1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with Substance Withdrawal Syndrome in 8 studies
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
1-(5-isoquinolinesulfonyl)-2-methylpiperazine : A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.
Substance Withdrawal Syndrome: Physiological and psychological symptoms associated with withdrawal from the use of a drug after prolonged administration or habituation. The concept includes withdrawal from smoking or drinking, as well as withdrawal from an administered drug.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (62.50) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zuo, W | 1 |
| Wu, L | 1 |
| Mei, Q | 1 |
| Zuo, Q | 1 |
| Zhou, Z | 1 |
| Fu, R | 1 |
| Li, W | 1 |
| Wu, W | 1 |
| Matthew, L | 1 |
| Ye, JH | 1 |
| Wang, J | 1 |
| Li, M | 1 |
| Wang, P | 1 |
| Zha, Y | 1 |
| He, Z | 1 |
| Li, Z | 1 |
| Tokuyama, S | 2 |
| Feng, Y | 1 |
| Wakabayashi, H | 2 |
| Ho, IK | 2 |
| Cruz, SL | 1 |
| Villarreal, JE | 1 |
| Volkow, ND | 1 |
| Maldonado, R | 2 |
| Valverde, O | 2 |
| Garbay, C | 1 |
| Roques, BP | 2 |
| Tzavara, E | 1 |
| Hanoune, J | 1 |
| Zhu, H | 1 |
| Feng, YZ | 1 |
| Lu, L | 1 |
| Zeng, S | 1 |
| Liu, D | 1 |
| Ceng, X | 1 |
8 other studies available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Substance Withdrawal Syndrome
| Article | Year |
|---|---|
Adaptation in 5-HT
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium-Calmodulin-Dependent Protein Kinase | 2019 |
Inhibition of the lateral habenular CaMKā
” abolishes naloxone-precipitated conditioned place aversion in morphine-dependent mice.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Avoidance Learning; Calcium-Calmodulin-Depen | 2017 |
Possible involvement of protein kinases in physical dependence on opioids: studies using protein kinase inhibitors, H-7 and H-8.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Behavior, Animal; Butorphanol; Cytosol; Enzy | 1995 |
Further evidence that naloxone acts as an inverse opiate agonist: implications for drug dependence and withdrawal.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Guinea Pigs; Ileum; In Vitro Techniques; Iso | 1996 |
Protein kinases in the locus coeruleus and periaqueductal gray matter are involved in the expression of opiate withdrawal.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aminosalicylic Acids; Animals; Enzyme Inhibitors; Iso | 1995 |
Protein kinases in the rat nucleus accumbens are involved in the aversive component of opiate withdrawal.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylyl Cyclases; Animals; Avoidance Learning; Behav | 1996 |
The role of glutamate in the locus coeruleus during opioid withdrawal and effects of H-7, a protein kinase inhibitor, on the action of glutamate in rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Butorphanol; Glutamic Acid; Infusions, Paren | 1998 |
Inhibition of the amygdala and hippocampal calcium/calmodulin-dependent protein kinase II attenuates the dependence and relapse to morphine differently in rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amygdala; Animals; Behavior, Animal; Calcium-Calmodul | 2000 |