1,2-dimethylhydrazine has been researched along with Cocarcinogenesis in 45 studies
1,2-Dimethylhydrazine: A DNA alkylating agent that has been shown to be a potent carcinogen and is widely used to induce colon tumors in experimental animals.
1,2-dimethylhydrazine : A member of the class of hydrazines that is hydrazine in which one of the hydrogens attached to each nitrogen is replaced by a methyl group. A powerful DNA alkylating agent and carcinogen, it is used to induce colon cancer in laboratory rats and mice.
Cocarcinogenesis: The combination of two or more different factors in the production of cancer.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Male, Sprague-Dawley rats were injected subcutaneously with the colon carcinogen 1,2-dimethylhydrazine (DMH) at a dosage of 9." | 5.29 | Colonic crypts located over lymphoid nodules of 1,2-dimethylhydrazine-treated rats are hyperplastic and at high risk of forming adenocarcinomas. ( Cameron, IL; Hardman, WE, 1994) |
| "The objective of this experiment was to compare the effects of diets with either a non-fermentable fibre source (cellulose) or a fermentable fibre source [galacto-oligosaccharide (GOS)], combined with different levels of dietary fat, on the development of colorectal cancer." | 3.70 | A comparison of the effects of dietary cellulose and fermentable galacto-oligosaccharide, in a rat model of colorectal carcinogenesis: fermentable fibre confers greater protection than non-fermentable fibre in both high and low fat backgrounds. ( Appel, MJ; Hollanders, VM; Wijnands, MV; Woutersen, RA, 1999) |
| "Patients with chronic ulcerative colitis have a significantly increased risk of colorectal cancer development." | 1.33 | Chronic colitis promotes tumor development. ( Nagawa, H; Sato, H; Shinozaki, M; Watanabe, T, 2006) |
| " Chronic administration of bombesin at both dosages with DMH caused significant increases in the incidence, number and depth of involvement of colon cancers; however, it did not affect the size and histological type of colon cancers." | 1.29 | Bombesin enhances experimental carcinogenesis induced in rat colon by 1,2-dimethylhydrazine. ( Ide, A; Iwama, T; Mishima, Y; Yoshinaga, K, 1994) |
| "Male, Sprague-Dawley rats were injected subcutaneously with the colon carcinogen 1,2-dimethylhydrazine (DMH) at a dosage of 9." | 1.29 | Colonic crypts located over lymphoid nodules of 1,2-dimethylhydrazine-treated rats are hyperplastic and at high risk of forming adenocarcinomas. ( Cameron, IL; Hardman, WE, 1994) |
| "To examine the influence of hypercholesteremia on 1,2-dimethylhydrazine (DMH)-induced rat colon cancer, Sprague-Dawley rats received dietary cholesterol (CH, 0-2%) and cholic acid (CA, 0." | 1.29 | Promotion of colon carcinogenesis through increasing lipid peroxidation induced in rats by a high cholesterol diet. ( Chu, CY; Hsu, JD; Tseng, TH; Wang, CJ, 1996) |
| "05) was lost when these dosed groups were compared with temporal control groups." | 1.27 | Chronic effects of dietary exposure to amosite and chrysotile asbestos in Syrian golden hamsters. ( McConnell, EE; Moore, JA; Rust, JH; Shefner, AM, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 25 (55.56) | 18.7374 |
| 1990's | 14 (31.11) | 18.2507 |
| 2000's | 5 (11.11) | 29.6817 |
| 2010's | 1 (2.22) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| de Moura, NA | 1 |
| Caetano, BFR | 1 |
| Bidinotto, LT | 1 |
| Rodrigues, MAM | 1 |
| Barbisan, LF | 1 |
| Steele, G | 2 |
| Chrissey, M | 1 |
| Gittes, R | 2 |
| Corson, J | 2 |
| Wilson, R | 2 |
| Il'nitskiĭ, AP | 1 |
| Ryzhova, NI | 1 |
| Chudina, AP | 1 |
| Nevzorova, NI | 1 |
| Nekrasova, EA | 1 |
| Shinozaki, M | 1 |
| Watanabe, T | 1 |
| Sato, H | 1 |
| Nagawa, H | 1 |
| Hirono, I | 1 |
| Ueno, I | 1 |
| Aiso, S | 1 |
| Yamaji, T | 1 |
| Golberg, L | 1 |
| Solt, DB | 1 |
| Cayama, E | 1 |
| Tsuda, H | 1 |
| Enomoto, K | 1 |
| Lee, G | 1 |
| Farber, E | 1 |
| Sloan, DA | 1 |
| Fleiszer, DM | 2 |
| Richards, GK | 2 |
| Murray, D | 1 |
| Brown, RA | 2 |
| McConnell, EE | 2 |
| Shefner, AM | 1 |
| Rust, JH | 1 |
| Moore, JA | 2 |
| Rutter, HA | 1 |
| Ulland, BM | 1 |
| Turusov, VS | 2 |
| Linnik, AB | 1 |
| Morozova, OV | 2 |
| Parfenov, IuD | 2 |
| Nutter, RL | 1 |
| Gridley, DS | 1 |
| Kettering, JD | 1 |
| Goude, AG | 1 |
| Slater, JM | 1 |
| A-Kareem, AM | 1 |
| Senterman, MK | 1 |
| Rose, RC | 1 |
| Nahrwold, DL | 1 |
| Crissey, M | 1 |
| Harte, P | 1 |
| Rubio, CA | 1 |
| Nylander, G | 1 |
| Pascale, RM | 1 |
| Simile, MM | 1 |
| De Miglio, MR | 1 |
| Nufris, A | 1 |
| Daino, L | 1 |
| Seddaiu, MA | 1 |
| Rao, PM | 2 |
| Rajalakshmi, S | 3 |
| Sarma, DS | 2 |
| Feo, F | 1 |
| Jagadeesan, V | 1 |
| Rao, NJ | 1 |
| Sesikeran, B | 1 |
| Moĭzhess, TG | 1 |
| Trukhanova, LS | 3 |
| Vasil'ev, IuM | 1 |
| Ide, A | 1 |
| Yoshinaga, K | 1 |
| Iwama, T | 1 |
| Mishima, Y | 1 |
| Hardman, WE | 1 |
| Cameron, IL | 1 |
| Denda, A | 1 |
| Laconi, E | 1 |
| Meenan, J | 1 |
| Hirose, M | 1 |
| Hoshiya, T | 1 |
| Akagi, K | 1 |
| Takahashi, S | 1 |
| Hara, Y | 1 |
| Ito, N | 3 |
| Salim, AS | 1 |
| Tseng, TH | 1 |
| Hsu, JD | 1 |
| Chu, CY | 1 |
| Wang, CJ | 1 |
| Ishizuka, S | 1 |
| Nagai, T | 1 |
| Kasai, T | 1 |
| Wijnands, MV | 1 |
| Appel, MJ | 1 |
| Hollanders, VM | 1 |
| Woutersen, RA | 1 |
| Hagiwara, A | 2 |
| Miyashita, K | 1 |
| Nakanishi, T | 1 |
| Sano, M | 1 |
| Tamano, S | 2 |
| Kadota, T | 1 |
| Koda, T | 2 |
| Nakamura, M | 2 |
| Imaida, K | 3 |
| Shirai, T | 2 |
| Yoshino, H | 1 |
| Ichihara, T | 1 |
| Kawabe, M | 1 |
| Aoki, H | 1 |
| Zhang, Z | 1 |
| Li, J | 1 |
| Lantry, LE | 1 |
| Wang, Y | 1 |
| Wiseman, RW | 1 |
| Lubet, RA | 1 |
| You, M | 1 |
| Chen, MF | 1 |
| Chen, LT | 1 |
| Boyce, HW | 1 |
| Takahashi, M | 1 |
| Kingsnorth, AN | 1 |
| LaMuraglia, GM | 1 |
| Ross, JS | 1 |
| Malt, RA | 1 |
| Klepikov, NN | 1 |
| Narasimhan, S | 1 |
| Schachter, H | 1 |
| Broitman, SA | 1 |
| Suzuki, K | 1 |
| Bruce, WR | 1 |
| Newberne, PM | 2 |
| Nauss, KM | 2 |
| Ito, A | 1 |
| Watanabe, H | 1 |
| Aoyama, H | 1 |
| Nakagawa, Y | 1 |
| Mori, M | 1 |
| Nishizumi, M | 1 |
| McGarrity, TJ | 1 |
| Locniskar, M | 1 |
| Kaufmann, P | 1 |
| Nelson, RL | 1 |
| Samelson, SL | 1 |
| Pence, BC | 1 |
| Buddingh, F | 1 |
3 reviews available for 1,2-dimethylhydrazine and Cocarcinogenesis
| Article | Year |
|---|---|
Modification of tumor development in the gastrointestinal tract.
Topics: 1,2-Dimethylhydrazine; Animals; Cocarcinogenesis; Diet; Dimethylhydrazines; Dimethylnitrosamine; Eso | 1991 |
Cholesterol conundrums: the relationship between dietary and serum cholesterol in colon cancer.
Topics: 1,2-Dimethylhydrazine; Adult; Animals; Azoxymethane; Cholesterol; Cholesterol, Dietary; Cholestyrami | 1986 |
Dietary fat and colon cancer: variable results in animal models.
Topics: 1,2-Dimethylhydrazine; Animals; Azoxymethane; Body Weight; Cocarcinogenesis; Colonic Neoplasms; Diet | 1986 |
42 other studies available for 1,2-dimethylhydrazine and Cocarcinogenesis
| Article | Year |
|---|---|
Dietary hemin promotes colonic preneoplastic lesions and DNA damage but not tumor development in a medium-term model of colon carcinogenesis in rats.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animal Feed; Animals; Caco-2 Cells; Cocarcinogenesis; Co | 2019 |
Potentiation of 1-2-dimethylhydrazine-induced bowel carcinogenesis by the urinary bladder carcinogen N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Cocarcinogenesis; Drug Synergism; FANFT | 1980 |
[Sodium nitrite-induced potentiation of spontaneous and 1,2-dimethylhydrazine-induced carcinogenesis in male mice F1 (C57 B1xCBA)].
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Cocarcinogenesis; Drug Synergism; Leukemia; Lung Neopla | 2004 |
Chronic colitis promotes tumor development.
Topics: 1,2-Dimethylhydrazine; Acetic Acid; Animals; Carcinogens; Cell Growth Processes; Cocarcinogenesis; C | 2006 |
Enhancing effect of dextran sulfate sodium on colorectal carcinogenesis by 1,2-dimethylhydrazine in rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenocarcinoma, Mucinous; Adenoma; Animals; Cocarcinogenesis; | 1983 |
Promotion of liver cancer development by brief exposure to dietary 2-acetylaminofluorene plus partial hepatectomy or carbon tetrachloride.
Topics: 1,2-Dimethylhydrazine; 2-Acetylaminofluorene; Animals; Benzo(a)pyrene; Benzopyrenes; Carbon Tetrachl | 1983 |
Increased incidence of experimental colon cancer associated with long-term metronidazole therapy.
Topics: 1,2-Dimethylhydrazine; Animals; Cocarcinogenesis; Colon; Colonic Neoplasms; Dietary Fiber; Dimethylh | 1983 |
Chronic effects of dietary exposure to amosite and chrysotile asbestos in Syrian golden hamsters.
Topics: 1,2-Dimethylhydrazine; Animals; Asbestos; Asbestos, Amosite; Asbestos, Serpentine; Body Weight; Coca | 1983 |
Chronic effects of dietary exposure to amosite asbestos and tremolite in F344 rats.
Topics: 1,2-Dimethylhydrazine; Animals; Asbestos; Asbestos, Amosite; Asbestos, Amphibole; Body Weight; Cocar | 1983 |
[Analysis of uterine sarcoma induced in mice in terms of the two-staged development of tumors].
Topics: 1,2-Dimethylhydrazine; Animals; Cocarcinogenesis; Dimethylhydrazines; Estradiol; Female; Mice; Mice, | 1984 |
BALB/c mice fed milk or beef protein: differences in response to 1,2-dimethylhydrazine carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Body Weight; Cattle; Cocarcinogenesis; Colonic Neoplasms; Cytotoxici | 1983 |
Effect of long-term metronidazole (MTZ) therapy on experimental colon cancer in rats.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Cocarcinogenesis; Colon; Colonic Neoplasms; Dimethylhyd | 1984 |
Bile acids: effects on absorption of 1,2-dimethylhydrazine and 7,12-dimethylbenz[a]anthracene in the colon of the rat and guinea pig.
Topics: 1,2-Dimethylhydrazine; 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Bile Acids and | 1982 |
Potentiation of dimethylhydrazine bowel carcinogenesis in rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinoma, Transitional Cell; Cocarcinogenesis; Colo | 1981 |
Further studies on the carcinogenesis of the colon of the rat with special reference to the absence of intestinal contents.
Topics: 1,2-Dimethylhydrazine; Animals; Bile Acids and Salts; Cocarcinogenesis; Colonic Neoplasms; Dimethylh | 1981 |
Chemoprevention by S-adenosyl-L-methionine of rat liver carcinogenesis initiated by 1,2-dimethylhydrazine and promoted by orotic acid.
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Cocarcinogenesis; Dimethylhydrazines; Liver | 1995 |
Effect of iron deficiency on DMH-induced gastrointestinal tract tumors and occurrence of hepatocyte abnormalities in Fischer rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Cocarcinogenesis; Colonic Neoplasms; Dimethylhydrazi | 1994 |
[Use of a foreign body as a promotor for detecting the ability of various chemical substances to initiate carcinogenesis in connective tissue].
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Cocarcinogenesis; Diethylnitrosamine; Dimethylhydrazine | 1994 |
Bombesin enhances experimental carcinogenesis induced in rat colon by 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Animals; Bombesin; Carcinogens; Cell Division; Cocarcinogenesis; Colonic Neop | 1994 |
Colonic crypts located over lymphoid nodules of 1,2-dimethylhydrazine-treated rats are hyperplastic and at high risk of forming adenocarcinomas.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Cell Cycle; Cell Division; Cocarcinogen | 1994 |
Sequential histopathological analysis of hepatocarcinogenesis in rats during promotion with orotic acid.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Carcinoma, Hepatocellular; Cocarcinogenesis; Diet; Dime | 1994 |
Co-carcinogenic effect of sulphasalazine.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Cocarcinogenesis; Dimethylhydrazines; Folic Acid Defici | 1993 |
Effects of green tea catechins in a rat multi-organ carcinogenesis model.
Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Anticarcinogenic Agents; Body Weight; Butylhydroxybutylnitr | 1993 |
The permissive role of oxygen-derived free radicals in the development of colonic cancer in the rat. A new theory for carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Cocarcinogenesis; Colonic Neoplasms; Dietary Fats; Dime | 1993 |
Promotion of colon carcinogenesis through increasing lipid peroxidation induced in rats by a high cholesterol diet.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Cholesterol; Cholesterol, Dietary; Chol | 1996 |
Administration of anti-asialo GM1 serum increases aberrant crypt foci induced by 1,2-dimethylhydrazine in the large bowel of rats.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Cocarcinogenesis; Colonic Neoplasms; Dimethylhydrazines | 1996 |
A comparison of the effects of dietary cellulose and fermentable galacto-oligosaccharide, in a rat model of colorectal carcinogenesis: fermentable fibre confers greater protection than non-fermentable fibre in both high and low fat backgrounds.
Topics: 1,2-Dimethylhydrazine; Animals; Bile Acids and Salts; Carcinogens; Cecum; Cellulose; Cocarcinogenesi | 1999 |
Pronounced inhibition by a natural anthocyanin, purple corn color, of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-associated colorectal carcinogenesis in male F344 rats pretreated with 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenocarcinoma, Mucinous; Adenoma; Administration, Oral; Anim | 2001 |
Prevention by natural food anthocyanins, purple sweet potato color and red cabbage color, of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-associated colorectal carcinogenesis in rats initiated with 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Adenoma; Administration, Oral; Animals; Anthocyanins; Anticarcinogenic Agents | 2002 |
p53 transgenic mice are highly susceptible to 1, 2-dimethylhydrazine-induced uterine sarcomas.
Topics: 1,2-Dimethylhydrazine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carcinogens; Cell Cycle Pro | 2002 |
The effect of endotoxin on 1,2-dimethylhydrazine-induced colonic tumors in rats.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Cocarcinogenesis; Colon; Colonic Neoplasms; Dimethylhyd | 1990 |
Vanadate supplements and 1,2-dimethylhydrazine induced colon cancer in mice: increased thymidine incorporation without enhanced carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Body Weight; Cocarcinogenesis; Colonic Neoplasms; Dimethylhydrazines | 1986 |
[Effect of estradiol dipropionate on the development of uterine sarcoma induced by 1,2-dimethylhydrazine in mice].
Topics: 1,2-Dimethylhydrazine; Alleles; Animals; Carcinogens; Cocarcinogenesis; Dimethylhydrazines; Estradio | 1989 |
Expression of N-acetylglucosaminyltransferase III in hepatic nodules during rat liver carcinogenesis promoted by orotic acid.
Topics: 1,2-Dimethylhydrazine; Animals; Cocarcinogenesis; Dimethylhydrazines; Enzyme Activation; Glucosyltra | 1988 |
[Modifying effect of ascorbic acid and sodium ascorbate on uterine carcomogenesis induced by 1,2-dimethylhydrazine in CBA mice].
Topics: 1,2-Dimethylhydrazine; Animals; Ascorbic Acid; Cocarcinogenesis; Dimethylhydrazines; Drug Synergism; | 1988 |
Increase by deoxycholic acid of the colonic nuclear damage induced by known carcinogens in C57BL/6J mice.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Cell Nucleus; Cocarcinogenesis; Colon; Colonic Neoplasm | 1986 |
Effect of 1,2-dimethylhydrazine and hydrogen peroxide for the duodenal tumorigenesis in relation to blood catalase activity in mice.
Topics: 1,2-Dimethylhydrazine; Animals; Catalase; Cocarcinogenesis; Dimethylhydrazines; Duodenal Neoplasms; | 1986 |
Effect of PCBs on DMH-induced colon tumorigenesis in rats.
Topics: 1,2-Dimethylhydrazine; Animals; Cocarcinogenesis; Colonic Neoplasms; Dimethylhydrazines; Male; Methy | 1985 |
Dimethylhydrazine and ethanol.
Topics: 1,2-Dimethylhydrazine; Animals; Cocarcinogenesis; Dimethylhydrazines; Ethanol; Methylhydrazines; Rat | 1986 |
Interaction of dietary fat and route of carcinogen administration on 1,2-dimethylhydrazine-induced colon tumorigenesis in rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Body Weight; Carcinogens; Cocarcinogenesis; Colonic | 1985 |
Neither dietary ethanol nor beer augments experimental colon carcinogenesis in rats.
Topics: 1,2-Dimethylhydrazine; Animals; Beer; Cocarcinogenesis; Colonic Neoplasms; Diet; Dimethylhydrazines; | 1985 |
The effect of carbon black ingestion on 1,2-dimethylhydrazine-induced colon carcinogenesis in rats and mice.
Topics: 1,2-Dimethylhydrazine; Animals; Carbon; Cocarcinogenesis; Colonic Neoplasms; Dimethylhydrazines; Fem | 1985 |