1,2-dimethylhydrazine has been researched along with Colitis in 16 studies
1,2-Dimethylhydrazine: A DNA alkylating agent that has been shown to be a potent carcinogen and is widely used to induce colon tumors in experimental animals.
1,2-dimethylhydrazine : A member of the class of hydrazines that is hydrazine in which one of the hydrogens attached to each nitrogen is replaced by a methyl group. A powerful DNA alkylating agent and carcinogen, it is used to induce colon cancer in laboratory rats and mice.
Colitis: Inflammation of the COLON section of the large intestine (INTESTINE, LARGE), usually with symptoms such as DIARRHEA (often with blood and mucus), ABDOMINAL PAIN, and FEVER.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In the present study, we investigated whether colonic neoplasms can be developed in mice initiated with a single injection of another genotoxic colonic carcinogen 1,2-dimethylhydrazine (DMH), instead of AOM and followed by exposure of DSS in drinking water." | 7.73 | Beta-Catenin mutations in a mouse model of inflammation-related colon carcinogenesis induced by 1,2-dimethylhydrazine and dextran sodium sulfate. ( Kohno, H; Sugie, S; Suzuki, R; Tanaka, T, 2005) |
| "Because ulcerative colitis predisposes to colonic cancer, for determination of the effect of colitis on experimental colon carcinogenesis, rectal instillations of peptides that attract and activate neutrophils were used to induce colitis in CD-1 (ICR) BR mice receiving 20 weekly injections of the carcinogen 1,2-dimethylhydrazine [(DMH) CAS: 540-73-8]." | 7.67 | Augmentation of 1,2-dimethylhydrazine-induced colon cancer by experimental colitis in mice: role of dietary vitamin E. ( Chester, JF; Gaissert, HA; Malt, RA; Ross, JS; Weitzman, SA, 1986) |
| "Colon carcinogenesis is long known to be associated with ulcerative colitis (UC), a chronic gastrointestinal disorder." | 5.43 | Melatonin modulated autophagy and Nrf2 signaling pathways in mice with colitis-associated colon carcinogenesis. ( Jena, GB; Kumar, V; Tikoo, KB; Trivedi, PP, 2016) |
| " The lack of the protective layer of mucus may cause inflammation which has been linked to colon carcinogenesis, therefore, the expression of markers such as cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (i-NOS) and macrophage infiltration was studied with immunohistochemistry (IH) in MDF harvested from F344 rats treated with the colon carcinogen 1,2-dimethylhydrazine (DMH)." | 3.75 | Mucin-depleted foci show strong activation of inflammatory markers in 1,2-dimethylhydrazine-induced carcinogenesis and are promoted by the inflammatory agent sodium dextran sulfate. ( Caderni, G; Dolara, P; Femia, AP; Luceri, C; Salvadori, M, 2009) |
| " In the present study, we investigated whether colonic neoplasms can be developed in mice initiated with a single injection of another genotoxic colonic carcinogen 1,2-dimethylhydrazine (DMH), instead of AOM and followed by exposure of DSS in drinking water." | 3.73 | Beta-Catenin mutations in a mouse model of inflammation-related colon carcinogenesis induced by 1,2-dimethylhydrazine and dextran sodium sulfate. ( Kohno, H; Sugie, S; Suzuki, R; Tanaka, T, 2005) |
| "Because ulcerative colitis predisposes to colonic cancer, for determination of the effect of colitis on experimental colon carcinogenesis, rectal instillations of peptides that attract and activate neutrophils were used to induce colitis in CD-1 (ICR) BR mice receiving 20 weekly injections of the carcinogen 1,2-dimethylhydrazine [(DMH) CAS: 540-73-8]." | 3.67 | Augmentation of 1,2-dimethylhydrazine-induced colon cancer by experimental colitis in mice: role of dietary vitamin E. ( Chester, JF; Gaissert, HA; Malt, RA; Ross, JS; Weitzman, SA, 1986) |
| "To study the effect of acetic acid colitis on 1,2-dimethylhydrazine-induced colon tumorigenesis, fischer 344 male rats, 10 weeks of age, were divided into three groups: one receiving 5% acetic acid enema (subgroup 1a); one receiving 10% acetic acid enema (subgroup 1b); and one not receiving acetic acid enema (group 2)." | 3.66 | Experimental colitis as a promoter in large-bowel tumorigenesis. ( Hagihara, PF, 1982) |
| "Some human epidemiological studies on colon cancer point to a possible preventive role of dietary fiber, but the results are confounded by the difference in the intake of many other food substances such as fat and the overall differences in the dietary pattern of the populations investigated." | 2.36 | Recent advances in dietary fiber and colorectal diseases. ( Freeman, HJ; Spiller, GA, 1981) |
| "Colon carcinogenesis is long known to be associated with ulcerative colitis (UC), a chronic gastrointestinal disorder." | 1.43 | Melatonin modulated autophagy and Nrf2 signaling pathways in mice with colitis-associated colon carcinogenesis. ( Jena, GB; Kumar, V; Tikoo, KB; Trivedi, PP, 2016) |
| "Colon cancer is the third most common malignant neoplasm in the world and it remains an important cause of death, especially in western countries." | 1.38 | Amelioration of 1,2 Dimethylhydrazine (DMH) induced colon oxidative stress, inflammation and tumor promotion response by tannic acid in Wistar rats. ( Ali, F; Hamiza, OO; Khan, AQ; Khan, R; Lateef, A; Rehman, MU; Sultana, S; Tahir, M, 2012) |
| "AOG may be useful for treatment of colitis and prevention of carcinogenesis in the clinics." | 1.36 | An apple oligogalactan prevents against inflammation and carcinogenesis by targeting LPS/TLR4/NF-κB pathway in a mouse model of colitis-associated colon cancer. ( Cao, SS; Feng, J; Guo, ZJ; Li, C; Li, Q; Li, YH; Liu, L; Mei, QB; Niu, YB; Sun, Y, 2010) |
| "Carcinoma was found in both the prolonged reactivation and saline-DMH groups." | 1.34 | Prolonged chronic inflammation progresses to dysplasia in a novel rat model of colitis-associated colon cancer. ( Appleyard, CB; Isidro, AA; Pagán, B; Santiago, C, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (31.25) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (31.25) | 29.6817 |
| 2010's | 6 (37.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Trivedi, PP | 1 |
| Jena, GB | 1 |
| Tikoo, KB | 1 |
| Kumar, V | 1 |
| Li, Y | 1 |
| Liu, C | 1 |
| Xiao, D | 1 |
| Han, J | 1 |
| Yue, Z | 1 |
| Sun, Y | 2 |
| Fan, L | 1 |
| Zhang, F | 1 |
| Meng, J | 1 |
| Zhang, R | 1 |
| Wang, Z | 1 |
| Mei, Q | 1 |
| Wen, A | 1 |
| Téllez-Bañuelos, MC | 1 |
| Haramati, J | 1 |
| Franco-Topete, K | 1 |
| Peregrina-Sandoval, J | 1 |
| Franco-Topete, R | 1 |
| Zaitseva, GP | 1 |
| Femia, AP | 2 |
| Dolara, P | 2 |
| Luceri, C | 2 |
| Salvadori, M | 2 |
| Caderni, G | 2 |
| Liu, L | 1 |
| Li, YH | 1 |
| Niu, YB | 1 |
| Guo, ZJ | 1 |
| Li, Q | 1 |
| Li, C | 1 |
| Feng, J | 1 |
| Cao, SS | 1 |
| Mei, QB | 1 |
| Bianchini, F | 1 |
| Salvianti, F | 1 |
| Pinzani, P | 1 |
| Calorini, L | 1 |
| Hamiza, OO | 1 |
| Rehman, MU | 1 |
| Tahir, M | 1 |
| Khan, R | 1 |
| Khan, AQ | 1 |
| Lateef, A | 1 |
| Ali, F | 1 |
| Sultana, S | 1 |
| Kohno, H | 1 |
| Suzuki, R | 1 |
| Sugie, S | 1 |
| Tanaka, T | 1 |
| Di Pace, RF | 1 |
| Massa, S | 1 |
| Ribeiro, OG | 1 |
| Cabrera, WH | 1 |
| De Franco, M | 1 |
| Starobinas, N | 1 |
| Seman, M | 1 |
| Ibañez, OC | 1 |
| Santiago, C | 1 |
| Pagán, B | 1 |
| Isidro, AA | 1 |
| Appleyard, CB | 1 |
| Spiller, GA | 1 |
| Freeman, HJ | 1 |
| Hagihara, PF | 1 |
| Furihata, T | 1 |
| Kawamata, H | 1 |
| Ohsugi, R | 1 |
| Sato, S | 1 |
| Kubota, K | 1 |
| Fujimori, T | 1 |
| Chester, JF | 2 |
| Gaissert, HA | 2 |
| Ross, JS | 2 |
| Malt, RA | 2 |
| Weitzman, SA | 2 |
| Phillips, RK | 1 |
| Cook, HT | 1 |
1 review available for 1,2-dimethylhydrazine and Colitis
| Article | Year |
|---|---|
Recent advances in dietary fiber and colorectal diseases.
Topics: 1,2-Dimethylhydrazine; Animals; Cellulose; Colitis; Colitis, Ulcerative; Colonic Diseases; Colonic N | 1981 |
15 other studies available for 1,2-dimethylhydrazine and Colitis
| Article | Year |
|---|---|
Melatonin modulated autophagy and Nrf2 signaling pathways in mice with colitis-associated colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Autophagy; Carcinogenesis; Carcinogens; Col | 2016 |
Trillium tschonoskii steroidal saponins suppress the growth of colorectal Cancer cells in vitro and in vivo.
Topics: 1,2-Dimethylhydrazine; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Caspase 3; Cell Prolif | 2015 |
Chronic exposure to endosulfan induces inflammation in murine colon via β-catenin expression and IL-6 production.
Topics: 1,2-Dimethylhydrazine; Administration, Oral; Animals; beta Catenin; Colitis; Colon; Colorectal Neopl | 2016 |
Mucin-depleted foci show strong activation of inflammatory markers in 1,2-dimethylhydrazine-induced carcinogenesis and are promoted by the inflammatory agent sodium dextran sulfate.
Topics: 1,2-Dimethylhydrazine; Animals; Azoxymethane; Carcinogens; Cell Transformation, Neoplastic; Colitis; | 2009 |
An apple oligogalactan prevents against inflammation and carcinogenesis by targeting LPS/TLR4/NF-κB pathway in a mouse model of colitis-associated colon cancer.
Topics: 1,2-Dimethylhydrazine; Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Colitis; Colonic Ne | 2010 |
Marie Ménard apples with high polyphenol content and a low-fat diet reduce 1,2-dimethylhydrazine-induced colon carcinogenesis in rats: effects on inflammation and apoptosis.
Topics: 1,2-Dimethylhydrazine; Animals; Anti-Infective Agents; Apoptosis; Colitis; Colon; Colonic Neoplasms; | 2012 |
Amelioration of 1,2 Dimethylhydrazine (DMH) induced colon oxidative stress, inflammation and tumor promotion response by tannic acid in Wistar rats.
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Antioxidants; Catalase; Colitis; Colon; Col | 2012 |
Beta-Catenin mutations in a mouse model of inflammation-related colon carcinogenesis induced by 1,2-dimethylhydrazine and dextran sodium sulfate.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Azoxymethane; beta Catenin; Colitis; Colonic Neoplas | 2005 |
Inverse genetic predisposition to colon versus lung carcinogenesis in mouse lines selected based on acute inflammatory responsiveness.
Topics: 1,2-Dimethylhydrazine; Acute Disease; Adenocarcinoma; Adenoma; Animals; Antiviral Agents; Carcinogen | 2006 |
Prolonged chronic inflammation progresses to dysplasia in a novel rat model of colitis-associated colon cancer.
Topics: 1,2-Dimethylhydrazine; Adenomatous Polyposis Coli Protein; Animals; Carcinoma; Chronic Disease; Coli | 2007 |
Experimental colitis as a promoter in large-bowel tumorigenesis.
Topics: 1,2-Dimethylhydrazine; Acetates; Adenocarcinoma; Adenoma; Animals; Colitis; Colonic Neoplasms; Dimet | 1982 |
[Colitis enhances the colorectal carcinogenesis in rats: correlation between the incidence of aberrant crypt foci and the incidence of tumors].
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Colitis; Colorectal Neoplasms; Precancerous Conditions; | 2001 |
Colonic cancer induced by 1,2-dimethylhydrazine: promotion by experimental colitis.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Colitis; Colonic Neoplasms; Dimethylhyd | 1989 |
Augmentation of 1,2-dimethylhydrazine-induced colon cancer by experimental colitis in mice: role of dietary vitamin E.
Topics: 1,2-Dimethylhydrazine; Animals; Cell Division; Colitis; Colonic Neoplasms; Diet; Dimethylhydrazines; | 1986 |
Effect of steel wire sutures on the incidence of chemically induced rodent colonic tumours.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Cicatrix; Colitis; Colonic Neoplasms; Dimethylhydrazine | 1986 |