1,2-dimethylhydrazine has been researched along with Disease Exacerbation in 12 studies
1,2-Dimethylhydrazine: A DNA alkylating agent that has been shown to be a potent carcinogen and is widely used to induce colon tumors in experimental animals.
1,2-dimethylhydrazine : A member of the class of hydrazines that is hydrazine in which one of the hydrogens attached to each nitrogen is replaced by a methyl group. A powerful DNA alkylating agent and carcinogen, it is used to induce colon cancer in laboratory rats and mice.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Phytic acid (PA) has been demonstrated to have a potent anticarcinogenic activity against colorectal cancer (CRC)." | 7.88 | Phytic acid improves intestinal mucosal barrier damage and reduces serum levels of proinflammatory cytokines in a 1,2-dimethylhydrazine-induced rat colorectal cancer model. ( Chen, C; Cheng, L; Li, X; Liu, C; Song, Y; Yang, F, 2018) |
| "Almost equal inhibitory effects on tubular adenocarcinomas were also observed in the rats given 150 ppm JTE-522 during the postinitiation stage, suggesting that its major anticancer action is at the postinitiation phase." | 5.33 | JTE-522, a selective cyclooxygenase-2 inhibitor, inhibits induction but not growth and invasion of 1,2-dimethylhydrazine-induced tubular adenocarcinomas of colon in rats. ( Fukushima, S; Hakoi, K; Moku, M; Morimura, K; Salim, EI; Shen, J; Wanibuchi, H; Wei, M, 2005) |
| "Phytic acid (PA) has been demonstrated to have a potent anticarcinogenic activity against colorectal cancer (CRC)." | 3.88 | Phytic acid improves intestinal mucosal barrier damage and reduces serum levels of proinflammatory cytokines in a 1,2-dimethylhydrazine-induced rat colorectal cancer model. ( Chen, C; Cheng, L; Li, X; Liu, C; Song, Y; Yang, F, 2018) |
| "Almost equal inhibitory effects on tubular adenocarcinomas were also observed in the rats given 150 ppm JTE-522 during the postinitiation stage, suggesting that its major anticancer action is at the postinitiation phase." | 1.33 | JTE-522, a selective cyclooxygenase-2 inhibitor, inhibits induction but not growth and invasion of 1,2-dimethylhydrazine-induced tubular adenocarcinomas of colon in rats. ( Fukushima, S; Hakoi, K; Moku, M; Morimura, K; Salim, EI; Shen, J; Wanibuchi, H; Wei, M, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (16.67) | 18.2507 |
| 2000's | 5 (41.67) | 29.6817 |
| 2010's | 4 (33.33) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Sadighparvar, S | 1 |
| Darband, SG | 1 |
| Ghaderi-Pakdel, F | 1 |
| Mihanfar, A | 1 |
| Majidinia, M | 1 |
| Liu, C | 1 |
| Chen, C | 1 |
| Yang, F | 1 |
| Li, X | 1 |
| Cheng, L | 1 |
| Song, Y | 1 |
| Chen, ZF | 1 |
| Ai, LY | 1 |
| Wang, JL | 1 |
| Ren, LL | 1 |
| Yu, YN | 1 |
| Xu, J | 1 |
| Chen, HY | 1 |
| Yu, J | 1 |
| Li, M | 1 |
| Qin, WX | 1 |
| Ma, X | 1 |
| Shen, N | 1 |
| Chen, YX | 1 |
| Hong, J | 1 |
| Fang, JY | 1 |
| Kuugbee, ED | 1 |
| Shang, X | 1 |
| Gamallat, Y | 1 |
| Bamba, D | 1 |
| Awadasseid, A | 1 |
| Suliman, MA | 1 |
| Zang, S | 1 |
| Ma, Y | 1 |
| Chiwala, G | 1 |
| Xin, Y | 1 |
| Shang, D | 1 |
| Sun, T | 1 |
| Liu, S | 1 |
| Zhou, Y | 1 |
| Yao, Z | 1 |
| Zhang, D | 1 |
| Cao, S | 1 |
| Wei, Z | 1 |
| Tan, B | 1 |
| Li, Y | 1 |
| Lian, Z | 1 |
| Wang, S | 1 |
| Li, W | 1 |
| Li, CB | 1 |
| Wei, M | 2 |
| Morimura, K | 2 |
| Wanibuchi, H | 2 |
| Shen, J | 2 |
| Doi, K | 1 |
| Mitsuhashi, M | 1 |
| Moku, M | 2 |
| Salim, EI | 2 |
| Fukushima, S | 2 |
| Hakoi, K | 1 |
| Kirley, SD | 1 |
| D'Apuzzo, M | 1 |
| Lauwers, GY | 1 |
| Graeme-Cook, F | 1 |
| Chung, DC | 1 |
| Zukerberg, LR | 1 |
| Jacoby, RF | 1 |
| Hohman, C | 1 |
| Marshall, DJ | 1 |
| Frick, TJ | 1 |
| Schlack, S | 1 |
| Broda, M | 1 |
| Smutko, J | 1 |
| Elliott, RW | 1 |
| Moen, CJ | 1 |
| van der Valk, MA | 1 |
| Bird, RP | 1 |
| Hart, AA | 1 |
| Demant, P | 1 |
| Schleiffer, R | 1 |
| Duranton, B | 1 |
| Gossé, F | 1 |
| Hasselmann, M | 1 |
| Raul, F | 1 |
12 other studies available for 1,2-dimethylhydrazine and Disease Exacerbation
| Article | Year |
|---|---|
Parasympathetic, but not sympathetic denervation, suppressed colorectal cancer progression.
Topics: 1,2-Dimethylhydrazine; Animals; Atropine; Carcinogenesis; Carcinogens; Colon; Colorectal Neoplasms; | 2021 |
Phytic acid improves intestinal mucosal barrier damage and reduces serum levels of proinflammatory cytokines in a 1,2-dimethylhydrazine-induced rat colorectal cancer model.
Topics: 1,2-Dimethylhydrazine; Animals; Body Weight; Cadherins; Claudin-1; Colon; Colorectal Neoplasms; Cyto | 2018 |
Probiotics Clostridium butyricum and Bacillus subtilis ameliorate intestinal tumorigenesis.
Topics: 1,2-Dimethylhydrazine; Administration, Oral; Animals; Apoptosis; Bacillus subtilis; Carcinogenesis; | 2015 |
Structural Change in Microbiota by a Probiotic Cocktail Enhances the Gut Barrier and Reduces Cancer via TLR2 Signaling in a Rat Model of Colon Cancer.
Topics: 1,2-Dimethylhydrazine; Animals; Bifidobacterium bifidum; Bifidobacterium longum subspecies infantis; | 2016 |
Evolutionary biologic changes of gut microbiota in an 'adenoma-carcinoma sequence' mouse colorectal cancer model induced by 1, 2-Dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Adenomatous Polyposis Coli Protein; Animals; Bacteri | 2017 |
Lack of inhibitory effects of lactic acid bacteria on 1,2-dimethylhydrazine-induced colon tumors in rats.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Colonic Neoplasms; Disease Progression; Lactococcus lac | 2003 |
Chemopreventive effect of JTE-522, a selective cyclooxygenase-2 inhibitor, on 1, 2-dimethylhydrazine-induced rat colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Benzenesulfonates; Bromodeoxyuridine; Carcinogens; Cell Division; Co | 2003 |
JTE-522, a selective cyclooxygenase-2 inhibitor, inhibits induction but not growth and invasion of 1,2-dimethylhydrazine-induced tubular adenocarcinomas of colon in rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Animals; Benzenesulfonates; Biomarkers, Tumor; Carci | 2005 |
The Cables gene on chromosome 18Q regulates colon cancer progression in vivo.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Animals; Carcinogens; Carrier Proteins; Chromosome D | 2005 |
Genetic analysis of colon cancer susceptibility in mice.
Topics: 1,2-Dimethylhydrazine; Animals; Base Sequence; Colonic Neoplasms; Crosses, Genetic; Dimethylhydrazin | 1994 |
Different genetic susceptibility to aberrant crypts and colon adenomas in mice.
Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Carcinogens; Colonic Diseases; Colonic Neoplasms; Crosses, | 1996 |
Blood polyamine levels after oral ornithine load, a diagnostic marker of hyperproliferative premalignant and malignant stages in a model of colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Animals; Biomarkers, Tumor; Biotransformation; Body | 2000 |