1-2-dilauroylphosphatidylcholine and Body-Weight

Efficacy of alpha-TEA formulated in liposome or biodegradable poly(D, L-lactide-co-glycolide) (PLGA) nanoparticle was evaluated in a BALB/c clone 66cl-4 mammary cancer mouse model using oral delivery. alpha-TEA-loaded liposome or nanoparticle at 5 mg, but not 2.5 mg/day, significantly reduced tumor burden (p < 0.001). Both formulations at 5 mg significantly reduced visible lung metastases and lymph node and lung micrometastatic tumor foci. Surprisingly, nanoparticle control mice exhibited significantly reduced tumor burden, lymph node, and lung micrometastatic tumor foci. Both formulations at 5 mg significantly enhanced tumor apoptosis. In summary, liposomes and nanoparticles are effective means for administering the lipophilic anticancer drug alpha-TEA.

Topics: Administration, Oral; Animals; Antineoplastic Agents; Apoptosis; Body Weight; Cell Line, Tumor; Female; Lactic Acid; Liposomes; Lung Neoplasms; Lymph Nodes; Lymphocytes; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Nanoparticles; Particle Size; Phosphatidylcholines; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Tocopherols; Tumor Burden