1,2-dimethylhydrazine has been researched along with Colitis, Ulcerative in 10 studies
1,2-Dimethylhydrazine: A DNA alkylating agent that has been shown to be a potent carcinogen and is widely used to induce colon tumors in experimental animals.
1,2-dimethylhydrazine : A member of the class of hydrazines that is hydrazine in which one of the hydrogens attached to each nitrogen is replaced by a methyl group. A powerful DNA alkylating agent and carcinogen, it is used to induce colon cancer in laboratory rats and mice.
Colitis, Ulcerative: Inflammation of the COLON that is predominantly confined to the MUCOSA. Its major symptoms include DIARRHEA, rectal BLEEDING, the passage of MUCUS, and ABDOMINAL PAIN.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Several studies have shown the anti-neoplastic effects of non-steroidal anti-inflammatory drugs (NSAIDs) on 1,2-dimethylhydrazine (DMH)-induced colon carcinogenesis, but how these drugs act in case of inflammation-augmented tumorigenesis is still not clear." | 3.80 | Activation of NF-κB: bridging the gap between inflammation and cancer in colitis-mediated colon carcinogenesis. ( Nehru, B; Sanyal, SN; Setia, S, 2014) |
| " A dosage of 40 micrograms/kg was lethal when given i." | 2.67 | Injection of recombinant tumor necrosis factor directly into liver metastases: an experimental and clinical approach. ( Geerling, RA; IJzermans, JN; Jeekel, J; Marquet, RL; Scheringa, M; van der Schelling, GP, 1992) |
| "Some human epidemiological studies on colon cancer point to a possible preventive role of dietary fiber, but the results are confounded by the difference in the intake of many other food substances such as fat and the overall differences in the dietary pattern of the populations investigated." | 2.36 | Recent advances in dietary fiber and colorectal diseases. ( Freeman, HJ; Spiller, GA, 1981) |
| "CICC was induced with the colon cancer agent 1,2 dimethyl hydrazine (DMH) along with dextran sodium sulfate (DSS)." | 1.46 | Dietary selenium protects adiponectin knockout mice against chronic inflammation induced colon cancer. ( Carson, JA; Chanda, A; Fayad, R; Greer, J; Kaur, K; Saxena, A; Truman, S, 2017) |
| "Patients with chronic ulcerative colitis have a significantly increased risk of colorectal cancer development." | 1.33 | Chronic colitis promotes tumor development. ( Nagawa, H; Sato, H; Shinozaki, M; Watanabe, T, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (30.00) | 18.7374 |
| 1990's | 1 (10.00) | 18.2507 |
| 2000's | 2 (20.00) | 29.6817 |
| 2010's | 4 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Setia, S | 1 |
| Nehru, B | 1 |
| Sanyal, SN | 1 |
| Liu, WX | 1 |
| Gu, SZ | 1 |
| Zhang, S | 1 |
| Ren, Y | 1 |
| Sang, LX | 1 |
| Dai, C | 1 |
| Nabil, HM | 1 |
| Hassan, BN | 1 |
| Tohamy, AA | 1 |
| Waaer, HF | 1 |
| Abdel Moneim, AE | 1 |
| Saxena, A | 1 |
| Fayad, R | 1 |
| Kaur, K | 1 |
| Truman, S | 1 |
| Greer, J | 1 |
| Carson, JA | 1 |
| Chanda, A | 1 |
| Wang, JG | 1 |
| Wang, DF | 1 |
| Lv, BJ | 1 |
| Si, JM | 1 |
| Shinozaki, M | 1 |
| Watanabe, T | 1 |
| Sato, H | 1 |
| Nagawa, H | 1 |
| Spiller, GA | 1 |
| Freeman, HJ | 1 |
| IJzermans, JN | 1 |
| Scheringa, M | 1 |
| van der Schelling, GP | 1 |
| Geerling, RA | 1 |
| Marquet, RL | 1 |
| Jeekel, J | 1 |
| Davey, PG | 1 |
| McGuinness, EE | 1 |
| Nicol, S | 1 |
| Wormsley, KG | 1 |
| Yardley, JH | 1 |
1 review available for 1,2-dimethylhydrazine and Colitis, Ulcerative
| Article | Year |
|---|---|
Recent advances in dietary fiber and colorectal diseases.
Topics: 1,2-Dimethylhydrazine; Animals; Cellulose; Colitis; Colitis, Ulcerative; Colonic Diseases; Colonic N | 1981 |
1 trial available for 1,2-dimethylhydrazine and Colitis, Ulcerative
| Article | Year |
|---|---|
Injection of recombinant tumor necrosis factor directly into liver metastases: an experimental and clinical approach.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adult; Aged; Animals; Carcinogens; Colitis, Ulcerative; Colon | 1992 |
8 other studies available for 1,2-dimethylhydrazine and Colitis, Ulcerative
| Article | Year |
|---|---|
Activation of NF-κB: bridging the gap between inflammation and cancer in colitis-mediated colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Celecoxib; Colitis, Ulcerative; Colonic Neoplasms; Cyclooxygenase 2 | 2014 |
Angiopoietin and vascular endothelial growth factor expression in colorectal disease models.
Topics: 1,2-Dimethylhydrazine; Angiopoietin-1; Angiopoietin-2; Animals; Colitis, Ulcerative; Colon; Colorect | 2015 |
Radioprotection of 1,2-dimethylhydrazine-initiated colon cancer in rats using low-dose γ rays by modulating multidrug resistance-1, cytokeratin 20, and β-catenin expression.
Topics: 1,2-Dimethylhydrazine; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; beta Cateni | 2016 |
Dietary selenium protects adiponectin knockout mice against chronic inflammation induced colon cancer.
Topics: 1,2-Dimethylhydrazine; Adiponectin; Animals; Basic Helix-Loop-Helix Transcription Factors; Carcinoge | 2017 |
A novel mouse model for colitis-associated colon carcinogenesis induced by 1,2-dimethylhydrazine and dextran sulfate sodium.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; beta Catenin; Carcinogens; Colitis, Ulcerative; Colo | 2004 |
Chronic colitis promotes tumor development.
Topics: 1,2-Dimethylhydrazine; Acetic Acid; Animals; Carcinogens; Cell Growth Processes; Cocarcinogenesis; C | 2006 |
Experimental colitis and colonic cancer in the rat.
Topics: 1,2-Dimethylhydrazine; Animals; Cell Transformation, Neoplastic; Colitis, Ulcerative; Colon; Colonic | 1985 |
Comments on comparative pathology of colonic neoplasia in cotton-top marmoset (Saguinus oedipus oedipus).
Topics: 1,2-Dimethylhydrazine; Animal Diseases; Animals; Azoxymethane; Callitrichinae; Colitis, Ulcerative; | 1985 |