmi, S | 1 |
| Sarma, DS | 1 |
| Ferré, J | 1 |
| Cuervas-Mons, M | 1 |
| Morte, L | 1 |
| Martínez, A | 1 |
| Ramón y Cajal, S | 1 |
| Sadrudin, AA | 1 |
| Lewin, MR | 1 |
| Cruse, JP | 1 |
| Rogers, AE | 1 |
| Nauss, KM | 2 |
| Kroes, R | 1 |
| Beems, RB | 1 |
| Bosland, MC | 1 |
| Bunnik, GS | 1 |
| Sinkeldam, EJ | 1 |
| Deschner, EE | 1 |
| Broitman, SA | 1 |
| Newberne, PM | 1 |
| Goldin, BR | 1 |
| Burenin, IS | 1 |
| Smirnova, IO | 1 |
| Valueva, IM | 1 |
| Amberger, H | 1 |
| Ahnen, DJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Double-blind, Randomized, Placebo-controlled Study to Evaluate the Effects of a Weight Management Program on Body Weight in Individuals Who Are Overweight and Otherwise Healthy[NCT04107155] | 54 participants (Actual) | Interventional | 2019-07-23 | Completed | |||
| A Randomized Controlled Trial to Evaluate the Effects of Repeated Periods of Modified Fasting to Support Healthy Natural Weight Management and Prevention of Weight Gain in Overweight But Generally Healthy Adults Over the Winter Holiday Period[NCT03372109] | 23 participants (Actual) | Interventional | 2017-11-14 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 reviews available for 1,2-dimethylhydrazine and Disease Models, Animal
| Article | Year |
|---|---|
Cancer inhibition by inositol hexaphosphate (IP6) and inositol: from laboratory to clinic.
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Carcinogens; Colonic Neoplasms; Disease Mod | 2003 |
Dimethylhydrazine model is not appropriate for evaluating effect of ethanol on colorectal cancer.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Colorectal Neoplasms; Disease Models, Animal; Ethanol; | 2007 |
Recent advances in dietary fiber and colorectal diseases.
Topics: 1,2-Dimethylhydrazine; Animals; Cellulose; Colitis; Colitis, Ulcerative; Colonic Diseases; Colonic N | 1981 |
Nutritional factors in lung, colon, and prostate carcinogenesis in animal models.
Topics: 1,2-Dimethylhydrazine; Androgens; Animals; Benzo(a)pyrene; Colonic Neoplasms; Diet; Dietary Fats; Di | 1986 |
Animal models of carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Cell Transformation, Neoplastic; Colonic Neoplasms; Dimethy | 1988 |
Cholesterol conundrums: the relationship between dietary and serum cholesterol in colon cancer.
Topics: 1,2-Dimethylhydrazine; Adult; Animals; Azoxymethane; Cholesterol; Cholesterol, Dietary; Cholestyrami | 1986 |
Dietary fat and colon cancer: variable results in animal models.
Topics: 1,2-Dimethylhydrazine; Animals; Azoxymethane; Body Weight; Cocarcinogenesis; Colonic Neoplasms; Diet | 1986 |
The metabolism of the intestinal microflora and its relationship to dietary fat, colon and breast cancer.
Topics: 1,2-Dimethylhydrazine; Amino Acids; Animals; Biotransformation; Breast Neoplasms; Carcinogens; Colon | 1986 |
102 other studies available for 1,2-dimethylhydrazine and Disease Models, Animal
| Article | Year |
|---|---|
Piclamilast mitigates 1,2-dimethylhydrazine induced colon cancer in rats through modulation of Ras/PI3K/Akt/mTOR and NF-κβ signaling.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Apoptosis; Benzamides; Cell Proliferation; Colo | 2021 |
Morin supplementation modulates PERK branch of UPR and mitigates 1,2-dimethylhydrazine-induced angiogenesis and oxidative stress in the colon of experimental rats.
Topics: 1,2-Dimethylhydrazine; Angiogenesis Inhibitors; Animals; Antioxidants; Colon; Disease Models, Animal | 2020 |
Protective effect of Matricaria chamomilla extract against 1,2-dimethylhydrazine-induced colorectal cancer in mice.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogenesis; Chamomile; Colon; Colonic Polyps; Colorectal Neoplas | 2020 |
Ethyl acetate fraction of Muntingia calabura L. exerts anti-colorectal cancer potential via regulating apoptotic and inflammatory pathways.
Topics: 1,2-Dimethylhydrazine; Acetates; Animals; Anti-Inflammatory Agents; Antineoplastic Agents, Phytogeni | 2020 |
Promising targets of chrysin and daidzein in colorectal cancer: Amphiregulin, CXCL1, and MMP-9.
Topics: 1,2-Dimethylhydrazine; Amphiregulin; Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; C | 2021 |
Amelioration of N,N'-dimethylhydrazine induced colon toxicity by epigallocatechin gallate in Wistar rats.
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Carcinogens; Catechin; Colonic Neoplasms; D | 2021 |
The Use of Natural Fiber-Rich Food Product Is Safe and Reduces Aberrant Crypt Foci in a Pre-Clinical Model.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animal Feed; Animals; Colon; Colorectal Neoplasms; Cytok | 2021 |
Inositol hexaphosphate suppresses colorectal cancer cell proliferation via the Akt/GSK-3β/β-catenin signaling cascade in a 1,2-dimethylhydrazine-induced rat model.
Topics: 1,2-Dimethylhydrazine; Animals; Apoptosis; beta Catenin; Cell Proliferation; Colorectal Neoplasms; D | 2017 |
Cardiac autonomic modulation induced by doxorubicin in a rodent model of colorectal cancer and the influence of fullerenol pretreatment.
Topics: 1,2-Dimethylhydrazine; Animals; Antibiotics, Antineoplastic; Cardiotonic Agents; Cardiotoxicity; Col | 2017 |
Precancerous ACF induction affects their regional distribution forsaking oxidative stress implication in 1,2-dimethylhydrazine-induced colon carcinogenesis model.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Antioxidants; Biomarkers, Tumor; Carcinogenesis | 2018 |
Protective effect of p-coumaric acid against 1,2 dimethylhydrazine induced colonic preneoplastic lesions in experimental rats.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Anticarcinogenic Agents; Carcinogenesis; Carcin | 2017 |
Asiatic acid abridges pre-neoplastic lesions, inflammation, cell proliferation and induces apoptosis in a rat model of colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Apoptosis; bcl-2-Associated X Protein; Caspase | 2017 |
Updated Histologic Classification of Adenomas and Carcinomas in the Colon of Carcinogen-treated Sprague-Dawley Rats.
Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Carcinogens; Colon; Colonic Neoplasms; Disease Models, Anim | 2017 |
Chemoprevention by Probiotics During 1,2-Dimethylhydrazine-Induced Colon Carcinogenesis in Rats.
Topics: 1,2-Dimethylhydrazine; Animals; Apoptosis; Carcinogens; Colonic Neoplasms; Disease Models, Animal; F | 2018 |
Immuno-therapeutic potential of Schistosoma mansoni and Trichinella spiralis antigens in a murine model of colon cancer.
Topics: 1,2-Dimethylhydrazine; Animals; Antigens, Helminth; Carcinogens; Colonic Neoplasms; Cytokines; Disea | 2019 |
Phytic acid improves intestinal mucosal barrier damage and reduces serum levels of proinflammatory cytokines in a 1,2-dimethylhydrazine-induced rat colorectal cancer model.
Topics: 1,2-Dimethylhydrazine; Animals; Body Weight; Cadherins; Claudin-1; Colon; Colorectal Neoplasms; Cyto | 2018 |
Supplementation of p-coumaric acid exhibits chemopreventive effect via induction of Nrf2 in a short-term preclinical model of colon cancer.
Topics: 1,2-Dimethylhydrazine; Animals; Antioxidants; Apoptosis; Carcinogens; Cell Proliferation; Colonic Ne | 2019 |
Chemopreventive effect of Callistemon citrinus (Curtis) Skeels against colon cancer induced by 1,2-dimethylhydrazine in rats.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Antineoplastic Agents, Phytogenic; Body Weight; | 2019 |
Inhibitory effect of a standardized pomegranate fruit extract on Wnt signalling in 1, 2-dimethylhydrazine induced rat colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Antineoplastic Agents, Phytogenic; Carcinogens; Colo | 2013 |
Protective role of aspirin, vitamin C, and zinc and their effects on zinc status in the DMH-induced colon carcinoma model.
Topics: 1,2-Dimethylhydrazine; Alkaline Phosphatase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antio | 2013 |
Identification of potential target genes of butyrate in dimethylhydrazine-induced colorectal cancer in mice.
Topics: 1,2-Dimethylhydrazine; Animals; Butyrates; Cell Adhesion; Cell Differentiation; Cell Movement; Cell | 2013 |
Activation of NF-κB: bridging the gap between inflammation and cancer in colitis-mediated colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Celecoxib; Colitis, Ulcerative; Colonic Neoplasms; Cyclooxygenase 2 | 2014 |
Wild-type K-ras has a tumour suppressor effect on carcinogen-induced murine colorectal adenoma formation.
Topics: 1,2-Dimethylhydrazine; Adenoma; Alleles; Animals; Apoptosis; Cell Proliferation; Colorectal Neoplasm | 2014 |
Protective effect of p-methoxycinnamic acid, an active phenolic acid against 1,2-dimethylhydrazine-induced colon carcinogenesis: modulating biotransforming bacterial enzymes and xenobiotic metabolizing enzymes.
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Bacteria; Biotransformation; Cinnamates; Co | 2014 |
Vitamin E supplementation in chemical colorectal carcinogenesis: a two-edged knife.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Biomarkers; Carcinogenesis; Carcinogens; Cell P | 2014 |
Rosmarinic acid inhibits DMH-induced cell proliferation in experimental rats.
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Antioxidants; Cell Proliferation; Cinnamate | 2015 |
Melatonin modulated autophagy and Nrf2 signaling pathways in mice with colitis-associated colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Autophagy; Carcinogenesis; Carcinogens; Col | 2016 |
Angiopoietin and vascular endothelial growth factor expression in colorectal disease models.
Topics: 1,2-Dimethylhydrazine; Angiopoietin-1; Angiopoietin-2; Animals; Colitis, Ulcerative; Colon; Colorect | 2015 |
Effects of Lactobacillus salivarius Ren on cancer prevention and intestinal microbiota in 1, 2-dimethylhydrazine-induced rat model.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Colon; Colonic Neoplasms; Disease Models, Animal; Gastr | 2015 |
Depletion of enteroendocrine and mucus-secreting cells is associated with colorectal carcinogenesis severity and impaired intestinal motility in rats.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Colorectal Neoplasms; Disease Models, Animal; E | 2016 |
Trypanosoma cruzi extracts elicit protective immune response against chemically induced colon and mammary cancers.
Topics: 1,2-Dimethylhydrazine; Animals; Antibodies, Protozoan; Antibody-Dependent Cell Cytotoxicity; Antigen | 2016 |
Structural Change in Microbiota by a Probiotic Cocktail Enhances the Gut Barrier and Reduces Cancer via TLR2 Signaling in a Rat Model of Colon Cancer.
Topics: 1,2-Dimethylhydrazine; Animals; Bifidobacterium bifidum; Bifidobacterium longum subspecies infantis; | 2016 |
Novel Combination of Prebiotics Galacto-Oligosaccharides and Inulin-Inhibited Aberrant Crypt Foci Formation and Biomarkers of Colon Cancer in Wistar Rats.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Ammonia; Animals; Anticarcinogenic Agents; Bacterial Pro | 2016 |
Colonic perianastomotic carcinogenesis in an experimental model.
Topics: 1,2-Dimethylhydrazine; Anastomosis, Surgical; Animals; Carcinogens; Carcinoma; Colon; Colonic Neopla | 2008 |
Effect of hesperetin, a citrus flavonoid, on bacterial enzymes and carcinogen-induced aberrant crypt foci in colon cancer rats: a dose-dependent study.
Topics: 1,2-Dimethylhydrazine; Animals; Bacteria; Body Weight; Carcinogens; Cell Transformation, Neoplastic; | 2008 |
Modifying effects of morin on the development of aberrant crypt foci and bacterial enzymes in experimental colon cancer.
Topics: 1,2-Dimethylhydrazine; Animals; Antioxidants; beta-Glucosidase; Carcinogens; Colon; Colonic Neoplasm | 2009 |
Long-term aerobic swimming training by rats reduces the number of aberrant crypt foci in 1,2-dimethylhydrazine-induced colon cancer.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Colonic Neoplasms; Disease Models, Animal; Male; Physic | 2008 |
Resveratrol attenuates 1,2-dimethylhydrazine (DMH) induced glycoconjugate abnormalities during various stages of colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Antineoplastic Agents, Phytogenic; Colonic Neoplasms; Disease Models | 2009 |
The cyclooxygenase-2 inhibitor etoricoxib is a potent chemopreventive agent of colon carcinogenesis in the rat model.
Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Anticarcinogenic Agents; Apoptosis; Biomarkers; Colonic Neo | 2009 |
Mucin-depleted foci show strong activation of inflammatory markers in 1,2-dimethylhydrazine-induced carcinogenesis and are promoted by the inflammatory agent sodium dextran sulfate.
Topics: 1,2-Dimethylhydrazine; Animals; Azoxymethane; Carcinogens; Cell Transformation, Neoplastic; Colitis; | 2009 |
Efficacy of the potential chemopreventive agent, hesperetin (citrus flavanone), on 1,2-dimethylhydrazine induced colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Antineoplastic Agents, Phytogenic; Catalase; Colon; | 2009 |
Efficacy of the potential chemopreventive agent, hesperetin (citrus flavanone), on 1,2-dimethylhydrazine induced colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Antineoplastic Agents, Phytogenic; Catalase; Colon; | 2009 |
Efficacy of the potential chemopreventive agent, hesperetin (citrus flavanone), on 1,2-dimethylhydrazine induced colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Antineoplastic Agents, Phytogenic; Catalase; Colon; | 2009 |
Efficacy of the potential chemopreventive agent, hesperetin (citrus flavanone), on 1,2-dimethylhydrazine induced colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Antineoplastic Agents, Phytogenic; Catalase; Colon; | 2009 |
Antioxidative and antiproliferative effects of astaxanthin during the initiation stages of 1,2-dimethyl hydrazine-induced experimental colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Administration, Oral; Animals; Antigens, Nuclear; Antioxidants; Cell Prolifer | 2009 |
Silibinin modulates biotransforming microbial enzymes and prevents 1,2-dimethylhydrazine-induced preneoplastic changes in experimental colon cancer.
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Bacteria; Body Weight; Colon; Colonic Neopl | 2009 |
Differential inhibitory effects of the polyphenol ellagic acid on inflammatory mediators NF-kappaB, iNOS, COX-2, TNF-alpha, and IL-6 in 1,2-dimethylhydrazine-induced rat colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Bi | 2010 |
Modulation of inflammatory changes in early stages of colon cancer through activation of PPARgamma by diclofenac.
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Apoptosis; Apoptotic Protease-Activating Fa | 2010 |
trans-Resveratrol reduces precancerous colonic lesions in dimethylhydrazine-treated rats.
Topics: 1,2-Dimethylhydrazine; Animals; Colon; Colonic Neoplasms; Disease Models, Animal; Humans; Male; Prec | 2010 |
Ethyl acetate fraction of adlay bran ethanolic extract inhibits oncogene expression and suppresses DMH-induced preneoplastic lesions of the colon in F344 rats through an anti-inflammatory pathway.
Topics: 1,2-Dimethylhydrazine; Acetates; Animals; Anti-Inflammatory Agents; Coix; Colonic Neoplasms; Cycloox | 2010 |
PI3-kinase/Wnt association mediates COX-2/PGE(2) pathway to inhibit apoptosis in early stages of colon carcinogenesis: chemoprevention by diclofenac.
Topics: 1,2-Dimethylhydrazine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; beta Catenin; Ca | 2010 |
Sodium butyrate does not decrease the evolution of precancerous lesions in rats.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Butyrates; Carcinogens; Colorectal Neoplasms; D | 2010 |
Mutant K-ras promotes carcinogen-induced murine colorectal tumourigenesis, but does not alter tumour chromosome stability.
Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Apoptosis; beta Catenin; Carcinogens; Cell Proliferation; C | 2011 |
Effect of kaempferol on lipid peroxidation and antioxidant status in 1,2-dimethyl hydrazine induced colorectal carcinoma in rats.
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Antineoplastic Agents, Phytogenic; Antioxid | 2011 |
Effect of myricetin on 1,2 dimethylhydrazine induced rat colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Antioxidants; Catalase; Colon; Colorectal N | 2011 |
Calcium prevents tumorigenesis in a mouse model of colorectal cancer.
Topics: 1,2-Dimethylhydrazine; Animals; Basic-Leucine Zipper Transcription Factors; Calcium; Calgranulin B; | 2011 |
The effect of rosmarinic acid on 1,2-dimethylhydrazine induced colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Antineoplastic Agents; Antioxidants; Carcinogens; Cinnamates; Coloni | 2013 |
Lack of inhibitory effects of green tea catechins in 1,2-dimetylhydrazine-induced rat intestinal carcinogenesis model: comparison of the different formulations, administration routes and doses.
Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Anticarcinogenic Agents; Body Weight; Carcinogenicity Tests | 2002 |
High susceptibility of nullizygous p53 knockout mice to colorectal tumor induction by 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Carcinoma; Cell Transformation, Neoplastic; Colorectal | 2003 |
The normal and metastases-bearing livers retain various specific subsets of live lymphocytes from portal circulation.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Analysis of Variance; Animals; Antigens, CD; Carcinogens; Cel | 2003 |
A novel mouse model for colitis-associated colon carcinogenesis induced by 1,2-dimethylhydrazine and dextran sulfate sodium.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; beta Catenin; Carcinogens; Colitis, Ulcerative; Colo | 2004 |
The potent colon carcinogen, 1,2-dimethylhydrazine induces mutations primarily in the colon.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Colon; Colonic Neoplasms; Diet; Disease Models, Animal; | 2004 |
Colorectal cancer and Coxibs.
Topics: 1,2-Dimethylhydrazine; Animals; Aspirin; Carcinogens; Colorectal Neoplasms; Cyclooxygenase Inhibitor | 2004 |
Influence of rofecoxib on experimental colonic carcinogenesis in rats.
Topics: 1,2-Dimethylhydrazine; Animals; Aspirin; Carcinogens; Colonic Neoplasms; Cyclooxygenase 2; Cyclooxyg | 2004 |
Beta-Catenin mutations in a mouse model of inflammation-related colon carcinogenesis induced by 1,2-dimethylhydrazine and dextran sodium sulfate.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Azoxymethane; beta Catenin; Colitis; Colonic Neoplas | 2005 |
Effect of ethanol consumption on colon cancer in an experimental model.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Colonic Neoplasms; Disease Models, Animal; Ethanol; Fem | 2005 |
Reduction of beta-glucuronidase and nitroreductase activity by yoghurt in a murine colon cancer model.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Carcinoma; Colon; Colonic Neoplasms; Diet Therapy; Dise | 2005 |
Chemopreventive efficacy of ginger, a naturally occurring anticarcinogen during the initiation, post-initiation stages of 1,2 dimethylhydrazine-induced colon cancer.
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Carcinogens; Chemoprevention; Colonic Neopl | 2005 |
Rat colonic lipid peroxidation and antioxidant status: the effects of dietary luteolin on 1,2-dimethylhydrazine challenge.
Topics: 1,2-Dimethylhydrazine; Animals; Ascorbic Acid; Carcinogens; Catalase; Colon; Colonic Neoplasms; Dise | 2005 |
Evaluation of the antitumor activity of interleukin-12 in an experimental murine model of colorectal cancer induced by 1,2 dimethyl-hydrazine (DMH).
Topics: 1,2-Dimethylhydrazine; Adjuvants, Immunologic; Animals; Colorectal Neoplasms; Disease Models, Animal | 2005 |
Cyclooxygenase-2 inhibition in colon experimental carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Aspirin; Colonic Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhib | 2005 |
Aged garlic extract has chemopreventative effects on 1,2-dimethylhydrazine-induced colon tumors in rats.
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Carcinogens; Colonic Neoplasms; Cysteine; D | 2006 |
Inverse genetic predisposition to colon versus lung carcinogenesis in mouse lines selected based on acute inflammatory responsiveness.
Topics: 1,2-Dimethylhydrazine; Acute Disease; Adenocarcinoma; Adenoma; Animals; Antiviral Agents; Carcinogen | 2006 |
Dietary supplementation of resveratrol suppresses colonic tumour incidence in 1,2-dimethylhydrazine-treated rats by modulating biotransforming enzymes and aberrant crypt foci development.
Topics: 1,2-Dimethylhydrazine; Animals; Antineoplastic Agents, Phytogenic; Bacteria; Carcinogens; Colon; Col | 2006 |
Survivin and Cyclooxygenase-2 are co-expressed in human and mouse colon carcinoma and in terminally differentiated colonocytes.
Topics: 1,2-Dimethylhydrazine; Animals; beta Catenin; Cell Differentiation; Colon; Cyclooxygenase 2; Disease | 2007 |
Evidence-based review versus points of view.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Colorectal Neoplasms; Disease Models, Animal; Ethanol; | 2007 |
Oral administration of a catalase-producing Lactococcus lactis can prevent a chemically induced colon cancer in mice.
Topics: 1,2-Dimethylhydrazine; Administration, Oral; Animals; Catalase; Colonic Neoplasms; Disease Models, A | 2008 |
Obesity-related promotion of aberrant crypt foci in DMH-treated obese Zucker rats correlates with dyslipidemia rather than hyperinsulinemia.
Topics: 1,2-Dimethylhydrazine; Animals; Caloric Restriction; Cell Division; Colonic Neoplasms; Comet Assay; | 2008 |
Dose-dependent effect of oregano (Origanum vulgare L.) on lipid peroxidation and antioxidant status in 1,2-dimethylhydrazine-induced rat colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Carcinogens; Chroma | 2008 |
Experimental cancer of the bowel in the Nb rat.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Colonic Neoplasms; Dimethylhydrazines; Disease Model | 1983 |
Effects of fecal stream on experimental colorectal carcinogenesis. Morphologic and histochemical changes.
Topics: 1,2-Dimethylhydrazine; Animals; Colonic Neoplasms; Dimethylhydrazines; Disease Models, Animal; Feces | 1982 |
Genetic analysis of colon cancer susceptibility in mice.
Topics: 1,2-Dimethylhydrazine; Animals; Base Sequence; Colonic Neoplasms; Crosses, Genetic; Dimethylhydrazin | 1994 |
Flat adenoma-adenocarcinoma sequence in the colon of rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Animals; Carcinogens; Colonic Neoplasms; Dimethylhyd | 1994 |
Colonoscopic colostomy model in rats for colon tumorigenesis studies.
Topics: 1,2-Dimethylhydrazine; Animals; Colonic Neoplasms; Colonoscopy; Colostomy; Dimethylhydrazines; Disea | 1994 |
[Establishment of a transplantable rat colon cancer and a model of metastasis].
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Cell Division; Colonic Neoplasms; Dimethylhydrazines | 1993 |
Effects of green tea catechins in a rat multi-organ carcinogenesis model.
Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Anticarcinogenic Agents; Body Weight; Butylhydroxybutylnitr | 1993 |
Effect of selenium on 1,2-dimethylhydrazine-induced intestinal cancer in rats.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Dimethylhydrazines; Disease Models, Animal; Drug Evalua | 1996 |
A comparative study of the influence of differing barley brans on DMH-induced intestinal tumours in male Sprague-Dawley rats.
Topics: 1,2-Dimethylhydrazine; Animals; Antineoplastic Agents; Body Weight; Butyrates; Butyric Acid; Carcino | 1996 |
Effect of supplemental L-arginine in a chemical-induced model of colorectal cancer.
Topics: 1,2-Dimethylhydrazine; Administration, Oral; Animals; Arginine; Carcinogens; Cell Division; Colorect | 1996 |
Influence of diets containing high and low risk factors for colon cancer on early stages of carcinogenesis in human flora-associated (HFA) rats.
Topics: 1,2-Dimethylhydrazine; Animals; Bacteria; Biomarkers; Body Weight; Colon; Colonic Diseases; Colonic | 1997 |
Changes in CD44 expression during carcinogenesis of the mouse colon.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Colonic Neoplasms; Disease Models, Animal; Female; Huma | 1997 |
[New means for the prophylaxis of colon cancer with the use of beta-glucuronidase inhibitors].
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Colonic Neoplasms; Disease Models, Animal; | 1998 |
Microsatellite instability, chemosensitivity and mutant frequency in a series of 1,2-dimethylhydrazine induced murine colon adenocarcinoma models.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agen | 1998 |
Gastric tumor induction by 1,2-dimethylhydrazine in Wistar rats with intestinal metaplasia caused by X-irradiation.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Disease Models, Animal; Gastric Mucosa; Intestinal Muco | 1999 |
Animal model in the study of colorectal carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Animals; Carcinogens; Carcinoma; Colorectal Neoplasm | 2000 |
Post-initiation effects of chlorophyllin and indole-3-carbinol in rats given 1,2-dimethylhydrazine or 2-amino-3-methyl- imidazo.
Topics: 1,2-Dimethylhydrazine; Adenosarcoma; Animals; Anticarcinogenic Agents; Antimutagenic Agents; Carcino | 2001 |
Early and late effects of wound healing on development of colon tumours in a model of colon carcinogenesis by 1,2-dimethylhydrazine in the rat.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Colonic Neoplasms; Dermatologic Surgica | 2000 |
A protective role of dietary vitamin D3 in rat colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Body Weight; Bromodeoxyuridine; Calcifediol; Calcitr | 2000 |
Orotic acid, a new promoter for experimental liver carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Arginine; Carcinogens; Diet; Disease Models, Animal; DNA; gamma-Glut | 1984 |
[The action of 5-fluorouracil in DMH-induced carcinogenesis in rats].
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Dimethylhydrazines; Disease Models, Animal; Drug Evalua | 1992 |
Induction of nephroblastoma-like renal tumours in rats by a single dose of 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Dimethylhydrazines; Disease Models, Animal; Female; Kid | 1985 |
Rodent models for carcinoma of the colon.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Alkylation; Animals; Colonic Neoplasms; Dietary Fats; Dietary | 1985 |
[Modelling of ovarian tumors in rats].
Topics: 1,2-Dimethylhydrazine; Animals; Dimethylhydrazines; Disease Models, Animal; Female; Methods; Neoplas | 1987 |
Different autochthonous models of colorectal cancer in the rat.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Colonic Neoplasms; Dimethylhydrazines; Dimethylnitro | 1986 |
Are animal models of colon cancer relevant to human disease.
Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Carcinoma; Colonic Neoplasms; Colonoscopy; Dimethylhydrazin | 1985 |