1,2,3,4-tetrahydroxy-nor-tropane has been researched along with Gaucher Disease in 2 studies
*Gaucher Disease: An autosomal recessive disorder caused by a deficiency of acid beta-glucosidase (GLUCOSYLCERAMIDASE) leading to intralysosomal accumulation of glycosylceramide mainly in cells of the MONONUCLEAR PHAGOCYTE SYSTEM. The characteristic Gaucher cells, glycosphingolipid-filled HISTIOCYTES, displace normal cells in BONE MARROW and visceral organs causing skeletal deterioration, hepatosplenomegaly, and organ dysfunction. There are several subtypes based on the presence and severity of neurological involvement. [MeSH]
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Allman, S; Butters, TD; Jensen, HH; Rasmussen, TS; Twigg, G | 1 |
| Adachi, I; Hirono, S; Kato, A; Koike, Y; Nakagawa, S; Nakagome, I; Nash, RJ | 1 |
2 other study(ies) available for 1,2,3,4-tetrahydroxy-nor-tropane and Gaucher Disease
| Article | Year |
|---|---|
Synthesis of N-alkylated noeurostegines and evaluation of their potential as treatment for Gaucher's disease.
Topics: Enzyme Assays; Gaucher Disease; Glucosylceramidase; Humans; Inhibitory Concentration 50; Nortropanes | 2011 |
Docking and SAR studies of calystegines: binding orientation and influence on pharmacological chaperone effects for Gaucher's disease.
Topics: Binding Sites; Catalytic Domain; Cell Line; Gaucher Disease; Glucosylceramidase; Humans; Hydrogen Bonding; Imino Pyranoses; Isomerism; Molecular Docking Simulation; Nortropanes; Solanaceous Alkaloids; Static Electricity; Structure-Activity Relationship; Tropanes | 2014 |