1,2-dimethylhydrazine has been researched along with Carcinoma, Hepatocellular in 3 studies
1,2-Dimethylhydrazine: A DNA alkylating agent that has been shown to be a potent carcinogen and is widely used to induce colon tumors in experimental animals.
1,2-dimethylhydrazine : A member of the class of hydrazines that is hydrazine in which one of the hydrogens attached to each nitrogen is replaced by a methyl group. A powerful DNA alkylating agent and carcinogen, it is used to induce colon cancer in laboratory rats and mice.
Carcinoma, Hepatocellular: A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Rats of 3 inbred strains (DA, HS and AS2) were dosed with 1,2-dimethylhydrazine 2HCl (DMH) or saline by gavage weekly for 10 wk." | 1.26 | The response of three inbred strains of rat to the carcinogen 1,2-dimethylhydrazine. ( Gavin, JB; Herdson, PB; Teague, CA, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Teague, CA | 1 |
| Gavin, JB | 1 |
| Herdson, PB | 1 |
| Denda, A | 1 |
| Laconi, E | 1 |
| Rao, PM | 1 |
| Rajalakshmi, S | 1 |
| Sarma, DS | 1 |
| Fujita, H | 1 |
| Nagano, K | 1 |
| Ochiai, M | 1 |
| Ushijima, T | 1 |
| Sugimura, T | 1 |
| Nagao, M | 1 |
| Matsushima, T | 1 |
3 other studies available for 1,2-dimethylhydrazine and Carcinoma, Hepatocellular
| Article | Year |
|---|---|
The response of three inbred strains of rat to the carcinogen 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma, Bile Duct; Animals; Carcinoma, Hepatocellular; Dimet | 1981 |
Sequential histopathological analysis of hepatocarcinogenesis in rats during promotion with orotic acid.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Carcinoma, Hepatocellular; Cocarcinogenesis; Diet; Dime | 1994 |
Difference in target organs in carcinogenesis with a heterocyclic amine, 2-amino-3,4-dimethylimidazo[4,5-f]quinoline, in different strains of mice.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Carcinoma, Hepatocellular; Cecal Neopla | 1999 |