1,2-dimethylhydrazine has been researched along with Colorectal Neoplasms in 125 studies
1,2-Dimethylhydrazine: A DNA alkylating agent that has been shown to be a potent carcinogen and is widely used to induce colon tumors in experimental animals.
1,2-dimethylhydrazine : A member of the class of hydrazines that is hydrazine in which one of the hydrogens attached to each nitrogen is replaced by a methyl group. A powerful DNA alkylating agent and carcinogen, it is used to induce colon cancer in laboratory rats and mice.
Colorectal Neoplasms: Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
| Excerpt | Relevance | Reference |
|---|---|---|
| "What is the central question of this study? What are the alleviative effects of the combination of exercise training and quercetin supplementation on colorectal cancer-related depression in rats with 1,2-dimethylhydrazine-induced colorectal cancer and what is the corresponding signalling pathway? What is the main finding and its importance? We showed that the combination of exercise training and quercetin supplementation resulted in a significant decrease in tumour incidence and improvement in depressive-like behaviours through modulation of the BDNF/TrKβ/β-catenin axis in the prefrontal cortex." | 7.96 | Combination of quercetin and exercise training attenuates depression in rats with 1,2-dimethylhydrazine-induced colorectal cancer: Possible involvement of inflammation and BDNF signalling. ( Babaei, G; Darband, SG; Ghaderi-Pakdel, F; Kaviani, M; Majidinia, M; Mihanfar, A; Mobaraki, K; Sadighparvar, S; Yousefi, B, 2020) |
| " This study was designed to evaluate the effects of fucoidan on gut flora and tumor prevention in 1,2-dimethylhydrazine-induced colorectal carcinogenesis in rats." | 7.96 | Effects of fucoidan on gut flora and tumor prevention in 1,2-dimethylhydrazine-induced colorectal carcinogenesis. ( Ji, X; Liang, H; Liu, Y; Sun, T; Xue, M; Zhang, L; Zhou, Z, 2020) |
| "Phytic acid (PA) has been demonstrated to have a potent anticarcinogenic activity against colorectal cancer (CRC)." | 7.88 | Phytic acid improves intestinal mucosal barrier damage and reduces serum levels of proinflammatory cytokines in a 1,2-dimethylhydrazine-induced rat colorectal cancer model. ( Chen, C; Cheng, L; Li, X; Liu, C; Song, Y; Yang, F, 2018) |
| "Colorectal cancer has been found to be attenuated either with prophylactic manipulation of gut microbiome with probiotics or celecoxib, a non-steroidal anti-inflammatory drug mainly by suppressing early pro-carcinogenic markers in various experimental studies." | 7.88 | Prophylactic intervention of probiotics (L.acidophilus, L.rhamnosus GG) and celecoxib modulate Bax-mediated apoptosis in 1,2-dimethylhydrazine-induced experimental colon carcinogenesis. ( Chandel, D; Sharaf, LK; Sharma, M; Shukla, G, 2018) |
| " The present study was carried out to divulge the protective potential of the probiotic Dahi containing Lactobacillus acidophilus LaVK2 and Bifidobacterium bifidum BbVK3 alone or in combination with piroxicam (PXC) on the development of early biomarkers of colorectal carcinogenesis in male Wistar rats administered 1,2-dimethylhydrazine (DMH)." | 7.80 | Probiotic Dahi containing Lactobacillus acidophilus and Bifidobacterium bifidum modulates the formation of aberrant crypt foci, mucin-depleted foci, and cell proliferation on 1,2-dimethylhydrazine-induced colorectal carcinogenesis in Wistar rats. ( Kansal, VK; Kruzliak, P; Kumari, A; Mohania, D, 2014) |
| "To investigate the hepatic dihydropyrimidine dehydrogenase (DPD) activity in colorectal cancer (CRC), which is critically important to create a patient-specific dosing regimen, we performed 5-FU pharmacokinetic studies in 1,2-dimethylhydrazine-induced CRC model rats (CRC rats)." | 7.79 | Pharmacokinetics of 5-fluorouracil and increased hepatic dihydropyrimidine dehydrogenase activity levels in 1,2-dimethylhydrazine-induced colorectal cancer model rats. ( Imoto, K; Ito, Y; Kobuchi, S; Okada, K; Takada, K, 2013) |
| " This study was to evaluate the preventive effects of coloclysis of NaB on 1,2-dimethylhydrazine (DMH)-induced tumorigenesis of colorectal cancer in mice." | 7.73 | [Inhibitory effect of sodium butyrate on 1,2-dimethylhydrazine-induced tumorigenesis of colorectal cancer in mice]. ( Geng, XL; Huang, LH; Li, TJ; Liu, CX; Wang, B; Zhang, SZ; Zhang, XW, 2005) |
| "The colorectal cancer has few to no symptoms and mostly the tumor is often diagnosed in the later stage of cancer." | 5.72 | Chemoprotective effect of theanine in 1,2-dimethylhydrazine-induced colorectal cancer in rats via suppression of inflammatory parameters. ( An, L; Li, G; Li, P; Ma, J; Zhang, T, 2022) |
| "In many developed countries, colorectal cancer is a leading cause of morbidity and mortality and its etiology is familiar to be a grouping of nutritional and environmental factors, less physical activity and hereditary factors." | 5.72 | Anti-inflammatory and Antioxidant Effect of Lycoperoside H against the 1,2-Dimethyl Hydrazine (DMH) Induced Colorectal Cancer in Rats. ( Liu, Y; Qi, X, 2022) |
| "Chrysin and daidzein treatment significantly (P < 0." | 5.62 | Promising targets of chrysin and daidzein in colorectal cancer: Amphiregulin, CXCL1, and MMP-9. ( Allam, RM; Salama, AAA, 2021) |
| "Background Colorectal cancer (CRC) is a major public health problem, with almost 1." | 5.56 | Protective effect of Matricaria chamomilla extract against 1,2-dimethylhydrazine-induced colorectal cancer in mice. ( Borjac, JM; El Joumaa, MM; Rizk, S; Taleb, RI, 2020) |
| "Initiation and induction of colon carcinogenesis were achieved through weekly subcutaneous injections of DMH (30 mg/kg body weight) for both 10 and 20 weeks." | 5.42 | Chemopreventive Effects of Azadirachta indica on Cancer Marker Indices and Ultrastructural Changes During 1,2-Dimethylhydrazine-Induced Colon Carcinogenesis in Rats. ( Liu, N; Sun, B; Wei, X; Wu, P, 2015) |
| " Colorectal cancer was induced in all animals by weekly subcutaneous injections of the colonic procarcinogen 1,2-dimethylhydrazine (DMH) at a dosage of 20 mg/kg body weight." | 5.29 | Effect of supplemental L-arginine in a chemical-induced model of colorectal cancer. ( Anderson, N; Hoper, M; Ma, Q; Rowlands, BJ, 1996) |
| " We investigated the effectivity of jaboticaba whole fruit ethanolic extract (FEX) in suppressing aberrant crypt foci (ACF), the earliest lesion of colorectal cancer (CRC), in 1,2-dimethylhydrazine (DMH)-induced rats and the underlying mechanisms related to the gut microbiota composition and short chain fatty acid (SCFA)." | 4.31 | Jaboticaba (Myrciaria cauliflora) Fruit Extract Suppressed Aberrant Crypt Formation in 1,2-Dimetylhydrazine-Induced Rats. ( Ardanareswari, K; Chung, YC; Liao, JW; Lowisia, W; Soedarini, B, 2023) |
| " This study was designed to evaluate the effects of fucoidan on gut flora and tumor prevention in 1,2-dimethylhydrazine-induced colorectal carcinogenesis in rats." | 3.96 | Effects of fucoidan on gut flora and tumor prevention in 1,2-dimethylhydrazine-induced colorectal carcinogenesis. ( Ji, X; Liang, H; Liu, Y; Sun, T; Xue, M; Zhang, L; Zhou, Z, 2020) |
| "What is the central question of this study? What are the alleviative effects of the combination of exercise training and quercetin supplementation on colorectal cancer-related depression in rats with 1,2-dimethylhydrazine-induced colorectal cancer and what is the corresponding signalling pathway? What is the main finding and its importance? We showed that the combination of exercise training and quercetin supplementation resulted in a significant decrease in tumour incidence and improvement in depressive-like behaviours through modulation of the BDNF/TrKβ/β-catenin axis in the prefrontal cortex." | 3.96 | Combination of quercetin and exercise training attenuates depression in rats with 1,2-dimethylhydrazine-induced colorectal cancer: Possible involvement of inflammation and BDNF signalling. ( Babaei, G; Darband, SG; Ghaderi-Pakdel, F; Kaviani, M; Majidinia, M; Mihanfar, A; Mobaraki, K; Sadighparvar, S; Yousefi, B, 2020) |
| "Colorectal cancer has been found to be attenuated either with prophylactic manipulation of gut microbiome with probiotics or celecoxib, a non-steroidal anti-inflammatory drug mainly by suppressing early pro-carcinogenic markers in various experimental studies." | 3.88 | Prophylactic intervention of probiotics (L.acidophilus, L.rhamnosus GG) and celecoxib modulate Bax-mediated apoptosis in 1,2-dimethylhydrazine-induced experimental colon carcinogenesis. ( Chandel, D; Sharaf, LK; Sharma, M; Shukla, G, 2018) |
| "Phytic acid (PA) has been demonstrated to have a potent anticarcinogenic activity against colorectal cancer (CRC)." | 3.88 | Phytic acid improves intestinal mucosal barrier damage and reduces serum levels of proinflammatory cytokines in a 1,2-dimethylhydrazine-induced rat colorectal cancer model. ( Chen, C; Cheng, L; Li, X; Liu, C; Song, Y; Yang, F, 2018) |
| "This work investigated the effects of Vitamin E (VE) on aberrant crypt foci (ACF) incidence, oxidative stress parameters (serum and hepatic VE concentration, and homocysteine, glutathione (GSH), and malondialdehyde (MDA) levels), and expression of both cyclooxygenase-2 (COX2) and proliferating cellular nuclear antigen (PCNA) in experimental colorectal carcinogenesis." | 3.80 | Vitamin E supplementation in chemical colorectal carcinogenesis: a two-edged knife. ( Cardoso, JF; Cohen, C; Garcia, SB; Vannucchi, H, 2014) |
| " The present study was carried out to divulge the protective potential of the probiotic Dahi containing Lactobacillus acidophilus LaVK2 and Bifidobacterium bifidum BbVK3 alone or in combination with piroxicam (PXC) on the development of early biomarkers of colorectal carcinogenesis in male Wistar rats administered 1,2-dimethylhydrazine (DMH)." | 3.80 | Probiotic Dahi containing Lactobacillus acidophilus and Bifidobacterium bifidum modulates the formation of aberrant crypt foci, mucin-depleted foci, and cell proliferation on 1,2-dimethylhydrazine-induced colorectal carcinogenesis in Wistar rats. ( Kansal, VK; Kruzliak, P; Kumari, A; Mohania, D, 2014) |
| "To investigate the hepatic dihydropyrimidine dehydrogenase (DPD) activity in colorectal cancer (CRC), which is critically important to create a patient-specific dosing regimen, we performed 5-FU pharmacokinetic studies in 1,2-dimethylhydrazine-induced CRC model rats (CRC rats)." | 3.79 | Pharmacokinetics of 5-fluorouracil and increased hepatic dihydropyrimidine dehydrogenase activity levels in 1,2-dimethylhydrazine-induced colorectal cancer model rats. ( Imoto, K; Ito, Y; Kobuchi, S; Okada, K; Takada, K, 2013) |
| "To evaluate the preventive effect of sodium butyrate in the appearance of aberrant crypt foci (ACF) in rats after induction with the carcinogen 1,2-dimethylhydrazine (DMH)." | 3.76 | Sodium butyrate does not decrease the evolution of precancerous lesions in rats. ( Glória, MB; Mendes, MC; Peluzio, Mdo C; Penido, LC; Rosa, DD; Silva, FG; Valente, FX, 2010) |
| " This study was to evaluate the preventive effects of coloclysis of NaB on 1,2-dimethylhydrazine (DMH)-induced tumorigenesis of colorectal cancer in mice." | 3.73 | [Inhibitory effect of sodium butyrate on 1,2-dimethylhydrazine-induced tumorigenesis of colorectal cancer in mice]. ( Geng, XL; Huang, LH; Li, TJ; Liu, CX; Wang, B; Zhang, SZ; Zhang, XW, 2005) |
| "The objective of this experiment was to compare the effects of diets with either a non-fermentable fibre source (cellulose) or a fermentable fibre source [galacto-oligosaccharide (GOS)], combined with different levels of dietary fat, on the development of colorectal cancer." | 3.70 | A comparison of the effects of dietary cellulose and fermentable galacto-oligosaccharide, in a rat model of colorectal carcinogenesis: fermentable fibre confers greater protection than non-fermentable fibre in both high and low fat backgrounds. ( Appel, MJ; Hollanders, VM; Wijnands, MV; Woutersen, RA, 1999) |
| "This study tested the effect of a new gastrin receptor antagonist, CR2945, on colorectal cancer induced by 1,2-dimethylhydrazine (DMH) in mice." | 3.70 | Inhibitory effect of a gastrin receptor antagonist, CR2945, on 1, 2-dimethylhydrazine-induced colorectal cancer in mice. ( Di Betta, E; Donato, F; Fontana, MG; Ghirardi, M; Moneghini, D; Salerni, B; Villanacci, V, 1999) |
| " A high incidence of colorectal adenocarcinomas with varied grades of cell differentiation can be induced by 1,2-dimethylhydrazine (DMH) in rats." | 3.69 | Preventive effect of 1-(2-tetrahydrofuryl)-5-fluorouracil in combination with uracil on colonic carcinogenesis induced by 1,2-dimethylhydrazine in rats. ( Iwama, T; Kawachi, Y; Kudo, H; Murakami, S; Okayasu, I; Sagara, T; Sakamoto, S; Tsukada, K, 1997) |
| "Bowl or colorectal cancer (CRC) is the third most common type of cancer with about two million new cases every year." | 1.72 | The Antitumor Activity of Ginger against Colorectal Cancer Induced by Dimethylhydrazine in Rats. ( Abdel-Rasol, MA; El-Beih, NM; El-Sayed, WM; Yahya, SS, 2022) |
| "procera in the rat model of colorectal cancer (CRC)." | 1.72 | Protective effect of methanol extract of latex of Calotropis procera in an experimental model of colorectal cancer. ( Das, P; Kumar, VL; Verma, S, 2022) |
| "The colorectal cancer has few to no symptoms and mostly the tumor is often diagnosed in the later stage of cancer." | 1.72 | Chemoprotective effect of theanine in 1,2-dimethylhydrazine-induced colorectal cancer in rats via suppression of inflammatory parameters. ( An, L; Li, G; Li, P; Ma, J; Zhang, T, 2022) |
| "In many developed countries, colorectal cancer is a leading cause of morbidity and mortality and its etiology is familiar to be a grouping of nutritional and environmental factors, less physical activity and hereditary factors." | 1.72 | Anti-inflammatory and Antioxidant Effect of Lycoperoside H against the 1,2-Dimethyl Hydrazine (DMH) Induced Colorectal Cancer in Rats. ( Liu, Y; Qi, X, 2022) |
| "For this, mice induced to carcinogenesis were fed with standard diet AIN-93 M (CON), diet AIN-93 M and VSL#3 (PRO) or diet AIN-93 M with yacon and VSL#3 (SYN)." | 1.72 | Synbiotic modulates intestinal microbiota metabolic pathways and inhibits DMH-induced colon tumorigenesis through c-myc and PCNA suppression. ( da Silva Duarte, V; de Luces Fortes Ferreira, CL; de Paula, SO; do Carmo Gouveia Peluzio, M; Dos Santos Cruz, BC; Ladeira Bernardes, A; Sousa Dias, R, 2022) |
| "Colorectal cancer is a highly prevalent disease, requiring effective strategies for prevention and treatment." | 1.62 | The Use of Natural Fiber-Rich Food Product Is Safe and Reduces Aberrant Crypt Foci in a Pre-Clinical Model. ( Baranoski, A; Bittencourt Junior, FF; da Silva Fleming de Almeida, T; do Amaral, LA; Duenhas Monreal, AC; Freitas Dos Santos, E; Leite Kassuya, CA; Milan Brochado Antoniolli-Silva, AC; Murino Rafacho, BP; Oliveira de Souza, GH; Oliveira, RJ; Souza Maris, R, 2021) |
| "Chrysin and daidzein treatment significantly (P < 0." | 1.62 | Promising targets of chrysin and daidzein in colorectal cancer: Amphiregulin, CXCL1, and MMP-9. ( Allam, RM; Salama, AAA, 2021) |
| "Background Colorectal cancer (CRC) is a major public health problem, with almost 1." | 1.56 | Protective effect of Matricaria chamomilla extract against 1,2-dimethylhydrazine-induced colorectal cancer in mice. ( Borjac, JM; El Joumaa, MM; Rizk, S; Taleb, RI, 2020) |
| "These results provide preliminary information for the development of a pharmacokinetic and toxicodynamic model of L-OHP for CRC therapy cycles." | 1.51 | Assessment of Oxaliplatin-induced Chronic Neuropathy and Anticancer Efficacy Through Pharmacokinetic and Toxicodynamic Evaluation of a Rat Model of Colorectal Cancer. ( Ito, Y; Kobuchi, S; Takahashi, C; Takesada, W, 2019) |
| "Colorectal tumors were studied 5 months after carcinogen injection to outbred albino rats with secondary immunodeficiency by common histological and immunobiochemical methods with the use of monoclonal and polyclonal antibodies to Ki-67, Bcl-2, p53, and VEGF." | 1.48 | New Experimental Facts on the Influence of Secondary Immunodeficiency on the Morphology and Biological Activity of Colorectal Tumor. ( Kostrova, OY; Merkulova, LM; Mikhailova, MN; Moskvichev, EV; Struchko, GY, 2018) |
| "After the induction of colorectal cancer, adult male Wistar rats were treated with saline (n = 7), DOX (1." | 1.46 | Cardiac autonomic modulation induced by doxorubicin in a rodent model of colorectal cancer and the influence of fullerenol pretreatment. ( Cerar, A; Finderle, Ž; Injac, R; Perše, M; Potočnik, N, 2017) |
| "Colorectal cancer is a global public health issue." | 1.46 | Prevention of DNA damage and anticarcinogenic activity of Activia ( Antoniolli-Silva, AC; Cantero, WB; Carreira, CM; Genez, LA; Limeiras, SM; Neves, SC; Ogo, FM; Oliveira, EJ; Oliveira, RJ; Pesarini, JR; Pessatto, LR; Schweich, LC; Silva, RA, 2017) |
| "weekly) for 15 weeks to initiate colon carcinogenesis." | 1.43 | Anti-proliferative and Apoptotic Effects of Basella rubra (L.) Against 1, 2-Dimethyl Hydrazine-induced Colon Carcinogenesis in Rats. ( Kilari, BP; Kotakadi, VS; Penchalaneni, J, 2016) |
| "Initiation and induction of colon carcinogenesis were achieved through weekly subcutaneous injections of DMH (30 mg/kg body weight) for both 10 and 20 weeks." | 1.42 | Chemopreventive Effects of Azadirachta indica on Cancer Marker Indices and Ultrastructural Changes During 1,2-Dimethylhydrazine-Induced Colon Carcinogenesis in Rats. ( Liu, N; Sun, B; Wei, X; Wu, P, 2015) |
| " In conclusion, the data collectively show that a 50% reduction in K-ras gene dosage and RNA expression promoted experimental colorectal tumourigenesis, consistent with wild-type K-ras having a tumour suppressor effect on carcinogen-induced murine colorectal adenoma formation." | 1.40 | Wild-type K-ras has a tumour suppressor effect on carcinogen-induced murine colorectal adenoma formation. ( Arends, MJ; Dong, G; Hamoudi, R; Ibrahim, AE; Luo, F; Poulogiannis, G; Ye, H; Zhang, W, 2014) |
| "Myricetin is a well known bioflavonoid that is claimed to have anti cancer action particularly in colorectal cancer." | 1.37 | Effect of myricetin on 1,2 dimethylhydrazine induced rat colon carcinogenesis. ( Nirmala, P; Ramanathan, M, 2011) |
| "After our serum metabonomic study of colorectal cancer (CRC) patients recently published in J." | 1.36 | Urinary metabonomic study on colorectal cancer. ( Cai, G; Cai, S; Chen, T; Jia, W; Liu, Y; Ni, Y; Qiu, Y; Su, M; Xu, LX; Xu, Y; Zhao, A, 2010) |
| "Pioglitazone was chosen as agonist of PPAR-gamma and GW9662 used as a specific complete antagonist of PPAR-gamma." | 1.35 | [Role of peroxisome proliferators-activated receptor-gamma in the chemical prevention therapy of sulindac for precancerous lesions of rats]. ( Han, YJ; Jin, Z; Li, CF; Li, J; Lv, YM; Zhang, YP, 2009) |
| "They suggest that Ca can reduce colorectal cancer risk in meat-eaters." | 1.35 | Beef meat promotion of dimethylhydrazine-induced colorectal carcinogenesis biomarkers is suppressed by dietary calcium. ( Corpet, DE; Guéraud, F; Pierre, F; Santarelli, R; Taché, S, 2008) |
| "Patients with chronic ulcerative colitis have a significantly increased risk of colorectal cancer development." | 1.33 | Chronic colitis promotes tumor development. ( Nagawa, H; Sato, H; Shinozaki, M; Watanabe, T, 2006) |
| "Colorectal tumors were induced by means of 15 s." | 1.31 | Animal model in the study of colorectal carcinogenesis. ( Cerar, A; Glavac, D; Ravnik-Glavac, M, 2000) |
| "The number and tumor score of colorectal tumors induced by 1,2-dymethylhydrazine in transgenic (Tg) mice carrying human c-Ha-ras genes were significantly reduced by ingestion of apple pectin (AP) or a culture condensate of Bifidobacterium longum (MB) when compared with a control diet." | 1.31 | Inhibitory effect of apple pectin and culture condensate of Bifidobacterium longum on colorectal tumors induced by 1,2-dimethylhydrazine in transgenic mice harboring human prototype c-Ha-ras genes. ( Hioki, K; Itoh, K; Itoh, T; Mitsuoka, T; Nakayama, H; Narushima, S; Nomura, T; Ohno, K; Takeuchi, S, 2000) |
| "In a rodent colorectal cancer model, nonsteroidal antiinflammatory drugs reduce tumor mass by increasing the rate of tumor cell apoptosis and decreasing proliferation." | 1.31 | Inhibition of beta-catenin translocation in rodent colorectal tumors: a novel explanation for the protective effect of nonsteroidal antiinflammatory drugs in colorectal cancer. ( Brown, WA; O'Brien, PE; Skinner, SA; Vogiagis, D, 2001) |
| "The incidence of colorectal tumors was high in both Tg- and non-Tg-GF mice (100%)." | 1.30 | Effect of mouse intestinal bacteria on incidence of colorectal tumors induced by 1,2-dimethylhydrazine injection in gnotobiotic transgenic mice harboring human prototype c-Ha-ras genes. ( Hioki, K; Itoh, K; Itoh, T; Mitsuoka, T; Nakayama, H; Narushima, S; Nomura, T, 1998) |
| "In a model of dimethylhydrazine-induced colorectal tumors in male mice aloin- or sennoside-enriched diets (0." | 1.29 | Sennosides and aloin do not promote dimethylhydrazine-induced colorectal tumors in mice. ( Baretton, G; Siegers, CP; Siemers, J, 1993) |
| " Colorectal cancer was induced in all animals by weekly subcutaneous injections of the colonic procarcinogen 1,2-dimethylhydrazine (DMH) at a dosage of 20 mg/kg body weight." | 1.29 | Effect of supplemental L-arginine in a chemical-induced model of colorectal cancer. ( Anderson, N; Hoper, M; Ma, Q; Rowlands, BJ, 1996) |
| "Total colorectal tumors induced were also fewer in the rats fed fish oil (p = 0." | 1.27 | A comparison of dietary fish oil and corn oil in experimental colorectal carcinogenesis. ( Andrianopoulos, G; Lands, WE; Nelson, RL; Souza, G; Tanure, JC, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (1.60) | 18.7374 |
| 1990's | 22 (17.60) | 18.2507 |
| 2000's | 31 (24.80) | 29.6817 |
| 2010's | 51 (40.80) | 24.3611 |
| 2020's | 19 (15.20) | 2.80 |
| Authors | Studies |
|---|---|
| Abdel-Rasol, MA | 1 |
| El-Beih, NM | 1 |
| Yahya, SS | 1 |
| El-Sayed, WM | 1 |
| Kumar, VL | 3 |
| Verma, S | 3 |
| Das, P | 3 |
| Sadighparvar, S | 3 |
| Darband, SG | 2 |
| Ghaderi-Pakdel, F | 2 |
| Mihanfar, A | 2 |
| Majidinia, M | 3 |
| Ma, J | 1 |
| Li, P | 1 |
| An, L | 1 |
| Zhang, T | 1 |
| Li, G | 1 |
| Liu, Y | 4 |
| Qi, X | 1 |
| Dos Santos Cruz, BC | 1 |
| da Silva Duarte, V | 1 |
| Sousa Dias, R | 1 |
| Ladeira Bernardes, A | 1 |
| de Paula, SO | 1 |
| de Luces Fortes Ferreira, CL | 1 |
| do Carmo Gouveia Peluzio, M | 1 |
| Valaei, A | 1 |
| Azadeh, F | 1 |
| Mostafavi Niaki, ST | 1 |
| Salehi, A | 1 |
| Shakib Khoob, M | 1 |
| Mirebrahimi, SHO | 1 |
| Kazemi, S | 1 |
| Hosseini, SM | 1 |
| Ardanareswari, K | 1 |
| Lowisia, W | 1 |
| Soedarini, B | 1 |
| Liao, JW | 1 |
| Chung, YC | 1 |
| de Oliveira, CS | 1 |
| Baptistella, MM | 1 |
| Siqueira, AP | 1 |
| Carvalho, MO | 1 |
| Ramos, LF | 1 |
| Souto, BS | 1 |
| de Almeida, LA | 1 |
| Dos Santos, EG | 1 |
| Novaes, RD | 4 |
| Nogueira, ESC | 1 |
| de Oliveira, PF | 1 |
| Vachiraarunwong, A | 1 |
| Tuntiwechapikul, W | 1 |
| Wongnoppavich, A | 1 |
| Meepowpan, P | 1 |
| Wongpoomchai, R | 1 |
| Soroka, Y | 1 |
| Kramar, S | 1 |
| Smahlii, Z | 1 |
| Lyebyedyeva, T | 1 |
| Kvasha, Y | 1 |
| Andriichuk, I | 1 |
| Nebesna, Z | 1 |
| Lisnychuk, N | 1 |
| Dos Reis, SO | 1 |
| da Luz, TC | 1 |
| da Silva Couto, CVM | 1 |
| Dalbó, J | 1 |
| Nunes, LC | 1 |
| Martins, MC | 1 |
| Silva, PI | 1 |
| da Silva, AMA | 1 |
| Trivilin, LO | 1 |
| Ghazizadeh Darband, S | 1 |
| Saboory, E | 1 |
| Kaviani, M | 2 |
| Mobaraki, K | 2 |
| Jabbari, N | 1 |
| El Joumaa, MM | 1 |
| Taleb, RI | 1 |
| Rizk, S | 1 |
| Borjac, JM | 1 |
| Xue, M | 1 |
| Liang, H | 1 |
| Ji, X | 1 |
| Zhou, Z | 1 |
| Sun, T | 2 |
| Zhang, L | 1 |
| Yousefi, B | 1 |
| Babaei, G | 1 |
| Lima, DAN | 1 |
| Pelegrini, BB | 1 |
| Uechi, FAA | 1 |
| Varago, RC | 1 |
| Pimenta, BB | 1 |
| Kaneshima, AMS | 1 |
| Kaneshima, EN | 1 |
| Souza, PDC | 1 |
| Pedroso, RB | 1 |
| Silveira, TGV | 1 |
| Becker, TCA | 1 |
| Salama, AAA | 1 |
| Allam, RM | 1 |
| do Amaral, LA | 1 |
| da Silva Fleming de Almeida, T | 1 |
| Oliveira de Souza, GH | 1 |
| Baranoski, A | 1 |
| Souza Maris, R | 1 |
| Bittencourt Junior, FF | 1 |
| Murino Rafacho, BP | 1 |
| Duenhas Monreal, AC | 1 |
| Leite Kassuya, CA | 1 |
| Milan Brochado Antoniolli-Silva, AC | 1 |
| Freitas Dos Santos, E | 1 |
| Oliveira, RJ | 3 |
| Yu, W | 1 |
| Liu, C | 4 |
| Li, X | 3 |
| Yang, F | 2 |
| Cheng, L | 2 |
| Song, Y | 2 |
| Limeiras, SM | 2 |
| Ogo, FM | 1 |
| Genez, LA | 1 |
| Carreira, CM | 1 |
| Oliveira, EJ | 1 |
| Pessatto, LR | 2 |
| Neves, SC | 1 |
| Pesarini, JR | 2 |
| Schweich, LC | 1 |
| Silva, RA | 1 |
| Cantero, WB | 2 |
| Antoniolli-Silva, AC | 2 |
| Oliveira, BC | 1 |
| Kassuya, CA | 1 |
| Monreal, AC | 1 |
| Antoniolli-Silva, R | 1 |
| Stefanello, ME | 1 |
| Potočnik, N | 1 |
| Perše, M | 2 |
| Cerar, A | 3 |
| Injac, R | 1 |
| Finderle, Ž | 1 |
| Thangaraj, K | 1 |
| Vaiyapuri, M | 1 |
| Abedi, J | 1 |
| Saatloo, MV | 1 |
| Nejati, V | 1 |
| Hobbenaghi, R | 1 |
| Tukmechi, A | 1 |
| Nami, Y | 1 |
| Khosroushahi, AY | 1 |
| Gungor, H | 1 |
| Ilhan, N | 1 |
| Eroksuz, H | 1 |
| Chen, C | 1 |
| Sharaf, LK | 1 |
| Sharma, M | 1 |
| Chandel, D | 1 |
| Shukla, G | 1 |
| Struchko, GY | 1 |
| Merkulova, LM | 1 |
| Moskvichev, EV | 1 |
| Kostrova, OY | 1 |
| Mikhailova, MN | 1 |
| Ito, Y | 2 |
| Kobuchi, S | 2 |
| Takesada, W | 1 |
| Takahashi, C | 1 |
| Vaish, V | 5 |
| Piplani, H | 2 |
| Rana, C | 2 |
| Vaiphei, K | 2 |
| Sanyal, SN | 6 |
| Sequetto, PL | 3 |
| Oliveira, TT | 3 |
| Soares, IA | 1 |
| Maldonado, IR | 2 |
| Mello, VJ | 3 |
| Pizziolo, VR | 2 |
| Almeida, MR | 2 |
| Yu, LN | 1 |
| Zhang, QL | 1 |
| Hua, X | 1 |
| Cui, YM | 1 |
| Zhang, NJ | 1 |
| Liao, WT | 1 |
| Ding, YQ | 1 |
| Chen, HM | 2 |
| Lin, YW | 2 |
| Wang, JL | 3 |
| Kong, X | 2 |
| Hong, J | 3 |
| Fang, JY | 3 |
| Augusto, LE | 1 |
| Silva, ME | 1 |
| Luo, F | 2 |
| Poulogiannis, G | 2 |
| Ye, H | 2 |
| Hamoudi, R | 2 |
| Dong, G | 2 |
| Zhang, W | 2 |
| Ibrahim, AE | 1 |
| Arends, MJ | 2 |
| Mohania, D | 1 |
| Kansal, VK | 1 |
| Kruzliak, P | 1 |
| Kumari, A | 1 |
| Cohen, C | 1 |
| Cardoso, JF | 1 |
| Garcia, SB | 1 |
| Vannucchi, H | 1 |
| Bielins'ka, IV | 1 |
| Lynchak, OV | 1 |
| Rybal'chenko, TV | 1 |
| Hurniak, OM | 1 |
| Liu, N | 1 |
| Sun, B | 1 |
| Wu, P | 1 |
| Wei, X | 1 |
| Liu, WX | 1 |
| Gu, SZ | 1 |
| Zhang, S | 1 |
| Ren, Y | 1 |
| Sang, LX | 1 |
| Dai, C | 1 |
| Li, Y | 2 |
| Xiao, D | 1 |
| Han, J | 1 |
| Yue, Z | 1 |
| Sun, Y | 1 |
| Fan, L | 1 |
| Zhang, F | 1 |
| Meng, J | 1 |
| Zhang, R | 1 |
| Wang, Z | 1 |
| Mei, Q | 1 |
| Wen, A | 1 |
| Jin, C | 1 |
| Zhu, J | 1 |
| Xia, T | 1 |
| Zhang, B | 1 |
| Fei, Y | 1 |
| Ma, B | 1 |
| Ye, J | 1 |
| Chen, W | 1 |
| Qi, G | 1 |
| Zeng, S | 1 |
| Takashima, T | 1 |
| Nozoe, K | 1 |
| Shobayashi, M | 1 |
| Kakugawa, K | 1 |
| Murakami, K | 1 |
| Jikihara, H | 1 |
| Zhou, L | 1 |
| Shimamoto, F | 1 |
| Vilela Gonçalves, R | 1 |
| Cupertino, MC | 1 |
| Santos, EC | 1 |
| Araújo, MR | 1 |
| Silva, E | 1 |
| Dong, Y | 1 |
| Wu, G | 1 |
| Chen, ZF | 1 |
| Ai, LY | 1 |
| Ren, LL | 1 |
| Yu, YN | 1 |
| Xu, J | 1 |
| Chen, HY | 1 |
| Yu, J | 1 |
| Li, M | 1 |
| Qin, WX | 1 |
| Ma, X | 1 |
| Shen, N | 2 |
| Chen, YX | 1 |
| Lenoir, M | 1 |
| Del Carmen, S | 1 |
| Cortes-Perez, NG | 1 |
| Lozano-Ojalvo, D | 1 |
| Muñoz-Provencio, D | 1 |
| Chain, F | 1 |
| Langella, P | 1 |
| de Moreno de LeBlanc, A | 2 |
| LeBlanc, JG | 1 |
| Bermúdez-Humarán, LG | 1 |
| Kilari, BP | 1 |
| Kotakadi, VS | 1 |
| Penchalaneni, J | 1 |
| Téllez-Bañuelos, MC | 1 |
| Haramati, J | 1 |
| Franco-Topete, K | 1 |
| Peregrina-Sandoval, J | 1 |
| Franco-Topete, R | 1 |
| Zaitseva, GP | 1 |
| Bordini, HP | 1 |
| Kremer, JL | 1 |
| Fagundes, TR | 1 |
| Melo, GP | 1 |
| Conchon-Costa, I | 1 |
| da Silva, SS | 1 |
| Cecchini, AL | 1 |
| Panis, C | 1 |
| Luiz, RC | 1 |
| Liu, S | 1 |
| Zhou, Y | 1 |
| Yao, Z | 1 |
| Zhang, D | 1 |
| Cao, S | 1 |
| Wei, Z | 1 |
| Tan, B | 1 |
| Lian, Z | 1 |
| Wang, S | 1 |
| Lee, SJ | 1 |
| Lim, KT | 1 |
| Zhang, YP | 1 |
| Lv, YM | 1 |
| Li, J | 1 |
| Han, YJ | 1 |
| Jin, Z | 1 |
| Li, CF | 1 |
| Qiu, Y | 1 |
| Cai, G | 1 |
| Su, M | 1 |
| Chen, T | 1 |
| Xu, Y | 1 |
| Ni, Y | 1 |
| Zhao, A | 1 |
| Cai, S | 1 |
| Xu, LX | 1 |
| Jia, W | 1 |
| Tanwar, L | 1 |
| Kaur, J | 1 |
| Silva, FG | 1 |
| Penido, LC | 1 |
| Valente, FX | 1 |
| Mendes, MC | 1 |
| Rosa, DD | 1 |
| Glória, MB | 1 |
| Peluzio, Mdo C | 1 |
| Nirmala, P | 2 |
| Ramanathan, M | 2 |
| Xiong, H | 1 |
| Wu, T | 1 |
| Zheng, WL | 1 |
| Zhang, SZ | 2 |
| Sun, JH | 1 |
| Yuan, H | 1 |
| Saini, MK | 1 |
| Kumar, RS | 1 |
| Kanmani, P | 1 |
| Yuvaraj, N | 1 |
| Paari, KA | 1 |
| Pattukumar, V | 1 |
| Thirunavukkarasu, C | 1 |
| Arul, V | 1 |
| de Paula Carli, A | 1 |
| de Abreu Vieira, PM | 1 |
| Silva, KT | 1 |
| de Sá Cota, RG | 1 |
| Carneiro, CM | 1 |
| Castro-Borges, W | 1 |
| de Andrade, MH | 1 |
| Ghadi, FE | 1 |
| Malhotra, A | 1 |
| Ghara, AR | 1 |
| Dhawan, DK | 1 |
| Okada, K | 1 |
| Imoto, K | 1 |
| Takada, K | 1 |
| Povey, AC | 1 |
| Badawi, AF | 1 |
| Cooper, DP | 1 |
| Hall, CN | 1 |
| Harrison, KL | 1 |
| Jackson, PE | 1 |
| Lees, NP | 1 |
| O'Connor, PJ | 1 |
| Margison, GP | 1 |
| Jia, X | 1 |
| Wang, W | 1 |
| Cui, W | 1 |
| Han, C | 1 |
| Sakai, H | 1 |
| Tsukamoto, T | 1 |
| Yamamoto, M | 1 |
| Shirai, N | 1 |
| Iidaka, T | 1 |
| Hirata, A | 1 |
| Yanai, T | 1 |
| Masegi, T | 1 |
| Donehower, LA | 1 |
| Tatematsu, M | 1 |
| Perdigón, G | 1 |
| Pickering, A | 1 |
| Chang, C | 1 |
| Vincent, JB | 1 |
| Femia, AP | 1 |
| Caderni, G | 1 |
| Vignali, F | 1 |
| Salvadori, M | 1 |
| Giannini, A | 1 |
| Biggeri, A | 1 |
| Gee, J | 1 |
| Przybylska, K | 1 |
| Cheynier, V | 1 |
| Dolara, P | 1 |
| Wang, JG | 1 |
| Wang, DF | 1 |
| Lv, BJ | 1 |
| Si, JM | 1 |
| Taxonera, C | 1 |
| Mendoza, JL | 1 |
| Onose, J | 1 |
| Imai, T | 3 |
| Hasumura, M | 3 |
| Cho, YM | 3 |
| Hirose, M | 3 |
| Liu, CX | 1 |
| Zhang, XW | 1 |
| Geng, XL | 1 |
| Li, TJ | 1 |
| Huang, LH | 1 |
| Wang, B | 1 |
| Coca, S | 1 |
| Enrech, S | 1 |
| Moreno García, V | 1 |
| Sáez, MA | 1 |
| Gutiérrez, C | 1 |
| Colmenarejo, A | 1 |
| Hernández, JM | 1 |
| Pérez Piqueras, J | 1 |
| Basterfield, L | 1 |
| Reul, JM | 1 |
| Mathers, JC | 1 |
| Shinozaki, M | 1 |
| Watanabe, T | 1 |
| Sato, H | 1 |
| Nagawa, H | 1 |
| Fukuta, K | 1 |
| Ota, Y | 2 |
| Takami, S | 2 |
| Nakagama, H | 1 |
| Pierre, F | 1 |
| Santarelli, R | 1 |
| Taché, S | 1 |
| Guéraud, F | 1 |
| Corpet, DE | 1 |
| Pérez Holanda, S | 1 |
| Patel, R | 1 |
| Ingle, A | 1 |
| Maru, GB | 1 |
| Nishikawa, A | 1 |
| Nobre-Leitão, C | 1 |
| Chaves, P | 1 |
| Fidalgo, P | 1 |
| Cravo, M | 1 |
| Gouveia-Oliveira, A | 1 |
| Ferra, MA | 1 |
| Mira, FC | 1 |
| Shetye, J | 1 |
| Mathiesen, T | 1 |
| Fagerberg, J | 1 |
| Rubio, C | 1 |
| Siegers, CP | 1 |
| Siemers, J | 1 |
| Baretton, G | 1 |
| Ma, Q | 2 |
| Hoper, M | 1 |
| Anderson, N | 1 |
| Rowlands, BJ | 2 |
| Kan, H | 1 |
| Onda, M | 1 |
| Tanaka, N | 1 |
| Furukawa, K | 1 |
| Rijnkels, JM | 2 |
| Hollanders, VM | 3 |
| Woutersen, RA | 3 |
| Koeman, JH | 2 |
| Alink, GM | 2 |
| Sakamoto, S | 2 |
| Kawachi, Y | 1 |
| Iwama, T | 1 |
| Tsukada, K | 1 |
| Sagara, T | 1 |
| Murakami, S | 1 |
| Kudo, H | 2 |
| Okayasu, I | 1 |
| Iida, K | 1 |
| Fujita, K | 1 |
| Hirai, H | 1 |
| Goto, H | 1 |
| Miyazaki, S | 1 |
| Arai, Y | 1 |
| Iwaki, H | 1 |
| Otake, M | 1 |
| Sassa, S | 1 |
| Maemura, M | 1 |
| Nakayama, T | 1 |
| Anisimov, VN | 2 |
| Zabezhinskiĭ, MA | 2 |
| Popovich, IG | 2 |
| Liberman, AI | 1 |
| Shmidt, JL | 1 |
| Jasani, B | 1 |
| Campbell, F | 1 |
| Navabi, H | 1 |
| Schmid, KW | 1 |
| Williams, GT | 1 |
| Narushima, S | 2 |
| Itoh, K | 2 |
| Mitsuoka, T | 2 |
| Nakayama, H | 2 |
| Itoh, T | 2 |
| Hioki, K | 2 |
| Nomura, T | 2 |
| Williamson, KE | 1 |
| O'rourke, D | 1 |
| Wijnands, MV | 1 |
| Appel, MJ | 1 |
| Fontana, MG | 1 |
| Donato, F | 1 |
| Villanacci, V | 1 |
| Ghirardi, M | 1 |
| Moneghini, D | 1 |
| Di Betta, E | 1 |
| Salerni, B | 1 |
| Evans, SR | 1 |
| Shchepotin, EI | 1 |
| Young, H | 1 |
| Rochon, J | 1 |
| Uskokovic, M | 1 |
| Shchepotin, IB | 1 |
| Ravnik-Glavac, M | 1 |
| Glavac, D | 1 |
| Ohno, K | 1 |
| Takeuchi, S | 1 |
| Furihata, T | 1 |
| Kawamata, H | 1 |
| Ohsugi, R | 1 |
| Sato, S | 1 |
| Kubota, K | 1 |
| Fujimori, T | 1 |
| Yoo, BH | 1 |
| Lee, BH | 1 |
| Kim, JS | 1 |
| Kim, NJ | 1 |
| Kim, SH | 1 |
| Ryu, KW | 1 |
| Hagiwara, A | 2 |
| Miyashita, K | 1 |
| Nakanishi, T | 1 |
| Sano, M | 1 |
| Tamano, S | 2 |
| Kadota, T | 1 |
| Koda, T | 2 |
| Nakamura, M | 2 |
| Imaida, K | 2 |
| Ito, N | 2 |
| Shirai, T | 2 |
| Brown, WA | 1 |
| Skinner, SA | 1 |
| Vogiagis, D | 1 |
| O'Brien, PE | 1 |
| Yoshino, H | 1 |
| Ichihara, T | 1 |
| Kawabe, M | 1 |
| Aoki, H | 1 |
| Philipp-Staheli, J | 1 |
| Kim, KH | 1 |
| Payne, SR | 1 |
| Gurley, KE | 1 |
| Liggitt, D | 1 |
| Longton, G | 1 |
| Kemp, CJ | 1 |
| Nelson, RL | 3 |
| Briley, S | 1 |
| Vaz, OP | 1 |
| Abcarian, H | 1 |
| Barsoum, GH | 1 |
| Thompson, H | 1 |
| Neoptolemos, JP | 1 |
| Keighley, MR | 1 |
| Nakagawa, Y | 1 |
| Watanabe, H | 1 |
| Takahashi, T | 1 |
| Ito, A | 1 |
| Dohi, K | 1 |
| Brodin, NT | 1 |
| Jansson, B | 1 |
| Sjögren, HO | 1 |
| Lam, LK | 1 |
| Zhang, J | 1 |
| Andrianopoulos, GD | 1 |
| Barch, DH | 1 |
| Bombeck, CT | 1 |
| Nyhus, LM | 1 |
| Nutter, RL | 1 |
| Kettering, JD | 1 |
| Aprecio, RM | 1 |
| Weeks, DA | 1 |
| Gridley, DS | 1 |
| Colacchio, TA | 1 |
| Memoli, VA | 1 |
| Hildebrandt, L | 1 |
| Tanure, JC | 1 |
| Andrianopoulos, G | 1 |
| Souza, G | 1 |
| Lands, WE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Plasma and Urine Metabolomics for Biomarker Discovery in Children With Eosinophilic Esophagitis[NCT03107819] | 24 participants (Actual) | Observational | 2017-03-29 | Completed | |||
| Natural Compounds to Reduce Nitrite in Meat Products: PHYTOME[NCT04138654] | Phase 1 | 78 participants (Actual) | Interventional | 2014-04-17 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for 1,2-dimethylhydrazine and Colorectal Neoplasms
| Article | Year |
|---|---|
DNA alkylation and repair in the large bowel: animal and human studies.
Topics: 1,2-Dimethylhydrazine; Alkylation; Animals; Carcinogens; Colon; Colonic Neoplasms; Colorectal Neopla | 2002 |
Impact of physical activity on intestinal cancer development in mice.
Topics: 1,2-Dimethylhydrazine; Animals; Azoxymethane; Body Mass Index; Body Weight; Carcinogens; Colorectal | 2005 |
Dimethylhydrazine model is not appropriate for evaluating effect of ethanol on colorectal cancer.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Colorectal Neoplasms; Disease Models, Animal; Ethanol; | 2007 |
[Melatonin inhibits large bowel carcinogenesis induced by 1,2-dimethylhydrazine in rats: effects and possible mechanisms].
Topics: 1,2-Dimethylhydrazine; Animals; Apoptosis; Carcinogens; Colorectal Neoplasms; DNA Repair; Free Radic | 2000 |
121 other studies available for 1,2-dimethylhydrazine and Colorectal Neoplasms
| Article | Year |
|---|---|
The Antitumor Activity of Ginger against Colorectal Cancer Induced by Dimethylhydrazine in Rats.
Topics: 1,2-Dimethylhydrazine; Animals; Chemical and Drug Induced Liver Injury; Cisplatin; Colonic Neoplasms | 2022 |
Protective effect of methanol extract of latex of Calotropis procera in an experimental model of colorectal cancer.
Topics: 1,2-Dimethylhydrazine; Animals; Biomarkers, Tumor; Calotropis; Colorectal Neoplasms; DNA Fragmentati | 2022 |
Parasympathetic, but not sympathetic denervation, suppressed colorectal cancer progression.
Topics: 1,2-Dimethylhydrazine; Animals; Atropine; Carcinogenesis; Carcinogens; Colon; Colorectal Neoplasms; | 2021 |
Chemoprotective effect of theanine in 1,2-dimethylhydrazine-induced colorectal cancer in rats via suppression of inflammatory parameters.
Topics: 1,2-Dimethylhydrazine; Animals; Anti-Inflammatory Agents; Antioxidants; Colorectal Neoplasms; Dose-R | 2022 |
Anti-inflammatory and Antioxidant Effect of Lycoperoside H against the 1,2-Dimethyl Hydrazine (DMH) Induced Colorectal Cancer in Rats.
Topics: 1,2-Dimethylhydrazine; Animals; Anti-Inflammatory Agents; Antioxidants; Body Weight; Colorectal Neop | 2022 |
Synbiotic modulates intestinal microbiota metabolic pathways and inhibits DMH-induced colon tumorigenesis through c-myc and PCNA suppression.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogenesis; Colorectal Neoplasms; Gastrointestinal Microbiome; M | 2022 |
Antioxidant and Anticancer Potentials of the Olive and Sesame Mixture against Dimethylhydrazine-Induced Colorectal Cancer in Wistar Rats.
Topics: 1,2-Dimethylhydrazine; Animals; Antioxidants; C-Reactive Protein; Carcinoembryonic Antigen; Colorect | 2022 |
Jaboticaba (Myrciaria cauliflora) Fruit Extract Suppressed Aberrant Crypt Formation in 1,2-Dimetylhydrazine-Induced Rats.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Butyrates; Colonic Neoplasms; Colorectal Neopla | 2023 |
Combination of vitamin D and probiotics inhibits chemically induced colorectal carcinogenesis in Wistar rats.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogenesis; Colonic Neoplasms; Colorectal Neoplasms; Probiotics; | 2023 |
2,4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone from Cleistocalyx nervosum var. paniala seeds attenuated the early stage of diethylnitrosamine and 1,2-dimethylhydrazine-induced colorectal carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogenesis; Colorectal Neoplasms; Diethylnitrosamine; Humans; Ra | 2023 |
NANOPARTICLES AND COLORECTAL CANCER: CAN THE USE OF METAL NANOPARTICLE COMPOSITIONS AFFECT OXIDATIVE STRESS MARKERS AND COLON HISTOLOGICAL CHANGES UNDER DMH-INDUCED CARCINOGENESIS.
Topics: 1,2-Dimethylhydrazine; Carcinogenesis; Colon; Colonic Neoplasms; Colorectal Neoplasms; Humans; Metal | 2023 |
Juçara (
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Carcinogenesis; Colorectal Neoplasms; Dietary S | 2020 |
Artesunate suppresses inflammation and oxidative stress in a rat model of colorectal cancer.
Topics: 1,2-Dimethylhydrazine; Administration, Oral; Animals; Anti-Inflammatory Agents; Antineoplastic Agent | 2019 |
The modulatory effects of exercise on the inflammatory and apoptotic markers in rats with 1,2-dimethylhydrazine-induced colorectal cancer.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Apoptosis; Apoptosis Regulatory Proteins; Carci | 2020 |
Protective effect of Matricaria chamomilla extract against 1,2-dimethylhydrazine-induced colorectal cancer in mice.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogenesis; Chamomile; Colon; Colonic Polyps; Colorectal Neoplas | 2020 |
Effects of fucoidan on gut flora and tumor prevention in 1,2-dimethylhydrazine-induced colorectal carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Antineoplastic Agents; Apoptosis; Bacteroidetes; Carcinogenesis; Col | 2020 |
Combination of quercetin and exercise training attenuates depression in rats with 1,2-dimethylhydrazine-induced colorectal cancer: Possible involvement of inflammation and BDNF signalling.
Topics: 1,2-Dimethylhydrazine; Animals; beta Catenin; Brain-Derived Neurotrophic Factor; Colorectal Neoplasm | 2020 |
Evaluation of Antineoplasic Activity of Zingiber Officinale Essential Oil in the Colorectal Region of Wistar Rats.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Antineoplastic Agents; Colorectal Neoplasms; Ma | 2020 |
Promising targets of chrysin and daidzein in colorectal cancer: Amphiregulin, CXCL1, and MMP-9.
Topics: 1,2-Dimethylhydrazine; Amphiregulin; Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; C | 2021 |
The Use of Natural Fiber-Rich Food Product Is Safe and Reduces Aberrant Crypt Foci in a Pre-Clinical Model.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animal Feed; Animals; Colon; Colorectal Neoplasms; Cytok | 2021 |
Inositol hexaphosphate suppresses colorectal cancer cell proliferation via the Akt/GSK-3β/β-catenin signaling cascade in a 1,2-dimethylhydrazine-induced rat model.
Topics: 1,2-Dimethylhydrazine; Animals; Apoptosis; beta Catenin; Cell Proliferation; Colorectal Neoplasms; D | 2017 |
Prevention of DNA damage and anticarcinogenic activity of Activia
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Anticarcinogenic Agents; Colorectal Neoplasms; | 2017 |
Effects of Moquiniastrum polymorphum ssp floccosum ethnolic extract on colorectal carcinogenesis induced by 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Antineoplastic Agents, Phytogenic; Asteraceae; | 2017 |
Cardiac autonomic modulation induced by doxorubicin in a rodent model of colorectal cancer and the influence of fullerenol pretreatment.
Topics: 1,2-Dimethylhydrazine; Animals; Antibiotics, Antineoplastic; Cardiotonic Agents; Cardiotoxicity; Col | 2017 |
Chemoprevention by artesunate in a preclinical model of colorectal cancer involves down regulation of β-catenin, suppression of angiogenesis, cellular proliferation and induction of apoptosis.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Apoptosis; Artemisinins; Artesunate; Aspirin; b | 2017 |
Orientin, a C-glycosyl dietary flavone, suppresses colonic cell proliferation and mitigates NF-κB mediated inflammatory response in 1,2-dimethylhydrazine induced colorectal carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Biomarkers, Tumor; | 2017 |
Selenium-Enriched Saccharomyces cerevisiae Reduces the Progression of Colorectal Cancer.
Topics: 1,2-Dimethylhydrazine; Animals; Biological Therapy; Colorectal Neoplasms; Male; Microbial Sensitivit | 2018 |
The effectiveness of cyclooxygenase-2 inhibitors and evaluation of angiogenesis in the model of experimental colorectal cancer.
Topics: 1,2-Dimethylhydrazine; Animals; Apoptosis; Celecoxib; Colorectal Neoplasms; Cyclooxygenase 2 Inhibit | 2018 |
Phytic acid improves intestinal mucosal barrier damage and reduces serum levels of proinflammatory cytokines in a 1,2-dimethylhydrazine-induced rat colorectal cancer model.
Topics: 1,2-Dimethylhydrazine; Animals; Body Weight; Cadherins; Claudin-1; Colon; Colorectal Neoplasms; Cyto | 2018 |
Prophylactic intervention of probiotics (L.acidophilus, L.rhamnosus GG) and celecoxib modulate Bax-mediated apoptosis in 1,2-dimethylhydrazine-induced experimental colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Apoptosis; bcl-2-Associated X Protein; Carcinogenesis; Carcinogens; | 2018 |
New Experimental Facts on the Influence of Secondary Immunodeficiency on the Morphology and Biological Activity of Colorectal Tumor.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Antibodies; Biomarkers, Tumor; Cell Differentiation; | 2018 |
Assessment of Oxaliplatin-induced Chronic Neuropathy and Anticancer Efficacy Through Pharmacokinetic and Toxicodynamic Evaluation of a Rat Model of Colorectal Cancer.
Topics: 1,2-Dimethylhydrazine; Animals; Colorectal Neoplasms; Dextran Sulfate; Female; Humans; Male; Oxalipl | 2019 |
NSAIDs may regulate EGR-1-mediated induction of reactive oxygen species and non-steroidal anti-inflammatory drug-induced gene (NAG)-1 to initiate intrinsic pathway of apoptosis for the chemoprevention of colorectal cancer.
Topics: 1,2-Dimethylhydrazine; Animals; Apoptosis; bcl-X Protein; Celecoxib; Colon; Colorectal Neoplasms; Cy | 2013 |
The flavonoid chrysin attenuates colorectal pathological remodeling reducing the number and severity of pre-neoplastic lesions in rats exposed to the carcinogen 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Colon; Colorectal Neoplasms; Female; Flavonoids; Precan | 2013 |
Tiam1 transgenic mice display increased tumor invasive and metastatic potential of colorectal cancer after 1,2-dimethylhydrazine treatment.
Topics: 1,2-Dimethylhydrazine; Animals; Colorectal Neoplasms; Guanine Nucleotide Exchange Factors; Mice; Mic | 2013 |
Identification of potential target genes of butyrate in dimethylhydrazine-induced colorectal cancer in mice.
Topics: 1,2-Dimethylhydrazine; Animals; Butyrates; Cell Adhesion; Cell Differentiation; Cell Movement; Cell | 2013 |
Naringin accelerates the regression of pre-neoplastic lesions and the colorectal structural reorganization in a murine model of chemical carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Colorectal Neoplasms; Female; Flavanones; Mice; Microsc | 2014 |
Wild-type K-ras has a tumour suppressor effect on carcinogen-induced murine colorectal adenoma formation.
Topics: 1,2-Dimethylhydrazine; Adenoma; Alleles; Animals; Apoptosis; Cell Proliferation; Colorectal Neoplasm | 2014 |
Probiotic Dahi containing Lactobacillus acidophilus and Bifidobacterium bifidum modulates the formation of aberrant crypt foci, mucin-depleted foci, and cell proliferation on 1,2-dimethylhydrazine-induced colorectal carcinogenesis in Wistar rats.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Bifidobacterium; Body Weight; Buffaloes; Carcin | 2014 |
Vitamin E supplementation in chemical colorectal carcinogenesis: a two-edged knife.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Biomarkers; Carcinogenesis; Carcinogens; Cell P | 2014 |
[Hematological effects of the protein kinase inhibitor maleimide derivative in dimethylhydrazin E-induced colorectal carcinogenesis of rats].
Topics: 1,2-Dimethylhydrazine; Anemia; Animals; Blood Cell Count; Colorectal Neoplasms; Hemoglobins; Male; M | 2014 |
Chemopreventive Effects of Azadirachta indica on Cancer Marker Indices and Ultrastructural Changes During 1,2-Dimethylhydrazine-Induced Colon Carcinogenesis in Rats.
Topics: 1,2-Dimethylhydrazine; Alkaline Phosphatase; Animals; Antineoplastic Agents; Azadirachta; Biomarkers | 2015 |
Angiopoietin and vascular endothelial growth factor expression in colorectal disease models.
Topics: 1,2-Dimethylhydrazine; Angiopoietin-1; Angiopoietin-2; Animals; Colitis, Ulcerative; Colon; Colorect | 2015 |
Trillium tschonoskii steroidal saponins suppress the growth of colorectal Cancer cells in vitro and in vivo.
Topics: 1,2-Dimethylhydrazine; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Caspase 3; Cell Prolif | 2015 |
Recombinant Salmonella-based CEACAM6 and 4-1BBL vaccine enhances T-cell immunity and inhibits the development of colorectal cancer in rats: In vivo effects of vaccine containing 4-1BBL and CEACAM6.
Topics: 1,2-Dimethylhydrazine; 4-1BB Ligand; Animals; Antigens, CD; Cancer Vaccines; Cell Adhesion Molecules | 2015 |
Inhibitory effect of various breads on DMH-induced aberrant crypt foci and colorectal tumours in rats.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Antioxidants; Bread; Colorectal Neoplasms; Male | 2015 |
Depletion of enteroendocrine and mucus-secreting cells is associated with colorectal carcinogenesis severity and impaired intestinal motility in rats.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Colorectal Neoplasms; Disease Models, Animal; E | 2016 |
Azadircta indica as a modulator of membrane stability parameters and surface changes during 1,2 dimethylhydrazine-induced colorectal carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Administration, Oral; Animals; Anticarcinogenic Agents; Azadi | 2015 |
Probiotics Clostridium butyricum and Bacillus subtilis ameliorate intestinal tumorigenesis.
Topics: 1,2-Dimethylhydrazine; Administration, Oral; Animals; Apoptosis; Bacillus subtilis; Carcinogenesis; | 2015 |
Lactobacillus casei BL23 regulates Treg and Th17 T-cell populations and reduces DMH-associated colorectal cancer.
Topics: 1,2-Dimethylhydrazine; Animals; Biomarkers; Colorectal Neoplasms; Cytokines; Female; Lacticaseibacil | 2016 |
Anti-proliferative and Apoptotic Effects of Basella rubra (L.) Against 1, 2-Dimethyl Hydrazine-induced Colon Carcinogenesis in Rats.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Antigens, Nuclear; Apoptosis; Biomarkers, Tumor | 2016 |
Chronic exposure to endosulfan induces inflammation in murine colon via β-catenin expression and IL-6 production.
Topics: 1,2-Dimethylhydrazine; Administration, Oral; Animals; beta Catenin; Colitis; Colon; Colorectal Neopl | 2016 |
Protective effect of metformin in an aberrant crypt foci model induced by 1,2-dimethylhydrazine: Modulation of oxidative stress and inflammatory process.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; AMP-Activated Protein Kinases; Animals; Cell Proliferati | 2017 |
Evolutionary biologic changes of gut microbiota in an 'adenoma-carcinoma sequence' mouse colorectal cancer model induced by 1, 2-Dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Adenomatous Polyposis Coli Protein; Animals; Bacteri | 2017 |
A 116-kDa phytoglycoprotein inhibits aberrant crypt foci formation through modulation of manganese superoxide dismutase, inducible nitric oxide synthase, cyclooxygenase-2, nuclear factor-kappa B, activator protein-1, and proliferating cell nuclear antigen
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Colorectal Neoplasms; Cyclooxygenase 2; Cytoprotection; | 2008 |
[Role of peroxisome proliferators-activated receptor-gamma in the chemical prevention therapy of sulindac for precancerous lesions of rats].
Topics: 1,2-Dimethylhydrazine; Anilides; Animals; Colorectal Neoplasms; Male; Pioglitazone; PPAR gamma; Prec | 2009 |
Urinary metabonomic study on colorectal cancer.
Topics: 1,2-Dimethylhydrazine; Adult; Aged; Animals; Case-Control Studies; Colorectal Neoplasms; Discriminan | 2010 |
Chemopreventive effects of non-steroidal anti-inflammatory drugs in early neoplasm of experimental colorectal cancer: an apoptosome study.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apopto | 2011 |
Sodium butyrate does not decrease the evolution of precancerous lesions in rats.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Butyrates; Carcinogens; Colorectal Neoplasms; D | 2010 |
Mutant K-ras promotes carcinogen-induced murine colorectal tumourigenesis, but does not alter tumour chromosome stability.
Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Apoptosis; beta Catenin; Carcinogens; Cell Proliferation; C | 2011 |
Effect of kaempferol on lipid peroxidation and antioxidant status in 1,2-dimethyl hydrazine induced colorectal carcinoma in rats.
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Antineoplastic Agents, Phytogenic; Antioxid | 2011 |
Effect of myricetin on 1,2 dimethylhydrazine induced rat colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Antioxidants; Catalase; Colon; Colorectal N | 2011 |
Non steroidal anti-inflammatory drugs modulate the physicochemical properties of plasma membrane in experimental colorectal cancer: a fluorescence spectroscopic study.
Topics: 1,2-Dimethylhydrazine; 2-Naphthylamine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blotting, | 2011 |
Calcium prevents tumorigenesis in a mouse model of colorectal cancer.
Topics: 1,2-Dimethylhydrazine; Animals; Basic-Leucine Zipper Transcription Factors; Calcium; Calgranulin B; | 2011 |
Bimodal visualization of colorectal uptake of nanoparticles in dimethylhydrazine-treated mice.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Colon; Colorectal Neoplasms; Enema; Flu | 2011 |
Chemoprevention of DMH-induced rat colon carcinoma initiation by combination administration of piroxicam and C-phycocyanin.
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Apoptosis; Carcinoma; Carrageenan; Colon; C | 2012 |
Lactobacillus plantarum AS1 isolated from south Indian fermented food Kallappam suppress 1,2-dimethyl hydrazine (DMH)-induced colorectal cancer in male Wistar rats.
Topics: 1,2-Dimethylhydrazine; Animals; Antioxidants; Carcinogens; Catalase; Colon; Colorectal Neoplasms; Fe | 2012 |
Bowman-Birk inhibitors, proteasome peptidase activities and colorectal pre neoplasias induced by 1,2-dimethylhydrazine in Swiss mice.
Topics: 1,2-Dimethylhydrazine; Animals; Blotting, Western; Carcinogens; Chromatography, Gel; Colorectal Neop | 2012 |
Role of Sulindac and Celecoxib in chemoprevention of colorectal cancer via intrinsic pathway of apoptosis: exploring NHE-1, intracellular calcium homeostasis and Calpain 9.
Topics: 1,2-Dimethylhydrazine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Calcium; Calpain | 2012 |
Selenium as a modulator of membrane stability parameters and surface changes during the initiation phase of 1,2-dimethylhydrazine induced colorectal carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Antioxidants; Carcinogens; Catalase; Cell M | 2012 |
Angiostatic properties of sulindac and celecoxib in the experimentally induced inflammatory colorectal cancer.
Topics: 1,2-Dimethylhydrazine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Cele | 2013 |
Pharmacokinetics of 5-fluorouracil and increased hepatic dihydropyrimidine dehydrogenase activity levels in 1,2-dimethylhydrazine-induced colorectal cancer model rats.
Topics: 1,2-Dimethylhydrazine; Animals; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Dihydrouracil | 2013 |
[Effects of tea on aberrant crypt foci and colorectal tumors in rats].
Topics: 1,2-Dimethylhydrazine; Animals; Antineoplastic Agents, Phytogenic; Colon; Colorectal Neoplasms; Pigm | 2000 |
High susceptibility of nullizygous p53 knockout mice to colorectal tumor induction by 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Carcinoma; Cell Transformation, Neoplastic; Colorectal | 2003 |
Yogurt feeding inhibits promotion and progression of experimental colorectal cancer.
Topics: 1,2-Dimethylhydrazine; Animals; Apoptosis; Carcinogens; CD4 Antigens; Colorectal Neoplasms; Cytokine | 2004 |
Chromium-containing biomimetic cation triaqua-mu3-oxo-mu-hexapropionatotrichromium(III) inhibits colorectal tumor formation in rats.
Topics: 1,2-Dimethylhydrazine; Animals; Biomimetics; Body Weight; Carcinogens; Cations; Cell Line, Tumor; Ch | 2004 |
Effect of polyphenolic extracts from red wine and 4-OH-coumaric acid on 1,2-dimethylhydrazine-induced colon carcinogenesis in rats.
Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Antioxidants; Carcinogens; Colonic Neoplasms; Colorectal Ne | 2005 |
A novel mouse model for colitis-associated colon carcinogenesis induced by 1,2-dimethylhydrazine and dextran sulfate sodium.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; beta Catenin; Carcinogens; Colitis, Ulcerative; Colo | 2004 |
Colorectal cancer and Coxibs.
Topics: 1,2-Dimethylhydrazine; Animals; Aspirin; Carcinogens; Colorectal Neoplasms; Cyclooxygenase Inhibitor | 2004 |
A new medium-term rat colon bioassay applying neoplastic lesions as endpoints for detection of carcinogenesis modifiers-validation with known modifiers.
Topics: 1,2-Dimethylhydrazine; Animals; Anthraquinones; Carcinogenicity Tests; Colorectal Neoplasms; Deoxych | 2006 |
[Inhibitory effect of sodium butyrate on 1,2-dimethylhydrazine-induced tumorigenesis of colorectal cancer in mice].
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Animals; Butyrates; Colorectal Neoplasms; Dose-Respo | 2005 |
Evaluation of the antitumor activity of interleukin-12 in an experimental murine model of colorectal cancer induced by 1,2 dimethyl-hydrazine (DMH).
Topics: 1,2-Dimethylhydrazine; Adjuvants, Immunologic; Animals; Colorectal Neoplasms; Disease Models, Animal | 2005 |
Chronic colitis promotes tumor development.
Topics: 1,2-Dimethylhydrazine; Acetic Acid; Animals; Carcinogens; Cell Growth Processes; Cocarcinogenesis; C | 2006 |
Significance of inflammation-associated regenerative mucosa characterized by Paneth cell metaplasia and beta-catenin accumulation for the onset of colorectal carcinogenesis in rats initiated with 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Animals; beta Catenin; Carcinogens; Colorectal Neoplasms; Inflammation; Injec | 2007 |
Beef meat promotion of dimethylhydrazine-induced colorectal carcinogenesis biomarkers is suppressed by dietary calcium.
Topics: 1,2-Dimethylhydrazine; Acetylcysteine; Animals; Antioxidants; Body Weight; Calcium, Dietary; Cattle; | 2008 |
Evidence-based review versus points of view.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Colorectal Neoplasms; Disease Models, Animal; Ethanol; | 2007 |
Polymeric black tea polyphenols inhibit 1,2-dimethylhydrazine induced colorectal carcinogenesis by inhibiting cell proliferation via Wnt/beta-catenin pathway.
Topics: 1,2-Dimethylhydrazine; Animals; beta Catenin; Carcinogens; Cell Proliferation; Colon; Colorectal Neo | 2008 |
A new medium-term rat colorectal bioassay applying neoplastic lesions as end points for detection of carcinogenesis modifiers effects with weak or controversial modifiers.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Body Weight; Carcinogenicity Tests; Carcinogens; Col | 2008 |
Calcium regulation of colonic crypt cell kinetics: evidence for a direct effect in mice.
Topics: 1,2-Dimethylhydrazine; Animals; Calcium; Carcinogens; Cell Division; Cell Transformation, Neoplastic | 1995 |
Ear tumours induced by experimental carcinogenesis in the rat: excision prevents early death.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogenicity Tests; Carcinogens; Carcinoma, Squamous Cell; Colore | 1994 |
Sennosides and aloin do not promote dimethylhydrazine-induced colorectal tumors in mice.
Topics: 1,2-Dimethylhydrazine; Adenoma; Aloe; Animals; Anthraquinones; Carcinogens; Carcinoma; Cathartics; C | 1993 |
Effect of supplemental L-arginine in a chemical-induced model of colorectal cancer.
Topics: 1,2-Dimethylhydrazine; Administration, Oral; Animals; Arginine; Carcinogens; Cell Division; Colorect | 1996 |
[Effect of green tea polyphenol fraction on 1,2-dimethylhydrazine (DMH)-induced colorectal carcinogenesis in the rat].
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Carcinogens; Colorectal Neoplasms; Dimethyl | 1996 |
Interaction of dietary fat with a vegetables-fruit mixture on 1,2-dimethylhydrazine-induced colorectal cancer in rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Animals; Body Weight; Carcinogens; Colorectal Neopla | 1997 |
Interaction of dietary fat and of a vegetables/fruit mixture on 1,2-dimethylhydrazine- or N-methyl-N'-nitro-N-nitrosoguanidine-induced colorectal cancer in rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Animals; Carcinogens; Colorectal Neoplasms; Dietary | 1997 |
Preventive effect of 1-(2-tetrahydrofuryl)-5-fluorouracil in combination with uracil on colonic carcinogenesis induced by 1,2-dimethylhydrazine in rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Cell Differentiatio | 1997 |
Preventive effects of polysaccharides extracted from human tubercle bacilli (specific substance of Maruyama) on colonic carcinogenesis in rats.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Colorectal Neoplasms; Humans; Male; Neoplasm Proteins; | 1997 |
[Effect of the enterosorbent Aqualen on intestinal carcinogenesis induced by 1,2-dimethylhydrazine in rats].
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Colorectal Neoplasms; Enterosorption; Femal | 1998 |
Clonal overexpression of metallothionein is induced by somatic mutation in morphologically normal colonic mucosa.
Topics: 1,2-Dimethylhydrazine; Animals; Clone Cells; Colon; Colorectal Neoplasms; Female; Gene Expression; I | 1998 |
Effect of mouse intestinal bacteria on incidence of colorectal tumors induced by 1,2-dimethylhydrazine injection in gnotobiotic transgenic mice harboring human prototype c-Ha-ras genes.
Topics: 1,2-Dimethylhydrazine; Animals; Colorectal Neoplasms; Female; Genes, ras; Germ-Free Life; Humans; In | 1998 |
The effects of l-arginine on crypt cell hyperproliferation in colorectal cancer.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Animals; Arginine; Carcinogens; Cell Division; Colon | 1999 |
A comparison of the effects of dietary cellulose and fermentable galacto-oligosaccharide, in a rat model of colorectal carcinogenesis: fermentable fibre confers greater protection than non-fermentable fibre in both high and low fat backgrounds.
Topics: 1,2-Dimethylhydrazine; Animals; Bile Acids and Salts; Carcinogens; Cecum; Cellulose; Cocarcinogenesi | 1999 |
Inhibitory effect of a gastrin receptor antagonist, CR2945, on 1, 2-dimethylhydrazine-induced colorectal cancer in mice.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Animals; Benzodiazepines; Carcinogens; Colorectal Ne | 1999 |
1,25-dihydroxyvitamin D3 synthetic analogs inhibit spontaneous metastases in a 1,2-dimethylhydrazine-induced colon carcinogenesis model.
Topics: 1,2-Dimethylhydrazine; Animals; Calcitriol; Calcium; Calcium Channel Agonists; Carcinogens; Colorect | 2000 |
Animal model in the study of colorectal carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Animals; Carcinogens; Carcinoma; Colorectal Neoplasm | 2000 |
Inhibitory effect of apple pectin and culture condensate of Bifidobacterium longum on colorectal tumors induced by 1,2-dimethylhydrazine in transgenic mice harboring human prototype c-Ha-ras genes.
Topics: 1,2-Dimethylhydrazine; Administration, Oral; Animals; Bifidobacterium; Colorectal Neoplasms; Culture | 2000 |
[Colitis enhances the colorectal carcinogenesis in rats: correlation between the incidence of aberrant crypt foci and the incidence of tumors].
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Colitis; Colorectal Neoplasms; Precancerous Conditions; | 2001 |
Effects of Shikunshito-Kamiho on fecal enzymes and formation of aberrant crypt foci induced by 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Carcinogens; Colorectal Neoplasms; Drugs, C | 2001 |
Pronounced inhibition by a natural anthocyanin, purple corn color, of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-associated colorectal carcinogenesis in male F344 rats pretreated with 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenocarcinoma, Mucinous; Adenoma; Administration, Oral; Anim | 2001 |
Inhibition of beta-catenin translocation in rodent colorectal tumors: a novel explanation for the protective effect of nonsteroidal antiinflammatory drugs in colorectal cancer.
Topics: 1,2-Dimethylhydrazine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; beta Catenin; Ca | 2001 |
Prevention by natural food anthocyanins, purple sweet potato color and red cabbage color, of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-associated colorectal carcinogenesis in rats initiated with 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Adenoma; Administration, Oral; Animals; Anthocyanins; Anticarcinogenic Agents | 2002 |
Pathway-specific tumor suppression. Reduction of p27 accelerates gastrointestinal tumorigenesis in Apc mutant mice, but not in Smad3 mutant mice.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Adenomatous Polyposis Coli Protein; Animals; beta Ca | 2002 |
The effect of vagotomy and pyloroplasty on colorectal tumor induction in the rat.
Topics: 1,2-Dimethylhydrazine; Analysis of Variance; Animals; Body Weight; Carcinogens; Colorectal Neoplasms | 1992 |
Dietary calcium does not reduce experimental colorectal carcinogenesis after small bowel resection despite reducing cellular proliferation.
Topics: 1,2-Dimethylhydrazine; Animals; Calcium, Dietary; Carcinogens; Cell Division; Colorectal Neoplasms; | 1992 |
Carcinogenicity of 1,2-dimethylhydrazine in colorectal tissue heterotopically transplanted into the glandular stomach of rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Colon; Colorectal Neoplasms; Dimethylhydrazines; Inj | 1992 |
Rat monoclonal antibodies produced against rat colorectal adenocarcinomas define tumor- and colon-associated, auto-immunogenic antigens.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Antibodies, Monoclonal; Antigens, Neoplasm; Antigens | 1990 |
Reduction of aberrant crypt formation in the colon of CF1 mice by potential chemopreventive agents.
Topics: 1,2-Dimethylhydrazine; Animals; Butylated Hydroxyanisole; Cecum; Colonic Neoplasms; Colorectal Neopl | 1991 |
The effect of mild stress on DMH-induced colorectal cancer.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Colorectal Neoplasms; Corticosterone; Dimethylhydrazine | 1990 |
Effects of dietary fat and protein on DMH-induced tumor development and immune responses.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Colorectal Neoplasms; Dietary Fats; Dietary Proteins; D | 1990 |
Antioxidants vs carotenoids. Inhibitors or promoters of experimental colorectal cancers.
Topics: 1,2-Dimethylhydrazine; Animals; Antioxidants; Ascorbic Acid; beta Carotene; Canthaxanthin; Carotenoi | 1989 |
A comparison of dietary fish oil and corn oil in experimental colorectal carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Colorectal Neoplasms; Corn Oil; Dimethylhydrazines; Fish Oils; Male; | 1988 |