1,2-dimethylhydrazine has been researched along with Diathesis in 7 studies
1,2-Dimethylhydrazine: A DNA alkylating agent that has been shown to be a potent carcinogen and is widely used to induce colon tumors in experimental animals.
1,2-dimethylhydrazine : A member of the class of hydrazines that is hydrazine in which one of the hydrogens attached to each nitrogen is replaced by a methyl group. A powerful DNA alkylating agent and carcinogen, it is used to induce colon cancer in laboratory rats and mice.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mice from strains with different susceptibility to the colon-specific carcinogen 1,2-dimethylhydrazine (DMH) were tested for DNA damage in liver, kidney and colon after administration of the compound at a dosage that has been reported to induce a high incidence of adenocarcinoma in the colon of rodents." | 3.67 | Correlation between incidence of 1,2-dimethylhydrazine-induced colon carcinomas and DNA damage in six genetically different mouse strains. ( Boffa, LC; Bolognesi, C, 1986) |
| "To study the effect of acetic acid colitis on 1,2-dimethylhydrazine-induced colon tumorigenesis, fischer 344 male rats, 10 weeks of age, were divided into three groups: one receiving 5% acetic acid enema (subgroup 1a); one receiving 10% acetic acid enema (subgroup 1b); and one not receiving acetic acid enema (group 2)." | 3.66 | Experimental colitis as a promoter in large-bowel tumorigenesis. ( Hagihara, PF, 1982) |
| "The predisposition to colon cancer is multigenetically controlled in animals and probably also in humans." | 1.29 | Fine mapping of colon tumor susceptibility (Scc) genes in the mouse, different from the genes known to be somatically mutated in colon cancer. ( Demant, P; Groot, PC; Hart, AA; Moen, CJ; Snoek, M, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (42.86) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wedemeyer, J | 1 |
| Galli, SJ | 1 |
| Oumouna-Benachour, K | 1 |
| Oumouna, M | 1 |
| Zerfaoui, M | 1 |
| Hans, C | 1 |
| Fallon, K | 1 |
| Boulares, AH | 1 |
| James, JT | 1 |
| Autrup, H | 1 |
| Hagihara, PF | 1 |
| Moen, CJ | 2 |
| Groot, PC | 1 |
| Hart, AA | 2 |
| Snoek, M | 1 |
| Demant, P | 2 |
| van der Valk, MA | 1 |
| Bird, RP | 1 |
| Bolognesi, C | 1 |
| Boffa, LC | 1 |
7 other studies available for 1,2-dimethylhydrazine and Diathesis
| Article | Year |
|---|---|
Decreased susceptibility of mast cell-deficient Kit(W)/Kit(W-v) mice to the development of 1, 2-dimethylhydrazine-induced intestinal tumors.
Topics: 1,2-Dimethylhydrazine; Animals; Bone Marrow Transplantation; Carcinogens; Cell Proliferation; Diseas | 2005 |
Intrinsic resistance to apoptosis of colon epithelial cells is a potential determining factor in the susceptibility of the A/J mouse strain to dimethylhydrazine-induced colon tumorigenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Apoptosis; Carcinogens; Caspase 3; Colon; Colonic Neoplasms; Disease | 2007 |
Methylated DNA adducts in the large intestine of ICR/Ha and C57BL/Ha mice given 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Disease Suscepti | 1983 |
Experimental colitis as a promoter in large-bowel tumorigenesis.
Topics: 1,2-Dimethylhydrazine; Acetates; Adenocarcinoma; Adenoma; Animals; Colitis; Colonic Neoplasms; Dimet | 1982 |
Fine mapping of colon tumor susceptibility (Scc) genes in the mouse, different from the genes known to be somatically mutated in colon cancer.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Chromosome Mapping; Colonic Neoplasms; Crosses, Genetic | 1996 |
Different genetic susceptibility to aberrant crypts and colon adenomas in mice.
Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Carcinogens; Colonic Diseases; Colonic Neoplasms; Crosses, | 1996 |
Correlation between incidence of 1,2-dimethylhydrazine-induced colon carcinomas and DNA damage in six genetically different mouse strains.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Colon; Colonic Neoplasms; Dimethylhydrazines; Diseas | 1986 |