1-1-diphenyl-2-picrylhydrazyl and Cross-Infection

Methanolic extracts of Chuquiraga straminea Sandwith, subfamily Barnadesioideae (Asteraceae) showed the presence of quercetin-3-O-glucoside, quercetin-3-O-rutinoside, kaempferol, kaempferol-3-O-glucoside and kaempferol-3-O-rutinoside. Antioxidant and antimicrobial activity was determined. The total extracts showed antioxidant activity by DPPH and ABTS method (SC50 14.5 to 34.9 microg/mL). A significantly positive correlation was observed between the antioxidant activity and the total phenolics (R2 > 0.93). The extracts were active against ten methicillin resistant and sensitive Staphylococcus aureus strains isolated from nosocomial infection (MIC values between 200 to 800 microg/mL). These preliminary studies are highly interesting as they open new ways for further applications in the treatment of infections by methicillin resistant S. aureus.

Topics: Antifungal Agents; Argentina; Asteraceae; Benzothiazoles; Biphenyl Compounds; Cross Infection; Ethnopharmacology; Flavonoids; Free Radical Scavengers; Humans; Methicillin Resistance; Microbial Sensitivity Tests; Picrates; Pilot Projects; Plant Components, Aerial; Plant Extracts; Staphylococcal Infections; Staphylococcus aureus; Sulfonic Acids