1,2-dimethylhydrazine has been researched along with Cancer of Gastrointestinal Tract in 15 studies
1,2-Dimethylhydrazine: A DNA alkylating agent that has been shown to be a potent carcinogen and is widely used to induce colon tumors in experimental animals.
1,2-dimethylhydrazine : A member of the class of hydrazines that is hydrazine in which one of the hydrogens attached to each nitrogen is replaced by a methyl group. A powerful DNA alkylating agent and carcinogen, it is used to induce colon cancer in laboratory rats and mice.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This study suggests that UDMH administered at the above dosage was not carcinogenic in this model." | 1.35 | Unsymmetrical DMH - an isomer of 1,2 DMH - is it potent to induce gastrointestinal carcinoma in rats? ( Christudoss, P; Fleming, JJ; Mathew, G; Pulimood, AB; Selvakumar, R, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (53.33) | 18.7374 |
| 1990's | 4 (26.67) | 18.2507 |
| 2000's | 3 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yamagishi, M | 1 |
| Natsume, M | 1 |
| Osakabe, N | 1 |
| Okazaki, K | 1 |
| Furukawa, F | 1 |
| Imazawa, T | 1 |
| Nishikawa, A | 1 |
| Hirose, M | 3 |
| Christudoss, P | 1 |
| Selvakumar, R | 1 |
| Pulimood, AB | 1 |
| Fleming, JJ | 1 |
| Mathew, G | 1 |
| McConnell, EE | 1 |
| Rutter, HA | 1 |
| Ulland, BM | 1 |
| Moore, JA | 1 |
| Klurfeld, DM | 1 |
| Aglow, E | 1 |
| Tepper, SA | 1 |
| Kritchevsky, D | 1 |
| Ronen, A | 1 |
| Heddle, JA | 1 |
| Koval, TM | 1 |
| Akagi, K | 1 |
| Hoshiya, T | 1 |
| Mizoguchi, Y | 1 |
| Ito, N | 2 |
| Shirai, T | 1 |
| Yada, H | 1 |
| Hakoi, K | 1 |
| Takahashi, S | 1 |
| Rao, J | 1 |
| Jagadeesan, V | 1 |
| Philipp-Staheli, J | 1 |
| Kim, KH | 1 |
| Payne, SR | 1 |
| Gurley, KE | 1 |
| Liggitt, D | 1 |
| Longton, G | 1 |
| Kemp, CJ | 1 |
| Takahashi, M | 1 |
| Imaida, K | 1 |
| Daniel, FB | 1 |
| DeAngelo, AB | 1 |
| Stober, JA | 1 |
| Pereira, MA | 1 |
| Olson, GR | 1 |
| O'Dwyer, PJ | 1 |
| McCabe, DP | 1 |
| Sickle-Santanello, BJ | 1 |
| Woltering, EA | 1 |
| Clausen, K | 1 |
| Martin, EW | 1 |
| Newberne, PM | 1 |
| Nauss, KM | 1 |
| Lindenschmidt, RC | 1 |
| Tryka, AF | 1 |
| Goad, ME | 1 |
| Witschi, HP | 1 |
2 reviews available for 1,2-dimethylhydrazine and Cancer of Gastrointestinal Tract
| Article | Year |
|---|---|
Modification of tumor development in the gastrointestinal tract.
Topics: 1,2-Dimethylhydrazine; Animals; Cocarcinogenesis; Diet; Dimethylhydrazines; Dimethylnitrosamine; Eso | 1991 |
Dietary fat and colon cancer: variable results in animal models.
Topics: 1,2-Dimethylhydrazine; Animals; Azoxymethane; Body Weight; Cocarcinogenesis; Colonic Neoplasms; Diet | 1986 |
13 other studies available for 1,2-dimethylhydrazine and Cancer of Gastrointestinal Tract
| Article | Year |
|---|---|
Chemoprevention of lung carcinogenesis by cacao liquor proanthocyanidins in a male rat multi-organ carcinogenesis model.
Topics: 1,2-Dimethylhydrazine; Animals; Anthocyanins; Anticarcinogenic Agents; Butylhydroxybutylnitrosamine; | 2003 |
Unsymmetrical DMH - an isomer of 1,2 DMH - is it potent to induce gastrointestinal carcinoma in rats?
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogenicity Tests; Dimethylhydrazines; Gastric Mucosa; Gastroint | 2008 |
Chronic effects of dietary exposure to amosite asbestos and tremolite in F344 rats.
Topics: 1,2-Dimethylhydrazine; Animals; Asbestos; Asbestos, Amosite; Asbestos, Amphibole; Body Weight; Cocar | 1983 |
Modification of dimethylhydrazine-induced carcinogenesis in rats by dietary cholesterol.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Cholesterol; Cholesterol, Dietary; Dimethylhydrazines; | 1983 |
Site-specific induction of nuclear anomalies (apoptotic bodies and micronuclei) by carcinogens in mice.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Cell Nucleus; Dimethylhydrazines; Esophageal Neoplasms; | 1984 |
Selective inhibition of replicative and repair DNA synthesis in mouse colon following administration of 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Animals; Caffeine; Colonic Neoplasms; Digestive System; Dimethylhydrazines; D | 1984 |
Modulating effects of ellagic acid, vanillin and quercetin in a rat medium term multi-organ carcinogenesis model.
Topics: 1,2-Dimethylhydrazine; Animals; Benzaldehydes; Butylhydroxybutylnitrosamine; Diethylnitrosamine; Dim | 1995 |
Modification of carcinogenesis by alpha-tocopherol, t-butylhydroquinone, propyl gallate and butylated hydroxytoluene in a rat multi-organ carcinogenesis model.
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Antioxidants; Butylated Hydroxytoluene; Car | 1993 |
Lipid peroxidation and activities of antioxidant enzymes in iron deficiency and effect of carcinogen feeding.
Topics: 1,2-Dimethylhydrazine; Administration, Oral; Animals; Carcinogens; Catalase; Cytosol; Dimethylhydraz | 1996 |
Pathway-specific tumor suppression. Reduction of p27 accelerates gastrointestinal tumorigenesis in Apc mutant mice, but not in Smad3 mutant mice.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Adenomatous Polyposis Coli Protein; Animals; beta Ca | 2002 |
Chloroform inhibition of 1,2-dimethylhydrazine-induced gastrointestinal tract tumors in the Fisher 344 rat.
Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Body Weight; Chloroform; Dimethylhydrazines; Gastrointestin | 1989 |
Use of polar solvents in chemoprevention of 1,2-dimethylhydrazine-induced colon cancer.
Topics: 1,2-Dimethylhydrazine; Animals; Body Weight; Colonic Neoplasms; Dimethyl Sulfoxide; Dimethylhydrazin | 1988 |
The effects of dietary butylated hydroxytoluene on liver and colon tumor development in mice.
Topics: 1,2-Dimethylhydrazine; Animals; Body Weight; Butylated Hydroxytoluene; Carcinogens; Colonic Neoplasm | 1986 |