1,10-phenanthroline has been researched along with Alzheimer Disease in 5 studies
1,10-phenanthroline: RN given refers to parent cpd; inhibits Zn-dependent metalloproteinases
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Alzheimer's disease is characterized by the deposits of the 4-kDa amyloid beta peptide (A beta)." | 1.31 | A novel gamma -secretase assay based on detection of the putative C-terminal fragment-gamma of amyloid beta protein precursor. ( Eckman, C; Golde, T; Musunuru, U; Onstead, L; Pinnix, I; Sambamurti, K; Sridharan, A; Tun, H; Ziani-Cherif, C, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gladis, EHE | 1 |
| Nagashri, K | 1 |
| Anisha, M | 1 |
| Joseph, J | 1 |
| Chitra, L | 1 |
| Kumar, CR | 1 |
| Basha, HM | 1 |
| Ponne, S | 1 |
| Boopathy, R | 1 |
| Streltsov, VA | 1 |
| Chandana Epa, V | 1 |
| James, SA | 1 |
| Churches, QI | 1 |
| Caine, JM | 1 |
| Kenche, VB | 1 |
| Barnham, KJ | 1 |
| Ma, G | 1 |
| Huang, F | 1 |
| Pu, X | 1 |
| Jia, L | 1 |
| Jiang, T | 1 |
| Li, L | 1 |
| Liu, Y | 1 |
| Pinnix, I | 1 |
| Musunuru, U | 1 |
| Tun, H | 1 |
| Sridharan, A | 1 |
| Golde, T | 1 |
| Eckman, C | 1 |
| Ziani-Cherif, C | 1 |
| Onstead, L | 1 |
| Sambamurti, K | 1 |
5 other studies available for 1,10-phenanthroline and Alzheimer Disease
| Article | Year |
|---|---|
Synthesis, characterisation, DNA binding, acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) activities and molecular docking studies of metal(II) complexes with 1,10-phenanthroline scaffold.
Topics: Acetylcholinesterase; Alzheimer Disease; Butyrylcholinesterase; Cholinesterase Inhibitors; Coordinat | 2023 |
Interaction of metal chelators with different molecular forms of acetylcholinesterase and its significance in Alzheimer's disease treatment.
Topics: Acetylcholinesterase; Alzheimer Disease; Amidohydrolases; Amyloid beta-Peptides; Chelating Agents; C | 2013 |
Structural insights into the interaction of platinum-based inhibitors with the Alzheimer's disease amyloid-β peptide.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Coordination Complexes; Humans; Light; Phenanthrolines; Pl | 2013 |
Identification of [PtCl2(phen)] binding modes in amyloid-β peptide and the mechanism of aggregation inhibition.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Binding Sites; Chromatography, High P | 2011 |
A novel gamma -secretase assay based on detection of the putative C-terminal fragment-gamma of amyloid beta protein precursor.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein | 2001 |