1-1-diphenyl-2-picrylhydrazyl has been researched along with Cognition-Disorders* in 3 studies
3 other study(ies) available for 1-1-diphenyl-2-picrylhydrazyl and Cognition-Disorders
| Article | Year |
|---|---|
Studies of the Anti-amnesic Effects and Mechanisms of Single and Combined Use of Donepezil and Ginkgo Ketoester Tablet on Scopolamine-Induced Memory Impairment in Mice.
Topics: Acetylcholine; Acetylcholinesterase; Amnesia; Animals; Benzothiazoles; Biphenyl Compounds; Brain-Derived Neurotrophic Factor; Cholinesterase Inhibitors; Cognition Disorders; Donepezil; Drug Therapy, Combination; Ginkgo biloba; Ginkgolides; Ligands; Malondialdehyde; Memory Disorders; Mice, Inbred ICR; Molecular Docking Simulation; Picrates; Plant Extracts; Receptor, trkB; Scopolamine; Sulfonic Acids; Superoxide Dismutase; Tablets | 2019 |
In vitro screening for anti-cholinesterase and antioxidant activity of methanolic extracts of ayurvedic medicinal plants used for cognitive disorders.
Inhibition of Acetylcholinesterase (AChE) is still considered as the main therapeutic strategy against Alzheimer's disease (AD). Many plant derived phytochemicals have shown AChE inhibitory activity in addition to the currently approved drugs for AD. In the present study, methanolic extracts of 20 plants used in Indian Ayurvedic system of medicine for improving cognitive function were screened for acetylcholinesterase inhibitory activity by Ellman's microplate colorimetric method. Out of 20 extracts, Emblica officinalis, Nardostachys jatamansi, Nelumbo nucifera, Punica granatum and Raulfia Serpentina showed IC50 values <100 µg/ml for acetylcholinesterase inhibitory activity. Antioxidant activities of these plants were assessed by DPPH scavenging assay. Among the extracts used, antioxidant activity was highest for Terminalia chebula and Emblica officinalis with IC50 values <10 µg/ml. Considering the complex multifactorial etiology of AD, these plant extracts will be safer and better candidates for the future disease modifying therapies against this devastating disease. Topics: Acetylcholinesterase; Antioxidants; Biphenyl Compounds; Cholinesterase Inhibitors; Cognition Disorders; Drug Evaluation, Preclinical; Humans; In Vitro Techniques; Methanol; Picrates; Plant Extracts; Plants, Medicinal | 2014 |
Antioxidant and memory enhancing effects of purple sweet potato anthocyanin and cordyceps mushroom extract.
The effects of purple sweet potato anthocyanin (SPA) and Cordyceps mushroom extract (CME) on lipid peroxidation, 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals and cognitive deficits were examined. Both SPA and CME exhibited DPPH radical scavenging activities with similar potency. In contrast, only SPA was shown to effectively inhibit lipid peroxidation initiated by Fe2+ and ascorbic acid in rat brain homogenates. Furthermore, SPA markedly enhanced cognitive performance, assessed by passive avoidance test in ethanol-treated mice. Combined treatments with SPA and CME did not significantly influence the effects of SPA alone. These results demonstrate that anthocyanin prepared from purple sweet potato exhibits memory enhancing effects, which may be associated with its antioxidant properties. Topics: Administration, Oral; Agaricales; Animals; Anthocyanins; Antioxidants; Avoidance Learning; Biphenyl Compounds; Brain; Cognition Disorders; Complex Mixtures; Cordyceps; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Ethanol; Free Radical Scavengers; Hydroxyl Radical; Ipomoea batatas; Lipid Peroxidation; Male; Memory Disorders; Mice; Mice, Inbred ICR; Phytotherapy; Picrates; Plant Extracts; Rats; Rats, Sprague-Dawley | 2003 |