1,2-dimethylhydrazine has been researched along with Cell Transformation, Neoplastic in 52 studies
1,2-Dimethylhydrazine: A DNA alkylating agent that has been shown to be a potent carcinogen and is widely used to induce colon tumors in experimental animals.
1,2-dimethylhydrazine : A member of the class of hydrazines that is hydrazine in which one of the hydrogens attached to each nitrogen is replaced by a methyl group. A powerful DNA alkylating agent and carcinogen, it is used to induce colon cancer in laboratory rats and mice.
Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chrysin and daidzein treatment significantly (P < 0." | 5.62 | Promising targets of chrysin and daidzein in colorectal cancer: Amphiregulin, CXCL1, and MMP-9. ( Allam, RM; Salama, AAA, 2021) |
| " This study was carried out to investigate the effect of troxerutin on xenobiotic metabolizing enzymes, colonic bacterial enzymes and the development of aberrant crypt foci (ACF) during 1,2-dimethylhydrazine (DMH) induced experimental rat colon carcinogenesis." | 3.80 | Modulatory effect of troxerutin on biotransforming enzymes and preneoplasic lesions induced by 1,2-dimethylhydrazine in rat colon carcinogenesis. ( Balasubramanian, T; Nalini, N; Sudha, M; Vinoth Kumar, R; Vinothkumar, R; Viswanathan, P, 2014) |
| " The present study was to evaluate the antiproliferative effects of hesperetin, a flavonoid commonly found in many herbal medicines and foods, on aberrant crypt foci (ACF), argyrophylic nucleolar organizer regions (AgNORs) and proliferating cell nuclear antigen (PCNA) in 1,2-dimethylhydrazine (DMH)-induced colon carcinogenesis in rats." | 3.79 | Antiproliferative efficacy of hesperetin (citrus flavanoid) in 1,2-dimethylhydrazine-induced colon cancer. ( Aranganathan, S; Nalini, N, 2013) |
| "The expression of the putative markers LGR-5 (leucine-rich-repeat-containing G-protein-coupled receptor 5), MSI-1 (Musashi-1) and DCAMKL-1 (doublecortin and calcium/calmodulin-dependent protein kinase-like-1) was studied in normal colon mucosa (NM), in the precancerous lesions Mucin Depleted Foci (MDF) and in macroscopic tumours (adenomas) of 1,2-dimethylhydrazine-treated rats." | 3.79 | Expression of LGR-5, MSI-1 and DCAMKL-1, putative stem cell markers, in the early phases of 1,2-dimethylhydrazine-induced rat colon carcinogenesis: correlation with nuclear β-catenin. ( Caderni, G; Dolara, P; Femia, AP; Salvadori, M, 2013) |
| " Groups 1, 3 and 5 were initiated by 1,2-dimethylhydrazine (DMH) 20 mg/kg body weight s." | 3.77 | Cancer chemopreventive potential of the Egyptian flaxseed oil in a rat colon carcinogenesis bioassay--implications for its mechanism of action. ( Abou-Shafey, AE; Elgendy, SA; Masoud, AA; Salim, EI, 2011) |
| " The lack of the protective layer of mucus may cause inflammation which has been linked to colon carcinogenesis, therefore, the expression of markers such as cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (i-NOS) and macrophage infiltration was studied with immunohistochemistry (IH) in MDF harvested from F344 rats treated with the colon carcinogen 1,2-dimethylhydrazine (DMH)." | 3.75 | Mucin-depleted foci show strong activation of inflammatory markers in 1,2-dimethylhydrazine-induced carcinogenesis and are promoted by the inflammatory agent sodium dextran sulfate. ( Caderni, G; Dolara, P; Femia, AP; Luceri, C; Salvadori, M, 2009) |
| "Weekly injections of dimethylhydrazine (DMH) (25 mg/kg), or azoxymethane (AOM) (8 mg/kg) to young adult male CDI mice for 1-2 months produced generalized intestinal crypt hyperplasia, which we measured in duodenum in terms of number of interphase and mitotic cells present in crypts." | 3.69 | Initiated stem cells in murine intestinal carcinogenesis: prolonged survival, control by NK cells, and progression. ( Altmann, GG; Lala, PK, 1994) |
| "Chrysin and daidzein treatment significantly (P < 0." | 1.62 | Promising targets of chrysin and daidzein in colorectal cancer: Amphiregulin, CXCL1, and MMP-9. ( Allam, RM; Salama, AAA, 2021) |
| "the third pathway of colonic carcinogenesis, remain unidentified." | 1.46 | The Histogenesis of the Third Pathway of Colonic Carcinogenesis in Rats. ( Rubio, CA, 2017) |
| "CICC was induced with the colon cancer agent 1,2 dimethyl hydrazine (DMH) along with dextran sodium sulfate (DSS)." | 1.46 | Dietary selenium protects adiponectin knockout mice against chronic inflammation induced colon cancer. ( Carson, JA; Chanda, A; Fayad, R; Greer, J; Kaur, K; Saxena, A; Truman, S, 2017) |
| "Genetic mutations relevant to human colon cancer have been described in this model, but comprehensive gene expression and genomic analysis have not been reported so far." | 1.36 | Gene expression profile and genomic alterations in colonic tumours induced by 1,2-dimethylhydrazine (DMH) in rats. ( Caderni, G; Dolara, P; Femia, AP; Giannini, A; Luceri, C; Toti, S, 2010) |
| "They suggest that Ca can reduce colorectal cancer risk in meat-eaters." | 1.35 | Beef meat promotion of dimethylhydrazine-induced colorectal carcinogenesis biomarkers is suppressed by dietary calcium. ( Corpet, DE; Guéraud, F; Pierre, F; Santarelli, R; Taché, S, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (23.08) | 18.7374 |
| 1990's | 9 (17.31) | 18.2507 |
| 2000's | 11 (21.15) | 29.6817 |
| 2010's | 19 (36.54) | 24.3611 |
| 2020's | 1 (1.92) | 2.80 |
| Authors | Studies |
|---|---|
| Salama, AAA | 1 |
| Allam, RM | 1 |
| Rubio, CA | 1 |
| Jain, S | 1 |
| Ghanghas, P | 1 |
| Rana, C | 1 |
| Sanyal, SN | 1 |
| Sharma, G | 1 |
| Rani, I | 1 |
| Kansal, S | 1 |
| Bhatnagar, A | 1 |
| Agnihotri, N | 1 |
| Ansil, PN | 1 |
| Prabha, SP | 1 |
| Nitha, A | 1 |
| Latha, MS | 1 |
| Umesalma, S | 1 |
| Nagendraprabhu, P | 1 |
| Sudhandiran, G | 1 |
| Vinothkumar, R | 1 |
| Vinoth Kumar, R | 1 |
| Sudha, M | 1 |
| Viswanathan, P | 1 |
| Balasubramanian, T | 1 |
| Nalini, N | 3 |
| Sun, T | 1 |
| Liu, S | 1 |
| Zhou, Y | 1 |
| Yao, Z | 1 |
| Zhang, D | 1 |
| Cao, S | 1 |
| Wei, Z | 1 |
| Tan, B | 1 |
| Li, Y | 1 |
| Lian, Z | 1 |
| Wang, S | 1 |
| Saxena, A | 1 |
| Fayad, R | 1 |
| Kaur, K | 1 |
| Truman, S | 1 |
| Greer, J | 1 |
| Carson, JA | 1 |
| Chanda, A | 1 |
| Aranganathan, S | 2 |
| Selvam, JP | 1 |
| Femia, AP | 5 |
| Dolara, P | 5 |
| Luceri, C | 3 |
| Salvadori, M | 4 |
| Caderni, G | 5 |
| Luo, F | 2 |
| Ye, H | 2 |
| Hamoudi, R | 2 |
| Dong, G | 2 |
| Zhang, W | 2 |
| Patek, CE | 1 |
| Poulogiannis, G | 2 |
| Arends, MJ | 2 |
| Toti, S | 1 |
| Giannini, A | 2 |
| Salvianti, F | 1 |
| Pinzani, P | 1 |
| Salim, EI | 1 |
| Abou-Shafey, AE | 1 |
| Masoud, AA | 1 |
| Elgendy, SA | 1 |
| Harzallah, HJ | 1 |
| Grayaa, R | 1 |
| Kharoubi, W | 1 |
| Maaloul, A | 2 |
| Hammami, M | 1 |
| Mahjoub, T | 2 |
| Ghadi, FE | 2 |
| Malhotra, A | 2 |
| Ghara, AR | 2 |
| Dhawan, DK | 2 |
| Jrah-Harzallah, H | 1 |
| Ben-Hadj-Khalifa, S | 1 |
| Almawi, WY | 1 |
| Houas, Z | 1 |
| Sakai, H | 1 |
| Tsukamoto, T | 1 |
| Yamamoto, M | 1 |
| Shirai, N | 1 |
| Iidaka, T | 1 |
| Hirata, A | 1 |
| Yanai, T | 1 |
| Masegi, T | 2 |
| Donehower, LA | 1 |
| Tatematsu, M | 1 |
| Kitamura, Y | 1 |
| Umemura, T | 1 |
| Okazaki, K | 1 |
| Kanki, K | 1 |
| Imazawa, T | 1 |
| Nishikawa, A | 1 |
| Hirose, M | 1 |
| Di Pace, RF | 1 |
| Massa, S | 1 |
| Ribeiro, OG | 1 |
| Cabrera, WH | 1 |
| De Franco, M | 1 |
| Starobinas, N | 1 |
| Seman, M | 1 |
| Ibañez, OC | 1 |
| Raul, F | 1 |
| Gosse, F | 1 |
| Osswald, AB | 1 |
| Bouhadjar, M | 1 |
| Foltzer-Jourdainne, C | 1 |
| Marescaux, J | 1 |
| Soler, L | 1 |
| Tarquini, E | 1 |
| Ferri, S | 1 |
| Pierre, F | 1 |
| Santarelli, R | 1 |
| Taché, S | 1 |
| Guéraud, F | 1 |
| Corpet, DE | 1 |
| Lan, A | 1 |
| Bruneau, A | 1 |
| Bensaada, M | 1 |
| Philippe, C | 1 |
| Bellaud, P | 1 |
| Rabot, S | 1 |
| Jan, G | 1 |
| Jacobs, LR | 1 |
| Melikiants, AG | 1 |
| Matveev, VV | 1 |
| Melikiants, LM | 1 |
| Wargovich, MJ | 1 |
| Medline, A | 1 |
| Bruce, WR | 1 |
| Traynor, OJ | 1 |
| Costa, NL | 1 |
| Wood, CB | 1 |
| Chang, WW | 1 |
| Nobre-Leitão, C | 1 |
| Chaves, P | 1 |
| Fidalgo, P | 1 |
| Cravo, M | 1 |
| Gouveia-Oliveira, A | 1 |
| Ferra, MA | 1 |
| Mira, FC | 1 |
| Altmann, GG | 1 |
| Lala, PK | 1 |
| Latham, P | 1 |
| Lund, EK | 1 |
| Johnson, IT | 1 |
| Panda, SK | 1 |
| Chattoraj, SC | 1 |
| Broitman, SA | 1 |
| Lifshitz, S | 1 |
| Lamprecht, SA | 1 |
| Benharroch, D | 1 |
| Prinsloo, I | 1 |
| Polak-Charcon, S | 1 |
| Schwartz, B | 1 |
| Kuraguchi, M | 1 |
| Cook, H | 1 |
| Williams, ED | 1 |
| Thomas, GA | 1 |
| Hupp, T | 1 |
| Buhr, H | 1 |
| Ivancovic, S | 1 |
| Beck, N | 1 |
| Gunning, WT | 1 |
| Castonguay, A | 1 |
| Goldblatt, PJ | 1 |
| Stoner, GD | 1 |
| Savov, G | 1 |
| Donchev, N | 1 |
| Jacoby, RF | 1 |
| Llor, X | 1 |
| Teng, BB | 1 |
| Davidson, NO | 1 |
| Brasitus, TA | 2 |
| Wali, RK | 1 |
| Baum, CL | 1 |
| Bolt, MJ | 1 |
| Dudeja, PK | 1 |
| Sitrin, MD | 1 |
| Deschner, EE | 1 |
| Stevens, RH | 1 |
| Cole, DA | 1 |
| Lindholm, PA | 1 |
| Cheng, HF | 1 |
| Suzuki, H | 2 |
| Umehara, N | 1 |
| Yamamoto, J | 1 |
| Iwata, Y | 1 |
| Matsumoto, K | 1 |
| Iriyama, K | 1 |
| Davey, PG | 1 |
| McGuinness, EE | 1 |
| Nicol, S | 1 |
| Wormsley, KG | 1 |
| Kennedy, MF | 1 |
| Tutton, PJ | 1 |
| Barkla, DH | 1 |
| Kumari, HL | 1 |
| Kamat, PL | 1 |
| D'Ambrosio, SM | 1 |
| Witiak, DT | 1 |
| Milo, GE | 1 |
1 review available for 1,2-dimethylhydrazine and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Animal models of carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Cell Transformation, Neoplastic; Colonic Neoplasms; Dimethy | 1988 |
51 other studies available for 1,2-dimethylhydrazine and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Promising targets of chrysin and daidzein in colorectal cancer: Amphiregulin, CXCL1, and MMP-9.
Topics: 1,2-Dimethylhydrazine; Amphiregulin; Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; C | 2021 |
The Histogenesis of the Third Pathway of Colonic Carcinogenesis in Rats.
Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Carcinogenesis; Carcinoma; Carcinoma, Signet Ring Cell; Cel | 2017 |
Role of GSK-3β in Regulation of Canonical Wnt/β-catenin Signaling and PI3-K/Akt Oncogenic Pathway in Colon Cancer.
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Apoptosis; Celecoxib; Cell Transformation, | 2017 |
Alterations in mitochondrial membrane in chemopreventive action of fish oil.
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Apoptosis; Calcium; Carcinogens; Caspase 3; | 2013 |
Chemopreventive effect of Amorphophallus campanulatus (Roxb.) blume tuber against aberrant crypt foci and cell proliferation in 1, 2-dimethylhydrazine induced colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Amorphophallus; Animals; Apoptosis; Carcinogens; Catalas | 2013 |
Antiproliferative and apoptotic-inducing potential of ellagic acid against 1,2-dimethyl hydrazine-induced colon tumorigenesis in Wistar rats.
Topics: 1,2-Dimethylhydrazine; Animals; Antineoplastic Agents; Apoptosis; Cell Proliferation; Cell Transform | 2014 |
Modulatory effect of troxerutin on biotransforming enzymes and preneoplasic lesions induced by 1,2-dimethylhydrazine in rat colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Anticoagulants; Biotransformation; Carcinogens; | 2014 |
Evolutionary biologic changes of gut microbiota in an 'adenoma-carcinoma sequence' mouse colorectal cancer model induced by 1, 2-Dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Adenomatous Polyposis Coli Protein; Animals; Bacteri | 2017 |
Dietary selenium protects adiponectin knockout mice against chronic inflammation induced colon cancer.
Topics: 1,2-Dimethylhydrazine; Adiponectin; Animals; Basic Helix-Loop-Helix Transcription Factors; Carcinoge | 2017 |
Effect of hesperetin, a citrus flavonoid, on bacterial enzymes and carcinogen-induced aberrant crypt foci in colon cancer rats: a dose-dependent study.
Topics: 1,2-Dimethylhydrazine; Animals; Bacteria; Body Weight; Carcinogens; Cell Transformation, Neoplastic; | 2008 |
Mucin-depleted foci show strong activation of inflammatory markers in 1,2-dimethylhydrazine-induced carcinogenesis and are promoted by the inflammatory agent sodium dextran sulfate.
Topics: 1,2-Dimethylhydrazine; Animals; Azoxymethane; Carcinogens; Cell Transformation, Neoplastic; Colitis; | 2009 |
K-ras exon 4A has a tumour suppressor effect on carcinogen-induced murine colonic adenoma formation.
Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Apoptosis; Carcinogens; Cell Proliferation; Cell Transforma | 2010 |
Gene expression profile and genomic alterations in colonic tumours induced by 1,2-dimethylhydrazine (DMH) in rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Cell Transformation, Neoplastic; Colonic Neoplasms; | 2010 |
Mutant K-ras promotes carcinogen-induced murine colorectal tumourigenesis, but does not alter tumour chromosome stability.
Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Apoptosis; beta Catenin; Carcinogens; Cell Proliferation; C | 2011 |
Sustained proliferation and resistance to apoptosis after a cytotoxic insult are early alterations in rat colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Apoptosis; Aspirin; bcl-2 Homologous Antagonist-Killer Protein; Biom | 2012 |
Cancer chemopreventive potential of the Egyptian flaxseed oil in a rat colon carcinogenesis bioassay--implications for its mechanism of action.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Adenoma; Animals; Anticarcinogenic Agents; Body Weight; | 2011 |
Thymoquinone, the Nigella sativa bioactive compound, prevents circulatory oxidative stress caused by 1,2-dimethylhydrazine in erythrocyte during colon postinitiation carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Benzoquinones; Catalase; Cell Transformation, Neoplastic; Colonic Ne | 2012 |
Selenium as a modulator of membrane stability parameters and surface changes during the initiation phase of 1,2-dimethylhydrazine induced colorectal carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Antioxidants; Carcinogens; Catalase; Cell M | 2012 |
Antiproliferative efficacy of hesperetin (citrus flavanoid) in 1,2-dimethylhydrazine-induced colon cancer.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Anticarcinogenic Agents; Carcinogens; Cell Tran | 2013 |
Effect of thymoquinone on 1,2-dimethyl-hydrazine-induced oxidative stress during initiation and promotion of colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Antioxidants; Benzoquinones; Body Weight; Carcinogens; Carcinoma; Ce | 2013 |
Chemopreventive effects of selenium on cancer marker indices and ultrastructural changes during 1,2 dimethylhydrazine-induced colon carcinogenesis in rats.
Topics: 1,2-Dimethylhydrazine; Alkaline Phosphatase; Animals; Antioxidants; Biomarkers, Tumor; Carcinogens; | 2013 |
Expression of LGR-5, MSI-1 and DCAMKL-1, putative stem cell markers, in the early phases of 1,2-dimethylhydrazine-induced rat colon carcinogenesis: correlation with nuclear β-catenin.
Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; beta Catenin; Biomarkers, Tumor; Celecoxib; Cell Nucleus; C | 2013 |
High susceptibility of nullizygous p53 knockout mice to colorectal tumor induction by 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Carcinoma; Cell Transformation, Neoplastic; Colorectal | 2003 |
Enhancing effects of simultaneous treatment with sodium nitrite on 2-amino-3-methylimidazo[4,5-f]quinoline-induced rat liver, colon and Zymbal's gland carcinogenesis after initiation with diethylnitrosamine and 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Administration, Oral; Alkylating Agents; Animals; Carcinogens; Cell Transform | 2006 |
Inverse genetic predisposition to colon versus lung carcinogenesis in mouse lines selected based on acute inflammatory responsiveness.
Topics: 1,2-Dimethylhydrazine; Acute Disease; Adenocarcinoma; Adenoma; Animals; Antiviral Agents; Carcinogen | 2006 |
Follow-up of tumor development in the colons of living rats and implications for chemoprevention trials: assessment of aspirin-difluoromethylornithine combination.
Topics: 1,2-Dimethylhydrazine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Aspi | 2007 |
K-ras mutations and mucin profile in preneoplastic lesions and colon tumors induced in rats by 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Animals; Cell Transformation, Neoplastic; Colonic Neoplasms; Genes, APC; Gene | 2008 |
Beef meat promotion of dimethylhydrazine-induced colorectal carcinogenesis biomarkers is suppressed by dietary calcium.
Topics: 1,2-Dimethylhydrazine; Acetylcysteine; Animals; Antioxidants; Body Weight; Calcium, Dietary; Cattle; | 2008 |
Increased induction of apoptosis by Propionibacterium freudenreichii TL133 in colonic mucosal crypts of human microbiota-associated rats treated with 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Animals; Apoptosis; Carcinogens; Cecum; Cell Proliferation; Cell Transformati | 2008 |
Stimulation of rat colonic crypt cell proliferative activity by wheat bran consumption during the stage of 1,2-dimethylhydrazine administration.
Topics: 1,2-Dimethylhydrazine; Animals; Cell Division; Cell Transformation, Neoplastic; Colon; Dietary Fiber | 1984 |
[Kinetic characteristics of the normal enterocyte population and in carcinogenesis].
Topics: 1,2-Dimethylhydrazine; Animals; Cell Adhesion; Cell Division; Cell Transformation, Neoplastic; Dimet | 1984 |
Early histopathologic events to evolution of colon cancer in C57BL/6 and CF1 mice treated with 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Animals; Cell Transformation, Neoplastic; Chromosome Aberrations; Colon; Colo | 1983 |
A scanning electron microscopy study of changes in the colonic mucus layer during chemical carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Cell Transformation, Neoplastic; Colonic Neoplasms; Dim | 1983 |
Degenerative behavior of epithelial cells in the colonic crypt of the mouse following administration of colonic carcinogen, 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Cell Division; Cell Transformation, Neoplastic; Colon; | 1981 |
Calcium regulation of colonic crypt cell kinetics: evidence for a direct effect in mice.
Topics: 1,2-Dimethylhydrazine; Animals; Calcium; Carcinogens; Cell Division; Cell Transformation, Neoplastic | 1995 |
Initiated stem cells in murine intestinal carcinogenesis: prolonged survival, control by NK cells, and progression.
Topics: 1,2-Dimethylhydrazine; Animals; Azoxymethane; Brunner Glands; Cell Survival; Cell Transformation, Ne | 1994 |
Dietary n-3 PUFA increases the apoptotic response to 1,2-dimethylhydrazine, reduces mitosis and suppresses the induction of carcinogenesis in the rat colon.
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Apoptosis; Carcinogens; Cell Division; Cell | 1999 |
Correlation of neomycin, faecal neutral and acid sterols with colon carcinogenesis in rats.
Topics: 1,2-Dimethylhydrazine; Animals; Anti-Bacterial Agents; Carcinogens; Cell Transformation, Neoplastic; | 1999 |
Apoptosis (programmed cell death) in colonic cells: from normal to transformed stage.
Topics: 1,2-Dimethylhydrazine; Animals; Apoptosis; Biomarkers; Carcinogens; Caspase 1; Cell Transformation, | 2001 |
Differences in susceptibility to colonic stem cell somatic mutation in three strains of mice.
Topics: 1,2-Dimethylhydrazine; Animals; Cell Transformation, Neoplastic; Colon; Ethylnitrosourea; Female; Ge | 2001 |
[Animal experiment studies of carcinogen-induced tumor development in colotomies in relation to suture materials].
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Cell Transformation, Neoplastic; Colon; Colonic Neoplas | 1992 |
Strain A/J mouse lung adenoma growth patterns vary when induced by different carcinogens.
Topics: 1,2-Dimethylhydrazine; Adenoma; Aflatoxins; Animals; Benzo(a)pyrene; Carcinogens; Cell Transformatio | 1991 |
Changes in the activities of jejunal glucosidases in experimental intestinal tumorigenesis induced by 1,2 dimethylhydrazine in rats fed different diets.
Topics: 1,2-Dimethylhydrazine; Administration, Oral; alpha-Glucosidases; Animals; beta-Galactosidase; Carboh | 1991 |
Mutations in the K-ras oncogene induced by 1,2-dimethylhydrazine in preneoplastic and neoplastic rat colonic mucosa.
Topics: 1,2-Dimethylhydrazine; Animals; Base Sequence; Cell Transformation, Neoplastic; Codon; Colonic Neopl | 1991 |
Down-regulation of protein kinase C activity in 1,2-dimethylhydrazine-induced rat colonic tumors.
Topics: 1,2-Dimethylhydrazine; Animals; Cell Membrane; Cell Transformation, Neoplastic; Colonic Neoplasms; C | 1991 |
Identification of environmental carcinogens utilizing T-cell mediated immunity.
Topics: 1,2-Dimethylhydrazine; 9,10-Dimethyl-1,2-benzanthracene; Animals; Asbestos; Carcinogens, Environment | 1986 |
Early mucosal changes in dimethylhydrazine-induced colonic carcinogenesis in rats.
Topics: 1,2-Dimethylhydrazine; Animals; Cell Transformation, Neoplastic; Colon; Colonic Neoplasms; Cytophoto | 1986 |
Effects of immunostimulation with OK432, coenzyme Q10, or levamisole on dimethylhydrazine-induced colonic carcinogenesis in rats.
Topics: 1,2-Dimethylhydrazine; Animals; Biological Products; Cell Transformation, Neoplastic; Coenzymes; Col | 1986 |
Experimental colitis and colonic cancer in the rat.
Topics: 1,2-Dimethylhydrazine; Animals; Cell Transformation, Neoplastic; Colitis, Ulcerative; Colon; Colonic | 1985 |
Adrenergic factors regulating cell division in the colonic crypt epithelium during carcinogenesis and in colonic adenoma and adenocarcinoma.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Animals; Cell Division; Cell Transformation, Neoplas | 1985 |
A comparative study of dimethylhydrazine regioisomers and the methylazoxymethanol metabolite of 1,1- and 1,2-dimethylhydrazine in relation to transformation in human fibroblasts.
Topics: 1,2-Dimethylhydrazine; Azo Compounds; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; | 1985 |