1,2-dimethylhydrazine has been researched along with Abnormalities, Autosome in 11 studies
1,2-Dimethylhydrazine: A DNA alkylating agent that has been shown to be a potent carcinogen and is widely used to induce colon tumors in experimental animals.
1,2-dimethylhydrazine : A member of the class of hydrazines that is hydrazine in which one of the hydrogens attached to each nitrogen is replaced by a methyl group. A powerful DNA alkylating agent and carcinogen, it is used to induce colon cancer in laboratory rats and mice.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Moreover, LJE attenuated colon cancer initiation and progression by decreasing aberrant crypt foci and LJE recovered the gut microbiome." | 1.62 | Ellagitannins from jabuticaba (Myrciaria jaboticaba) seeds attenuated inflammation, oxidative stress, aberrant crypt foci, and modulated gut microbiota in rats with 1,2 dimethyl hydrazine-induced colon carcinogenesis. ( Almeida, LA; Azevedo, L; de Oliveira, PF; do Carmo, MAV; Feitoza, LQ; Ferreira, EB; Fidelis, M; Granato, D; Hellström, J; Marques, MJ; Novaes, RD; Oh, WY; Shahidi, F, 2021) |
| "Human risk assessment of the toxic potency of chemicals typically includes genotoxicity assays for predicting carcinogenicity." | 1.56 | Multiple-endpoint genotoxicity assay for colon carcinogen 1,2-dimethylhydrazine. ( Fujii, W; Hayashi, M; Hori, H; Kitagawa, Y; Masumura, K; Momonami, A; Shimoyoshi, S; Tanaka, Y; Yamada, M, 2020) |
| "Buprenorphine was injected subcutaneously twice a day with at least a 6-hr interval for 2 days from just after partial hepatectomy." | 1.42 | Effect of buprenorphine on genotoxicity evaluation of chemicals by the rat liver micronucleus test with partial hepatectomy. ( Hattori, C; Itoh, S; Nagata, M; Takasaki, W, 2015) |
| " In the present study, we assessed a twice dosing regimen, in which the genotoxicant is dosed both before and after partial hepatectomy, using the four chromosome aberration inducers used in the previous study." | 1.42 | Assessment of a twice dosing regimen both before and after partial hepatectomy in the rat liver micronucleus test. ( Hattori, C; Igarashi, M; Itoh, S; Nagata, M, 2015) |
| "For mutagenic study chromosome aberrations tests (ChA) in bone marrow cells and sperm head anomaly test (SHA) were used." | 1.30 | [The influence of melatonin on mutagenicity and antitumor action of cytostatic drugs in mice]. ( Anisimov, VN; Mikheev, VS; Musatov, SA; Rosenfeld, SV; Togo, EF, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (45.45) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 1 (9.09) | 29.6817 |
| 2010's | 2 (18.18) | 24.3611 |
| 2020's | 2 (18.18) | 2.80 |
| Authors | Studies |
|---|---|
| Hori, H | 1 |
| Shimoyoshi, S | 1 |
| Tanaka, Y | 1 |
| Momonami, A | 1 |
| Masumura, K | 1 |
| Yamada, M | 1 |
| Fujii, W | 1 |
| Kitagawa, Y | 1 |
| Hayashi, M | 1 |
| do Carmo, MAV | 1 |
| Fidelis, M | 1 |
| de Oliveira, PF | 1 |
| Feitoza, LQ | 1 |
| Marques, MJ | 1 |
| Ferreira, EB | 1 |
| Oh, WY | 1 |
| Shahidi, F | 1 |
| Hellström, J | 1 |
| Almeida, LA | 1 |
| Novaes, RD | 1 |
| Granato, D | 1 |
| Azevedo, L | 1 |
| Itoh, S | 2 |
| Nagata, M | 2 |
| Hattori, C | 2 |
| Takasaki, W | 1 |
| Igarashi, M | 1 |
| Kolumbaeva, SZh | 1 |
| Shalakhmetova, TM | 1 |
| Begimbetova, DA | 1 |
| Bersimbaev, RI | 1 |
| Kalimagambetov, AM | 1 |
| Wargovich, MJ | 2 |
| Medline, A | 1 |
| Bruce, WR | 2 |
| Goldberg, MT | 1 |
| Newmark, HL | 1 |
| Boffa, LC | 1 |
| Gruss, RJ | 1 |
| Allfrey, VG | 1 |
| Musatov, SA | 1 |
| Rosenfeld, SV | 1 |
| Togo, EF | 1 |
| Mikheev, VS | 1 |
| Anisimov, VN | 1 |
| Couch, DB | 1 |
| Gingerich, JD | 1 |
| Stuart, E | 1 |
| Heddle, JA | 1 |
| Ashby, J | 1 |
| Mirkova, E | 1 |
11 other studies available for 1,2-dimethylhydrazine and Abnormalities, Autosome
| Article | Year |
|---|---|
Multiple-endpoint genotoxicity assay for colon carcinogen 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Animals; Bone Marrow Cells; Carcinogens; Chromosome Aberrations; Colon; Colon | 2020 |
Ellagitannins from jabuticaba (Myrciaria jaboticaba) seeds attenuated inflammation, oxidative stress, aberrant crypt foci, and modulated gut microbiota in rats with 1,2 dimethyl hydrazine-induced colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Chromosome Aberrations; Colonic Neoplasms; Gastrointest | 2021 |
Effect of buprenorphine on genotoxicity evaluation of chemicals by the rat liver micronucleus test with partial hepatectomy.
Topics: 1,2-Dimethylhydrazine; Analgesics; Animals; Benzimidazoles; Buprenorphine; Carbamates; Cells, Cultur | 2015 |
Assessment of a twice dosing regimen both before and after partial hepatectomy in the rat liver micronucleus test.
Topics: 1,2-Dimethylhydrazine; Animals; Benzimidazoles; Carbamates; Chromosome Aberrations; Colchicine; Diet | 2015 |
[Mutagenic effect of the rocket fuel component asymmetric dimethylhydrazine on rats of various ages].
Topics: 1,2-Dimethylhydrazine; Age Factors; Animals; Bone Marrow Cells; Chromosome Aberrations; Environmenta | 2007 |
Early histopathologic events to evolution of colon cancer in C57BL/6 and CF1 mice treated with 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Animals; Cell Transformation, Neoplastic; Chromosome Aberrations; Colon; Colo | 1983 |
Nuclear aberrations as a short-term test for genotoxicity to the colon: evaluation of nineteen agents in mice.
Topics: 1,2-Dimethylhydrazine; Animals; Antioxidants; Carcinogens; Chromosome Aberrations; Colon; Dimethylhy | 1983 |
Aberrant and nonrandom methylation of chromosomal DNA-binding proteins of colonic epithelial cells by 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Amino Acids; Animals; Carrier Proteins; Cell Fractionation; Cell Nucleus; Chr | 1982 |
[The influence of melatonin on mutagenicity and antitumor action of cytostatic drugs in mice].
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Antineoplastic Agents; Bone Marrow Cells; C | 1997 |
Induction of sister chromatid exchanges in murine colonic tissue.
Topics: 1,2-Dimethylhydrazine; Animals; Bromodeoxyuridine; Chromosome Aberrations; Colon; Colonic Neoplasms; | 1986 |
Re-evaluation of 1,2-dimethylhydrazine in the mouse bone marrow micronucleus assay: observation of a positive response.
Topics: 1,2-Dimethylhydrazine; Animals; Bone Marrow; Cell Nucleus; Chromosome Aberrations; Dimethylhydrazine | 1987 |