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1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Wallerian Degeneration

1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with Wallerian Degeneration in 2 studies

1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
1-(5-isoquinolinesulfonyl)-2-methylpiperazine : A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.

Wallerian Degeneration: Degeneration of distal aspects of a nerve axon following injury to the cell body or proximal portion of the axon. The process is characterized by fragmentation of the axon and its MYELIN SHEATH.

Research Excerpts

ExcerptRelevanceReference
" Injection of 10 microM and 100 microM Y-27632 induced extension of the optic axons beyond the crush site, with the latter dosage giving stronger regeneration."1.35Differential effects of two ROCK inhibitors, Fasudil and Y-27632, on optic nerve regeneration in adult cats. ( Ichikawa, M; Sagawa, H; Saito, K; Tokita, Y; Watanabe, M; Yoshida, J, 2008)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Sun, X1
Minohara, M1
Kikuchi, H1
Ishizu, T1
Tanaka, M1
Piao, H1
Osoegawa, M1
Ohyagi, Y1
Shimokawa, H1
Kira, J1
Ichikawa, M1
Yoshida, J1
Saito, K1
Sagawa, H1
Tokita, Y1
Watanabe, M1

Other Studies

2 other studies available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Wallerian Degeneration

ArticleYear
The selective Rho-kinase inhibitor Fasudil is protective and therapeutic in experimental autoimmune encephalomyelitis.
    Journal of neuroimmunology, 2006, Volume: 180, Issue:1-2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Central Nervous System; Chemotaxis, Leukocyt

2006
Differential effects of two ROCK inhibitors, Fasudil and Y-27632, on optic nerve regeneration in adult cats.
    Brain research, 2008, Mar-27, Volume: 1201

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Axons; Cats; Cells, Cultured; Dose-R

2008