1,2-dimethylhydrazine has been researched along with Carcinoma, Anaplastic in 32 studies
1,2-Dimethylhydrazine: A DNA alkylating agent that has been shown to be a potent carcinogen and is widely used to induce colon tumors in experimental animals.
1,2-dimethylhydrazine : A member of the class of hydrazines that is hydrazine in which one of the hydrogens attached to each nitrogen is replaced by a methyl group. A powerful DNA alkylating agent and carcinogen, it is used to induce colon cancer in laboratory rats and mice.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Groups 1, 3 and 5 were initiated by 1,2-dimethylhydrazine (DMH) 20 mg/kg body weight s." | 3.77 | Cancer chemopreventive potential of the Egyptian flaxseed oil in a rat colon carcinogenesis bioassay--implications for its mechanism of action. ( Abou-Shafey, AE; Elgendy, SA; Masoud, AA; Salim, EI, 2011) |
| "CBA female mice, at the 17th day of pregnancy, received single intraperitoneal injection of diethylstilbestrol (DES) at the dose of 1 mg/kg body weight (b." | 3.70 | 1,2-Dimethylhydrazine carcinogenesis in CBA male mice prenatally treated with diethylstilbestrol. ( Samoilov, D; Trukhanova, L; Turusov, V, 2000) |
| "the third pathway of colonic carcinogenesis, remain unidentified." | 1.46 | The Histogenesis of the Third Pathway of Colonic Carcinogenesis in Rats. ( Rubio, CA, 2017) |
| "Carcinoma was found in both the prolonged reactivation and saline-DMH groups." | 1.34 | Prolonged chronic inflammation progresses to dysplasia in a novel rat model of colitis-associated colon cancer. ( Appleyard, CB; Isidro, AA; Pagán, B; Santiago, C, 2007) |
| "Yoghurt feeding inhibits induced colon cancer in mice." | 1.33 | Reduction of beta-glucuronidase and nitroreductase activity by yoghurt in a murine colon cancer model. ( de Moreno de LeBlanc, A; Perdigón, G, 2005) |
| "Colorectal tumors were induced by means of 15 s." | 1.31 | Animal model in the study of colorectal carcinogenesis. ( Cerar, A; Glavac, D; Ravnik-Glavac, M, 2000) |
| "In a model of dimethylhydrazine-induced colorectal tumors in male mice aloin- or sennoside-enriched diets (0." | 1.29 | Sennosides and aloin do not promote dimethylhydrazine-induced colorectal tumors in mice. ( Baretton, G; Siegers, CP; Siemers, J, 1993) |
| " The dose-response study shows a sharp increase (from 5 to 75%) of the epithelial renal tumour incidence in the range of 2, 4 and 8 injections of DMH." | 1.28 | [1,2-dimethylhydrazine induction of epithelial tumors of the kidneys in CBA strain mice]. ( Chemeris, GIu; Lanko, NS; Parfenov, IuD; Turusov, VS, 1990) |
| "Peritoneal carcinomatosis, a common spreading of human colon carcinoma, can be obtained by intraperitoneal injection of colon tumor cells in rats." | 1.27 | Treatment with endotoxins of peritoneal carcinomatosis induced by colon tumor cells in the rat. ( Jeannin, JF; Lagadec, P; Olsson, O; Pelletier, H; Reisser, D, 1987) |
| "All colonic neoplasms were histologically classified either as adenomas or carcinomas with groups being allocated into tumour-free (n = 16) or tumour-bearing (n = 54), the latter group being further sub-divided into animals with adenoma alone (n = 8) and those with carcinoma (n = 46)." | 1.27 | Changes in serum lipids related to the presence of experimental colon cancer. ( Barton, TP; Cruse, JP; Lewin, MR, 1987) |
| "Microcarcinomas are considered as initial stages of endocrine cell carcinoma." | 1.27 | Changes in intestinal mucosa above lymph follicles during carcinogenesis in rats. A light and electron microscopic study. ( Shimamoto, F; Vollmer, E, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (31.25) | 18.7374 |
| 1990's | 4 (12.50) | 18.2507 |
| 2000's | 14 (43.75) | 29.6817 |
| 2010's | 4 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rubio, CA | 1 |
| Pérez-Holanda, S | 1 |
| Rodrigo, L | 1 |
| Pinyol-Felis, C | 1 |
| Vinyas-Salas, J | 1 |
| Moreira, AP | 1 |
| Sabarense, CM | 1 |
| Dias, CM | 1 |
| Lunz, W | 1 |
| Natali, AJ | 1 |
| Glória, MB | 1 |
| Peluzio, MC | 1 |
| Saini, MK | 1 |
| Vaiphei, K | 1 |
| Sanyal, SN | 1 |
| Salim, EI | 1 |
| Abou-Shafey, AE | 1 |
| Masoud, AA | 1 |
| Elgendy, SA | 1 |
| Jrah-Harzallah, H | 1 |
| Ben-Hadj-Khalifa, S | 1 |
| Almawi, WY | 1 |
| Maaloul, A | 1 |
| Houas, Z | 1 |
| Mahjoub, T | 1 |
| Yamagishi, M | 1 |
| Natsume, M | 1 |
| Osakabe, N | 1 |
| Okazaki, K | 1 |
| Furukawa, F | 1 |
| Imazawa, T | 1 |
| Nishikawa, A | 1 |
| Hirose, M | 3 |
| Kanna, PS | 1 |
| Mahendrakumar, CB | 1 |
| Chakraborty, T | 1 |
| Hemalatha, P | 1 |
| Banerjee, P | 1 |
| Chatterjee, M | 1 |
| Sakai, H | 1 |
| Tsukamoto, T | 1 |
| Yamamoto, M | 1 |
| Shirai, N | 1 |
| Iidaka, T | 1 |
| Hirata, A | 1 |
| Yanai, T | 1 |
| Masegi, T | 1 |
| Donehower, LA | 1 |
| Tatematsu, M | 1 |
| Nakaji, S | 2 |
| Ishiguro, S | 1 |
| Iwane, S | 1 |
| Ohta, M | 1 |
| Sugawara, K | 2 |
| Sakamoto, J | 1 |
| Fukuda, S | 1 |
| de Moreno de LeBlanc, A | 1 |
| Perdigón, G | 1 |
| Zoghbi, S | 1 |
| Drouin, E | 1 |
| Claustre, J | 1 |
| Bara, J | 2 |
| Scoazec, JY | 1 |
| Plaisancié, P | 1 |
| Santiago, C | 1 |
| Pagán, B | 1 |
| Isidro, AA | 1 |
| Appleyard, CB | 1 |
| Weitz, H | 1 |
| Kirscheneder, C | 1 |
| Wiebecke, B | 1 |
| Eder, M | 1 |
| Hattori, T | 1 |
| Helpap, B | 1 |
| Gedigk, P | 1 |
| Ee, HC | 1 |
| Erler, T | 1 |
| Bhathal, PS | 1 |
| Young, GP | 1 |
| James, RJ | 1 |
| Siegers, CP | 1 |
| Siemers, J | 1 |
| Baretton, G | 1 |
| Chitra, S | 1 |
| Viswanathan, P | 1 |
| Nalini, N | 1 |
| Sabitha, K | 1 |
| Menon, VP | 1 |
| Turusov, V | 1 |
| Trukhanova, L | 1 |
| Samoilov, D | 1 |
| Ravnik-Glavac, M | 1 |
| Cerar, A | 1 |
| Glavac, D | 1 |
| Endo, T | 1 |
| Ookawa, K | 1 |
| Tanaka, M | 1 |
| Tsuchida, S | 1 |
| Hoshiya, T | 1 |
| Mizoguchi, Y | 1 |
| Nakamura, A | 1 |
| Akagi, K | 1 |
| Shirai, T | 3 |
| Hagiwara, A | 1 |
| Yoshino, H | 1 |
| Ichihara, T | 1 |
| Kawabe, M | 1 |
| Tamano, S | 1 |
| Aoki, H | 1 |
| Koda, T | 1 |
| Nakamura, M | 1 |
| Imaida, K | 1 |
| Ito, N | 2 |
| Turusov, VS | 1 |
| Lanko, NS | 1 |
| Parfenov, IuD | 1 |
| Chemeris, GIu | 1 |
| Heitman, DW | 1 |
| Ord, VA | 1 |
| Hunter, KE | 1 |
| Cameron, IL | 1 |
| Jansson, B | 1 |
| Brodin, T | 1 |
| Sjögren, HO | 1 |
| Decaens, C | 1 |
| Gautier, R | 1 |
| Daher, N | 1 |
| Burtin, P | 1 |
| Lagadec, P | 1 |
| Jeannin, JF | 1 |
| Reisser, D | 1 |
| Pelletier, H | 1 |
| Olsson, O | 1 |
| Barton, TP | 1 |
| Cruse, JP | 1 |
| Lewin, MR | 1 |
| Shimamoto, F | 1 |
| Vollmer, E | 1 |
| Ikawa, E | 1 |
| Thamavit, W | 1 |
| Ahnen, DJ | 1 |
32 other studies available for 1,2-dimethylhydrazine and Carcinoma, Anaplastic
| Article | Year |
|---|---|
The Histogenesis of the Third Pathway of Colonic Carcinogenesis in Rats.
Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Carcinogenesis; Carcinoma; Carcinoma, Signet Ring Cell; Cel | 2017 |
Colonic perianastomotic carcinogenesis in an experimental model.
Topics: 1,2-Dimethylhydrazine; Anastomosis, Surgical; Animals; Carcinogens; Carcinoma; Colon; Colonic Neopla | 2008 |
Fish oil ingestion reduces the number of aberrant crypt foci and adenoma in 1,2-dimethylhydrazine-induced colon cancer in rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Carcinoma; Colonic Neoplasms; Fatty Aci | 2009 |
Chemoprevention of DMH-induced rat colon carcinoma initiation by combination administration of piroxicam and C-phycocyanin.
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Apoptosis; Carcinoma; Carrageenan; Colon; C | 2012 |
Cancer chemopreventive potential of the Egyptian flaxseed oil in a rat colon carcinogenesis bioassay--implications for its mechanism of action.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Adenoma; Animals; Anticarcinogenic Agents; Body Weight; | 2011 |
Effect of thymoquinone on 1,2-dimethyl-hydrazine-induced oxidative stress during initiation and promotion of colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Antioxidants; Benzoquinones; Body Weight; Carcinogens; Carcinoma; Ce | 2013 |
Chemoprevention of lung carcinogenesis by cacao liquor proanthocyanidins in a male rat multi-organ carcinogenesis model.
Topics: 1,2-Dimethylhydrazine; Animals; Anthocyanins; Anticarcinogenic Agents; Butylhydroxybutylnitrosamine; | 2003 |
Effect of vanadium on colonic aberrant crypt foci induced in rats by 1,2 dimethyl hydrazine.
Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Carcinogens; Carcinoma; Colon; Colonic Neoplasms; Cytochrom | 2003 |
High susceptibility of nullizygous p53 knockout mice to colorectal tumor induction by 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Carcinoma; Cell Transformation, Neoplastic; Colorectal | 2003 |
The prevention of colon carcinogenesis in rats by dietary cellulose is greater than the promotive effect of dietary lard as assessed by repeated endoscopic observation.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinoma; Cellulose; Colonic Neoplasms; Colonoscopy; Dietary Fats; | 2004 |
Reduction of beta-glucuronidase and nitroreductase activity by yoghurt in a murine colon cancer model.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Carcinoma; Colon; Colonic Neoplasms; Diet Therapy; Dise | 2005 |
Intestinal MUC2 and gastric M1/MUC5AC in preneoplastic lesions induced by 1,2-dimethylhydrazine in rat: a sequential analysis.
Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; beta Catenin; Carcinogens; Carcinoma; Cell Line, Tumor; Col | 2007 |
Prolonged chronic inflammation progresses to dysplasia in a novel rat model of colitis-associated colon cancer.
Topics: 1,2-Dimethylhydrazine; Adenomatous Polyposis Coli Protein; Animals; Carcinoma; Chronic Disease; Coli | 2007 |
The effect of cholecystectomy on the induction of colorectal tumors in mice by 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Carcinogens; Carcinoma; Cholecystectomy; Colonic Neoplasms; | 1984 |
Development and cell kinetics of colonic tumors induced in mice by dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Animals; Autoradiography; Carcinoma; Cell Division; | 1983 |
Cdx-2 homeodomain protein expression in human and rat colorectal adenoma and carcinoma.
Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Carcinoma; CDX2 Transcription Factor; Colon; Colonic Neopla | 1995 |
Sennosides and aloin do not promote dimethylhydrazine-induced colorectal tumors in mice.
Topics: 1,2-Dimethylhydrazine; Adenoma; Aloe; Animals; Anthraquinones; Carcinogens; Carcinoma; Cathartics; C | 1993 |
Role of redchilli (Capsaicin) in the formation of colonic carcinoma.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinoma; Colonic Diseases; Colonic Neoplasms; Dimethylhydrazines; | 1997 |
1,2-Dimethylhydrazine carcinogenesis in CBA male mice prenatally treated with diethylstilbestrol.
Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Carcinoma; Colonic Neoplasms; Diethylstilbestrol; Female; I | 2000 |
Animal model in the study of colorectal carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Animals; Carcinogens; Carcinoma; Colorectal Neoplasm | 2000 |
Differences in carcinogenesis by the length of carcinogen exposure period in rat colon.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Carcinoma; Colonic Neoplasms; Genes, APC; Genes, ras; M | 2001 |
Green tea catechins enhance tumor development in the colon without effects in the lung or thyroid after pretreatment with 1,2-Dimethylhydrazine or 2,2'-dihydroxy-di-n-propylnitrosamine in male F344 rats.
Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Body Weight; Carcinogens; Carcinoma; Catechin; Colonic Neop | 2001 |
Prevention by natural food anthocyanins, purple sweet potato color and red cabbage color, of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-associated colorectal carcinogenesis in rats initiated with 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Adenoma; Administration, Oral; Animals; Anthocyanins; Anticarcinogenic Agents | 2002 |
[1,2-dimethylhydrazine induction of epithelial tumors of the kidneys in CBA strain mice].
Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Carcinogens; Carcinoma; Cystadenocarcinoma; Dimethylhydrazi | 1990 |
Effect of dietary cellulose on cell proliferation and progression of 1,2-dimethylhydrazine-induced colon carcinogenesis in rats.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinoma; Cell Division; Cellulose; Colon; Colonic Neoplasms; Dieta | 1989 |
Recognition of a high molecular weight glycoprotein (HMW-GP) associated with rat colon cancer cells by rat monoclonal antibodies.
Topics: 1,2-Dimethylhydrazine; Animals; Antibodies, Monoclonal; Antibodies, Neoplasm; Antigens, Neoplasm; Ca | 1989 |
Induction of rat intestinal carcinogenesis with single doses, low and high repeated doses of 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinoma; Dimethylhydrazines; Dose-Response Relationship, Drug; Dru | 1989 |
Treatment with endotoxins of peritoneal carcinomatosis induced by colon tumor cells in the rat.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinoma; Colonic Neoplasms; Dimethylhydrazines; Endotoxins; Female | 1987 |
Changes in serum lipids related to the presence of experimental colon cancer.
Topics: 1,2-Dimethylhydrazine; Adenoma; Alanine Transaminase; Alkaline Phosphatase; Animals; Carcinoma; Chol | 1987 |
Changes in intestinal mucosa above lymph follicles during carcinogenesis in rats. A light and electron microscopic study.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinoma; Cecum; Colonic Neoplasms; Dimethylhydrazines; Duodenum; F | 1987 |
Modification by five antioxidants of 1,2-dimethylhydrazine-initiated colon carcinogenesis in F344 rats.
Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Antioxidants; Ascorbic Acid; Butylated Hydroxyanisole; Buty | 1985 |
Are animal models of colon cancer relevant to human disease.
Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Carcinoma; Colonic Neoplasms; Colonoscopy; Dimethylhydrazin | 1985 |