Compounds > 1-1-diphenyl-2-picrylhydrazyl

1-1-diphenyl-2-picrylhydrazyl and Precursor-Cell-Lymphoblastic-Leukemia-Lymphoma

1-1-diphenyl-2-picrylhydrazyl has been researched along with Precursor-Cell-Lymphoblastic-Leukemia-Lymphoma* in 2 studies

Other Studies

2 other study(ies) available for 1-1-diphenyl-2-picrylhydrazyl and Precursor-Cell-Lymphoblastic-Leukemia-Lymphoma

Article	Year
Evaluation of biological activities of Alpinia mutica Roxb. and its chemical constituents. Pakistan journal of pharmaceutical sciences, 2013, Volume: 26, Issue:2 Phytochemicals investigation on rhizomes of Alpinia mutica has afforded five compounds namely 5,6-dehydrokawain (1), flavokawin B (2), pinostrobin (3) and pinocembrin (4) together with β-sitosterol (5). All crude extracts of the plant demonstrated strong cytotoxicity against CEMss (human T4 lymphoblastoid) cancer cells with IC50 values less than 19 μg/mL, while flavokawin B (2) was the most cytotoxic isolate with IC50 value 1.86±0.37 μg/mL. Most of the crude extracts and isolated compounds showed weak activity in antimicrobial and diphenylpicrylhydrazyl (DPPH) radical scavenging activity tests. Topics: Alpinia; Anti-Infective Agents; Antineoplastic Agents, Phytogenic; Bacteria; Biphenyl Compounds; Cell Line, Tumor; Cell Survival; Disk Diffusion Antimicrobial Tests; Dose-Response Relationship, Drug; Free Radical Scavengers; Humans; Inhibitory Concentration 50; Molecular Structure; Picrates; Plant Extracts; Plants, Medicinal; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Rhizome	2013
The apoptotic and anti-proliferative activity of Origanum majorana extracts on human leukemic cell line. Leukemia research, 2010, Volume: 34, Issue:8 Scientists are constantly searching for phytochemicals and compounds with anti-cancer and antioxidant activity. In this study, the anti-proliferative activity of plant extracts from Origanum majorana (marjoram) was tested on human lymphoblastic leukemia cell line Jurkat. Cytotoxicity was examined using non-radioactive cytotoxicity assay and the IC(50) was calculated. At non-cytotoxic concentrations, the viability of cells decreased with increase of concentration of plant extract. The anti-proliferative effect was also found to be dose-dependent. Analysis via flow cytometry shows that marjoram extracts stimulated apoptosis. Induction of apoptosis was caused by an up-regulation of p53 protein levels and down-regulation of Bcl-2alpha. Marjoram exhibited a strong scavenging activity (SC(50)=0.03mg dry weight). The conclusions from this study suggest that marjoram extracts exhibit anti-proliferative effect and high antioxidant activity. For that it merits further investigation as a potential therapeutic agent. Topics: Apoptosis; Biphenyl Compounds; Blotting, Western; Cell Proliferation; Free Radical Scavengers; Humans; Origanum; Phytotherapy; Picrates; Plant Extracts; Precursor Cell Lymphoblastic Leukemia-Lymphoma; RNA, Messenger; Tumor Cells, Cultured	2010

Article

Year

Evaluation of biological activities of Alpinia mutica Roxb. and its chemical constituents.

Pakistan journal of pharmaceutical sciences, 2013, Volume: 26, Issue:2

Phytochemicals investigation on rhizomes of Alpinia mutica has afforded five compounds namely 5,6-dehydrokawain (1), flavokawin B (2), pinostrobin (3) and pinocembrin (4) together with β-sitosterol (5). All crude extracts of the plant demonstrated strong cytotoxicity against CEMss (human T4 lymphoblastoid) cancer cells with IC50 values less than 19 μg/mL, while flavokawin B (2) was the most cytotoxic isolate with IC50 value 1.86±0.37 μg/mL. Most of the crude extracts and isolated compounds showed weak activity in antimicrobial and diphenylpicrylhydrazyl (DPPH) radical scavenging activity tests.

Topics: Alpinia; Anti-Infective Agents; Antineoplastic Agents, Phytogenic; Bacteria; Biphenyl Compounds; Cell Line, Tumor; Cell Survival; Disk Diffusion Antimicrobial Tests; Dose-Response Relationship, Drug; Free Radical Scavengers; Humans; Inhibitory Concentration 50; Molecular Structure; Picrates; Plant Extracts; Plants, Medicinal; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Rhizome

2013

The apoptotic and anti-proliferative activity of Origanum majorana extracts on human leukemic cell line.

Leukemia research, 2010, Volume: 34, Issue:8

Scientists are constantly searching for phytochemicals and compounds with anti-cancer and antioxidant activity. In this study, the anti-proliferative activity of plant extracts from Origanum majorana (marjoram) was tested on human lymphoblastic leukemia cell line Jurkat. Cytotoxicity was examined using non-radioactive cytotoxicity assay and the IC(50) was calculated. At non-cytotoxic concentrations, the viability of cells decreased with increase of concentration of plant extract. The anti-proliferative effect was also found to be dose-dependent. Analysis via flow cytometry shows that marjoram extracts stimulated apoptosis. Induction of apoptosis was caused by an up-regulation of p53 protein levels and down-regulation of Bcl-2alpha. Marjoram exhibited a strong scavenging activity (SC(50)=0.03mg dry weight). The conclusions from this study suggest that marjoram extracts exhibit anti-proliferative effect and high antioxidant activity. For that it merits further investigation as a potential therapeutic agent.

Topics: Apoptosis; Biphenyl Compounds; Blotting, Western; Cell Proliferation; Free Radical Scavengers; Humans; Origanum; Phytotherapy; Picrates; Plant Extracts; Precursor Cell Lymphoblastic Leukemia-Lymphoma; RNA, Messenger; Tumor Cells, Cultured

2010