Compounds > 1-2-3-4-tetrahydro-beta-carboline-3-carboxylic-acid--(s)-isomer

1-2-3-4-tetrahydro-beta-carboline-3-carboxylic-acid--(s)-isomer and Disease-Models--Animal

1-2-3-4-tetrahydro-beta-carboline-3-carboxylic-acid--(s)-isomer has been researched along with Disease-Models--Animal* in 1 studies

Other Studies

1 other study(ies) available for 1-2-3-4-tetrahydro-beta-carboline-3-carboxylic-acid--(s)-isomer and Disease-Models--Animal

ArticleYear
Synthesis and antithrombotic activity of carbolinecarboxyl RGD sequence.
    Bioorganic & medicinal chemistry letters, 2002, Feb-25, Volume: 12, Issue:4

    3S-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid, RGDS, RGDV, RGDF and their linkers were synthesized. The anti-aggregation and adhesion of platelet indicated that the in vitro activities of the linkers remained at the same level as RGDS, RGDV, and RGDF (p>0.05). The antithrombotic activities in vivo suggested, however, that the potencies of RGDS, RGDV and RGDF were enhanced by the introduction of 3S-1,2,3,4-tetrahydro-beta-carboline-3-carboxyl group into their alpha amino group (p<0.05, 0.01 or 0.001).

    Topics: Animals; Carbolines; Cell Adhesion; Disease Models, Animal; Fibrinolytic Agents; Humans; Male; Oligopeptides; Platelet Aggregation; Rabbits; Rats; Rats, Wistar; Structure-Activity Relationship; Thrombosis; Tumor Cells, Cultured

2002