1,2-dimethylhydrazine has been researched along with Cancer of Rectum in 25 studies
1,2-Dimethylhydrazine: A DNA alkylating agent that has been shown to be a potent carcinogen and is widely used to induce colon tumors in experimental animals.
1,2-dimethylhydrazine : A member of the class of hydrazines that is hydrazine in which one of the hydrogens attached to each nitrogen is replaced by a methyl group. A powerful DNA alkylating agent and carcinogen, it is used to induce colon cancer in laboratory rats and mice.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Razoxane was given from week 25 until the end of experiment (week 35) to see if this drug could inhibit the development of tumours." | 1.27 | Inhibition of experimental colorectal cancer by razoxane (ICRF-159). ( Gilbert, JM; Kark, AE; Slavin, G; Thompson, EM, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (84.00) | 18.7374 |
| 1990's | 3 (12.00) | 18.2507 |
| 2000's | 1 (4.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dubina, MV | 1 |
| Petrishev, NN | 1 |
| Panchebko, AV | 1 |
| Fedorov, ES | 1 |
| Anisimov, VN | 1 |
| Hirono, I | 1 |
| Ueno, I | 1 |
| Aiso, S | 1 |
| Yamaji, T | 1 |
| Golberg, L | 1 |
| Hladík, V | 2 |
| Choluj, B | 2 |
| Vozenílek, J | 2 |
| Toth, B | 1 |
| Patil, K | 1 |
| James, JT | 1 |
| Shamsuddin, AM | 1 |
| Trump, BF | 1 |
| Weitz, H | 1 |
| Kirscheneder, C | 1 |
| Wiebecke, B | 1 |
| Eder, M | 1 |
| Gilbert, JM | 1 |
| Thompson, EM | 1 |
| Slavin, G | 1 |
| Kark, AE | 1 |
| Carachi, R | 1 |
| Beeley, JG | 1 |
| Traynor, OJ | 1 |
| Wood, CB | 1 |
| Costa, N | 1 |
| Tatematsu, M | 1 |
| Katsuyama, T | 1 |
| Nakanowatari, J | 1 |
| Hasegawa, R | 1 |
| Imaida, K | 1 |
| Fukushima, S | 1 |
| Ito, N | 1 |
| Filipe, MI | 1 |
| Scurr, JH | 1 |
| Ellis, H | 1 |
| Ingram, DM | 1 |
| Castleden, WM | 1 |
| Ee, HC | 1 |
| Erler, T | 1 |
| Bhathal, PS | 1 |
| Young, GP | 1 |
| James, RJ | 1 |
| Bjorkman, DJ | 1 |
| Samowitz, WS | 1 |
| Brigham, EJ | 1 |
| Peterson, BJ | 1 |
| Straight, RC | 1 |
| Siegers, CP | 1 |
| Bumann, D | 1 |
| Trepkau, HD | 1 |
| Schadwinkel, B | 1 |
| Baretton, G | 1 |
| Rowlatt, C | 1 |
| Cruse, JP | 1 |
| Barton, T | 1 |
| Sadrudin, AA | 1 |
| Lewin, MR | 1 |
| Zhang, WD | 1 |
| Greene, FL | 1 |
| Lamb, LS | 1 |
| Barwick, M | 1 |
| McGarrity, TJ | 2 |
| Via, EA | 1 |
| Colony, PC | 1 |
| Maley, MA | 1 |
| Agrez, MV | 1 |
| House, AK | 1 |
| Amberger, H | 1 |
| Colacchio, TA | 1 |
| Memoli, VA | 1 |
| Kolár, Z | 1 |
| Dufek, V | 1 |
| Krepela, E | 1 |
| Vicar, J | 1 |
| Král, V | 1 |
1 review available for 1,2-dimethylhydrazine and Cancer of Rectum
| Article | Year |
|---|---|
Colorectal cancer in animal models--a review.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Rats; Rectal Neo | 1987 |
24 other studies available for 1,2-dimethylhydrazine and Cancer of Rectum
| Article | Year |
|---|---|
[Circadian features of carcinogenesis of the large intestine induced by 1,2-dimethylhydrazine in rats].
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Circadian Rhythm; Colonic Neoplasms; Data Interpretatio | 2002 |
Enhancing effect of dextran sulfate sodium on colorectal carcinogenesis by 1,2-dimethylhydrazine in rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenocarcinoma, Mucinous; Adenoma; Animals; Cocarcinogenesis; | 1983 |
[The effect of appendectomy and cholecystectomy on the origin and development of carcinoma of the large intestine and rectum].
Topics: 1,2-Dimethylhydrazine; Animals; Appendectomy; Carcinogens; Cholecystectomy; Dimethylhydrazines; Fema | 1984 |
[An experimental model of cancer of the large intestine].
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Animals; Carcinogens; Cholestyramine Resin; Colonic | 1984 |
Enhancing effect of vitamin E on murine intestinal tumorigenesis by 1,2-dimethylhydrazine dihydrochloride.
Topics: 1,2-Dimethylhydrazine; Anal Gland Neoplasms; Animals; Cecal Neoplasms; Colonic Neoplasms; Diet; Dime | 1983 |
Comparative study of the morphologic, histochemical, and proliferative changes induced in the large intestine of ICR/Ha and C57BL/Ha mice by 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Animals; Cell Division; Colonic Neoplasms; Dimethylhydrazines; Female; Histoc | 1983 |
The effect of cholecystectomy on the induction of colorectal tumors in mice by 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Carcinogens; Carcinoma; Cholecystectomy; Colonic Neoplasms; | 1984 |
Inhibition of experimental colorectal cancer by razoxane (ICRF-159).
Topics: 1,2-Dimethylhydrazine; Animals; Body Weight; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Dru | 1984 |
Polyamines in colorectal cancer--a clinical and experimental approach.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Humans; Male; Ne | 1983 |
Ultrastructural alterations in the colonic mucus layer during carcinogenesis : a scanning electron microscopy study.
Topics: 1,2-Dimethylhydrazine; Animals; Colonic Neoplasms; Dimethylhydrazines; Humans; Intestinal Mucosa; Ma | 1982 |
Region-specific patterns of mucin reaction demonstrated by paradoxical concanavalin A-staining in normal colonic epithelium and in colorectal cancers induced in rats by 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Animals; Colon; Colonic Neoplasms; Concanavalin A; Dimethylhydrazines; Epithe | 1982 |
Effects of fecal stream on experimental colorectal carcinogenesis. Morphologic and histochemical changes.
Topics: 1,2-Dimethylhydrazine; Animals; Colonic Neoplasms; Dimethylhydrazines; Disease Models, Animal; Feces | 1982 |
Glucose increases experimentally induced colorectal cancer: a preliminary report.
Topics: 1,2-Dimethylhydrazine; Animals; Colonic Neoplasms; Dimethylhydrazines; Glucose; Male; Rats; Rats, In | 1981 |
Cdx-2 homeodomain protein expression in human and rat colorectal adenoma and carcinoma.
Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Carcinoma; CDX2 Transcription Factor; Colon; Colonic Neopla | 1995 |
Fluorescence localization of early colonic cancer in the rat by hematoporphyrin derivative.
Topics: 1,2-Dimethylhydrazine; Animals; Colonic Neoplasms; Dimethylhydrazines; False Positive Reactions; Fem | 1991 |
Role of iron in cell proliferation and tumorigenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogenicity Tests; Carcinogens; Cell Division; Cell Line; Coloni | 1991 |
Comparison of the significance of three histopathological thresholds of malignancy in experimental colorectal tumours.
Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Carcinogens; Carcinoma in Situ; Colonic Neoplasms; Dimethyl | 1989 |
[Cocarcinogenic and promoting effects of choleretic cholagogues on large bowel carcinogenesis evoked by 1,2-dimethylhydrazine in Wistar rats].
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Cholagogues and Choleretics; Colonic Neoplasms; Dimethy | 1988 |
Qualitative and quantitative changes in sialomucins during 1,2-dimethylhydrazine-induced colon carcinogenesis in the rat.
Topics: 1,2-Dimethylhydrazine; Animals; Colon; Colonic Neoplasms; Diet; Dimethylhydrazines; Ethanol; Mucins; | 1987 |
Growth factor-induced proliferative responses of human and DMH-induced rat colorectal tumour cell lines.
Topics: 1,2-Dimethylhydrazine; Animals; Cell Division; Cell Line; Colonic Neoplasms; Dimethylhydrazines; Epi | 1986 |
Different autochthonous models of colorectal cancer in the rat.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Colonic Neoplasms; Dimethylhydrazines; Dimethylnitro | 1986 |
Chemoprevention of colorectal neoplasms. Ascorbic acid and beta-carotene.
Topics: 1,2-Dimethylhydrazine; Animals; Ascorbic Acid; beta Carotene; Body Weight; Carotenoids; Colonic Neop | 1986 |
Dimethylhydrazine and ethanol.
Topics: 1,2-Dimethylhydrazine; Animals; Cocarcinogenesis; Dimethylhydrazines; Ethanol; Methylhydrazines; Rat | 1986 |
Changes in tissue and serum activity of cathepsin B-like cysteine proteinase during colorectal carcinogenesis by 1,2-dimethylhydrazine in mice.
Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Cathepsin B; Cathepsins; Colonic Neoplasms; Dimethylhydrazi | 1985 |