1-1-dimethyl-4-acetylpiperazinium has been researched along with Cell-Transformation--Neoplastic* in 1 studies
1 other study(ies) available for 1-1-dimethyl-4-acetylpiperazinium and Cell-Transformation--Neoplastic
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HPIP is an essential scaffolding protein running through the EGFR-RAS-ERK pathway and drives tumorigenesis.
The EGFR-RAS-ERK pathway plays a key role in cancer development and progression. However, the integral assembly of EGFR-RAS-ERK signaling complexes from the upstream component EGFR to the downstream component ERK is largely unknown. Here, we show that hematopoietic PBX-interacting protein (HPIP) interacts with all classical components of the EGFR-RAS-ERK pathway and forms at least two complexes with overlapping components. Experiments of HPIP knockout or knockdown and chemical inhibition of HPIP expression showed that HPIP is required for EGFR-RAS-ERK signaling complex formation, EGFR-RAS-ERK signaling activation, and EGFR-RAS-ERK signaling-mediated promotion of aerobic glycolysis as well as cancer cell growth in vitro and in vivo. HPIP expression is correlated with EGFR-RAS-ERK signaling activation and predicts worse clinical outcomes in patients with lung cancer. These results provide insights into EGFR-RAS-ERK signaling complex formation and EGFR-RAS-ERK signaling regulation and suggest that HPIP may be a promising therapeutic target for cancer with dysregulated EGFR-RAS-ERK signaling. Topics: Cell Transformation, Neoplastic; ErbB Receptors; Humans; MAP Kinase Signaling System; Transcription Factors | 2023 |