1-1-diphenyl-2-picrylhydrazyl has been researched along with Hypoglycemia* in 2 studies
2 other study(ies) available for 1-1-diphenyl-2-picrylhydrazyl and Hypoglycemia
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A Series of Ferulic Acid Amides Reveals Unexpected Peroxiredoxin 1 Inhibitory Activity with in vivo Antidiabetic and Hypolipidemic Effects.
Insulin resistance is a major pathophysiological feature in the development of type 2 diabetes (T2DM). Ferulic acid is known for attenuating the insulin resistance and reducing the blood glucose in T2DM rats. In this work, we designed and synthesized a library of new ferulic acid amides (FAA), which could be considered as ring opening derivatives of the antidiabetic PPARγ agonists Thiazolidinediones (TZDs). However, since these compounds displayed weak PPAR transactivation capacity, we employed a proteomics approach to unravel their molecular target(s) and identified the peroxiredoxin 1 (PRDX1) as a direct binding target of FAAs. Interestingly, PRDX1, a protein with antioxidant and chaperone activity, has been implied in the development of T2DM by inducing hepatic insulin resistance. SPR, mass spectrometry-based studies, docking experiments and in vitro inhibition assay confirmed that compounds VIe and VIf bound PRDX1 and induced a dose-dependent inhibition. Furthermore, VIe and VIf significantly improved hyperglycemia and hyperlipidemia in streptozotocin-nicotinamide (STZ-NA)-induced diabetic rats as confirmed by histopathological examinations. These results provide guidance for developing the current FAAs as new potential antidiabetic agents. Topics: Amides; Animals; Biphenyl Compounds; Cell Survival; Coumaric Acids; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Hypoglycemia; Hypoglycemic Agents; Hypolipidemic Agents; Male; Models, Molecular; Molecular Structure; Peroxiredoxins; Picrates; Rats; Rats, Sprague-Dawley; Rats, Wistar; Streptozocin; Structure-Activity Relationship; Tumor Cells, Cultured | 2021 |
Pycnalin, a new α-glucosidase inhibitor from Acer pycnanthum.
A new compound, pycnalin (1), together with four known compounds, ginnalins A (2), B (3), C (4), and 3,6-di-O-galloyl-1,5-anhydro-D-glucitol (3,6-di-GAG) (5), were isolated from Acer pycnanthum. The structure of 1 was determined on the basis of 2D-NMR spectral data and synthesis of 1. Pycnalin (1) is the first 1,5-anhydro-D-mannitol linked to a gallic acid, while compounds 2-5 were 1,5-anhydro-D-glucitol linked to gallic acids. All compounds were tested in vitro for α-glucosidase inhibitory and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activities. Pycnalin (1) exhibited moderate α-glucosidase inhibitory activity as well as free radical scavenging activity. Ginnalin A (2) and 3,6-di-GAG (5), which have two galloyl groups, exhibited potent α-glucosidase inhibition, compared to those of other compounds 1, 3, and 4 containing a galloyl group. These results suggest that α-glucosidase inhibition is influenced by the number of galloyl groups. Topics: Acer; Biphenyl Compounds; Deoxyglucose; Enzyme Inhibitors; Free Radical Scavengers; Gallic Acid; Glycoside Hydrolase Inhibitors; Glycosides; Humans; Hypoglycemia; Hypoglycemic Agents; Magnetic Resonance Spectroscopy; Picrates; Plant Extracts; Sorbitol | 2011 |