1,2-dimethylhydrazine has been researched along with Aberrant Crypt Foci in 61 studies
1,2-Dimethylhydrazine: A DNA alkylating agent that has been shown to be a potent carcinogen and is widely used to induce colon tumors in experimental animals.
1,2-dimethylhydrazine : A member of the class of hydrazines that is hydrazine in which one of the hydrogens attached to each nitrogen is replaced by a methyl group. A powerful DNA alkylating agent and carcinogen, it is used to induce colon cancer in laboratory rats and mice.
Aberrant Crypt Foci: Clusters of colonic crypts that appear different from the surrounding mucosa when visualized after staining. They are of interest as putative precursors to colorectal adenomas and potential biomarkers for colorectal carcinoma.
| Excerpt | Relevance | Reference |
|---|---|---|
| "2 mol% PlsEtn in EtnGpl) in 1,2-dimethylhydrazine (DMH)-induced aberrant crypt foci (ACF) in vivo, and elucidated the possible underlying mechanisms behind it." | 8.02 | Dietary PlsEtn Ameliorates Colon Mucosa Inflammatory Stress and ACF in DMH-Induced Colon Carcinogenesis Mice: Protective Role of Vinyl Ether Linkage. ( Kinoshita, M; Miyazawa, T; Nakagawa, K; Nguma, E; Otoki, Y; Tominaga, Y; Yamamoto, A; Yamashita, S, 2021) |
| " The aim of this study was to investigate the ability of RA to prevent 1,2-dimethylhydrazine (DMH)-induced primary DNA damage and aberrant crypt foci (ACF) in Wistar rat colon." | 7.81 | Chemopreventive effects of rosmarinic acid on rat colon carcinogenesis. ( Cleto, SS; Cunha, WR; Furtado, RA; Munari, CC; Oliveira, BR; Silva, LR; Tavares, DC, 2015) |
| " In our study, we have evaluated the effect of different doses of zingerone on lipid peroxidation (thiobarbituric acid-reactive substances, lipid hydroxyl radical and conjugated dienes), tissue enzymatic antioxidants (superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase), and nonenzymatic antioxidants (reduced glutathione, vitamin E, vitamin C), and also the formation of aberrant crypt foci (ACF) in male albino Wistar rats with colon cancer induced using 1,2-dimethylhydrazine (DMH)." | 7.80 | Chemopreventive effect of zingerone against colon carcinogenesis induced by 1,2-dimethylhydrazine in rats. ( Nalini, N; Sudha, M; Vinothkumar, R, 2014) |
| " The present study was carried out to divulge the protective potential of the probiotic Dahi containing Lactobacillus acidophilus LaVK2 and Bifidobacterium bifidum BbVK3 alone or in combination with piroxicam (PXC) on the development of early biomarkers of colorectal carcinogenesis in male Wistar rats administered 1,2-dimethylhydrazine (DMH)." | 7.80 | Probiotic Dahi containing Lactobacillus acidophilus and Bifidobacterium bifidum modulates the formation of aberrant crypt foci, mucin-depleted foci, and cell proliferation on 1,2-dimethylhydrazine-induced colorectal carcinogenesis in Wistar rats. ( Kansal, VK; Kruzliak, P; Kumari, A; Mohania, D, 2014) |
| "The present study has aimed to evaluate chemopreventive potential of d-carvone on oxidative stress markers, biotransforming enzymes, incidence of colonic polyps and aberrant crypt foci (ACF) in 1,2-dimethylhydrazine (DMH)-induced experimental colon carcinogenesis." | 7.79 | Modulating effect of d-carvone on 1,2-dimethylhydrazine-induced pre-neoplastic lesions, oxidative stress and biotransforming enzymes, in an experimental model of rat colon carcinogenesis. ( Balasubramanian, T; Kabalimoorthy, J; Nalini, N; Sudha, M; Vinothkumar, R; Viswanathan, P, 2013) |
| "This study investigated the effect of short curcumin treatment, a natural antioxidant on 1,2-dimethylhydrazine (DMH)-induced aberrant crypt foci (ACF) in mice." | 7.78 | Short curcumin treatment modulates oxidative stress, arginase activity, aberrant crypt foci, and TGF-β1 and HES-1 transcripts in 1,2-dimethylhydrazine-colon carcinogenesis in mice. ( Bounaama, A; Djerdjouri, B; Laroche-Clary, A; Le Morvan, V; Robert, J, 2012) |
| "We here tested whether the secondary plant compound flavone affects the development of aberrant crypt foci and microadenomas triggered in C57BL/6J mice by 1,2-dimethylhydrazine." | 7.76 | Flavone induces changes in intermediary metabolism that prevent microadenoma formation in colonic tissue of carcinogen-treated mice. ( Daniel, H; Diehl, D; Oesterle, D; Wenzel, U; Winkelmann, I, 2010) |
| "To investigate the chemopreventive effects of pioglitazone (exogenous PPAR gamma ligand) on rat colon aberrant crypt foci, a rat carcinogenesis model induced by dimethylhydrazine (DMH), and to compare pioglitazone with sulindac (a NSAID)." | 7.72 | [Pioglitazone, a peroxisome proliferators-activated receptor gamma ligand, inhibits dimethylhydrazine (DMH) induced aberrant crypt foci in rats]. ( Dong, X; Jin, Z; Li, J; Lv, Y, 2003) |
| "Karanjin treatment also increased the antioxidants, catalase, glutathione and superoxide dismutase." | 5.62 | Effects of karanjin on dimethylhydrazine induced colon carcinoma and aberrant crypt foci are facilitated by alteration of the p53/Bcl2/BAX pathway for apoptosis. ( Fan, Q; Wang, C; Xie, Y; Zhang, J, 2021) |
| "Treatment with zingerone to DMH treated rats, resulted in alterations in the activity of the cytochrome P450 2E1 and CEA." | 5.51 | Chemopreventive efficacy zingerone (4-[4-hydroxy-3-methylphenyl] butan-2-one) in experimental colon carcinogenesis in Wistar rats. ( Al Saeedan, A; Ganaie, MA; Jan, BL; Khatlani, T; Madhkali, H; Rehman, MU; Sheikh, IA; Wani, K, 2019) |
| "Colon cancer is thought to develop in a stepwise fashion." | 5.48 | Precancerous ACF induction affects their regional distribution forsaking oxidative stress implication in 1,2-dimethylhydrazine-induced colon carcinogenesis model. ( Clichici, S; Djerdjouri, B; Moulahoum, H; Nagy, AL, 2018) |
| "For this purpose, colon cancer was induced by DMH in rats (20 mg/kg body weight for 5 weeks) and groups of animals were given dietary caraway essential oils at two levels (0." | 5.39 | Effect of dietary caraway essential oils on expression of β-catenin during 1,2-dimethylhydrazine-induced colonic carcinogenesis. ( Allameh, A; Ashrafi-Helan, J; Dadkhah, A; Fatemi, F; Rahbarizadeh, F, 2013) |
| " We investigated the effectivity of jaboticaba whole fruit ethanolic extract (FEX) in suppressing aberrant crypt foci (ACF), the earliest lesion of colorectal cancer (CRC), in 1,2-dimethylhydrazine (DMH)-induced rats and the underlying mechanisms related to the gut microbiota composition and short chain fatty acid (SCFA)." | 4.31 | Jaboticaba (Myrciaria cauliflora) Fruit Extract Suppressed Aberrant Crypt Formation in 1,2-Dimetylhydrazine-Induced Rats. ( Ardanareswari, K; Chung, YC; Liao, JW; Lowisia, W; Soedarini, B, 2023) |
| "2 mol% PlsEtn in EtnGpl) in 1,2-dimethylhydrazine (DMH)-induced aberrant crypt foci (ACF) in vivo, and elucidated the possible underlying mechanisms behind it." | 4.02 | Dietary PlsEtn Ameliorates Colon Mucosa Inflammatory Stress and ACF in DMH-Induced Colon Carcinogenesis Mice: Protective Role of Vinyl Ether Linkage. ( Kinoshita, M; Miyazawa, T; Nakagawa, K; Nguma, E; Otoki, Y; Tominaga, Y; Yamamoto, A; Yamashita, S, 2021) |
| " The present study investigated the chemopreventive effect of HPLC-fingerprinted EEB on 1,2-dimethylhydrazine (DMH)-induced aberrant crypt foci (ACF) formation in mice." | 3.83 | Ethanolic Extract of Bark from Salix aegyptiaca Ameliorates 1,2-dimethylhydrazine-induced Colon Carcinogenesis in Mice by Reducing Oxidative Stress. ( Banerjee, S; Bounaama, A; Ceyhan, MS; Djerdjouri, B; Enayat, S; Moulahoum, H, 2016) |
| " The objective of the present study is to evaluate the anticancer activity of UMB on 1,2-dimethylhydrazine (DMH)-induced rat colon tumorigenesis to determine the development of aberrant crypt foci (ACF), agyrophylic nucleolar organizer regions (AgNORs), mast cell recruitment, pro-inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1β and also study the expressions of inducible nitric oxide synthase, cyclooxygenase (COX)-2, and apoptotic markers." | 3.83 | Anti-inflammatory and proapoptotic effects of umbelliferone in colon carcinogenesis. ( Muthu, R; Selvaraj, N; Vaiyapuri, M, 2016) |
| "The goal of this study was to investigate the preventive effects of defatted flaxseed meal on the appearance of aberrant crypt foci (ACF) in mice treated with 1,2-dimethylhydrazine (DMH)." | 3.81 | Defatted flaxseed meal prevents the appearance of aberrant crypt foci in the colon of mice increasing the gene expression of p53. ( Comastri, DS; de Paula, SO; Ferreira, CL; Gomides, AF; Gonçalves, RV; Peluzio, Mdo C, 2015) |
| "This study was aimed to investigate the effect of sinapic acid (SA) on 1,2-dimethylhydrazine (DMH) induced experimental rat colon carcinogenesis." | 3.81 | Effect of sinapic acid on 1,2 dimethylhydrazine induced aberrant crypt foci, biotransforming bacterial enzymes and circulatory oxidative stress status in experimental rat colon carcinogenesis. ( Balaji, C; Muthukumaran, J; Nalini, N, 2015) |
| " The aim of this study was to investigate the ability of RA to prevent 1,2-dimethylhydrazine (DMH)-induced primary DNA damage and aberrant crypt foci (ACF) in Wistar rat colon." | 3.81 | Chemopreventive effects of rosmarinic acid on rat colon carcinogenesis. ( Cleto, SS; Cunha, WR; Furtado, RA; Munari, CC; Oliveira, BR; Silva, LR; Tavares, DC, 2015) |
| " In our study, we have evaluated the effect of different doses of zingerone on lipid peroxidation (thiobarbituric acid-reactive substances, lipid hydroxyl radical and conjugated dienes), tissue enzymatic antioxidants (superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase), and nonenzymatic antioxidants (reduced glutathione, vitamin E, vitamin C), and also the formation of aberrant crypt foci (ACF) in male albino Wistar rats with colon cancer induced using 1,2-dimethylhydrazine (DMH)." | 3.80 | Chemopreventive effect of zingerone against colon carcinogenesis induced by 1,2-dimethylhydrazine in rats. ( Nalini, N; Sudha, M; Vinothkumar, R, 2014) |
| " This study was carried out to investigate the effect of troxerutin on xenobiotic metabolizing enzymes, colonic bacterial enzymes and the development of aberrant crypt foci (ACF) during 1,2-dimethylhydrazine (DMH) induced experimental rat colon carcinogenesis." | 3.80 | Modulatory effect of troxerutin on biotransforming enzymes and preneoplasic lesions induced by 1,2-dimethylhydrazine in rat colon carcinogenesis. ( Balasubramanian, T; Nalini, N; Sudha, M; Vinoth Kumar, R; Vinothkumar, R; Viswanathan, P, 2014) |
| "This work investigated the effects of Vitamin E (VE) on aberrant crypt foci (ACF) incidence, oxidative stress parameters (serum and hepatic VE concentration, and homocysteine, glutathione (GSH), and malondialdehyde (MDA) levels), and expression of both cyclooxygenase-2 (COX2) and proliferating cellular nuclear antigen (PCNA) in experimental colorectal carcinogenesis." | 3.80 | Vitamin E supplementation in chemical colorectal carcinogenesis: a two-edged knife. ( Cardoso, JF; Cohen, C; Garcia, SB; Vannucchi, H, 2014) |
| " The present study was carried out to divulge the protective potential of the probiotic Dahi containing Lactobacillus acidophilus LaVK2 and Bifidobacterium bifidum BbVK3 alone or in combination with piroxicam (PXC) on the development of early biomarkers of colorectal carcinogenesis in male Wistar rats administered 1,2-dimethylhydrazine (DMH)." | 3.80 | Probiotic Dahi containing Lactobacillus acidophilus and Bifidobacterium bifidum modulates the formation of aberrant crypt foci, mucin-depleted foci, and cell proliferation on 1,2-dimethylhydrazine-induced colorectal carcinogenesis in Wistar rats. ( Kansal, VK; Kruzliak, P; Kumari, A; Mohania, D, 2014) |
| "The present study has aimed to evaluate chemopreventive potential of d-carvone on oxidative stress markers, biotransforming enzymes, incidence of colonic polyps and aberrant crypt foci (ACF) in 1,2-dimethylhydrazine (DMH)-induced experimental colon carcinogenesis." | 3.79 | Modulating effect of d-carvone on 1,2-dimethylhydrazine-induced pre-neoplastic lesions, oxidative stress and biotransforming enzymes, in an experimental model of rat colon carcinogenesis. ( Balasubramanian, T; Kabalimoorthy, J; Nalini, N; Sudha, M; Vinothkumar, R; Viswanathan, P, 2013) |
| " The present study was to evaluate the antiproliferative effects of hesperetin, a flavonoid commonly found in many herbal medicines and foods, on aberrant crypt foci (ACF), argyrophylic nucleolar organizer regions (AgNORs) and proliferating cell nuclear antigen (PCNA) in 1,2-dimethylhydrazine (DMH)-induced colon carcinogenesis in rats." | 3.79 | Antiproliferative efficacy of hesperetin (citrus flavanoid) in 1,2-dimethylhydrazine-induced colon cancer. ( Aranganathan, S; Nalini, N, 2013) |
| "This study investigated the effect of short curcumin treatment, a natural antioxidant on 1,2-dimethylhydrazine (DMH)-induced aberrant crypt foci (ACF) in mice." | 3.78 | Short curcumin treatment modulates oxidative stress, arginase activity, aberrant crypt foci, and TGF-β1 and HES-1 transcripts in 1,2-dimethylhydrazine-colon carcinogenesis in mice. ( Bounaama, A; Djerdjouri, B; Laroche-Clary, A; Le Morvan, V; Robert, J, 2012) |
| " Groups 1, 3 and 5 were initiated by 1,2-dimethylhydrazine (DMH) 20 mg/kg body weight s." | 3.77 | Cancer chemopreventive potential of the Egyptian flaxseed oil in a rat colon carcinogenesis bioassay--implications for its mechanism of action. ( Abou-Shafey, AE; Elgendy, SA; Masoud, AA; Salim, EI, 2011) |
| "We here tested whether the secondary plant compound flavone affects the development of aberrant crypt foci and microadenomas triggered in C57BL/6J mice by 1,2-dimethylhydrazine." | 3.76 | Flavone induces changes in intermediary metabolism that prevent microadenoma formation in colonic tissue of carcinogen-treated mice. ( Daniel, H; Diehl, D; Oesterle, D; Wenzel, U; Winkelmann, I, 2010) |
| "To evaluate the preventive effect of sodium butyrate in the appearance of aberrant crypt foci (ACF) in rats after induction with the carcinogen 1,2-dimethylhydrazine (DMH)." | 3.76 | Sodium butyrate does not decrease the evolution of precancerous lesions in rats. ( Glória, MB; Mendes, MC; Peluzio, Mdo C; Penido, LC; Rosa, DD; Silva, FG; Valente, FX, 2010) |
| " We therefore examined the modifying effect of boiled garlic powder (BGP) on 1,2-dimethylhydrazine-induced mucin-depleted foci (MDF) and aberrant crypt foci (ACF), preneoplastic lesions, in the rat colorectum." | 3.76 | Inhibition of 1, 2-dimethylhydrazine-induced mucin-depleted foci and O⁶-methylguanine DNA adducts in the rat colorectum by boiled garlic powder. ( Beppu, H; Chihara, T; Higashiguchi, T; Kaneko, T; Mizutani, K; Shimpo, K; Sonoda, S, 2010) |
| "To investigate the chemopreventive effects of pioglitazone (exogenous PPAR gamma ligand) on rat colon aberrant crypt foci, a rat carcinogenesis model induced by dimethylhydrazine (DMH), and to compare pioglitazone with sulindac (a NSAID)." | 3.72 | [Pioglitazone, a peroxisome proliferators-activated receptor gamma ligand, inhibits dimethylhydrazine (DMH) induced aberrant crypt foci in rats]. ( Dong, X; Jin, Z; Li, J; Lv, Y, 2003) |
| "Karanjin treatment also increased the antioxidants, catalase, glutathione and superoxide dismutase." | 1.62 | Effects of karanjin on dimethylhydrazine induced colon carcinoma and aberrant crypt foci are facilitated by alteration of the p53/Bcl2/BAX pathway for apoptosis. ( Fan, Q; Wang, C; Xie, Y; Zhang, J, 2021) |
| "Colorectal cancer is a highly prevalent disease, requiring effective strategies for prevention and treatment." | 1.62 | The Use of Natural Fiber-Rich Food Product Is Safe and Reduces Aberrant Crypt Foci in a Pre-Clinical Model. ( Baranoski, A; Bittencourt Junior, FF; da Silva Fleming de Almeida, T; do Amaral, LA; Duenhas Monreal, AC; Freitas Dos Santos, E; Leite Kassuya, CA; Milan Brochado Antoniolli-Silva, AC; Murino Rafacho, BP; Oliveira de Souza, GH; Oliveira, RJ; Souza Maris, R, 2021) |
| "The DMH treatment increased aberrant crypt foci (ACF), Proliferating cell nuclear antigen (PCNA), and TBARS levels, along with decreased antioxidant defenses (GSH, GSH-Px, and catalase)." | 1.62 | Piclamilast mitigates 1,2-dimethylhydrazine induced colon cancer in rats through modulation of Ras/PI3K/Akt/mTOR and NF-κβ signaling. ( Abdel-Wahab, BA; Albarqi, HA; Aljadaan, AM; Alqhtani, H; Hassanein, EHM; Khateeb, MM; Walbi, IA, 2021) |
| "Treatment with zingerone to DMH treated rats, resulted in alterations in the activity of the cytochrome P450 2E1 and CEA." | 1.51 | Chemopreventive efficacy zingerone (4-[4-hydroxy-3-methylphenyl] butan-2-one) in experimental colon carcinogenesis in Wistar rats. ( Al Saeedan, A; Ganaie, MA; Jan, BL; Khatlani, T; Madhkali, H; Rehman, MU; Sheikh, IA; Wani, K, 2019) |
| "Colon cancer is thought to develop in a stepwise fashion." | 1.48 | Precancerous ACF induction affects their regional distribution forsaking oxidative stress implication in 1,2-dimethylhydrazine-induced colon carcinogenesis model. ( Clichici, S; Djerdjouri, B; Moulahoum, H; Nagy, AL, 2018) |
| "Colorectal cancer is a global public health issue." | 1.46 | Prevention of DNA damage and anticarcinogenic activity of Activia ( Antoniolli-Silva, AC; Cantero, WB; Carreira, CM; Genez, LA; Limeiras, SM; Neves, SC; Ogo, FM; Oliveira, EJ; Oliveira, RJ; Pesarini, JR; Pessatto, LR; Schweich, LC; Silva, RA, 2017) |
| "weekly) for 15 weeks to initiate colon carcinogenesis." | 1.43 | Anti-proliferative and Apoptotic Effects of Basella rubra (L.) Against 1, 2-Dimethyl Hydrazine-induced Colon Carcinogenesis in Rats. ( Kilari, BP; Kotakadi, VS; Penchalaneni, J, 2016) |
| "Here we examine the effect of wheat on colon cancer risk in early and late postinitiation stages in carcinogen-treated rats." | 1.42 | Wheat Type (Class) Influences Development and Regression of Colon Cancer Risk Markers in Rats. ( Gallaher, DD; Islam, A, 2015) |
| "For this purpose, colon cancer was induced by DMH in rats (20 mg/kg body weight for 5 weeks) and groups of animals were given dietary caraway essential oils at two levels (0." | 1.39 | Effect of dietary caraway essential oils on expression of β-catenin during 1,2-dimethylhydrazine-induced colonic carcinogenesis. ( Allameh, A; Ashrafi-Helan, J; Dadkhah, A; Fatemi, F; Rahbarizadeh, F, 2013) |
| "To investigate the anti-colon cancer effects of berberine and possible relationship with cyclooxygenase-2." | 1.36 | [Preventive effects of berberine on experimental colon cancer and relationship with cyclooxygenase-2 expression]. ( Wu, K; Yang, J; Zhou, Q, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (1.64) | 29.6817 |
| 2010's | 50 (81.97) | 24.3611 |
| 2020's | 10 (16.39) | 2.80 |
| Authors | Studies |
|---|---|
| Abdel-Wahab, BA | 1 |
| Alqhtani, H | 1 |
| Walbi, IA | 1 |
| Albarqi, HA | 1 |
| Aljadaan, AM | 1 |
| Khateeb, MM | 1 |
| Hassanein, EHM | 1 |
| Ardanareswari, K | 1 |
| Lowisia, W | 1 |
| Soedarini, B | 1 |
| Liao, JW | 1 |
| Chung, YC | 1 |
| Subarmaniam, T | 1 |
| Mahmad Rusli, RN | 1 |
| Perumal, KV | 1 |
| Yong, YK | 1 |
| Hadizah, S | 1 |
| Othman, F | 1 |
| Salem, K | 1 |
| Shafie, NH | 1 |
| Hasham, R | 1 |
| Yin, KB | 1 |
| Abdul Kadir, KK | 1 |
| Bahari, H | 1 |
| Zakaria, ZA | 1 |
| Espírito Santo, SG | 1 |
| Da Silva, TC | 1 |
| Cogliati, B | 1 |
| Barbisan, LF | 3 |
| Romualdo, GR | 1 |
| Dos Reis, SO | 1 |
| da Luz, TC | 1 |
| da Silva Couto, CVM | 1 |
| Dalbó, J | 1 |
| Nunes, LC | 1 |
| Martins, MC | 1 |
| Silva, PI | 1 |
| da Silva, AMA | 1 |
| Trivilin, LO | 1 |
| de Moura, NA | 1 |
| Caetano, BFR | 1 |
| Bidinotto, LT | 1 |
| Rodrigues, MAM | 1 |
| Ghazizadeh Darband, S | 1 |
| Saboory, E | 1 |
| Sadighparvar, S | 1 |
| Kaviani, M | 1 |
| Mobaraki, K | 1 |
| Jabbari, N | 1 |
| Majidinia, M | 1 |
| Zhang, J | 1 |
| Xie, Y | 1 |
| Fan, Q | 1 |
| Wang, C | 1 |
| Lima, DAN | 1 |
| Pelegrini, BB | 1 |
| Uechi, FAA | 1 |
| Varago, RC | 1 |
| Pimenta, BB | 1 |
| Kaneshima, AMS | 1 |
| Kaneshima, EN | 1 |
| Souza, PDC | 1 |
| Pedroso, RB | 1 |
| Silveira, TGV | 1 |
| Becker, TCA | 1 |
| Nguma, E | 1 |
| Tominaga, Y | 1 |
| Yamashita, S | 1 |
| Otoki, Y | 1 |
| Yamamoto, A | 1 |
| Nakagawa, K | 1 |
| Miyazawa, T | 1 |
| Kinoshita, M | 1 |
| do Amaral, LA | 1 |
| da Silva Fleming de Almeida, T | 1 |
| Oliveira de Souza, GH | 1 |
| Baranoski, A | 1 |
| Souza Maris, R | 1 |
| Bittencourt Junior, FF | 1 |
| Murino Rafacho, BP | 1 |
| Duenhas Monreal, AC | 1 |
| Leite Kassuya, CA | 1 |
| Milan Brochado Antoniolli-Silva, AC | 1 |
| Freitas Dos Santos, E | 1 |
| Oliveira, RJ | 3 |
| Limeiras, SM | 2 |
| Ogo, FM | 1 |
| Genez, LA | 1 |
| Carreira, CM | 1 |
| Oliveira, EJ | 1 |
| Pessatto, LR | 2 |
| Neves, SC | 1 |
| Pesarini, JR | 2 |
| Schweich, LC | 1 |
| Silva, RA | 1 |
| Cantero, WB | 2 |
| Antoniolli-Silva, AC | 2 |
| Oliveira, BC | 1 |
| Kassuya, CA | 1 |
| Monreal, AC | 1 |
| Antoniolli-Silva, R | 1 |
| Stefanello, ME | 1 |
| Moulahoum, H | 2 |
| Nagy, AL | 1 |
| Djerdjouri, B | 3 |
| Clichici, S | 1 |
| Sharma, SH | 1 |
| Chellappan, DR | 1 |
| Chinnaswamy, P | 1 |
| Nagarajan, S | 1 |
| Verma, S | 1 |
| Das, P | 1 |
| Kumar, VL | 1 |
| Siddique, AI | 1 |
| Mani, V | 1 |
| Renganathan, S | 1 |
| Ayyanar, R | 1 |
| Nagappan, A | 1 |
| Namasivayam, N | 1 |
| El-Khadragy, MF | 1 |
| Nabil, HM | 1 |
| Hassan, BN | 1 |
| Tohamy, AA | 1 |
| Waaer, HF | 1 |
| Yehia, HM | 1 |
| Alharbi, AM | 1 |
| Moneim, AEA | 1 |
| Ganaie, MA | 1 |
| Al Saeedan, A | 1 |
| Madhkali, H | 1 |
| Jan, BL | 1 |
| Khatlani, T | 1 |
| Sheikh, IA | 1 |
| Rehman, MU | 1 |
| Wani, K | 1 |
| López-Mejia, A | 1 |
| Ortega-Pérez, LG | 1 |
| Godinez-Hernández, D | 1 |
| Nateras-Marin, B | 1 |
| Meléndez-Herrera, E | 1 |
| Rios-Chavez, P | 1 |
| da Silva, FR | 1 |
| Dias, MC | 1 |
| Rodrigues, MA | 1 |
| Gomides, AF | 2 |
| Paula, SO | 1 |
| Rosa, DD | 2 |
| Oliveira, LL | 1 |
| Comastri, DS | 2 |
| Peluzio, Mdo C | 3 |
| Vinothkumar, R | 5 |
| Sudha, M | 3 |
| Nalini, N | 7 |
| Viswanathan, P | 2 |
| Kabalimoorthy, J | 1 |
| Balasubramanian, T | 3 |
| Ansil, PN | 1 |
| Prabha, SP | 1 |
| Nitha, A | 1 |
| Latha, MS | 1 |
| Vinoth Kumar, R | 1 |
| Mohania, D | 1 |
| Kansal, VK | 1 |
| Kruzliak, P | 1 |
| Kumari, A | 1 |
| Summart, R | 1 |
| Chewonarin, T | 2 |
| Furtado, RA | 1 |
| Oliveira, BR | 1 |
| Silva, LR | 1 |
| Cleto, SS | 1 |
| Munari, CC | 1 |
| Cunha, WR | 1 |
| Tavares, DC | 1 |
| Prasad, VG | 1 |
| Kawade, S | 1 |
| Jayashree, BS | 1 |
| Reddy, ND | 1 |
| Francis, A | 1 |
| Nayak, PG | 1 |
| Kishore, A | 1 |
| Nandakumar, K | 1 |
| Rao, CM | 1 |
| Shenoy, RR | 1 |
| Cohen, C | 1 |
| Cardoso, JF | 1 |
| Garcia, SB | 2 |
| Vannucchi, H | 1 |
| Gonçalves, RV | 1 |
| de Paula, SO | 1 |
| Ferreira, CL | 1 |
| Qi, G | 1 |
| Zeng, S | 1 |
| Takashima, T | 1 |
| Nozoe, K | 1 |
| Shobayashi, M | 1 |
| Kakugawa, K | 1 |
| Murakami, K | 1 |
| Jikihara, H | 1 |
| Zhou, L | 1 |
| Shimamoto, F | 1 |
| Novaes, RD | 1 |
| Sequetto, PL | 1 |
| Vilela Gonçalves, R | 1 |
| Cupertino, MC | 1 |
| Santos, EC | 1 |
| Mello, VJ | 1 |
| Araújo, MR | 1 |
| Silva, E | 1 |
| Oliveira, TT | 1 |
| Balaji, C | 1 |
| Muthukumaran, J | 1 |
| Islam, A | 1 |
| Gallaher, DD | 1 |
| Muthu, R | 1 |
| Selvaraj, N | 1 |
| Vaiyapuri, M | 1 |
| Kilari, BP | 1 |
| Kotakadi, VS | 1 |
| Penchalaneni, J | 1 |
| Bounaama, A | 2 |
| Enayat, S | 1 |
| Ceyhan, MS | 1 |
| Banerjee, S | 1 |
| Qamar, TR | 1 |
| Syed, F | 1 |
| Nasir, M | 1 |
| Rehman, H | 1 |
| Zahid, MN | 1 |
| Liu, RH | 1 |
| Iqbal, S | 1 |
| Bordini, HP | 1 |
| Kremer, JL | 1 |
| Fagundes, TR | 1 |
| Melo, GP | 1 |
| Conchon-Costa, I | 1 |
| da Silva, SS | 1 |
| Cecchini, AL | 1 |
| Panis, C | 1 |
| Luiz, RC | 1 |
| Taya, S | 1 |
| Thumvijit, T | 1 |
| Punvittayagul, C | 1 |
| Wongpoomchai, R | 1 |
| Winkelmann, I | 1 |
| Diehl, D | 1 |
| Oesterle, D | 1 |
| Daniel, H | 1 |
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61 other studies available for 1,2-dimethylhydrazine and Aberrant Crypt Foci
| Article | Year |
|---|---|
Piclamilast mitigates 1,2-dimethylhydrazine induced colon cancer in rats through modulation of Ras/PI3K/Akt/mTOR and NF-κβ signaling.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Apoptosis; Benzamides; Cell Proliferation; Colo | 2021 |
Jaboticaba (Myrciaria cauliflora) Fruit Extract Suppressed Aberrant Crypt Formation in 1,2-Dimetylhydrazine-Induced Rats.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Butyrates; Colonic Neoplasms; Colorectal Neopla | 2023 |
The Potential Chemopreventive Effect of
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Andrographis paniculata; Animals; Anticarcinogenic Agent | 2023 |
Panx1 knockout promotes preneoplastic aberrant crypt foci development in a chemically induced model of mouse colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Carcinogenesis; Colon; Colonic Neoplasms; Conne | 2023 |
Juçara (
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Carcinogenesis; Colorectal Neoplasms; Dietary S | 2020 |
Dietary hemin promotes colonic preneoplastic lesions and DNA damage but not tumor development in a medium-term model of colon carcinogenesis in rats.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animal Feed; Animals; Caco-2 Cells; Cocarcinogenesis; Co | 2019 |
The modulatory effects of exercise on the inflammatory and apoptotic markers in rats with 1,2-dimethylhydrazine-induced colorectal cancer.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Apoptosis; Apoptosis Regulatory Proteins; Carci | 2020 |
Effects of karanjin on dimethylhydrazine induced colon carcinoma and aberrant crypt foci are facilitated by alteration of the p53/Bcl2/BAX pathway for apoptosis.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Apoptosis; bcl-2-Associated X Protein; Benzopyr | 2021 |
Evaluation of Antineoplasic Activity of Zingiber Officinale Essential Oil in the Colorectal Region of Wistar Rats.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Antineoplastic Agents; Colorectal Neoplasms; Ma | 2020 |
Dietary PlsEtn Ameliorates Colon Mucosa Inflammatory Stress and ACF in DMH-Induced Colon Carcinogenesis Mice: Protective Role of Vinyl Ether Linkage.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Apoptosis; Carcinogenesis; Colon; Dietary Expos | 2021 |
The Use of Natural Fiber-Rich Food Product Is Safe and Reduces Aberrant Crypt Foci in a Pre-Clinical Model.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animal Feed; Animals; Colon; Colorectal Neoplasms; Cytok | 2021 |
Prevention of DNA damage and anticarcinogenic activity of Activia
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Anticarcinogenic Agents; Colorectal Neoplasms; | 2017 |
Effects of Moquiniastrum polymorphum ssp floccosum ethnolic extract on colorectal carcinogenesis induced by 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Antineoplastic Agents, Phytogenic; Asteraceae; | 2017 |
Precancerous ACF induction affects their regional distribution forsaking oxidative stress implication in 1,2-dimethylhydrazine-induced colon carcinogenesis model.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Antioxidants; Biomarkers, Tumor; Carcinogenesis | 2018 |
Protective effect of p-coumaric acid against 1,2 dimethylhydrazine induced colonic preneoplastic lesions in experimental rats.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Anticarcinogenic Agents; Carcinogenesis; Carcin | 2017 |
Chemoprevention by artesunate in a preclinical model of colorectal cancer involves down regulation of β-catenin, suppression of angiogenesis, cellular proliferation and induction of apoptosis.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Apoptosis; Artemisinins; Artesunate; Aspirin; b | 2017 |
Asiatic acid abridges pre-neoplastic lesions, inflammation, cell proliferation and induces apoptosis in a rat model of colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Apoptosis; bcl-2-Associated X Protein; Caspase | 2017 |
Bone Marrow Cell Therapy on 1,2-Dimethylhydrazine (DMH)-Induced Colon Cancer in Rats.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; ATP Binding Cassette Transporter, Subfamily B, | 2018 |
Chemopreventive efficacy zingerone (4-[4-hydroxy-3-methylphenyl] butan-2-one) in experimental colon carcinogenesis in Wistar rats.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Anticarcinogenic Agents; Carcinogenesis; Coloni | 2019 |
Chemopreventive effect of Callistemon citrinus (Curtis) Skeels against colon cancer induced by 1,2-dimethylhydrazine in rats.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Antineoplastic Agents, Phytogenic; Body Weight; | 2019 |
Lack of protective effects of zinc gluconate against rat colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Administration, Oral; Animals; Anticarcinogenic Agents; | 2013 |
Use of defatted flaxseed meal reduces precancerous colon lesions in C57BL/6 mice.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Carcinogens; Colon; Colonic Neoplasms; Fatty Ac | 2013 |
Chemopreventive effect of zingerone against colon carcinogenesis induced by 1,2-dimethylhydrazine in rats.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Anticarcinogenic Agents; Antioxidants; Carcinog | 2014 |
Modulating effect of d-carvone on 1,2-dimethylhydrazine-induced pre-neoplastic lesions, oxidative stress and biotransforming enzymes, in an experimental model of rat colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Body Weight; Carcinogenesis; Chemoprevention; C | 2013 |
Chemopreventive effect of Amorphophallus campanulatus (Roxb.) blume tuber against aberrant crypt foci and cell proliferation in 1, 2-dimethylhydrazine induced colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Amorphophallus; Animals; Apoptosis; Carcinogens; Catalas | 2013 |
Modulatory effect of troxerutin on biotransforming enzymes and preneoplasic lesions induced by 1,2-dimethylhydrazine in rat colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Anticoagulants; Biotransformation; Carcinogens; | 2014 |
Probiotic Dahi containing Lactobacillus acidophilus and Bifidobacterium bifidum modulates the formation of aberrant crypt foci, mucin-depleted foci, and cell proliferation on 1,2-dimethylhydrazine-induced colorectal carcinogenesis in Wistar rats.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Bifidobacterium; Body Weight; Buffaloes; Carcin | 2014 |
Purple rice extract supplemented diet reduces DMH- induced aberrant crypt foci in the rat colon by inhibition of bacterial β-glucuronidase.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Carcinogens; Colon; Dietary Supplements; DNA Ad | 2014 |
Chemopreventive effects of rosmarinic acid on rat colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Adenocarcinoma; Animals; Antioxidants; Carcinogenesis; C | 2015 |
Iminoflavones combat 1,2-dimethyl hydrazine-induced aberrant crypt foci development in colon cancer.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Cell Line, Tumor; Colonic Neoplasms; Flavones; | 2014 |
Vitamin E supplementation in chemical colorectal carcinogenesis: a two-edged knife.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Biomarkers; Carcinogenesis; Carcinogens; Cell P | 2014 |
Defatted flaxseed meal prevents the appearance of aberrant crypt foci in the colon of mice increasing the gene expression of p53.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Bifidobacterium; Colon; Colonic Neoplasms; Flax | 2015 |
Inhibitory effect of various breads on DMH-induced aberrant crypt foci and colorectal tumours in rats.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Antioxidants; Bread; Colorectal Neoplasms; Male | 2015 |
Depletion of enteroendocrine and mucus-secreting cells is associated with colorectal carcinogenesis severity and impaired intestinal motility in rats.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Colorectal Neoplasms; Disease Models, Animal; E | 2016 |
Effect of sinapic acid on 1,2 dimethylhydrazine induced aberrant crypt foci, biotransforming bacterial enzymes and circulatory oxidative stress status in experimental rat colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Anti-Infective Agents; Carcinogenesis; Catalase | 2015 |
Wheat Type (Class) Influences Development and Regression of Colon Cancer Risk Markers in Rats.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; beta Catenin; Biomarkers, Tumor; Carcinogens; C | 2015 |
Anti-inflammatory and proapoptotic effects of umbelliferone in colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Anti-Inflammatory Agents; Antigens, Nuclear; An | 2016 |
Anti-proliferative and Apoptotic Effects of Basella rubra (L.) Against 1, 2-Dimethyl Hydrazine-induced Colon Carcinogenesis in Rats.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Antigens, Nuclear; Apoptosis; Biomarkers, Tumor | 2016 |
Ethanolic Extract of Bark from Salix aegyptiaca Ameliorates 1,2-dimethylhydrazine-induced Colon Carcinogenesis in Mice by Reducing Oxidative Stress.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Anticarcinogenic Agents; Carcinogens; Chromatog | 2016 |
Novel Combination of Prebiotics Galacto-Oligosaccharides and Inulin-Inhibited Aberrant Crypt Foci Formation and Biomarkers of Colon Cancer in Wistar Rats.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Ammonia; Animals; Anticarcinogenic Agents; Bacterial Pro | 2016 |
Protective effect of metformin in an aberrant crypt foci model induced by 1,2-dimethylhydrazine: Modulation of oxidative stress and inflammatory process.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; AMP-Activated Protein Kinases; Animals; Cell Proliferati | 2017 |
Effect of Spirogyra neglecta on the early stages of 1, 2-dimethylhydrazine-induced colon carcinogenesis in rats.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Anticarcinogenic Agents; Apoptosis; Aryl Hydroc | 2018 |
Flavone induces changes in intermediary metabolism that prevent microadenoma formation in colonic tissue of carcinogen-treated mice.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Adenoma; Animals; Antineoplastic Agents, Phytogenic; Apo | 2010 |
Chemopreventive effects of non-steroidal anti-inflammatory drugs in early neoplasm of experimental colorectal cancer: an apoptosome study.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apopto | 2011 |
Inhibitory effects of dietary caraway essential oils on 1,2-dimethylhydrazine-induced colon carcinogenesis is mediated by liver xenobiotic metabolizing enzymes.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Carum; Colon; Colonic Neoplasms; Cytochrome P-4 | 2011 |
Sodium butyrate does not decrease the evolution of precancerous lesions in rats.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Butyrates; Carcinogens; Colorectal Neoplasms; D | 2010 |
Cancer chemopreventive potential of luteolin-7-O-glucoside isolated from Ophiorrhiza mungos Linn.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Anticarcinogenic Agents; Antioxidants; Apoptosi | 2011 |
Inhibition of 1, 2-dimethylhydrazine-induced mucin-depleted foci and O⁶-methylguanine DNA adducts in the rat colorectum by boiled garlic powder.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Colon; Colonic Neoplasms; DNA Adducts; Garlic; | 2010 |
[Preventive effects of berberine on experimental colon cancer and relationship with cyclooxygenase-2 expression].
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Berberine; Body Weight; Colonic Neoplasms; Cycl | 2010 |
The protective role of Lychnophora ericoides Mart. (Brazilian arnica) in 1,2-dimethylhydrazine-induced experimental colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antica | 2011 |
Multivitamin and mineral supplementation in 1,2-dimethylhydrazine induced experimental colon carcinogenesis and evaluation of free radical status, antioxidant potential, and incidence of ACF.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Anticarcinogenic Agents; Antioxidants; Colonic | 2012 |
Cancer chemopreventive potential of the Egyptian flaxseed oil in a rat colon carcinogenesis bioassay--implications for its mechanism of action.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Adenoma; Animals; Anticarcinogenic Agents; Body Weight; | 2011 |
The modulatory influence of p-methoxycinnamic acid, an active rice bran phenolic acid, against 1,2-dimethylhydrazine-induced lipid peroxidation, antioxidant status and aberrant crypt foci in rat colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Catalase; Cinnamates; Colonic Neoplasms; Glutat | 2012 |
Effect of dietary caraway essential oils on expression of β-catenin during 1,2-dimethylhydrazine-induced colonic carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Anticarcinogenic Agents; beta Catenin; Carcinog | 2013 |
Ellagic acid modulates antioxidant status, ornithine decarboxylase expression, and aberrant crypt foci progression in 1,2-dimethylhydrazine-instigated colon preneoplastic lesions in rats.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Anticarcinogenic Agents; Antioxidants; Carcinog | 2012 |
Antiproliferative efficacy of hesperetin (citrus flavanoid) in 1,2-dimethylhydrazine-induced colon cancer.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Anticarcinogenic Agents; Carcinogens; Cell Tran | 2013 |
Modulatory efficacy of rosmarinic acid on premalignant lesions and antioxidant status in 1,2-dimethylhydrazine induced rat colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Anticarcinogenic Agents; Antioxidants; Carcinog | 2012 |
Short curcumin treatment modulates oxidative stress, arginase activity, aberrant crypt foci, and TGF-β1 and HES-1 transcripts in 1,2-dimethylhydrazine-colon carcinogenesis in mice.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Antioxidants; Apoptosis; Arginase; Basic Helix- | 2012 |
Glucagon-like peptide-1 (GLP-1) receptor agonism or DPP-4 inhibition does not accelerate neoplasia in carcinogen treated mice.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Adenoma; Anatomy, Cross-Sectional; Animals; Chlorocebus | 2012 |
Probiotics Lactobacillus rhamnosus GG, Lactobacillus acidophilus suppresses DMH-induced procarcinogenic fecal enzymes and preneoplastic aberrant crypt foci in early colon carcinogenesis in Sprague Dawley rats.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Body Weight; Colonic Neoplasms; Feces; Glucuron | 2013 |
[Pioglitazone, a peroxisome proliferators-activated receptor gamma ligand, inhibits dimethylhydrazine (DMH) induced aberrant crypt foci in rats].
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Colonic Neoplasms; Female; Intestinal Mucosa; P | 2003 |