1,10-phenanthroline has been researched along with Leukemia in 2 studies
1,10-phenanthroline: RN given refers to parent cpd; inhibits Zn-dependent metalloproteinases
Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pyrrolidine dithiocarbamate (PDTC) has been considered as a potential anticancer drug due to its powerful apoptogenic effect towards cancer cells, where Cu(2+) plays a distinct yet undefined role." | 5.35 | Cu2+ is required for pyrrolidine dithiocarbamate to inhibit histone acetylation and induce human leukemia cell apoptosis. ( Chen, J; Du, C; Kang, J; Wang, J, 2008) |
| "Pyrrolidine dithiocarbamate (PDTC) has been considered as a potential anticancer drug due to its powerful apoptogenic effect towards cancer cells, where Cu(2+) plays a distinct yet undefined role." | 1.35 | Cu2+ is required for pyrrolidine dithiocarbamate to inhibit histone acetylation and induce human leukemia cell apoptosis. ( Chen, J; Du, C; Kang, J; Wang, J, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, J | 1 |
| Du, C | 1 |
| Kang, J | 1 |
| Wang, J | 1 |
| Rebeiz, N | 1 |
| Arkins, S | 1 |
| Kelley, KW | 1 |
| Durack, G | 1 |
| Rebeiz, CA | 1 |
2 other studies available for 1,10-phenanthroline and Leukemia
| Article | Year |
|---|---|
Cu2+ is required for pyrrolidine dithiocarbamate to inhibit histone acetylation and induce human leukemia cell apoptosis.
Topics: Acetylation; Apoptosis; Butyrates; Cell Line, Tumor; Cell Proliferation; Chelating Agents; Copper; C | 2008 |
Modulator of heme biosynthesis induces apoptosis in leukemia cells.
Topics: Aminolevulinic Acid; Animals; Apoptosis; Cell Cycle; Cell Division; Cell Membrane Permeability; Cell | 2001 |