1-2-4-trioxane and Parasitemia

1-2-4-trioxane has been researched along with Parasitemia* in 1 studies

Other Studies

1 other study(ies) available for 1-2-4-trioxane and Parasitemia

ArticleYear
New functionalized 1,2,4-trioxepanes: synthesis and antimalarial activity against multi-drug resistant P. yoelii in mice.
    Bioorganic & medicinal chemistry letters, 2008, Oct-01, Volume: 18, Issue:19

    A series of new amino functionalized 1,2,4-trioxepanes 8-16 and ester functionalized 1,2,4-trioxepanes 17-19 have been synthesized and evaluated against multi-drug resistant Plasmodium yoelii in Swiss mice. Amino functionalized trioxepanes 14, the most active compound of the series, showed 100% clearance of parasitaemia by oral route on day 4 and 75% protection to the treated mice beyond day 28.

    Topics: Administration, Oral; Animals; Antimalarials; Artemisinins; Combinatorial Chemistry Techniques; Drug Resistance, Multiple; Heterocyclic Compounds; Mice; Parasitemia; Plasmodium yoelii; Propanols; Structure-Activity Relationship

2008