1-1-diphenyl-2-picrylhydrazyl and Peptic-Ulcer

The aqueous extract of C. borivilianum (250 mg/kg for 7 days) significantly reverted the elevated levels of plasma glucose, triglycerides, cholesterol and serum corticosterone and also reduced the ulcer index, adrenal gland weight more as effectively as the standard drug (diazepam) in rats. At 125 mg/kg po, it showed a mild anti-stress activity. Under in vitro 1,1-diphenyl-2-picrylhydrazyl (DPPH*) free radical scavenging assay and lipid peroxidation assay the extract considerably inhibited, in a dose-dependent manner, the levels of DPPH* free radicals and thiobarbituric acid reactive substances, respectively thus showing significant antioxidant property. The results suggested that it could be used for the treatment of oxidative stress-induced disorders.

Topics: Adrenal Glands; Animals; Antioxidants; Asparagaceae; Biphenyl Compounds; Free Radical Scavengers; Hydrazines; Lipid Peroxidation; Male; Organ Size; Peptic Ulcer; Picrates; Plant Extracts; Plant Roots; Powders; Rats; Rats, Wistar; Restraint, Physical; Stress, Psychological