1,2-dimethylhydrazine has been researched along with Adenocarcinoma in 166 studies
1,2-Dimethylhydrazine: A DNA alkylating agent that has been shown to be a potent carcinogen and is widely used to induce colon tumors in experimental animals.
1,2-dimethylhydrazine : A member of the class of hydrazines that is hydrazine in which one of the hydrogens attached to each nitrogen is replaced by a methyl group. A powerful DNA alkylating agent and carcinogen, it is used to induce colon cancer in laboratory rats and mice.
Adenocarcinoma: A malignant epithelial tumor with a glandular organization.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The aim of this study was to investigate the ability of RA to prevent 1,2-dimethylhydrazine (DMH)-induced primary DNA damage and aberrant crypt foci (ACF) in Wistar rat colon." | 7.81 | Chemopreventive effects of rosmarinic acid on rat colon carcinogenesis. ( Cleto, SS; Cunha, WR; Furtado, RA; Munari, CC; Oliveira, BR; Silva, LR; Tavares, DC, 2015) |
| " This study was to evaluate the preventive effects of coloclysis of NaB on 1,2-dimethylhydrazine (DMH)-induced tumorigenesis of colorectal cancer in mice." | 7.73 | [Inhibitory effect of sodium butyrate on 1,2-dimethylhydrazine-induced tumorigenesis of colorectal cancer in mice]. ( Geng, XL; Huang, LH; Li, TJ; Liu, CX; Wang, B; Zhang, SZ; Zhang, XW, 2005) |
| " In the present study, we investigated whether colonic neoplasms can be developed in mice initiated with a single injection of another genotoxic colonic carcinogen 1,2-dimethylhydrazine (DMH), instead of AOM and followed by exposure of DSS in drinking water." | 7.73 | Beta-Catenin mutations in a mouse model of inflammation-related colon carcinogenesis induced by 1,2-dimethylhydrazine and dextran sodium sulfate. ( Kohno, H; Sugie, S; Suzuki, R; Tanaka, T, 2005) |
| "The modifying effect of pregnancy and lactation on carcinogenesis induced by single injection of 1,2-dimethylhydrazine to female rats 30 days before mating has been studied." | 7.68 | [Modifying effects of changes connected with pregnancy on 1,2-dimethylhydrazine-induced carcinogenesis in rats]. ( Blinova, GA; Mikheev, AM; Napalkov, NP, 1990) |
| "Three different tumour cell lines (Per113, Per192, Per237) were established from colon adenocarcinomas induced by 1,2-dimethylhydrazine (DMH) inbred male Wistar/Wag rats." | 7.67 | Three new rat colon tumour cell lines from 1,2-dimethylhydrazine induced adenocarcinomas: morphology, karyotype and clonogenicity. ( Agrez, MV; House, AK; Jenkyn, DJ; Maley, MA, 1987) |
| "Almost equal inhibitory effects on tubular adenocarcinomas were also observed in the rats given 150 ppm JTE-522 during the postinitiation stage, suggesting that its major anticancer action is at the postinitiation phase." | 5.33 | JTE-522, a selective cyclooxygenase-2 inhibitor, inhibits induction but not growth and invasion of 1,2-dimethylhydrazine-induced tubular adenocarcinomas of colon in rats. ( Fukushima, S; Hakoi, K; Moku, M; Morimura, K; Salim, EI; Shen, J; Wanibuchi, H; Wei, M, 2005) |
| " weekly after the 1st 2 drug doses, the dosage as base being 9." | 5.29 | Action of estrogen and adrenocorticoids on adenocarcinoma induction by 1,2-dimethylhydrazine in male rats. ( Gershbein, LL, 1993) |
| "Male, Sprague-Dawley rats were injected subcutaneously with the colon carcinogen 1,2-dimethylhydrazine (DMH) at a dosage of 9." | 5.29 | Colonic crypts located over lymphoid nodules of 1,2-dimethylhydrazine-treated rats are hyperplastic and at high risk of forming adenocarcinomas. ( Cameron, IL; Hardman, WE, 1994) |
| " The aim of this study was to investigate the ability of RA to prevent 1,2-dimethylhydrazine (DMH)-induced primary DNA damage and aberrant crypt foci (ACF) in Wistar rat colon." | 3.81 | Chemopreventive effects of rosmarinic acid on rat colon carcinogenesis. ( Cleto, SS; Cunha, WR; Furtado, RA; Munari, CC; Oliveira, BR; Silva, LR; Tavares, DC, 2015) |
| " In the present study, we investigated whether colonic neoplasms can be developed in mice initiated with a single injection of another genotoxic colonic carcinogen 1,2-dimethylhydrazine (DMH), instead of AOM and followed by exposure of DSS in drinking water." | 3.73 | Beta-Catenin mutations in a mouse model of inflammation-related colon carcinogenesis induced by 1,2-dimethylhydrazine and dextran sodium sulfate. ( Kohno, H; Sugie, S; Suzuki, R; Tanaka, T, 2005) |
| " This study was to evaluate the preventive effects of coloclysis of NaB on 1,2-dimethylhydrazine (DMH)-induced tumorigenesis of colorectal cancer in mice." | 3.73 | [Inhibitory effect of sodium butyrate on 1,2-dimethylhydrazine-induced tumorigenesis of colorectal cancer in mice]. ( Geng, XL; Huang, LH; Li, TJ; Liu, CX; Wang, B; Zhang, SZ; Zhang, XW, 2005) |
| " adenomas in 1,2-dimethylhydrazine (DMH)-treated CF1 mice." | 3.70 | Colonic cell proliferation and aberrant crypt foci formation are inhibited by dairy glycosphingolipids in 1, 2-dimethylhydrazine-treated CF1 mice. ( Dillehay, DL; Merrill, AH; Schmelz, EM; Sullards, MC, 2000) |
| "This study tested the effect of a new gastrin receptor antagonist, CR2945, on colorectal cancer induced by 1,2-dimethylhydrazine (DMH) in mice." | 3.70 | Inhibitory effect of a gastrin receptor antagonist, CR2945, on 1, 2-dimethylhydrazine-induced colorectal cancer in mice. ( Di Betta, E; Donato, F; Fontana, MG; Ghirardi, M; Moneghini, D; Salerni, B; Villanacci, V, 1999) |
| " injections of 1,2-dimethylhydrazine (DMH) at a single dose of 21 mg/kg of body weight." | 3.69 | Melatonin and colon carcinogenesis: I. Inhibitory effect of melatonin on development of intestinal tumors induced by 1,2-dimethylhydrazine in rats. ( Anisimov, VN; Popovich, IG; Zabezhinski, MA, 1997) |
| " A high incidence of colorectal adenocarcinomas with varied grades of cell differentiation can be induced by 1,2-dimethylhydrazine (DMH) in rats." | 3.69 | Preventive effect of 1-(2-tetrahydrofuryl)-5-fluorouracil in combination with uracil on colonic carcinogenesis induced by 1,2-dimethylhydrazine in rats. ( Iwama, T; Kawachi, Y; Kudo, H; Murakami, S; Okayasu, I; Sagara, T; Sakamoto, S; Tsukada, K, 1997) |
| "Supplementation of the diet of CF1 mice with sphingomyelin isolated from milk has been shown to reduce the number of aberrant crypt foci (ACF) and the appearance of colonic adenocarcinoma induced by 1,2-dimethylhydrazine (Schmelz et al." | 3.69 | Suppression of aberrant colonic crypt foci by synthetic sphingomyelins with saturated or unsaturated sphingoid base backbones. ( Bushnev, AS; Dillehay, DL; Liotta, DC; Merrill, AH; Schmelz, EM, 1997) |
| "The modifying effect of pregnancy and lactation on carcinogenesis induced by single injection of 1,2-dimethylhydrazine to female rats 30 days before mating has been studied." | 3.68 | [Modifying effects of changes connected with pregnancy on 1,2-dimethylhydrazine-induced carcinogenesis in rats]. ( Blinova, GA; Mikheev, AM; Napalkov, NP, 1990) |
| "Protein kinase C activity and the profile of protein kinase C isozymes alpha, beta, and gamma were examined in subcellular fractions of 1,2-dimethylhydrazine induced colonic adenocarcinomas, surrounding uninvolved colonic mucosa and colonic mucosa from age matched control rats." | 3.68 | Alterations in protein kinase C in 1,2-dimethylhydrazine induced colonic carcinogenesis. ( Craven, PA; DeRubertis, FR, 1992) |
| " Fischer F344 rats receiving 20mg/kg of 1,2-dimethylhydrazine per week for 20 weeks developed adenocarcinoma of the colon." | 3.68 | [Establishment of a transplantable rat colon cancer and a model of metastasis]. ( Yasuda, S, 1993) |
| "N-linked glycopeptides were prepared from colonic tumor (adenocarcinoma) and mucosa in rats treated with carrageenan, an indigestible polysaccharide, and 1,2-dimethylhydrazine." | 3.67 | N-acetylneuraminic acid and N-glycolylneuraminic acid in glycopeptides of colonic tumor and mucosa in rats treated with carrageenan and 1,2-dimethylhydrazine. ( Arakawa, S; Ishihara, H; Tejima, S; Wakazono, H, 1989) |
| "Recently, our laboratory, utilizing the 1,2-dimethylhydrazine model of colonic adenocarcinoma, demonstrated alterations in the 'dynamic component' of fluidity in brush-border membranes prepared from distal colonocytes of rats administered this agent for 5, 10 and 15 weeks, i." | 3.67 | The role of sphingomyelin synthetase and sphingomyelinase in 1,2-dimethylhydrazine-induced lipid alterations of rat colonic plasma membranes. ( Brasitus, TA; Dahiya, R; Dudeja, PK, 1986) |
| "Using NIH3T3 cell transfection assay, activated c-K-ras was detected in two cell lines, TRb and TSb, obtained from a single colon adenocarcinoma induced in a rat by 1,2-dimethylhydrazine." | 3.67 | Activated K-ras in tumorigenic and non-tumorigenic cell variants from a rat colon adenocarcinoma, induced by dimethylhydrazine. ( Caignard, A; Kitagawa, Y; Nagao, M; Sato, S, 1988) |
| "5% corn oil or lard 2 weeks before, during, and until 1 week after sc injection of 15 mg azoxymethane [(AOM) CAS: 25843-45-2]/kg body weight, once weekly for 2 weeks (designated as initiation)." | 3.67 | Effect of different levels of dietary corn oil and lard during the initiation phase of colon carcinogenesis in F344 rats. ( Maruyama, H; Reddy, BS, 1986) |
| "Three different tumour cell lines (Per113, Per192, Per237) were established from colon adenocarcinomas induced by 1,2-dimethylhydrazine (DMH) inbred male Wistar/Wag rats." | 3.67 | Three new rat colon tumour cell lines from 1,2-dimethylhydrazine induced adenocarcinomas: morphology, karyotype and clonogenicity. ( Agrez, MV; House, AK; Jenkyn, DJ; Maley, MA, 1987) |
| "Mice from strains with different susceptibility to the colon-specific carcinogen 1,2-dimethylhydrazine (DMH) were tested for DNA damage in liver, kidney and colon after administration of the compound at a dosage that has been reported to induce a high incidence of adenocarcinoma in the colon of rodents." | 3.67 | Correlation between incidence of 1,2-dimethylhydrazine-induced colon carcinomas and DNA damage in six genetically different mouse strains. ( Boffa, LC; Bolognesi, C, 1986) |
| "Diallyl sulfide, a thioether found naturally in garlic, when given by gavage to C57BL/6J mice inhibited by 74% the incidence and reduced the frequency of colorectal adenocarcinoma induced by 20 weekly injections of 1,2-dimethylhydrazine." | 3.67 | Diallyl sulfide, a flavor component of garlic (Allium sativum), inhibits dimethylhydrazine-induced colon cancer. ( Wargovich, MJ, 1987) |
| "The induction of adenocarcinomas in distal colons of noninbred female Swiss Webster white mice by 1,2-dimethylhydrazine (DMH) is preceded by the development of hyperplasia of mucosal glands, which includes absolute increases in both the total number of cells and labeled cells per crypt." | 3.66 | Changes in crypt cell populations of mouse colon during recovery from treatment with 1,2-dimethylhydrazine. ( Richards, TC, 1981) |
| "Gut endocrine cells in a total of 122 intestinal-tract adenocarcinomas induced in inbred Wistar rats by 1,2-dimethylhydrazine dihydrochloride were examined histologically, ultrastructurally, and immunohistochemically for gastrin, somatostatin, vasoactive-intestinal polypeptide (VIP), and glicentin (enteroglucagon)." | 3.66 | Gut endocrine cells in rat intestinal-tract carcinoma induced by 1,2-dimethylhydrazine. ( Shimamoto, F; Tahara, E; Yanaihara, N, 1983) |
| "To study the effect of acetic acid colitis on 1,2-dimethylhydrazine-induced colon tumorigenesis, fischer 344 male rats, 10 weeks of age, were divided into three groups: one receiving 5% acetic acid enema (subgroup 1a); one receiving 10% acetic acid enema (subgroup 1b); and one not receiving acetic acid enema (group 2)." | 3.66 | Experimental colitis as a promoter in large-bowel tumorigenesis. ( Hagihara, PF, 1982) |
| " A dosage of 40 micrograms/kg was lethal when given i." | 2.67 | Injection of recombinant tumor necrosis factor directly into liver metastases: an experimental and clinical approach. ( Geerling, RA; IJzermans, JN; Jeekel, J; Marquet, RL; Scheringa, M; van der Schelling, GP, 1992) |
| "Colon cancer is accompanied by a decrease of epithelial barrier properties, which are determined by tight junction (TJ) proteins between adjacent epithelial cells." | 1.62 | Effects of 1,2-Dimethylhydrazine on Barrier Properties of Rat Large Intestine and IPEC-J2 Cells. ( Amasheh, S; Bekusova, V; Droessler, L; Markov, AG, 2021) |
| "Colorectal tumors were studied 5 months after carcinogen injection to outbred albino rats with secondary immunodeficiency by common histological and immunobiochemical methods with the use of monoclonal and polyclonal antibodies to Ki-67, Bcl-2, p53, and VEGF." | 1.48 | New Experimental Facts on the Influence of Secondary Immunodeficiency on the Morphology and Biological Activity of Colorectal Tumor. ( Kostrova, OY; Merkulova, LM; Mikhailova, MN; Moskvichev, EV; Struchko, GY, 2018) |
| "DLD-1 human colon cancer cells were utilized to investigate the effect of AGE on anti-cell proliferation." | 1.42 | Aged garlic extract inhibits 1,2-dimethylhydrazine-induced colon tumor development by suppressing cell proliferation. ( Hirokawa, M; Jikihara, H; Nozoe, K; Qi, G; Sato, H; Shimamoto, F; Sugihara, Y, 2015) |
| "Genetic mutations relevant to human colon cancer have been described in this model, but comprehensive gene expression and genomic analysis have not been reported so far." | 1.36 | Gene expression profile and genomic alterations in colonic tumours induced by 1,2-dimethylhydrazine (DMH) in rats. ( Caderni, G; Dolara, P; Femia, AP; Giannini, A; Luceri, C; Toti, S, 2010) |
| "Almost equal inhibitory effects on tubular adenocarcinomas were also observed in the rats given 150 ppm JTE-522 during the postinitiation stage, suggesting that its major anticancer action is at the postinitiation phase." | 1.33 | JTE-522, a selective cyclooxygenase-2 inhibitor, inhibits induction but not growth and invasion of 1,2-dimethylhydrazine-induced tubular adenocarcinomas of colon in rats. ( Fukushima, S; Hakoi, K; Moku, M; Morimura, K; Salim, EI; Shen, J; Wanibuchi, H; Wei, M, 2005) |
| "Further studies on fresh human tumors were conducted with a novel topoisomerase II inhibitor, NC-190." | 1.33 | Image analysis using the fluorochromasia assay to quantify tumor drug sensitivity. ( Gibbs, JF; Rustum, YM; Slocum, HK, 2005) |
| "Colorectal tumors were induced by means of 15 s." | 1.31 | Animal model in the study of colorectal carcinogenesis. ( Cerar, A; Glavac, D; Ravnik-Glavac, M, 2000) |
| "Carcinoma in situ was identified in two specimens by fluorescence, and one fluorescent specimen contained dysplasia." | 1.29 | Photo detection of carcinoma of the colon in a rat model: a pilot study. ( Clements, BM; McBrearty, FX; von Rueden, DG; Woratyla, S, 1993) |
| "To examine the influence of hypercholesteremia on 1,2-dimethylhydrazine (DMH)-induced rat colon cancer, Sprague-Dawley rats received dietary cholesterol (CH, 0-2%) and cholic acid (CA, 0." | 1.29 | Promotion of colon carcinogenesis through increasing lipid peroxidation induced in rats by a high cholesterol diet. ( Chu, CY; Hsu, JD; Tseng, TH; Wang, CJ, 1996) |
| " weekly after the 1st 2 drug doses, the dosage as base being 9." | 1.29 | Action of estrogen and adrenocorticoids on adenocarcinoma induction by 1,2-dimethylhydrazine in male rats. ( Gershbein, LL, 1993) |
| "Male, Sprague-Dawley rats were injected subcutaneously with the colon carcinogen 1,2-dimethylhydrazine (DMH) at a dosage of 9." | 1.29 | Colonic crypts located over lymphoid nodules of 1,2-dimethylhydrazine-treated rats are hyperplastic and at high risk of forming adenocarcinomas. ( Cameron, IL; Hardman, WE, 1994) |
| "To evaluate possible nephroblastoma induction in young Sprague-Dawley male rats by 1,2-dimethylhydrazine (DMH), agents including inhibitors and stimulators of the carcinogenesis were tested concurrently in 2 experiments." | 1.29 | Tumors produced in rats with a single dosage of 1,2-dimethylhydrazine. ( Amir-Mokri, E; Brown, ME; Gershbein, LL; Rezai, VK, 1993) |
| "Melatonin was also shown to inhibit carcinogenesis in the small intestine." | 1.29 | [Effect of melatonin on 1,2-dimethylhydrazine-induced intestinal tumors in rats]. ( Anisimov, VN; Muratov, EI; Popovich, IG, 1996) |
| "Hydralazine and isoniazid were also tested by the subcutaneous (sc) route at weekly dosages of 17 and 83 mg/kg, respectively, in both intact and partially hepatectomized rats, but many succumbed after 7 to 49 weeks of treatment." | 1.28 | Action of hydrazine drugs in tumor-free and 1,2-dimethylhydrazine-treated male rats. ( Gershbein, LL; Rao, KC, 1992) |
| "Colon cancer was detected in two male monkeys after total DMH doses of 1080 and 3696 mg (528 and 400 mg/kg body wt." | 1.28 | Tumor induction in monkeys after administration of dimethylhydrazine. ( Beniashvili, DS; Krutovskikh, VA; Sartania, MS; Turusov, VS, 1992) |
| "The incidence of intestinal cancer in the control group (dimethylhydrazine only) was 91 percent; in groups provided with inorganic germanium one month before and during dimethylhydrazine treatment, and during dimethylhydrazine treatment only, it was 91 and 78 percent; in groups provided with organic germanium one month before and during dimethylhydrazine treatment, and during dimethylhydrazine treatment only, it was 64 and 64 percent; in groups provided with natural organic germanium one month before and during dimethylhydrazine treatment and during dimethylhydrazine treatment only, it was 50 and 45 percent." | 1.28 | Effect of germanium on 1,2-dimethylhydrazine-induced intestinal cancer in rats. ( Ho, YS; Jao, SW; Lee, W, 1990) |
| "Colonic cancers were induced in rats by subcutaneous injection of 1,2-Dimethylhydrazine." | 1.28 | [Growth rate of experimental colonic cancer in rats]. ( Shibusawa, M; Takimoto, M; Tsunoda, A, 1990) |
| "Indomethacin was given orally to 40 of the rats." | 1.28 | Effect of indomethacin in autotransplanted colonic tumors. ( Duvander, A; Rubio, CA; Sveander, M; Wallin, B; Ware, J, 1989) |
| "Using colonic cancer induced by DMH as experimental model, carcinogenic rate in the rats with or without partial colectomy was compared in order to study the etiology of the local recurrence of large bowel cancer after radical resection and observe the influence of operative injury on carcinogenesis." | 1.27 | [Colonic cancer induced by 1,2-dimethylhydrazine (DMH) in rats after partial colectomy]. ( Wang, CG; Wang, JF; Wang, JP, 1987) |
| " Because dosage schedules are known from previous experiments with the Nb rat, this animal model may be useful for evaluating the effects of cytotoxic drugs on experimental bowel cancer." | 1.27 | Experimental cancer of the bowel in the Nb rat. ( Drago, JR; Joehl, RJ, 1983) |
| "Colon cancer was produced in rats by weekly injections (20 mg/kg b." | 1.27 | Stimulating effect of pentagastrin on cancer cell proliferation kinetics in chemically induced colon cancer in rats. ( Lamote, J; Willems, G, 1988) |
| "In DMH-induced colonic cancer, the incidence as well as the concentration was higher in male rats (60." | 1.27 | Steroid receptors in dimethylhydrazine-induced colon carcinogenesis. ( Demura, H; Demura, R; Jibiki, K; Kato, Y; Nakamura, S; Oda, S; Odagiri, E, 1985) |
| "Rats of 3 inbred strains (DA, HS and AS2) were dosed with 1,2-dimethylhydrazine 2HCl (DMH) or saline by gavage weekly for 10 wk." | 1.26 | The response of three inbred strains of rat to the carcinogen 1,2-dimethylhydrazine. ( Gavin, JB; Herdson, PB; Teague, CA, 1981) |
| "Cholesterol feeding of rats with colon cancer induced by dimethylhydrazine results in reduced survival and an increased incidence of metastatic colon cancer." | 1.26 | Dietary cholesterol deprivation improves survival and reduces incidence of metastatic colon cancer in dimethylhydrazine-pretreated rats. ( Clark, CG; Cruse, JP; Lewin, MR, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 65 (39.16) | 18.7374 |
| 1990's | 57 (34.34) | 18.2507 |
| 2000's | 31 (18.67) | 29.6817 |
| 2010's | 12 (7.23) | 24.3611 |
| 2020's | 1 (0.60) | 2.80 |
| Authors | Studies |
|---|---|
| Bekusova, V | 1 |
| Droessler, L | 1 |
| Amasheh, S | 1 |
| Markov, AG | 1 |
| Yang, Y | 1 |
| Takahara, K | 1 |
| Kumrungsee, T | 1 |
| Kimoto, A | 1 |
| Shimamoto, F | 3 |
| Kato, N | 2 |
| Struchko, GY | 1 |
| Merkulova, LM | 1 |
| Moskvichev, EV | 1 |
| Kostrova, OY | 1 |
| Mikhailova, MN | 1 |
| Sadik, NA | 1 |
| Shaker, OG | 1 |
| Furtado, RA | 1 |
| Oliveira, BR | 1 |
| Silva, LR | 1 |
| Cleto, SS | 1 |
| Munari, CC | 1 |
| Cunha, WR | 1 |
| Tavares, DC | 1 |
| Jikihara, H | 1 |
| Qi, G | 1 |
| Nozoe, K | 1 |
| Hirokawa, M | 1 |
| Sato, H | 1 |
| Sugihara, Y | 1 |
| Dong, Y | 1 |
| Wu, G | 1 |
| Sun, T | 1 |
| Liu, S | 1 |
| Zhou, Y | 1 |
| Yao, Z | 1 |
| Zhang, D | 1 |
| Cao, S | 1 |
| Wei, Z | 1 |
| Tan, B | 1 |
| Li, Y | 1 |
| Lian, Z | 1 |
| Wang, S | 1 |
| Soroka, Y | 1 |
| Lisnychuk, N | 1 |
| Demkiv, I | 1 |
| Oleshchuk, O | 1 |
| Panchenko, AV | 1 |
| Petrishchev, NN | 1 |
| Kvetnoĭ, IM | 1 |
| Anisimov, VN | 5 |
| Aranganathan, S | 1 |
| Nalini, N | 1 |
| Moreira, AP | 1 |
| Sabarense, CM | 1 |
| Dias, CM | 1 |
| Lunz, W | 1 |
| Natali, AJ | 1 |
| Glória, MB | 1 |
| Peluzio, MC | 1 |
| Femia, AP | 1 |
| Luceri, C | 2 |
| Toti, S | 1 |
| Giannini, A | 1 |
| Dolara, P | 1 |
| Caderni, G | 2 |
| Chadha, VD | 1 |
| Garg, ML | 1 |
| Dhawan, D | 1 |
| Karaca, O | 1 |
| Ertekin, T | 1 |
| Canoz, O | 1 |
| Ulger, H | 1 |
| Soysal, H | 1 |
| Kus, I | 1 |
| Wu, T | 1 |
| Zheng, WL | 1 |
| Zhang, SZ | 2 |
| Sun, JH | 1 |
| Yuan, H | 1 |
| Steele, G | 4 |
| Chrissey, M | 1 |
| Gittes, R | 2 |
| Corson, J | 2 |
| Wilson, R | 2 |
| Onose, J | 1 |
| Imai, T | 2 |
| Hasumura, M | 2 |
| Ueda, M | 1 |
| Hirose, M | 4 |
| Hur, K | 1 |
| Kim, JR | 1 |
| Yoon, BI | 1 |
| Lee, JK | 1 |
| Choi, JH | 1 |
| Oh, GT | 1 |
| Kim, DY | 1 |
| Durowicz, S | 1 |
| Olszewski, WL | 1 |
| Noguera Aguilar, JF | 1 |
| Amengual Antich, I | 1 |
| Plaza Martínez, A | 1 |
| Tortajada Collado, C | 1 |
| Morón Canis, JM | 1 |
| Pujol Tugores, JJ | 1 |
| Wang, JG | 1 |
| Wang, DF | 1 |
| Lv, BJ | 1 |
| Si, JM | 1 |
| Wei, M | 1 |
| Morimura, K | 1 |
| Wanibuchi, H | 1 |
| Shen, J | 1 |
| Salim, EI | 1 |
| Moku, M | 1 |
| Hakoi, K | 1 |
| Fukushima, S | 1 |
| Kohno, H | 1 |
| Suzuki, R | 1 |
| Sugie, S | 1 |
| Tanaka, T | 2 |
| Gibbs, JF | 1 |
| Rustum, YM | 1 |
| Slocum, HK | 1 |
| Liu, CX | 1 |
| Zhang, XW | 1 |
| Geng, XL | 1 |
| Li, TJ | 1 |
| Huang, LH | 1 |
| Wang, B | 1 |
| Kirley, SD | 1 |
| D'Apuzzo, M | 1 |
| Lauwers, GY | 1 |
| Graeme-Cook, F | 1 |
| Chung, DC | 1 |
| Zukerberg, LR | 1 |
| Tsukamoto, T | 1 |
| Sakai, H | 1 |
| Hirata, A | 1 |
| Fukami, H | 1 |
| Tatematsu, M | 1 |
| Di Pace, RF | 1 |
| Massa, S | 1 |
| Ribeiro, OG | 1 |
| Cabrera, WH | 1 |
| De Franco, M | 1 |
| Starobinas, N | 1 |
| Seman, M | 1 |
| Ibañez, OC | 1 |
| Chin, YW | 1 |
| Jung, HA | 1 |
| Liu, Y | 1 |
| Su, BN | 1 |
| Castoro, JA | 1 |
| Keller, WJ | 1 |
| Pereira, MA | 1 |
| Kinghorn, AD | 1 |
| Marzocchini, R | 1 |
| Malentacchi, F | 1 |
| Biagini, M | 1 |
| Cirelli, D | 1 |
| Raugei, G | 1 |
| Cho, YM | 1 |
| Ota, Y | 1 |
| Takami, S | 1 |
| Nishikawa, A | 1 |
| Tahara, E | 1 |
| Yanaihara, N | 1 |
| Takemiya, M | 2 |
| Miyayama, H | 2 |
| Takeuchi, T | 2 |
| Hirono, I | 1 |
| Ueno, I | 1 |
| Aiso, S | 1 |
| Yamaji, T | 1 |
| Golberg, L | 1 |
| Teague, CA | 1 |
| Gavin, JB | 1 |
| Herdson, PB | 1 |
| Jacobs, LR | 2 |
| Choluj, B | 1 |
| Hladík, V | 1 |
| Vozenílek, J | 1 |
| Howarth, AE | 1 |
| Pihl, E | 1 |
| Decaëns, C | 2 |
| Rosa, B | 1 |
| Bara, J | 3 |
| Daher, N | 2 |
| Burtin, P | 1 |
| Ross, DS | 1 |
| Madara, J | 1 |
| Lahey, SJ | 1 |
| Ravikumar, TS | 2 |
| Wilson, RE | 1 |
| Munroe, AE | 1 |
| Wright, D | 1 |
| King, VP | 1 |
| Stevens, RH | 2 |
| Cole, DA | 2 |
| Joehl, RJ | 1 |
| Drago, JR | 1 |
| Kamiya, J | 1 |
| Saito, Y | 2 |
| Muto, T | 1 |
| Morioka, Y | 1 |
| Morgenstern, L | 1 |
| Amodeo, P | 1 |
| Vimadalal, S | 1 |
| Jones, FE | 1 |
| Komorowski, RA | 1 |
| Condon, RE | 1 |
| Rubio, CA | 4 |
| Nylander, G | 2 |
| Wallin, B | 2 |
| Sveander, M | 3 |
| Alun, ML | 2 |
| Duvander, A | 3 |
| Meek, ES | 1 |
| Hattori, T | 1 |
| Helpap, B | 1 |
| Gedigk, P | 1 |
| Mizutani, T | 1 |
| Mitsuoka, T | 1 |
| Newaz, SN | 1 |
| Fang, WF | 1 |
| Strobel, HW | 1 |
| Richards, TC | 1 |
| Kowal, EP | 1 |
| Markus, G | 1 |
| Cruse, JP | 1 |
| Lewin, MR | 1 |
| Clark, CG | 1 |
| Hagihara, PF | 1 |
| Krutovskikh, VA | 3 |
| Turusov, VS | 3 |
| Crissey, M | 1 |
| Harte, P | 1 |
| Bird, RP | 1 |
| Gershbein, LL | 5 |
| Jagadeesan, V | 1 |
| Rao, NJ | 1 |
| Sesikeran, B | 1 |
| Narisawa, T | 1 |
| Fukaura, Y | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Double-blind, Randomized, Placebo-controlled Study to Evaluate the Effects of a Weight Management Program on Body Weight in Individuals Who Are Overweight and Otherwise Healthy[NCT04107155] | 54 participants (Actual) | Interventional | 2019-07-23 | Completed | |||
| A Randomized Controlled Trial to Evaluate the Effects of Repeated Periods of Modified Fasting to Support Healthy Natural Weight Management and Prevention of Weight Gain in Overweight But Generally Healthy Adults Over the Winter Holiday Period[NCT03372109] | 23 participants (Actual) | Interventional | 2017-11-14 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for 1,2-dimethylhydrazine and Adenocarcinoma
| Article | Year |
|---|---|
Role of aberrant crypt foci in understanding the pathogenesis of colon cancer.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Animals; Azoxymethane; Carcinogens; Cholic Acid; Cho | 1995 |
Gastrointestinal tumours after stapler vs vicryl anastomoses in carcinogen-treated rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; | 1990 |
1 trial available for 1,2-dimethylhydrazine and Adenocarcinoma
| Article | Year |
|---|---|
Injection of recombinant tumor necrosis factor directly into liver metastases: an experimental and clinical approach.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adult; Aged; Animals; Carcinogens; Colitis, Ulcerative; Colon | 1992 |
163 other studies available for 1,2-dimethylhydrazine and Adenocarcinoma
| Article | Year |
|---|---|
Effects of 1,2-Dimethylhydrazine on Barrier Properties of Rat Large Intestine and IPEC-J2 Cells.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Cell Line; Claudins; Colonic Neoplasms; | 2021 |
Consumption of Low-Dose of Ethanol Suppresses Colon Tumorigenesis in 1,2-Dimethylhydrazine-Treated Rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Antineoplastic Agents; Carcinogenesis; Colon; Coloni | 2019 |
New Experimental Facts on the Influence of Secondary Immunodeficiency on the Morphology and Biological Activity of Colorectal Tumor.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Antibodies; Biomarkers, Tumor; Cell Differentiation; | 2018 |
Inhibitory effect of a standardized pomegranate fruit extract on Wnt signalling in 1, 2-dimethylhydrazine induced rat colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Antineoplastic Agents, Phytogenic; Carcinogens; Colo | 2013 |
Chemopreventive effects of rosmarinic acid on rat colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Adenocarcinoma; Animals; Antioxidants; Carcinogenesis; C | 2015 |
Aged garlic extract inhibits 1,2-dimethylhydrazine-induced colon tumor development by suppressing cell proliferation.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Animals; Anticarcinogenic Agents; Blotting, Western; | 2015 |
Azadircta indica as a modulator of membrane stability parameters and surface changes during 1,2 dimethylhydrazine-induced colorectal carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Administration, Oral; Animals; Anticarcinogenic Agents; Azadi | 2015 |
Evolutionary biologic changes of gut microbiota in an 'adenoma-carcinoma sequence' mouse colorectal cancer model induced by 1, 2-Dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Adenomatous Polyposis Coli Protein; Animals; Bacteri | 2017 |
SORPTION CORRECTION OF NEPHRON SUB-MICROSCOPIC CHANGES CAUSED BY NEOPLASTIC CHRONIC INTOXICATION WITH THE APPLICATION OF CYTOSTATIC THERAPY.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adsorption; Animals; Antineoplastic Agents; Carbon; Colonic N | 2017 |
[Colon carcinogenesis in rat vs. variable light].
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Antioxidants; Carcinogens; Cell Differentiation; Cel | 2008 |
Efficacy of the potential chemopreventive agent, hesperetin (citrus flavanone), on 1,2-dimethylhydrazine induced colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Antineoplastic Agents, Phytogenic; Catalase; Colon; | 2009 |
Efficacy of the potential chemopreventive agent, hesperetin (citrus flavanone), on 1,2-dimethylhydrazine induced colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Antineoplastic Agents, Phytogenic; Catalase; Colon; | 2009 |
Efficacy of the potential chemopreventive agent, hesperetin (citrus flavanone), on 1,2-dimethylhydrazine induced colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Antineoplastic Agents, Phytogenic; Catalase; Colon; | 2009 |
Efficacy of the potential chemopreventive agent, hesperetin (citrus flavanone), on 1,2-dimethylhydrazine induced colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Antineoplastic Agents, Phytogenic; Catalase; Colon; | 2009 |
Fish oil ingestion reduces the number of aberrant crypt foci and adenoma in 1,2-dimethylhydrazine-induced colon cancer in rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Carcinoma; Colonic Neoplasms; Fatty Aci | 2009 |
Gene expression profile and genomic alterations in colonic tumours induced by 1,2-dimethylhydrazine (DMH) in rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Cell Transformation, Neoplastic; Colonic Neoplasms; | 2010 |
Influence of extraneous supplementation of zinc on trace elemental profile leading to prevention of dimethylhydrazine-induced colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Antineoplastic Agents; Carcinogens; Chemoprevention; | 2010 |
Effect of endostatin on 1,2-dimethylhydrazine-induced colon tumor in mice.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Analysis of Variance; Angiogenesis Inhibitors; Animals; Colon | 2012 |
Bimodal visualization of colorectal uptake of nanoparticles in dimethylhydrazine-treated mice.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Colon; Colorectal Neoplasms; Enema; Flu | 2011 |
Potentiation of 1-2-dimethylhydrazine-induced bowel carcinogenesis by the urinary bladder carcinogen N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Cocarcinogenesis; Drug Synergism; FANFT | 1980 |
Rapid induction of colorectal tumors in rats initiated with 1,2-dimethylhydrazine followed by dextran sodium sulfate treatment.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Body Weight; Carcinogens; Colonic Neoplasms; Dextran | 2003 |
Overexpression of cyclin D1 and cyclin E in 1,2-dimethylhydrazine dihydrochloride-induced rat colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Animals; Carcinogens; Cell Cycle; Colon; Colonic Neo | 2000 |
The normal and metastases-bearing livers retain various specific subsets of live lymphocytes from portal circulation.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Analysis of Variance; Animals; Antigens, CD; Carcinogens; Cel | 2003 |
Influence of the surgical manipulation of the colon in colonic induced carcinogenesis in rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Anastomosis, Surgical; Animals; Colon; Colonic Neoplasms; Mal | 2004 |
A novel mouse model for colitis-associated colon carcinogenesis induced by 1,2-dimethylhydrazine and dextran sulfate sodium.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; beta Catenin; Carcinogens; Colitis, Ulcerative; Colo | 2004 |
JTE-522, a selective cyclooxygenase-2 inhibitor, inhibits induction but not growth and invasion of 1,2-dimethylhydrazine-induced tubular adenocarcinomas of colon in rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Animals; Benzenesulfonates; Biomarkers, Tumor; Carci | 2005 |
Beta-Catenin mutations in a mouse model of inflammation-related colon carcinogenesis induced by 1,2-dimethylhydrazine and dextran sodium sulfate.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Azoxymethane; beta Catenin; Colitis; Colonic Neoplas | 2005 |
Image analysis using the fluorochromasia assay to quantify tumor drug sensitivity.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Antineoplastic Agents; Biopsy; Cell Survival; Coloni | 2005 |
[Inhibitory effect of sodium butyrate on 1,2-dimethylhydrazine-induced tumorigenesis of colorectal cancer in mice].
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Animals; Butyrates; Colorectal Neoplasms; Dose-Respo | 2005 |
The Cables gene on chromosome 18Q regulates colon cancer progression in vivo.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Animals; Carcinogens; Carrier Proteins; Chromosome D | 2005 |
Three-dimensional analysis of isolated hexosaminidase-altered aberrant crypts from colons of 1,2-dimethylhydrazine-treated rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; beta-N-Acetylhexosaminidases; Biomarkers, Tumor; Bro | 2006 |
Inverse genetic predisposition to colon versus lung carcinogenesis in mouse lines selected based on acute inflammatory responsiveness.
Topics: 1,2-Dimethylhydrazine; Acute Disease; Adenocarcinoma; Adenoma; Animals; Antiviral Agents; Carcinogen | 2006 |
Anti-oxidant constituents of the roots and stolons of licorice (Glycyrrhiza glabra).
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Anticarcinogenic Agents; Antioxidants; Carcinogens; Chalcones | 2007 |
The expression of low molecular weight protein tyrosine phosphatase is up-regulated in 1,2-dimethylhydrazine-induced colon tumours in rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Colonic Neoplasms; Gene Expression Regu | 2008 |
A new medium-term rat colorectal bioassay applying neoplastic lesions as end points for detection of carcinogenesis modifiers effects with weak or controversial modifiers.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Body Weight; Carcinogenicity Tests; Carcinogens; Col | 2008 |
Gut endocrine cells in rat intestinal-tract carcinoma induced by 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Chromaffin System; Dimethylhydrazines; | 1983 |
Pathogenesis of 1,2-dimethylhydrazine-induced carcinomas in rat intestine. II. Histochemical and ultrastructural characteristics of glycoproteins of 1,2-dimethylhydrazine-induced carcinoma cells.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenocarcinoma, Mucinous; Animals; Dimethylhydrazines; Glycop | 1982 |
Enhancing effect of dextran sulfate sodium on colorectal carcinogenesis by 1,2-dimethylhydrazine in rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenocarcinoma, Mucinous; Adenoma; Animals; Cocarcinogenesis; | 1983 |
The response of three inbred strains of rat to the carcinogen 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma, Bile Duct; Animals; Carcinoma, Hepatocellular; Dimet | 1981 |
Pathogenesis of 1,2-dimethylhydrazine-induced carcinomas in rat intestine. I. The induction of mucin producing carcinomas in rat intestine.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenocarcinoma, Mucinous; Animals; Cecal Neoplasms; Colonic N | 1982 |
Enhancement of rat colon carcinogenesis by wheat bran consumption during the stage of 1,2-dimethylhydrazine administration.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Colonic Neoplasms; Dietary Fiber; Dimet | 1983 |
[An experimental model of cancer of the large intestine].
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Animals; Carcinogens; Cholestyramine Resin; Colonic | 1984 |
High-fat diet promotes and causes distal shift of experimental rat colonic cancer--beer and alcohol do not.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Alcohol Drinking; Animals; Beer; Carcinogens; Coloni | 1984 |
Effect of 13 cis retinoic acid on early precancerous antigenic goblet-cell modifications and induction of cancer during 1,2-dimethylhydrazine carcinogenesis in rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; | 1983 |
Effects of specific active immunization on tumor recurrence following primary tumor resection in WF rats with 1,2-dimethylhydrazine-induced bowel cancer.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; | 1984 |
Identification of carcinogens by measurement of cell-mediated immunity. IV. Antitumor immunity following perinatal exposure to 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Colonic Neoplasms; Cytotoxicity, Immuno | 1983 |
Experimental cancer of the bowel in the Nb rat.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Colonic Neoplasms; Dimethylhydrazines; Disease Model | 1983 |
[Strain differences in susceptibility of rat colon to 1,2-dimethyl-hydrazine].
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Animals; Colonic Neoplasms; Dimethylhydrazines; Meth | 1983 |
Effects of choledochojejunostomy with Roux-en-Y exclusion on dimethylhydrazine induced neoplasms in rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Bile; Colonic Neoplasms; Common Bile Duct; Dimethylh | 1984 |
The effects of ascorbic acid and butylated hydroxyanisole in the chemoprevention of 1,2-dimethylhydrazine-induced large bowel neoplasms.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Administration, Oral; Animals; Anisoles; Ascorbic Ac | 1984 |
Carcinogenesis at colonic anastomotic sites. An animal study.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Animals; Colon; Colonic Neoplasms; Dimethylhydrazine | 1984 |
Antibody-dependent cell cytotoxicity in chemical-induced rat pancreas and colon cancer.
Topics: 1,2-Dimethylhydrazine; 9,10-Dimethyl-1,2-benzanthracene; Adenocarcinoma; Animals; Antibody-Dependent | 1981 |
Development and cell kinetics of colonic tumors induced in mice by dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Animals; Autoradiography; Carcinoma; Cell Division; | 1983 |
Effect of Konjac mannan on 1,2-dimethylhydrazine-induced intestinal carcinogenesis in Fischer 344 rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Body Weight; Carcinogens; Colonic Neoplasms; Dimethy | 1983 |
Metabolism of the carcinogen 1,2-dimethylhydrazine by isolated human colon microsomes and human colon tumor cells in culture.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adult; Biotransformation; Carcinogens; Cells, Cultured; Colon | 1983 |
Changes in crypt cell populations of mouse colon during recovery from treatment with 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Colonic Neoplasms; Dimethylhydrazines; Drug Administ | 1981 |
Kinetic properties of thymidine kinase from the cytosol of a rat colon adenocarcinoma.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Colonic Neoplasms; Cytosol; Dimethylhyd | 1982 |
Dietary cholesterol deprivation improves survival and reduces incidence of metastatic colon cancer in dimethylhydrazine-pretreated rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Cholesterol, Dietary; Colonic Neoplasms; Dimethylhyd | 1982 |
Experimental colitis as a promoter in large-bowel tumorigenesis.
Topics: 1,2-Dimethylhydrazine; Acetates; Adenocarcinoma; Adenoma; Animals; Colitis; Colonic Neoplasms; Dimet | 1982 |
[Morphogenesis of experimental cancer of the large intestine (according to the results of scanning electron and light microscopy)].
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Animals; Carcinogens; Colonic Neoplasms; Dimethylhyd | 1982 |
Potentiation of dimethylhydrazine bowel carcinogenesis in rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinoma, Transitional Cell; Cocarcinogenesis; Colo | 1981 |
Induction of colon adenocarcinomas in rats fed trypsin and tamoxifen diets by parenteral and intragastric 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Body Weight; Carcinogens; Colonic Neoplasms; Diet; D | 1994 |
Effect of iron deficiency on DMH-induced gastrointestinal tract tumors and occurrence of hepatocyte abnormalities in Fischer rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Cocarcinogenesis; Colonic Neoplasms; Dimethylhydrazi | 1994 |
Prevention of 1,2-dimethylhydrazine-induced colon tumorigenesis by HMG-CoA reductase inhibitors, pravastatin and simvastatin, in ICR mice.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Anticarcinogenic Agents; Carcinogens; Cholesterol; C | 1994 |
Colonic crypts located over lymphoid nodules of 1,2-dimethylhydrazine-treated rats are hyperplastic and at high risk of forming adenocarcinomas.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Cell Cycle; Cell Division; Cocarcinogen | 1994 |
Flat adenoma-adenocarcinoma sequence in the colon of rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Animals; Carcinogens; Colonic Neoplasms; Dimethylhyd | 1994 |
Experimental carcinogenesis in the rat intestine induced by two different carcinogens--evaluation of carcinogenic action and its effect on ornithine decarboxylase activity.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Animals; Biomarkers, Tumor; Carcinogens; Dimethylhyd | 1994 |
Dietary sphingomyelin inhibits 1,2-dimethylhydrazine-induced colon cancer in CF1 mice.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Administration, Oral; Animals; Carcinogens; Cell Div | 1994 |
Action of estrogen and adrenocorticoids on adenocarcinoma induction by 1,2-dimethylhydrazine in male rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Body Weight; Carcinogens; Colon; Colonic Neoplasms; | 1993 |
[Establishment of a transplantable rat colon cancer and a model of metastasis].
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Cell Division; Colonic Neoplasms; Dimethylhydrazines | 1993 |
Pilot study on alcohol-induced chemonecrosis of hepatic metastases from colonic cancer. A new approach for percutaneous localized dynamic destruction of the hepatic spread.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adult; Aged; Animals; Carcinogens; Colectomy; Colon; Colonic | 1993 |
Tumors produced in rats with a single dosage of 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; | 1993 |
Sulphated bile acid per se inhibits colonic carcinogenesis in mice.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Administration, Oral; Administration, Rectal; Animal | 1993 |
Photo detection of carcinoma of the colon in a rat model: a pilot study.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Animals; Carcinogens; Carcinoma in Situ; Colonic Neo | 1993 |
Tissue and cell-specific patterns of expression of rat liver and intestinal fatty acid binding protein during development and in experimental colonic and small intestinal adenocarcinomas.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Carrier Proteins; Colon; Colonic Neopla | 1993 |
Distribution of lymphoid nodules, aberrant crypt foci and tumours in the colon of carcinogen-treated rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Colon; Colonic Neoplasms; Dimethylhydra | 1996 |
Promotion of colon carcinogenesis through increasing lipid peroxidation induced in rats by a high cholesterol diet.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Cholesterol; Cholesterol, Dietary; Chol | 1996 |
[Inhibition of colorectal carcinoma induced by 1, 2-dimethylhydrazine in mice with tea polyphenols].
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Anticarcinogenic Agents; Carcinogens; Colonic Neopla | 1995 |
Sphingomyelin consumption suppresses aberrant colonic crypt foci and increases the proportion of adenomas versus adenocarcinomas in CF1 mice treated with 1,2-dimethylhydrazine: implications for dietary sphingolipids and colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Animals; Colonic Neoplasms; Dimethylhydrazines; Fema | 1996 |
[Effect of melatonin on 1,2-dimethylhydrazine-induced intestinal tumors in rats].
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; | 1996 |
Cyclosporin A enhances locoregional metastasis of the CC531 rat colon tumour.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Antibiotics, Antineoplastic; Carcinogens; Colonic Ne | 1997 |
Zinc deprivation promotes progression of 1,2-dimethylhydrazine-induced colon tumors but reduces malignant invasion in mice.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Body Weight; Carcinogens; Carcinoma in Situ; Collage | 1997 |
Interaction of dietary fat with a vegetables-fruit mixture on 1,2-dimethylhydrazine-induced colorectal cancer in rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Animals; Body Weight; Carcinogens; Colorectal Neopla | 1997 |
Interaction of dietary fat and of a vegetables/fruit mixture on 1,2-dimethylhydrazine- or N-methyl-N'-nitro-N-nitrosoguanidine-induced colorectal cancer in rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Animals; Carcinogens; Colorectal Neoplasms; Dietary | 1997 |
Suppression of aberrant colonic crypt foci by synthetic sphingomyelins with saturated or unsaturated sphingoid base backbones.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Antineoplastic Agents; Colonic Neoplasms; Diet; Dime | 1997 |
Preventive effect of 1-(2-tetrahydrofuryl)-5-fluorouracil in combination with uracil on colonic carcinogenesis induced by 1,2-dimethylhydrazine in rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Cell Differentiatio | 1997 |
Melatonin and colon carcinogenesis: I. Inhibitory effect of melatonin on development of intestinal tumors induced by 1,2-dimethylhydrazine in rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Anticarcinogenic Agents; Body Weight; Colonic Neopla | 1997 |
The nonfermentable dietary fiber lignin alters putative colon cancer risk factors but does not protect against DMH-induced colon cancer in rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Bile Acids and Salts; Body Weight; Carcinogens; Colo | 1997 |
Microsatellite instability, chemosensitivity and mutant frequency in a series of 1,2-dimethylhydrazine induced murine colon adenocarcinoma models.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agen | 1998 |
The effects of l-arginine on crypt cell hyperproliferation in colorectal cancer.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Animals; Arginine; Carcinogens; Cell Division; Colon | 1999 |
Presence of well-differentiated distal, but not poorly differentiated proximal, rat colon carcinomas is correlated with increased cell proliferation in and lengthening of colon crypts.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Cell Division; Cell Size; Colon; Coloni | 1999 |
The relationship between 1,2-dimethylhydrazine dose and the induction of colon tumours: tumour development in female SWR mice does not require a K-ras mutational event.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Base Sequence; Carcinogens; Colonic Neoplasms; DNA P | 1999 |
Immunomodulatory effects of tumor-associated fibroblasts in colorectal-tumor development.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Cell Division; Colonic Neoplasms; Fibroblasts; Gene | 1999 |
Inhibitory effect of a gastrin receptor antagonist, CR2945, on 1, 2-dimethylhydrazine-induced colorectal cancer in mice.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Animals; Benzodiazepines; Carcinogens; Colorectal Ne | 1999 |
Difference in target organs in carcinogenesis with a heterocyclic amine, 2-amino-3,4-dimethylimidazo[4,5-f]quinoline, in different strains of mice.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Carcinoma, Hepatocellular; Cecal Neopla | 1999 |
A probiotic strain of L. acidophilus reduces DMH-induced large intestinal tumors in male Sprague-Dawley rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Body Weight; Carcinogens; Colonic Neoplasms; Fatty A | 1999 |
Inhibitory effect of synthetic interferon inductor Cycloferone on 1,2-dimethylhydrazine-induced colon carcinogenesis in rats.
Topics: 1,2-Dimethylhydrazine; Acridines; Adenocarcinoma; Animals; Anticarcinogenic Agents; Body Weight; Car | 2000 |
Colonic cell proliferation and aberrant crypt foci formation are inhibited by dairy glycosphingolipids in 1, 2-dimethylhydrazine-treated CF1 mice.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Animals; Apoptosis; Carcinogens; Colonic Neoplasms; | 2000 |
Melatonin and colon carcinogenesis. III. Effect of melatonin on proliferative activity and apoptosis in colon mucosa and colon tumors induced by 1,2-dimethylhydrazine in rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Apoptosis; Carcinogens; Cell Division; Colonic Neopl | 2000 |
Animal model in the study of colorectal carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Animals; Carcinogens; Carcinoma; Colorectal Neoplasm | 2000 |
Early and late effects of wound healing on development of colon tumours in a model of colon carcinogenesis by 1,2-dimethylhydrazine in the rat.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Colonic Neoplasms; Dermatologic Surgica | 2000 |
Blood polyamine levels after oral ornithine load, a diagnostic marker of hyperproliferative premalignant and malignant stages in a model of colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Animals; Biomarkers, Tumor; Biotransformation; Body | 2000 |
A protective role of dietary vitamin D3 in rat colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Body Weight; Bromodeoxyuridine; Calcifediol; Calcitr | 2000 |
Pronounced inhibition by a natural anthocyanin, purple corn color, of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-associated colorectal carcinogenesis in male F344 rats pretreated with 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenocarcinoma, Mucinous; Adenoma; Administration, Oral; Anim | 2001 |
Colonic endocrine cells in rats with chemically induced colon carcinoma.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Colon; Colonic Neoplasms; Enteroendocri | 2001 |
1,2-Dimethylhydrazine-induced colon carcinoma and lymphoma in msh2(-/-) mice.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Alkylating Agents; Animals; Apoptosis; Base Pair Mismatch; Ca | 2001 |
Supplemental silk protein, sericin, suppresses colon tumorigenesis in 1,2-dimethylhydrazine-treated mice by reducing oxidative stress and cell proliferation.
Topics: 1,2-Dimethylhydrazine; 8-Hydroxy-2'-Deoxyguanosine; Adenocarcinoma; Adenoma; Aldehydes; Animals; Apo | 2001 |
Chemoprevention of 2-amino-1-methyl-6-phenylimidazo- [4,5-b]pyridine-induced colon carcinogenesis by 1-O-hexyl-2,3,5-trimethylhydroquinone after initiation with 1,2-dimethylhydrazine in F344 rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animal Feed; Animals; Carcinogens; Colonic Neoplasms; DNA Add | 2002 |
Pathway-specific tumor suppression. Reduction of p27 accelerates gastrointestinal tumorigenesis in Apc mutant mice, but not in Smad3 mutant mice.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Adenomatous Polyposis Coli Protein; Animals; beta Ca | 2002 |
Dietary supplementation with pectin and guar gum on 1,2-dimethylhydrazine-induced colon carcinogenesis in rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Colonic Neoplasms; Dietary Fiber; Dimet | 1992 |
Histological reactivity of a monoclonal antibody against rat colon cancer cells on human and rat normal gut and colonic tumours.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Antibodies, Monoclonal; Blood Group Antigens; Carboh | 1992 |
Carcinogenicity of 1,2-dimethylhydrazine in colorectal tissue heterotopically transplanted into the glandular stomach of rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Colon; Colorectal Neoplasms; Dimethylhydrazines; Inj | 1992 |
Alterations in protein kinase C in 1,2-dimethylhydrazine induced colonic carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Colon; Colonic Neoplasms; Dimethylhydra | 1992 |
Action of hydrazine drugs in tumor-free and 1,2-dimethylhydrazine-treated male rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Administration, Oral; Animals; Carcinogens; Colonic Neoplasms | 1992 |
Tumor induction in monkeys after administration of dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Colonic Neoplasms; Dimethylhydrazines; Dose-Response | 1992 |
Rat monoclonal antibodies produced against rat colorectal adenocarcinomas define tumor- and colon-associated, auto-immunogenic antigens.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Antibodies, Monoclonal; Antigens, Neoplasm; Antigens | 1990 |
The thalidomide analog, EM 12, enhances 1,2-dimethylhydrazine-induction of rat colon adenocarcinomas.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Azoxymethane; Body Weight; Carcinogens; Colon; Dimet | 1991 |
Quantification of acid mucins in the descending colon of rats having simultaneously growing colonic tumors.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Alcian Blue; Animals; Carcinogens; Colon; Colonic Neoplasms; | 1991 |
Alterations in lectin binding in the proximal and distal colon of Sprague-Dawley rats with 1,2 dimethylhydrazine administration.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Colon; Colonic Neoplasms; Dimethylhydra | 1991 |
Effects of dietary perilla oil, soybean oil and safflower oil on 7,12-dimethylbenz[a]anthracene (DMBA) and 1,2-dimethyl-hydrazine (DMH)-induced mammary gland and colon carcinogenesis in female SD rats.
Topics: 1,2-Dimethylhydrazine; 9,10-Dimethyl-1,2-benzanthracene; Adenocarcinoma; Adenofibroma; Adenoma; alph | 1990 |
[Effects of hyperthermochemotherapy on activities of DNA-synthesizing enzymes in 1, 2-dimethylhydrazine (DMH)-induced colon carcinomas in rats].
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Colo | 1990 |
Effect of germanium on 1,2-dimethylhydrazine-induced intestinal cancer in rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenocarcinoma, Mucinous; Animals; Carcinogens; Dimethylhydra | 1990 |
[Growth rate of experimental colonic cancer in rats].
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenocarcinoma, Mucinous; Animals; Barium Sulfate; Colonic Ne | 1990 |
[Modifying effects of changes connected with pregnancy on 1,2-dimethylhydrazine-induced carcinogenesis in rats].
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma, Bile Duct; Animals; Colonic Neoplasms; Dimethylhydra | 1990 |
Lipid absorption and intestinal tumour incidence in rats fed on varying levels of calcium and butterfat.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Butter; Calcium, Dietary; Carcinogens; Colonic Neopl | 1990 |
Effect of polyamine oxidase inhibition on the colonic malignant transformation process induced by 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Acetyltransferases; Adenocarcinoma; Animals; Base Sequence; Carcinogens; Colo | 1990 |
An assessment of the risk of neoplasia in long-term ileal reservoirs using the DMH rodent model.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; | 1990 |
[The induction of cancer of the large intestine in Macaca fascicularis monkeys with 1,2-dimethylhydrazine].
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Dimethylhydrazines; Dose-Response Relat | 1990 |
Colonic cancer induced by 1,2-dimethylhydrazine: promotion by experimental colitis.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Colitis; Colonic Neoplasms; Dimethylhyd | 1989 |
Effect of indomethacin in autotransplanted colonic tumors.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; | 1989 |
Reduction of DMH-induced colon tumors in rats fed psyllium husk or cellulose.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Cellulose; Colonic Neoplasms; Dietary F | 1987 |
[Colonic cancer induced by 1,2-dimethylhydrazine (DMH) in rats after partial colectomy].
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenocarcinoma, Mucinous; Animals; Colectomy; Colonic Neoplas | 1987 |
Experimental liver metastasis. Implications of clonal proclivity and organ specificity.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Cecal Neoplasms; Colonic Neoplasms; Dimethylhydrazin | 1989 |
Premalignant alterations in rat colonic N1-acetylspermidine levels induced by 1,2-dimethylhydrazine: effects of a high corn oil dietary regimen.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Biogenic Polyamines; Colonic Neoplasms; Corn Oil; Di | 1989 |
N-acetylneuraminic acid and N-glycolylneuraminic acid in glycopeptides of colonic tumor and mucosa in rats treated with carrageenan and 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carrageenan; Colonic Neoplasms; Dimethylhydrazines; | 1989 |
Mast cells in experimental and human cancerogenesis.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinoma, Squamous Cell; Cervix Uteri; Colon; Colon | 1987 |
Rodent models for carcinoma of the colon.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Alkylation; Animals; Colonic Neoplasms; Dietary Fats; Dietary | 1985 |
Relationship between colonic luminal pH, cell proliferation, and colon carcinogenesis in 1,2-dimethylhydrazine treated rats fed high fiber diets.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Cell Division; Cellulose; Colon; Colonic Neoplasms; | 1986 |
The role of sphingomyelin synthetase and sphingomyelinase in 1,2-dimethylhydrazine-induced lipid alterations of rat colonic plasma membranes.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Colon; Colonic Neoplasms; Dimethylhydrazines; Male; | 1986 |
The interaction of retrovirus and chemical carcinogen in experimental colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; | 1987 |
Activated K-ras in tumorigenic and non-tumorigenic cell variants from a rat colon adenocarcinoma, induced by dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Base Sequence; Colonic Neoplasms; Dimethylhydrazines | 1988 |
A protective effect of sulindac against chemically-induced primary colonic tumours in mice.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Animals; Carcinogens; Colonic Neoplasms; Dimethylhyd | 1988 |
Rat colonic carcinogenesis after ureterosigmoidostomy: pathogenesis and immunohistological study.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Animals; Antigens, Neoplasm; Colon, Sigmoid; Colonic | 1988 |
Stimulating effect of pentagastrin on cancer cell proliferation kinetics in chemically induced colon cancer in rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Cell Division; Colonic Neoplasms; Dimethylhydrazines | 1988 |
Cellular proliferation in proximal and distal rat colon during 1,2-dimethylhydrazine-induced carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Autoradiography; Carcinogens; Cell Division; Colonic | 1988 |
Interactions of selenium deficiency, vitamin E, polyunsaturated fat, and saturated fat on azoxymethane-induced colon carcinogenesis in male F344 rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Animals; Azoxymethane; Colonic Neoplasms; Dietary Fa | 1986 |
Expression of developmentally regulated crypt cell antigens in human and rat intestinal tumors.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Antibodies, Monoclonal; Antigens; Carcinoembryonic A | 1986 |
Effect of different levels of dietary corn oil and lard during the initiation phase of colon carcinogenesis in F344 rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Azoxymethane; Bile Acids and Salts; Body Weight; Col | 1986 |
Selenium and cabbage and colon carcinogenesis in mice.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Animals; Body Weight; Brassica; Colonic Neoplasms; D | 1987 |
[Effect of the epidermal growth factor on 1,2-dimethylhydrazine-induced carcinogenesis in the rat intestinal mucosa].
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Dimethylhydrazines; Epidermal Growth Factor; Intesti | 1987 |
[Inhibition of chemically induced tumors in mice by concanavalin A: reaction and detection of changes in the composition of intestinal glycoconjugates using lectins].
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Colonic Neoplasms; Concanavalin A; Dimethylhydrazine | 1987 |
Three new rat colon tumour cell lines from 1,2-dimethylhydrazine induced adenocarcinomas: morphology, karyotype and clonogenicity.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Cell Line; Colonic Neoplasms; Dimethylhydrazines; Gr | 1987 |
Different autochthonous models of colorectal cancer in the rat.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Colonic Neoplasms; Dimethylhydrazines; Dimethylnitro | 1986 |
Monitoring the histogenesis of colonic tumors in the Sprague-Dawley rat.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Colon; Colonic Neoplasms; Dimethylhydra | 1986 |
Activity of N-[N'-(2-chloroethyl)-N'-nitrosocarbamoyl]-alanine and derivatives against transplantable adenocarcinomata of the mouse colon (MAC).
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Alanine; Animals; Antineoplastic Agents; Colonic Neoplasms; D | 1986 |
[Serial endoscopic examinations of 1,2-dimethylhydrazine induced colon tumors in rat and effects of fecal stream].
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Carcinogens; Colonic Neoplasms; Colonoscopy; Dimethy | 1986 |
[Protein kinase activity and phosphorylation of endogenous proteins in the rat colonic mucosa during chemical carcinogenesis].
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Colonic Neoplasms; Dimethylhydrazines; Intestinal Mu | 1986 |
[Experimental carcinogenesis on the rat intestine induced by combination of 1, 2-dimethylhydrazine and n-methyl-n'-nitro-n-nitrosoguanidine].
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Colonic Neoplasms; Dimethylhydrazines; Male; Methylh | 1986 |
1,2-Dimethylhydrazine-induced alterations in colonic plasma membrane fluidity: restriction to the luminal region.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Cell Membrane; Colon; Colonic Neoplasms; Dimethylhyd | 1987 |
Diallyl sulfide, a flavor component of garlic (Allium sativum), inhibits dimethylhydrazine-induced colon cancer.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Allyl Compounds; Animals; Carcinogens; Colonic Neoplasms; Dim | 1987 |
Correlation between incidence of 1,2-dimethylhydrazine-induced colon carcinomas and DNA damage in six genetically different mouse strains.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Colon; Colonic Neoplasms; Dimethylhydrazines; Diseas | 1986 |
Interaction of dietary fat and route of carcinogen administration on 1,2-dimethylhydrazine-induced colon tumorigenesis in rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Body Weight; Carcinogens; Cocarcinogenesis; Colonic | 1985 |
Adrenergic factors regulating cell division in the colonic crypt epithelium during carcinogenesis and in colonic adenoma and adenocarcinoma.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Animals; Cell Division; Cell Transformation, Neoplas | 1985 |
Steroid receptors in dimethylhydrazine-induced colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Animals; Colon; Colonic Neoplasms; Dimethylhydrazine | 1985 |
Effects of vitamin E deficiency on 1,2-dimethylhydrazine-induced intestinal carcinogenesis in rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Animals; Carcinogens; Dimethylhydrazines; Intestinal | 1985 |
[Development of 1,2-dimethylhydrazine-induced colonic neoplasia in rats and changes in cellular proteins of colonic mucosa].
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Colon; Colonic Neoplasms; Dimethylhydrazines; Electr | 1985 |