Compounds > 1-1-diethyl-2-hydroxy-2-nitrosohydrazine

1-1-diethyl-2-hydroxy-2-nitrosohydrazine and Amyotrophic-Lateral-Sclerosis

1-1-diethyl-2-hydroxy-2-nitrosohydrazine has been researched along with Amyotrophic-Lateral-Sclerosis* in 1 studies

Other Studies

1 other study(ies) available for 1-1-diethyl-2-hydroxy-2-nitrosohydrazine and Amyotrophic-Lateral-Sclerosis

Article	Year
Effect of nitric oxide on lymphocytes from sporadic amyotrophic lateral sclerosis patients: toxic or protective role? Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2006, Volume: 27, Issue:5 Markers of oxidative and nitrosative stress have been found in spinal cord, cortex, cerebrospinal fluid and plasma of patients affected by amyotrophic lateral sclerosis (ALS), a fatal disorder characterised by progressive motor neuron degeneration. In this study, we investigated the effect of the NO-releasing agent, diethylamine NONOate (NONO), on lymphocytes from patients affected by the sporadic form of ALS (SALS) and controls by flow cytometry. In the same experimental conditions we investigated the expression of the antioxidant proteins, Bcl-2 and SOD1. Incubation with NONO induced cell damage in control lymphocytes but did not further damage the already affected untreated SALS lymphocytes. The incubation with NONO induced a time-dependent decrease of Bcl-2 and SOD1 in control lymphocytes. Surprisingly, in SALS lymphocytes the NONO treatment increased the expression of these proteins, which in basal conditions was depressed compared to control lymphocytes. Topics: Amyotrophic Lateral Sclerosis; Analysis of Variance; Blotting, Western; Case-Control Studies; Humans; Hydrazines; Lymphocytes; Nitric Oxide; Nitric Oxide Donors; Proto-Oncogene Proteins c-bcl-2; Superoxide Dismutase; Superoxide Dismutase-1; Time Factors	2006

Article

Year

Effect of nitric oxide on lymphocytes from sporadic amyotrophic lateral sclerosis patients: toxic or protective role?

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2006, Volume: 27, Issue:5

Markers of oxidative and nitrosative stress have been found in spinal cord, cortex, cerebrospinal fluid and plasma of patients affected by amyotrophic lateral sclerosis (ALS), a fatal disorder characterised by progressive motor neuron degeneration. In this study, we investigated the effect of the NO-releasing agent, diethylamine NONOate (NONO), on lymphocytes from patients affected by the sporadic form of ALS (SALS) and controls by flow cytometry. In the same experimental conditions we investigated the expression of the antioxidant proteins, Bcl-2 and SOD1. Incubation with NONO induced cell damage in control lymphocytes but did not further damage the already affected untreated SALS lymphocytes. The incubation with NONO induced a time-dependent decrease of Bcl-2 and SOD1 in control lymphocytes. Surprisingly, in SALS lymphocytes the NONO treatment increased the expression of these proteins, which in basal conditions was depressed compared to control lymphocytes.

Topics: Amyotrophic Lateral Sclerosis; Analysis of Variance; Blotting, Western; Case-Control Studies; Humans; Hydrazines; Lymphocytes; Nitric Oxide; Nitric Oxide Donors; Proto-Oncogene Proteins c-bcl-2; Superoxide Dismutase; Superoxide Dismutase-1; Time Factors

2006